Agneta Nordberg

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease
    Agneta Nordberg
    Neurotec Department, Division of Molecular Neuropharmacology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Alzheimer Dis Assoc Disord 20:S12-8. 2006
  2. ncbi Toward an early diagnosis and treatment of Alzheimer's disease
    Agneta Nordberg
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Huddinge University Hospital, Stockholm, Sweden
    Int Psychogeriatr 15:223-37. 2003
  3. ncbi [Administration of symptom-relieving drugs in Alzheimer disease is beneficial]
    Agneta Nordberg
    Geriatriska kliniken, Karolinska Universitetssjukhuset, Huddinge
    Lakartidningen 103:369-71. 2006
  4. ncbi PET studies and cholinergic therapy in Alzheimer's disease
    A Nordberg
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Huddinge, Sweden
    Rev Neurol (Paris) 155:S53-63. 1999
  5. ncbi PET imaging of amyloid in Alzheimer's disease
    Agneta Nordberg
    Karolinska Institute, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Lancet Neurol 3:519-27. 2004
  6. ncbi Is amyloid plaque imaging the key to monitoring brain pathology of Alzheimer's disease in vivo?
    Agneta Nordberg
    Neurotec Department, Karolinska Institutet, Karolinska University Hospital Huddinge B84, 141 86 Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 31:1540-3. 2004
  7. ncbi Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw)
    Agneta Nordberg
    Karolinska Institutet, Neurotec, Division of Molecular Neuropharmacology, Huddinge University Hospital, Stockholm, Sweden
    J Neurochem 81:655-8. 2002
  8. ncbi Lovastatin stimulates up-regulation of alpha7 nicotinic receptors in cultured neurons without cholesterol dependency, a mechanism involving production of the alpha-form of secreted amyloid precursor protein
    Jin Xiu
    Neurotec Department, Division of Molecular Neuropharmacology, Karolinska Institutet, Stockholm, Sweden
    J Neurosci Res 82:531-41. 2005
  9. ncbi Selective nicotinic receptor consequences in APP(SWE) transgenic mice
    Ivan Bednar
    Divisions of Molecular Neuropharmacology, Occupational Therapy and Elderly Care Research NEUROTEC, S 141 86 Stockholm, Sweden
    Mol Cell Neurosci 20:354-65. 2002
  10. doi Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers
    Michael Scholl
    Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden
    Neurology 79:229-36. 2012

Collaborators

Detail Information

Publications127 found, 100 shown here

  1. ncbi Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease
    Agneta Nordberg
    Neurotec Department, Division of Molecular Neuropharmacology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Alzheimer Dis Assoc Disord 20:S12-8. 2006
    ..If such experimental in vitro observations can be extrapolated into clinical neuroprotective properties, AChE inhibitors could positively modulate the disease course of AD...
  2. ncbi Toward an early diagnosis and treatment of Alzheimer's disease
    Agneta Nordberg
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Huddinge University Hospital, Stockholm, Sweden
    Int Psychogeriatr 15:223-37. 2003
    ..There is a great optimism for early diagnosis and effective treatment of AD in the future...
  3. ncbi [Administration of symptom-relieving drugs in Alzheimer disease is beneficial]
    Agneta Nordberg
    Geriatriska kliniken, Karolinska Universitetssjukhuset, Huddinge
    Lakartidningen 103:369-71. 2006
  4. ncbi PET studies and cholinergic therapy in Alzheimer's disease
    A Nordberg
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Huddinge, Sweden
    Rev Neurol (Paris) 155:S53-63. 1999
    ....
  5. ncbi PET imaging of amyloid in Alzheimer's disease
    Agneta Nordberg
    Karolinska Institute, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Lancet Neurol 3:519-27. 2004
    ..Additional compounds will probably be developed that are suitable not only for PET but also for single photon emission CT (SPECT)...
  6. ncbi Is amyloid plaque imaging the key to monitoring brain pathology of Alzheimer's disease in vivo?
    Agneta Nordberg
    Neurotec Department, Karolinska Institutet, Karolinska University Hospital Huddinge B84, 141 86 Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 31:1540-3. 2004
  7. ncbi Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw)
    Agneta Nordberg
    Karolinska Institutet, Neurotec, Division of Molecular Neuropharmacology, Huddinge University Hospital, Stockholm, Sweden
    J Neurochem 81:655-8. 2002
    ..These results indicate that nicotine may effectively reduce amyloid beta peptide aggregation in brain and that nicotinic drug treatment may be a novel protective therapy in Alzheimer's disease...
  8. ncbi Lovastatin stimulates up-regulation of alpha7 nicotinic receptors in cultured neurons without cholesterol dependency, a mechanism involving production of the alpha-form of secreted amyloid precursor protein
    Jin Xiu
    Neurotec Department, Division of Molecular Neuropharmacology, Karolinska Institutet, Stockholm, Sweden
    J Neurosci Res 82:531-41. 2005
    ..We also show that the up-regulation of alpha7 nAChRs stimulated by lovastatin is involved in a mechanism that enhances production of alphaAPPs during APP processing...
  9. ncbi Selective nicotinic receptor consequences in APP(SWE) transgenic mice
    Ivan Bednar
    Divisions of Molecular Neuropharmacology, Occupational Therapy and Elderly Care Research NEUROTEC, S 141 86 Stockholm, Sweden
    Mol Cell Neurosci 20:354-65. 2002
    ..The upregulation of the nAChRs probably reflects compensatory mechanisms in response to Abeta burden in the brains of Tg+ mice...
  10. doi Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers
    Michael Scholl
    Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden
    Neurology 79:229-36. 2012
    ..To investigate the particular pathology of the Arctic APP (APParc) early-onset familial Alzheimer disease (eoFAD) mutation for the first time in vivo with PET in comparison with other eoFAD mutations and sporadic Alzheimer disease (sAD)...
  11. ncbi Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice
    Ewa Hellström-Lindahl
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge B84, S 141 86 Stockholm, Sweden
    Eur J Neurosci 19:2703-10. 2004
    ..Further studies are required to identify potential mechanisms of the nicotine's amyloid-reducing effect...
  12. doi Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease
    Taher Darreh-Shori
    Division of Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 34:2465-81. 2013
    ..Further studies are needed to explore the therapeutic potential of manipulating BuChE activity or astroglial functional status...
  13. doi Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease
    Maria Eriksdotter-Jonhagen
    Departments of Neurobiology, Caring Sciences and Society, Karolinska Institutet, Stockholm, Sweden maria eriksdotter jonhagen ki se
    Dement Geriatr Cogn Disord 33:18-28. 2012
    ..Here we report the results of a first-in-man study of encapsulated cell (EC) biodelivery of NGF to the basal forebrain of AD patients with the primary objective to explore safety and tolerability...
  14. ncbi Effect of subchronic treatment of memantine, galantamine, and nicotine in the brain of Tg2576 (APPswe) transgenic mice
    Christina Unger
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Pharmacol Exp Ther 317:30-6. 2006
    ..These different effects might have therapeutic relevance, and this knowledge might be applicable to the development of new effective therapeutic strategies for AD...
  15. ncbi Higher expression of alpha7 nicotinic acetylcholine receptors in human fetal compared to adult brain
    Lena Falk
    Neurotec Department, Division of Molecular Neuropharmacology, Huddinge University Hospital, S 141 86, Stockholm, Sweden
    Brain Res Dev Brain Res 142:151-60. 2003
    ..The high expression of alpha7 nicotinic acetylcholine receptors in fetal compared to adult brain supports the view that these receptors play an important role during brain development...
  16. pmc ³H-deprenyl and ³H-PIB autoradiography show different laminar distributions of astroglia and fibrillar β-amyloid in Alzheimer brain
    Amelia Marutle
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum floor 5, Stockholm S 14186, Sweden
    J Neuroinflammation 10:90. 2013
    ..This information could aid the development of specific biomarkers to accurately chart disease progression...
  17. pmc Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels
    Anna M Lilja
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e58752. 2013
    ..In contrast, lowering Aβ levels in Tg2576 mice when Aβ plaque pathology is prominent mainly alters the levels of proinflammatory cytokines and chemokines...
  18. doi Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo
    Taher Darreh-Shori
    Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 32:2320.e15-32. 2011
    ....
  19. doi Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease
    Ahmadul Kadir
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Neurobiol Aging 33:198.e1-14. 2012
    ..The rCMRglc starts to decline in MCI patients and became more pronounced in clinical stage which related to continuous decline in cognition...
  20. ncbi Changes in brain 11C-nicotine binding sites in patients with mild Alzheimer's disease following rivastigmine treatment as assessed by PET
    Ahmadul Kadir
    Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, Novum floor 5, 141 86, Stockholm, Sweden
    Psychopharmacology (Berl) 191:1005-14. 2007
    ..Thus, we used positron emission tomography (PET) technique as a sensitive approach to assess longitudinal changes in the nicotine binding sites in the brains of patients with AD...
  21. ncbi PET imaging of amyloid deposition in patients with mild cognitive impairment
    Anton Forsberg
    Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
    Neurobiol Aging 29:1456-65. 2008
    ..01). The PIB retention in MCI converters was comparable to AD patients (p>0.01). Correlations were observed in the MCI patients between PIB retention and CSF Abeta(1-42), total Tau and episodic memory, respectively...
  22. ncbi Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord
    E Hellström-Lindahl
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden
    Brain Res Dev Brain Res 108:147-60. 1998
    ..The early presence of nAChR proteins and gene transcripts shown in the present study suggests an important role for nAChRs in modulating dendritic outgrowth, establishment of neuronal connections and synaptogenesis during development...
  23. doi Time course of glucose metabolism in relation to cognitive performance and postmortem neuropathology in Met146Val PSEN1 mutation carriers
    Michael Scholl
    Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 24:495-506. 2011
    ..We here show that FDG PET can depict in vivo the aggressive disease progression in eoFAD mutation carriers in relationship to neuropathology...
  24. doi Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity
    Fuxiang Bao
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 33:825.e1-13. 2012
    ..These novel findings suggest that distinct Aβ oligomers induce impairment of cholinergic neurotransmission in AD pathogenesis...
  25. doi Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice
    Monika M Hedberg
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Neurodegener Dis 7:379-88. 2010
    ..In this study, the aim was to investigate whether HX could affect the AD-related neuropathology in vivo in two mouse models...
  26. doi Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue
    Ruiqing Ni
    Alzheimer Neurobiology Centre, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Brain 136:2217-27. 2013
    ..BF-227 shows mainly binding to site 3 and FDDNP shows only some binding to site 2. Different amyloid tracers may provide new insight into the pathophysiological mechanisms in the progression of Alzheimer's disease...
  27. ncbi High selective expression of alpha7 nicotinic receptors on astrocytes in the brains of patients with sporadic Alzheimer's disease and patients carrying Swedish APP 670/671 mutation: a possible association with neuritic plaques
    Wen Feng Yu
    Division of Molecular Neuropharmacology, Neurotec Department, Karolinska Institutet, Karolinska University Hospital Huddinge, B84, S 141 86 Stockholm, Sweden
    Exp Neurol 192:215-25. 2005
    ..The elevated expression of alpha7 nAChR on astrocytes might participate in Abeta cascade and formation of neuritic plaques, thereby playing an important role in the pathogenesis of AD...
  28. ncbi Expression of the alpha7, alpha4 and alpha3 nicotinic receptor subtype in the brain and adrenal medulla of transgenic mice carrying genes coding for human AChE and beta-amyloid
    Malahat Mousavi
    Karolinska Institute, Department of Neurotec, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, Novum 5th floor, S 14186 Stockholm, Sweden
    Int J Dev Neurosci 24:269-73. 2006
    ..The findings may have implications for a better understanding the underlying mechanism for AD-related pathogenesis...
  29. ncbi Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain
    E Hellström-Lindahl
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Molecular Neuropharmacology, Karolinska Institute, Huddinge University Hospital, S 14186 Huddinge, Sweden
    Brain Res Mol Brain Res 66:94-103. 1999
    ..The increased mRNA level of alpha7 previously found in lymphocytes, and now also in the hippocampus of AD patients, indicate that subunit specific changes in gene expression of nAChRs is associated with AD...
  30. doi Combination of 18F-FDG PET and cerebrospinal fluid biomarkers as a better predictor of the progression to Alzheimer's disease in mild cognitive impairment patients
    Il Han Choo
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 33:929-39. 2013
    ..In conclusion, our findings highlight that the combination of regional glucose metabolic assessment by PET and CSF biomarkers evaluation can significantly improve AD predictive diagnostic accuracy of each respective method...
  31. ncbi Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells
    Zhi zhong Guan
    Division of Molecular Neuropharmacology, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Karolinska Institutet, Huddinge University Hospital B84, SE 141 86 Stockholm, Sweden
    Neurochem Int 43:243-9. 2003
    ..Generally, high dose of nicotine may induce neurotoxicity and stimulate oxidative stress, while reasonably low concentration may act as an antioxidant and play an important role for neuroprotective effect...
  32. doi The use of PIB-PET as a dual pathological and functional biomarker in AD
    Anton Forsberg
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
    Biochim Biophys Acta 1822:380-5. 2012
    ..This might be important for diagnosis of AD, enrichment of patients in clinical trials and evaluation of treatment effects. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease...
  33. ncbi Retinoic acid and nerve growth factor induce differential regulation of nicotinic acetylcholine receptor subunit expression in SN56 cells
    Mats Nilbratt
    Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Neurosci Res 85:504-14. 2007
    ..The present results show that RA and NGF have different effects on the expression of ChAT and the morphology and the expression pattern of different nAChR subunits in cholinergic SN56 cells...
  34. pmc A European multicentre PET study of fibrillar amyloid in Alzheimer's disease
    Agneta Nordberg
    Alzheimer Neurobiology Centre, Geriatric Clinic, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 40:104-14. 2013
    ..To serve as an early biomarker in AD the amyloid PET tracers need to be analysed in multicentre clinical studies...
  35. doi Modulation of α7 nicotinic acetylcholine receptor and fibrillar amyloid-β interactions in Alzheimer's disease brain
    Ruiqing Ni
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 33:841-51. 2013
    ....
  36. pmc Neurotrophic and neuroprotective actions of (-)- and (+)-phenserine, candidate drugs for Alzheimer's disease
    Anna M Lilja
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    PLoS ONE 8:e54887. 2013
    ....
  37. ncbi Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons
    Mats Nilbratt
    Karolinska Institutet, Karolinska University Hospital Huddinge, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
    J Cell Mol Med 14:1476-84. 2010
    ....
  38. pmc Β-amyloid 1-42 oligomers impair function of human embryonic stem cell-derived forebrain cholinergic neurons
    Linn Wicklund
    Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e15600. 2010
    ..We propose that it may be possible for future AD therapies to promote the maturation of functional stem cell-derived neurons by altering the brain microenvironment with trophic support and by targeting different aggregation forms of Aβ...
  39. doi Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease
    Ahmadul Kadir
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Sweden
    Ann Neurol 63:621-31. 2008
    ....
  40. pmc Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients
    Agneta Nordberg
    Karolinska Institute, Division of Alzheimer Neurobiology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Alzheimer Res 6:4-14. 2009
    ....
  41. pmc Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease
    Ahmadul Kadir
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Brain 134:301-17. 2011
    ....
  42. ncbi Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia
    A Marutle
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, S-141 86, Stockholm, Sweden
    J Chem Neuroanat 22:115-26. 2001
    ....
  43. ncbi Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice
    W F Yu
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Neuroscience 146:1618-28. 2007
    ..These data suggest that increased levels of alpha4, alpha3-containing nAChRs, co-assembled with the alpha5 nAChR subunit, may contribute to the normal brain development of alpha7 -/- and alpha7 +/- mice...
  44. ncbi Effects of statins on alpha7 nicotinic receptor, cholinesterase and alpha-form of secreted amyloid precursor peptide in SH-SY5Y cells
    Julia Roensch
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Stockholm, Sweden
    Neurochem Int 50:800-6. 2007
    ....
  45. ncbi Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the alpha7, alpha4 and beta2 subunits in response to nanomolar concentrations of the beta-amyloid peptide(1-42)
    Jin Xiu
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, B84, S 14186 Stockholm, Sweden
    Neurochem Int 47:281-90. 2005
    ..We propose that the enhanced expression of alpha7, alpha4 and beta2 nAChRs by astrocytes stimulated directly by nanomolar concentrations of Abeta(1-42) might be related to ongoing defensive or compensative mechanisms...
  46. ncbi Selective changes in the levels of nicotinic acetylcholine receptor protein and of corresponding mRNA species in the brains of patients with Parkinson's disease
    Zhi zhong Guan
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, S 141 86 Stockholm, Sweden
    Brain Res 956:358-66. 2002
    ..These findings reveal selective losses of the alpha3- and beta2-containing nAChRs and an increase in the alpha7 nAChRs that might be related to the pathogenesis of PD...
  47. ncbi Neuronal nicotinic and muscarinic receptor subtypes at different ages of transgenic mice overexpressing human acetylcholinesterase
    Marie M Svedberg
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Neurosci Lett 340:148-52. 2003
    ....
  48. doi Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG
    Stephen F Carter
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Nucl Med 53:37-46. 2012
    ..Along with (11)C-DED PET, (11)C-Pittsburgh compound B ((11)C-PIB; fibrillar Aβ deposition), (18)F-FDG (glucose metabolism), T1 MRI, cerebrospinal fluid, and neuropsychologic data were acquired from the patients...
  49. ncbi Effect of subchronic galantamine treatment on neuronal nicotinic and muscarinic receptor subtypes in transgenic mice overexpressing human acetylcholinesterase
    Marie M Svedberg
    Division of Molecular Neuropharmacology, Department of Neurotec, Karolinska Institutet, Huddinge University Hospital B84, S 141 86 Stockholm, Sweden
    Neuropharmacology 47:558-71. 2004
    ..This study shows regional and receptor subtype specific changes in the nicotinic receptor subtypes compared to the muscarinic receptors following galantamine treatment in FVB/N and hAChE-Tg mice...
  50. ncbi Selective changes in expression of different nicotinic receptor subtypes in brain and adrenal glands of mice carrying human mutated gene for APP or over-expressing human acetylcholinestrase
    Malahat Mousavi
    Department of Neurotec, Division of Molecular Neuropharmacology, Karolinska Institute, Karolinska University Hospital, Huddinge B84, S 141 86 Stockholm, Sweden
    Int J Dev Neurosci 22:545-9. 2004
    ..Deposition of beta-amyloid (Abeta) may impair neurotransmitter activity in brain as well as in the adrenal gland...
  51. ncbi Influence of cholesterol and lovastatin on alpha-form of secreted amyloid precursor protein and expression of alpha7 nicotinic receptor on astrocytes
    Jin Xiu
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, 141 86 Stockholm, Sweden
    Neurochem Int 49:459-65. 2006
    ....
  52. ncbi Elevated levels of Abeta1-40 and Abeta1-42 do not alter the binding sites of nicotinic receptor subtypes in the brain of APPswe and PS1 double transgenic mice
    Amelia Marutle
    Division of Molecular Neuropharmacology, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Karolinska Institutet, Huddinge University Hospital, B84, 141 86, Stockholm, Sweden
    Neurosci Lett 328:269-72. 2002
    ..The findings indicate that elevated Abeta levels in the brains of APPswe/PS1 mice do not alter the number of alpha4beta2 and alpha7 receptors, the two major brain nAChR subtypes...
  53. ncbi Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesterase
    Marie M Svedberg
    Karolinska Institutet, Neurotec, Division of Molecular Neuropharmacology, Huddinge University Hospital, Stockholm, Sweden
    J Mol Neurosci 18:211-22. 2002
    ....
  54. ncbi Cerebral glucose metabolism, cerebrospinal fluid-beta-amyloid1-42 (CSF-Abeta42), tau and apolipoprotein E genotype in long-term rivastigmine and tacrine treated Alzheimer disease (AD) patients
    E Stefanova
    Karolinska Institutet, Department of Clinical Neuroscience Occupational Therapy and Elderly Care Research NEUROTEC, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, 141 86, Stockholm, Sweden
    Neurosci Lett 338:159-63. 2003
    ..There was no significant change in Abeta42 after 1-year treatment with either rivastigmine or tacrine. This study shows that the two long-term cholinesterase inhibitor treatments exert different effects on biological markers for AD...
  55. ncbi PET imaging of cortical 11C-nicotine binding correlates with the cognitive function of attention in Alzheimer's disease
    Ahmadul Kadir
    Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge, Novum floor 5, Stockholm, 141 86, Sweden
    Psychopharmacology (Berl) 188:509-20. 2006
    ..The alpha4 and alpha7 nAChR subunits were suggested to play an important role in cognitive function. Positron emission tomography (PET) has so far been used to visualize neuronal nAChRs in vivo by 11C-nicotine binding...
  56. ncbi Early changes in Abeta levels in the brain of APPswe transgenic mice--implication on synaptic density, alpha7 neuronal nicotinic acetylcholine- and N-methyl-D-aspartate receptor levels
    Christina Unger
    Karolinska Institutet, Department of Neurotec, Division of Molecular Neuropharmacology, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Mol Cell Neurosci 30:218-27. 2005
    ..The results may provide important information about the onset and consequences of Abeta pathology in this transgenic mouse model...
  57. ncbi Suppressed expression of nicotinic acetylcholine receptors by nanomolar beta-amyloid peptides in PC12 cells
    Z Z Guan
    Division of Molecular Neuropharmacology, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    J Neural Transm 108:1417-33. 2001
    ..The results presented in this study lead to a hypothesis that Abeta can degenerate nAChRs early in the course of AD before the formation of abundant Abeta fibrils...
  58. ncbi Regional distribution of subtypes of nicotinic receptors in human brain and effect of aging studied by (+/-)-[3H]epibatidine
    A Marutle
    Department of Neuroscience and Family Medicine, Division of Molecular Neuropharmacology, Karolinska Institutet, Huddinge University Hospital, B 84 Huddinge S 141 86, Sweden
    Brain Res 801:143-9. 1998
    ..The findings indicate that a specifically modulate regional nicotinic receptors in human brain...
  59. doi Apolipoprotein ε4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer's disease
    Taher Darreh-Shori
    Division of Alzheimer Neurobiology Center, Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
    J Alzheimers Dis 28:443-58. 2012
    ..APOE4-dependent outcome of BCHE-K genotype as AD risk factor arises through a differential phenotypic modulation of BuChE. Future pharmacogenetic studies should include assessment of the subjects' true phenotypic display of BuChE...
  60. doi Characterization of the brain β-amyloid isoform pattern at different ages of Tg2576 mice
    Tamanna Mustafiz
    Division of Alzheimer Neurobiology, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    Neurodegener Dis 8:352-63. 2011
    ..Our objective was to investigate the consequences of Aβ, especially on tau phosphorylation at specific epitopes important for Alzheimer's disease...
  61. doi Functional interactions of fibrillar and oligomeric amyloid-β with alpha7 nicotinic receptors in Alzheimer's disease
    Anna M Lilja
    Karolinska Institutet, Division of Alzheimer Neurobiology, Department of Neurobiology, Care Sciences and Society, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Alzheimers Dis 23:335-47. 2011
    ..Our findings demonstrate that fibrillar Aβ exerts neurotoxic effects mediated partly through a blockade of α7 nAChRs, whilst oligomeric Aβ may act as a ligand activating α7 nAChRs, thereby stimulating downstream signaling pathways...
  62. ncbi Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients
    T Darreh-Shori
    Karolinska Institute, Neurotec Department, Stockholm, Sweden
    J Neurochem 88:1102-13. 2004
    ..0001). Thus, evaluation of changes in the composition of CSF AChE variants may yield important information referring to the therapeutic efficacy and/or development of drug tolerance in AD patients treated with anti-cholinesterases...
  63. ncbi Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months
    T Darreh-Shori
    Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Neurology 59:563-72. 2002
    ..To study the long-term dual inhibitory effects of rivastigmine on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in patients with AD...
  64. ncbi Longitudinal changes in quantitative EEG during long-term tacrine treatment of patients with Alzheimer's disease
    V Jelic
    Karolinska Institute, Department of Clinical Neuroscience and Family Medicine, Huddinge University Hospital, Sweden
    Neurosci Lett 254:85-8. 1998
    ..These findings suggest that slowing in fast EEG frequencies during chronic treatment with AChE inhibitors may provide an early indicator of declining treatment efficiency...
  65. doi Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation
    Michael Scholl
    Division of Alzheimer Neurobiology, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 32:1388-99. 2011
    ..Global cortical CMRglc and cognition were distinctly decreased. PIB binding was comparable with sporadic AD patterns but showing slightly higher striatal levels...
  66. doi The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase
    Taher Darreh-Shori
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Sweden
    Neurobiol Aging 32:1236-48. 2011
    ..In conclusion, ApoE ε4 might impart its pathological role through high protein expression and interaction with BuChE, which in turn might modulate central cholinergic activity and Aβ load in the brain...
  67. ncbi Amyloid imaging in Alzheimer's disease
    Agneta Nordberg
    Karolinska Institutet, Division of Molecular Neuropharmacology, Department of Neurobiology, Care Sciences and Society, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Opin Neurol 20:398-402. 2007
    ..This paper reviews the progress in developing amyloid imaging ligands to be used to measure amyloid in vivo in the brain of patients with Alzheimer's disease...
  68. ncbi Influence of lipid peroxidation on the nicotinic acetylcholine receptors in PC12 cells
    Z Guan
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Molecular Neuropharmacology, Huddinge University Hospital B84, Karolinska Institutet, S 141 86, Huddinge, Sweden
    Neurosci Lett 286:163-6. 2000
    ..These results demonstrate that lipid peroxidation in cellular membranes can induce a reduction in numbers of neuronal nAChRs...
  69. ncbi Expression of nicotinic acetylcholine receptors in human and rat adrenal medulla
    M Mousavi
    Karolinska Institutet, Department of Neurotec, Huddinge University Hospital, Stockholm, Sweden
    Life Sci 70:577-90. 2001
    ..Sub-chronic treatment of nicotine to rats did not influence level of the nAChRs in the adrenal medulla. In conclusion, the expression of nAChRs in adrenal medulla is age- related and species dependent...
  70. ncbi Longitudinal PET evaluation of cerebral glucose metabolism in rivastigmine treated patients with mild Alzheimer's disease
    E Stefanova
    Division of Molecular Neuropharmacology, Neurotec Department, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Neural Transm 113:205-18. 2006
    ..5-12'mg) of rivastigmine. These results suggest a stabilization effect of rivastigmine on CMRglc in mild AD patients receiving long-term rivastigmine treatment...
  71. ncbi Correlation of oxidative stress and the loss of the nicotinic receptor alpha 4 subunit in the temporal cortex of patients with Alzheimer's disease
    Wen Feng Yu
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, S 141 86 Stockholm, Sweden
    Neurosci Lett 338:13-6. 2003
    ..We suggest that lipid peroxidation might be a sensitive target in AD brain and related the mechanism of the loss of the nAChR alpha4 subunit in the disease...
  72. doi Long-term effects of galantamine treatment on brain functional activities as measured by PET in Alzheimer's disease patients
    Connor Keller
    Division of Alzheimer Neurobiology, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Alzheimers Dis 24:109-23. 2011
    ..This stabilization in rCMRglc was also correlated with a stabilization of cognition. Our results ultimately suggest that treatment with galantamine has a long-term positive effect on brain perfusion and rCMRglc and stabilizes cognition...
  73. doi The use of PET in Alzheimer disease
    Agneta Nordberg
    Division of Alzheimer Neurobiology, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital Huddinge, Novum, Stockholm, Sweden
    Nat Rev Neurol 6:78-87. 2010
    ..For the near future, multitracer PET studies are unlikely to be used routinely in the clinic for AD, being both burdensome and expensive; however, such studies are very informative in a research context...
  74. ncbi Smoking during pregnancy: a way to transfer the addiction to the next generation?
    Ewa Hellström-Lindahl
    Karolinska Institutet, Neurotec, Division of Molecular Neuropharmacology, Huddinge University Hospital, Stockholm, Sweden
    Respiration 69:289-93. 2002
    ..A direct specific action on the developing human brain is plausible during the major part of the prenatal life, since the nicotinic receptors are already present in the brain during the first trimester...
  75. ncbi Loss of nicotinic receptors induced by beta-amyloid peptides in PC12 cells: possible mechanism involving lipid peroxidation
    Zhi zhong Guan
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Molecular Neuropharmacology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    J Neurosci Res 71:397-406. 2003
    ..These findings suggest that lipid peroxidation stimulated by A betas might be a mechanism for the loss of nAChRs associated with the pathogenesis of AD...
  76. pmc Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation
    Marjan Shafaati
    Department of Laboratory Medicine Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Huddinge, Sweden
    J Lipid Res 52:1004-10. 2011
    ..We discuss the possibility of a vicious circle in the brains of the patients with familial AD whereby neurodegenerative changes cause an accumulation of 27OHC that further accelerates neurodegeneration...
  77. ncbi Modulation of dopamine release by the nicotinic agonist epibatidine in the frontal cortex and the nucleus accumbens of naive and chronic nicotine treated rats
    Ivan Bednar
    Department of Neurotec, Division of Molecular Neuropharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, SE 14186 Stockholm, Sweden
    Neurochem Int 45:1049-55. 2004
    ..Different mechanisms in modulation of DA release appears to be involved in the rat brain by (+/-)epibatidine compare to (-)nicotine...
  78. ncbi Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment
    E Arnaiz
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy, and Elderly Care Research NEUROTEC, Huddinge University Hospital, Sweden
    Neuroreport 12:851-5. 2001
    ..Measures of temporoparietal cerebral metabolism and visuospatial function may aid in predicting the evolution to AD for patients with MCI...
  79. doi Amyloid plaque imaging in vivo: current achievement and future prospects
    Agneta Nordberg
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska University Hospital Huddinge, Novum 5th floor, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 35:S46-50. 2008
    ..Despite a probable whole cascade of events in the brain leading to impairment of cognition, amyloid is still the target for diagnosis and treatment...
  80. ncbi Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
    ....
  81. ncbi Reduced levels of Abeta 40 and Abeta 42 in brains of smoking controls and Alzheimer's patients
    E Hellström-Lindahl
    Department of Neurotec, Division of Molecular Neuropharmacology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Neurobiol Dis 15:351-60. 2004
    ..These results indicate that selective nicotinic receptor agonists may be a novel protective therapy in AD by reducing Abeta levels as well as the loss of nicotinic receptors in AD brain...
  82. ncbi Reduced expression of neuronal nicotinic acetylcholine receptors during the early stages of damage by oxidative stress in PC12 cells
    Z Z Guan
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Molecular Neuropharmacology, Huddinge University Hospital, Karolinska Institutet, S 14136 Stockholm, Sweden
    J Neurosci Res 66:551-8. 2001
    ....
  83. ncbi Nicotine-induced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain
    E Hellström-Lindahl
    Department of Clinical Neuroscience, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Neuroscience 105:527-34. 2001
    ..These findings support the assumption of a potential risk of disturbance in the functional role of nicotinic receptors during brain development as a consequence of maternal smoking during pregnancy...
  84. ncbi Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism
    T Darreh-Shori
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Stockholm, Sweden
    Neurobiol Dis 24:326-33. 2006
    ..Thus, low BuChE in a patient's CSF may predict extensive incorporation in neuritic plaques, increased neurotoxicity and greater central neurodegeneration...
  85. ncbi Chronic treatments with tacrine and (-)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat
    X Zhang
    Division of Molecular Neuropharmacology, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    J Neural Transm 109:377-92. 2002
    ..These data differ from what have been earlier observed in the brain of young adult rat following tacrine treatment, revealing some dynamic changes in receptor properties in the brain during aging...
  86. ncbi Smoking during early pregnancy affects the expression pattern of both nicotinic and muscarinic acetylcholine receptors in human first trimester brainstem and cerebellum
    L Falk
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, S 141 86, Stockholm, Sweden
    Neuroscience 132:389-97. 2005
    ..The findings indicate that early prenatal nicotine exposure affects the normal developmental pattern of the cholinergic system in human fetal brain...
  87. ncbi Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer's disease
    V Jelic
    Karolinska Institutet, Neurotec, Division of Geriatric Medicine, B 84, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    Neurobiol Aging 21:533-40. 2000
    ....
  88. ncbi Preserved cognitive function after 12 months of treatment with rivastigmine in mild Alzheimer's disease in comparison with untreated AD and MCI patients
    O Almkvist
    Neurotec Department, Karolinska Institutet, Stockholm, Sweden
    Eur J Neurol 11:253-61. 2004
    ..In conclusion, a clear beneficial effect of rivastigmine was shown on cognitive function for patients with mild AD and plasma values of ChE inhibition were associated with attention...
  89. ncbi Transgenic mice as a model for Alzheimer's disease
    Christina Unger Lithner
    Karolinska Institutet, NVS, Division of Alzheimer Neurobiology, Novum Floor 4, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Curr Alzheimer Res 8:818-31. 2011
    ....
  90. doi Target-specific PET probes for neurodegenerative disorders related to dementia
    Ahmadul Kadir
    Division of Alzheimer Neurobiology, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Nucl Med 51:1418-30. 2010
    ..The development of molecular imaging is important for early diagnosis of dementia, selection of patients for therapies, and evaluation of therapies...
  91. ncbi Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice
    Nagat Abbas
    Division of Geriatric Medicine B84, Karolinska Institute, Huddinge University Hospital, S 141 86 Stockholm, Sweden
    J Neuroimmunol 126:50-7. 2002
    ..These observations call for further studies on the potential role of anti-inflammatory therapeutic strategies for AD...
  92. doi Amyloid imaging in early detection of Alzheimer's disease
    Agneta Nordberg
    Division of Alzheimer Neurobiology, Karolinska Institutet, Karolinska University Hospital Huddinge, Novum 5th floor, SE 141 86 Stockholm, Sweden
    Neurodegener Dis 7:136-8. 2010
    ..PET Abeta imaging will also be used for discrimination of AD from other dementia disorders, as well for the evaluation of anti-Abeta drugs...
  93. ncbi Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum-free suspension and adherent cultures
    Roxana Nat
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Huddinge, Sweden
    Glia 55:385-99. 2007
    ..Our system successfully generates human RG cells and could be an effective source for neuronal replacement, since RG cells predominantly generate neurons and provide them with support and guidance...
  94. doi Amyloid imaging in Alzheimer's disease
    Agneta Nordberg
    Karolinska Institutet, Division of Alzheimer Neurobiology, and Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Novum 5th floor, S 141 86 Stockholm, Sweden
    Neuropsychologia 46:1636-41. 2008
    ..This opens up new possibilities for early diagnosis as well as new tools for monitoring anti-amyloid therapy in AD...
  95. ncbi Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease
    M Mousavi
    Karolinska Institute, Department of Neurotec, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, 141 86, Stockholm, Sweden
    Neuroscience 122:515-20. 2003
    ..The up-regulation of nAChRs in smoking groups and the loss of these receptors in AD patients were not correlated to any changes at the mRNA level suggesting that these changes may reflect post-transcriptional events...
  96. ncbi Development of ligands for in vivo imaging of cerebral nicotinic receptors
    W Sihver
    Department of Medical Pharmacology, Karolinska Institute, Huddinge Hospital, Sweden
    Behav Brain Res 113:143-57. 2000
    ..Analogs of A-85380 appear to be the most promising candidates because of their low toxicity and high selectivity for the alpha4beta2 subtype of nAChRs...
  97. ncbi PET imaging of the in vivo brain acetylcholinesterase activity and nicotine binding in galantamine-treated patients with AD
    A Kadir
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Neurobiol Aging 29:1204-17. 2008
    ..At the individual level, the in vivo cortical AChE inhibition and (11)C-nicotine binding were associated with changes in the attention domain of cognition rather than episodic memory...
  98. ncbi A follow-up study of the family with the Swedish APP 670/671 Alzheimer's disease mutation
    L O Wahlund
    Department of Clinical Neuroscience and Family Medicine, Division of Geriatric Medicine, B 56, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden
    Dement Geriatr Cogn Disord 10:526-33. 1999
    ..To study the progression of Alzheimer's disease (AD) at a very early stage and to evaluate clinical markers of presymptomatic AD...
  99. ncbi Inhibition of acetylcholinesterase in CSF versus brain assessed by 11C-PMP PET in AD patients treated with galantamine
    T Darreh-Shori
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Division of Molecular Neuropharmacology, Novum, 5th Floor, 141 86 Stockholm, Sweden
    Neurobiol Aging 29:168-84. 2008
    ..A positive cognitive response seems to dependent on the AChE inhibition level, which is balanced by an increased protein level of the AChE-R variant in the patients...
  100. ncbi The alpha7 nicotinic receptors in human fetal brain and spinal cord
    Lena Falk
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Neurochem 80:457-65. 2002
    ..The increasing levels of the alpha7 nicotinic acetylcholine receptor during the first trimester support the important role of nAChRs for the development of the central nervous system...
  101. doi The future: new methods of imaging exploration in Alzheimer's disease
    Agneta Nordberg
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Front Neurol Neurosci 24:47-53. 2009
    ....