Ola Nilsson

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Gradients in bone morphogenetic protein-related gene expression across the growth plate
    Ola Nilsson
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Endocrinol 193:75-84. 2007
  2. ncbi request reprint Depletion of resting zone chondrocytes during growth plate senescence
    Lenneke Schrier
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, CRC, Room 1 3330, 10 Center Drive, MSC 1103, Bethesda, Maryland 20892, USA
    J Endocrinol 189:27-36. 2006
  3. pmc Spatial and temporal regulation of gene expression in the mammalian growth plate
    Julian C K Lui
    Developmental Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Bone 46:1380-90. 2010
  4. pmc An extensive genetic program occurring during postnatal growth in multiple tissues
    Gabriela P Finkielstain
    Developmental Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    Endocrinology 150:1791-800. 2009
  5. doi request reprint Growth-inhibiting conditions slow growth plate senescence
    Patricia Forcinito
    Developmental Endocrinology Branch, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, CRC, Room 1 3330, 10 Center Drive, MSC 1103, Bethesda, Maryland 20892 1103, USA
    J Endocrinol 208:59-67. 2011
  6. pmc Catch-up growth after hypothyroidism is caused by delayed growth plate senescence
    Rose Marino
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, MD 20892 1103, USA
    Endocrinology 149:1820-8. 2008
  7. pmc Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation
    Anenisia C Andrade
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Bone 40:1361-9. 2007
  8. ncbi request reprint The role of p27Kip1 in the regulation of growth plate chondrocyte proliferation in mice
    Joyce A M Emons
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Pediatr Res 60:288-93. 2006
  9. ncbi request reprint Growth plate senescence is associated with loss of DNA methylation
    Ola Nilsson
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Endocrinol 186:241-9. 2005
  10. pmc Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height
    Julian C Lui
    Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 21:5193-201. 2012

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Gradients in bone morphogenetic protein-related gene expression across the growth plate
    Ola Nilsson
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Endocrinol 193:75-84. 2007
    ..Thus, BMP signaling gradients may be a key mechanism responsible for spatial regulation of chondrocyte proliferation and differentiation in growth plate cartilage...
  2. ncbi request reprint Depletion of resting zone chondrocytes during growth plate senescence
    Lenneke Schrier
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, CRC, Room 1 3330, 10 Center Drive, MSC 1103, Bethesda, Maryland 20892, USA
    J Endocrinol 189:27-36. 2006
    ..We speculate that estrogen might accelerate senescence by a proliferation-independent mechanism, or by increasing the loss of proliferative capacity per cell cycle...
  3. pmc Spatial and temporal regulation of gene expression in the mammalian growth plate
    Julian C K Lui
    Developmental Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Bone 46:1380-90. 2010
    ....
  4. pmc An extensive genetic program occurring during postnatal growth in multiple tissues
    Gabriela P Finkielstain
    Developmental Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    Endocrinology 150:1791-800. 2009
    ....
  5. doi request reprint Growth-inhibiting conditions slow growth plate senescence
    Patricia Forcinito
    Developmental Endocrinology Branch, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, CRC, Room 1 3330, 10 Center Drive, MSC 1103, Bethesda, Maryland 20892 1103, USA
    J Endocrinol 208:59-67. 2011
    ....
  6. pmc Catch-up growth after hypothyroidism is caused by delayed growth plate senescence
    Rose Marino
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, MD 20892 1103, USA
    Endocrinology 149:1820-8. 2008
    ..The findings demonstrate that growth inhibition due to hypothyroidism slows the developmental program of growth plate senescence, including the normal decline in the rate of longitudinal bone growth, thus accounting for catch-up growth...
  7. pmc Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation
    Anenisia C Andrade
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Bone 40:1361-9. 2007
    ..The six identified Wnt genes showed a similar pattern of expression during chondrocyte differentiation, suggesting overlapping or interacting roles in postnatal endochondral bone formation...
  8. ncbi request reprint The role of p27Kip1 in the regulation of growth plate chondrocyte proliferation in mice
    Joyce A M Emons
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Pediatr Res 60:288-93. 2006
    ....
  9. ncbi request reprint Growth plate senescence is associated with loss of DNA methylation
    Ola Nilsson
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Endocrinol 186:241-9. 2005
    ....
  10. pmc Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height
    Julian C Lui
    Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 21:5193-201. 2012
    ....
  11. ncbi request reprint Endocrine regulation of the growth plate
    Ola Nilsson
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1862, USA
    Horm Res 64:157-65. 2005
    ..This review provides an overview of the endocrine signals that regulate longitudinal bone growth, their interactions, and the mechanisms by which they affect growth plate chondrogenesis...
  12. ncbi request reprint Lack of telomere shortening with age in mouse resting zone chondrocytes
    Benjamin U Nwosu
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Horm Res 63:125-8. 2005
    ..Previous studies suggest that growth plate chondrocytes have a finite proliferative capacity in vivo. We therefore hypothesized that telomere shortening in resting zone chondrocytes leads to replicative senescence...
  13. ncbi request reprint Fibroblast growth factor expression in the postnatal growth plate
    Jacob E Lazarus
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Bone 40:577-86. 2007
    ..We also found temporal changes in FGF and FGFR expression which may contribute to growth plate senescence and thus help determine the size of the adult skeleton...
  14. pmc Growth plate senescence and catch-up growth
    Julian C Lui
    Developmental Endocrinology Branch, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1103, USA
    Endocr Dev 21:23-9. 2011
    ..Consequently, growth plates are less senescent after these conditions resolve and therefore grow more rapidly than is normal for age, resulting in catch-up growth...
  15. ncbi request reprint Impact of growth plate senescence on catch-up growth and epiphyseal fusion
    Ola Nilsson
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Pediatr Nephrol 20:319-22. 2005
    ..This concept has provided insight into clinical phenomena including catch-up growth after transient growth inhibition, catch-down growth after transient estrogen exposure, and epiphyseal fusion...
  16. ncbi request reprint The role of the resting zone in growth plate chondrogenesis
    Veronica Abad
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 10N262, 10 Center Drive MSC 1862, Bethesda, MD 20892, USA
    Endocrinology 143:1851-7. 2002
    ....
  17. ncbi request reprint Fundamental limits on longitudinal bone growth: growth plate senescence and epiphyseal fusion
    Ola Nilsson
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Endocrinol Metab 15:370-4. 2004
    ..In some mammals, including humans, proliferative exhaustion is followed by epiphyseal fusion, an abrupt event in which the growth plate cartilage is replaced completely by bone...
  18. doi request reprint Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract
    Yvonne Arvidsson
    Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska University Hospital, Gula straket 8, SE 413 45 Goteborg, Sweden
    Endocr Relat Cancer 15:569-81. 2008
    ..Identification of APLP1 in NE tumours offers a novel target for treatment and may also serve as a tumour-specific marker...
  19. ncbi request reprint Raloxifene acts as an estrogen agonist on the rabbit growth plate
    Ola Nilsson
    Pediatric Endocrinology Unit, Department of Women and Child Health, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Endocrinology 144:1481-5. 2003
    ..As expected, the uterus was enlarged by estrogen, but not raloxifene, treatment. We conclude that raloxifene acts as an estrogen agonist on the growth plate, accelerating growth plate senescence and thus hastening epiphyseal fusion...
  20. ncbi request reprint Apoptosis is developmentally regulated in rat growth plate
    Dionisios Chrysis
    Department of Woman and Child Health, Pediatric Endocrine Unit, Astrid Lindgren Children s Hospital, Karolinska Institute, Stockholm, Sweden
    Endocrine 18:271-8. 2002
    ..Our results show that apoptosis is developmentally regulated in the rat growth plate. In older animals, with decreased growth rate and growth plate height, apoptosis is significantly increased, especially in THPCs...
  21. ncbi request reprint Estrogen receptor-alpha and -beta are expressed throughout postnatal development in the rat and rabbit growth plate
    Ola Nilsson
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    J Endocrinol 173:407-14. 2002
    ..Therefore, we conclude that ERalpha and ERbeta are both expressed in the mammalian growth plate. The temporal and anatomical pattern suggests that ER expression in the hypertrophic zone in particular may play a role in epiphyseal fusion...
  22. ncbi request reprint Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation
    Jenny Nyberg
    The Arvid Carlsson Institute for Neuroscience at the Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, 413 45 Goteborg, Sweden
    J Neurosci 25:1816-25. 2005
    ..This investigation demonstrates the presence of GIP in the brain for the first time and provides evidence for a regulatory function for GIP in progenitor cell proliferation...
  23. ncbi request reprint Localization of estrogen receptors-alpha and -beta and androgen receptor in the human growth plate at different pubertal stages
    Ola Nilsson
    Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    J Endocrinol 177:319-26. 2003
    ..05). In summary, our findings suggest that ERalpha, ERbeta and AR are expressed in the human growth plate throughout pubertal development, with no difference between the sexes...