Research Topics
Genomes and Genes | Ola NilssonSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
Gradients in bone morphogenetic protein-related gene expression across the growth plateOla Nilsson
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Endocrinol 193:75-84. 2007..Thus, BMP signaling gradients may be a key mechanism responsible for spatial regulation of chondrocyte proliferation and differentiation in growth plate cartilage...- Depletion of resting zone chondrocytes during growth plate senescenceLenneke Schrier
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, CRC, Room 1-3330, 10 Center Drive, MSC 1103, Bethesda, Maryland 20892, USA
J Endocrinol 189:27-36. 2006..We speculate that estrogen might accelerate senescence by a proliferation-independent mechanism, or by increasing the loss of proliferative capacity per cell cycle... 
Spatial and temporal regulation of gene expression in the mammalian growth plateJulian C K Lui
Developmental Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Bone 46:1380-90. 2010....- An extensive genetic program occurring during postnatal growth in multiple tissuesGabriela P Finkielstain
Developmental Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
Endocrinology 150:1791-800. 2009.... 
Growth-inhibiting conditions slow growth plate senescencePatricia Forcinito
Developmental Endocrinology Branch, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, CRC, Room 1 3330, 10 Center Drive, MSC 1103, Bethesda, Maryland 20892 1103, USA
J Endocrinol 208:59-67. 2011....- Catch-up growth after hypothyroidism is caused by delayed growth plate senescenceRose Marino
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, MD 20892 1103, USA
Endocrinology 149:1820-8. 2008..The findings demonstrate that growth inhibition due to hypothyroidism slows the developmental program of growth plate senescence, including the normal decline in the rate of longitudinal bone growth, thus accounting for catch-up growth... - Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiationAnenisia C Andrade
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Bone 40:1361-9. 2007..The six identified Wnt genes showed a similar pattern of expression during chondrocyte differentiation, suggesting overlapping or interacting roles in postnatal endochondral bone formation... - The role of p27Kip1 in the regulation of growth plate chondrocyte proliferation in miceJoyce A M Emons
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Pediatr Res 60:288-93. 2006.... - Growth plate senescence is associated with loss of DNA methylationOla Nilsson
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Endocrinol 186:241-9. 2005.... - Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate heightJulian C Lui
Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Hum Mol Genet 21:5193-201. 2012.... - Endocrine regulation of the growth plateOla Nilsson
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1862, USA
Horm Res 64:157-65. 2005..This review provides an overview of the endocrine signals that regulate longitudinal bone growth, their interactions, and the mechanisms by which they affect growth plate chondrogenesis... - Lack of telomere shortening with age in mouse resting zone chondrocytesBenjamin U Nwosu
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
Horm Res 63:125-8. 2005..Previous studies suggest that growth plate chondrocytes have a finite proliferative capacity in vivo. We therefore hypothesized that telomere shortening in resting zone chondrocytes leads to replicative senescence... - Fibroblast growth factor expression in the postnatal growth plateJacob E Lazarus
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Bone 40:577-86. 2007..We also found temporal changes in FGF and FGFR expression which may contribute to growth plate senescence and thus help determine the size of the adult skeleton... - Growth plate senescence and catch-up growthJulian C Lui
Developmental Endocrinology Branch, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1103, USA
Endocr Dev 21:23-9. 2011..Consequently, growth plates are less senescent after these conditions resolve and therefore grow more rapidly than is normal for age, resulting in catch-up growth... - Impact of growth plate senescence on catch-up growth and epiphyseal fusionOla Nilsson
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Pediatr Nephrol 20:319-22. 2005..This concept has provided insight into clinical phenomena including catch-up growth after transient growth inhibition, catch-down growth after transient estrogen exposure, and epiphyseal fusion... - The role of the resting zone in growth plate chondrogenesisVeronica Abad
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 10N262, 10 Center Drive MSC 1862, Bethesda, MD 20892, USA
Endocrinology 143:1851-7. 2002.... - Fundamental limits on longitudinal bone growth: growth plate senescence and epiphyseal fusionOla Nilsson
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Trends Endocrinol Metab 15:370-4. 2004..In some mammals, including humans, proliferative exhaustion is followed by epiphyseal fusion, an abrupt event in which the growth plate cartilage is replaced completely by bone... - Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tractYvonne Arvidsson
Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska University Hospital, Gula straket 8, SE 413 45 Goteborg, Sweden
Endocr Relat Cancer 15:569-81. 2008..Identification of APLP1 in NE tumours offers a novel target for treatment and may also serve as a tumour-specific marker... - Raloxifene acts as an estrogen agonist on the rabbit growth plateOla Nilsson
Pediatric Endocrinology Unit, Department of Women and Child Health, Karolinska Institutet, SE 17176 Stockholm, Sweden
Endocrinology 144:1481-5. 2003..As expected, the uterus was enlarged by estrogen, but not raloxifene, treatment. We conclude that raloxifene acts as an estrogen agonist on the growth plate, accelerating growth plate senescence and thus hastening epiphyseal fusion... - Apoptosis is developmentally regulated in rat growth plateDionisios Chrysis
Department of Woman and Child Health, Pediatric Endocrine Unit, Astrid Lindgren Children s Hospital, Karolinska Institute, Stockholm, Sweden
Endocrine 18:271-8. 2002..Our results show that apoptosis is developmentally regulated in the rat growth plate. In older animals, with decreased growth rate and growth plate height, apoptosis is significantly increased, especially in THPCs... - Estrogen receptor-alpha and -beta are expressed throughout postnatal development in the rat and rabbit growth plateOla Nilsson
Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
J Endocrinol 173:407-14. 2002..Therefore, we conclude that ERalpha and ERbeta are both expressed in the mammalian growth plate. The temporal and anatomical pattern suggests that ER expression in the hypertrophic zone in particular may play a role in epiphyseal fusion... - Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferationJenny Nyberg
The Arvid Carlsson Institute for Neuroscience at the Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, 413 45 Goteborg, Sweden
J Neurosci 25:1816-25. 2005..This investigation demonstrates the presence of GIP in the brain for the first time and provides evidence for a regulatory function for GIP in progenitor cell proliferation... - Localization of estrogen receptors-alpha and -beta and androgen receptor in the human growth plate at different pubertal stagesOla Nilsson
Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
J Endocrinol 177:319-26. 2003..05). In summary, our findings suggest that ERalpha, ERbeta and AR are expressed in the human growth plate throughout pubertal development, with no difference between the sexes...