E Naslund

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Reduced food intake after jejunoileal bypass: a possible association with prolonged gastric emptying and altered gut hormone patterns
    E Naslund
    Department of Surgery, Karolinska Institute, Danderyd Hospital, Sweden
    Am J Clin Nutr 66:26-32. 1997
  2. ncbi Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin
    Erik Naslund
    Division of Surgery, Karolinska Institutet Danderyd Hospital, SE 182 88 Danderyd, Stockholm, Sweden
    Regul Pept 106:89-95. 2002
  3. ncbi The gut and food intake: an update for surgeons
    E Naslund
    Division of Surgery, Karolinska Institutet Danderyd Hospital, SE 182 88 Danderyd, Sweden
    J Gastrointest Surg 5:556-67. 2001
  4. ncbi GLP-1 inhibits gastric emptying of water but does not influence plasma
    E Naslund
    Dept of Surgery, Danderyd Hospital, Sweden
    Scand J Gastroenterol 36:156-62. 2001
  5. ncbi Associations of leptin, insulin resistance and thyroid function with long-term weight loss in dieting obese men
    E Naslund
    Division of Surgery, Danderyd Hospital, Sweden
    J Intern Med 248:299-308. 2000
  6. ncbi GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans
    E Naslund
    Division of Surgery, Danderyd Hospital, Karolinska Institutet, SE 182 88, Stockholm, Sweden
    Am J Physiol 277:R910-6. 1999
  7. ncbi Three-year results of laparoscopic vertical banded gastroplasty
    E Naslund
    Division of Surgery, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Obes Surg 9:369-73. 1999
  8. ncbi Glucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men
    E Naslund
    Department of Surgery, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden
    Am J Clin Nutr 68:525-30. 1998
  9. ncbi An adjustable vertical banded gastroplasty does not eliminate the risk of staple-line disruption
    E Naslund
    Division of Surgery, Karolinska Institute at Danderyd Hospital, Stockholm, Sweden
    Obes Surg 8:434-6. 1998
  10. ncbi Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity
    E Naslund
    Department of Surgery, Karolinska Institute, Stockholm, Sweden
    Obes Surg 8:253-60. 1998

Collaborators

Detail Information

Publications37

  1. ncbi Reduced food intake after jejunoileal bypass: a possible association with prolonged gastric emptying and altered gut hormone patterns
    E Naslund
    Department of Surgery, Karolinska Institute, Danderyd Hospital, Sweden
    Am J Clin Nutr 66:26-32. 1997
    ..That gastric emptying is prolonged and gut hormone patterns are altered with low postprandial plasma cholecystokinin and high neurotensin plasma concentrations may at least partly account for these observations...
  2. ncbi Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin
    Erik Naslund
    Division of Surgery, Karolinska Institutet Danderyd Hospital, SE 182 88 Danderyd, Stockholm, Sweden
    Regul Pept 106:89-95. 2002
    ..The effect of LY315902 on motor control is mediated through the GLP-1 receptor and seems partly dependent on the L-arginine/NO pathway...
  3. ncbi The gut and food intake: an update for surgeons
    E Naslund
    Division of Surgery, Karolinska Institutet Danderyd Hospital, SE 182 88 Danderyd, Sweden
    J Gastrointest Surg 5:556-67. 2001
    ..Possibly knowledge derived from basic research in neurogastroenterology can translate into advances in surgical treatment of obesity...
  4. ncbi GLP-1 inhibits gastric emptying of water but does not influence plasma
    E Naslund
    Dept of Surgery, Danderyd Hospital, Sweden
    Scand J Gastroenterol 36:156-62. 2001
    ..Glucagon-like peptide-1 (GLP-1) has been shown to inhibit gastric emptying of a caloric load but the effect on a non-caloric load is unknown...
  5. ncbi Associations of leptin, insulin resistance and thyroid function with long-term weight loss in dieting obese men
    E Naslund
    Division of Surgery, Danderyd Hospital, Sweden
    J Intern Med 248:299-308. 2000
    ..The aim of the present study was to identify predictors of weight loss in obese men participating in a 2-year behaviour modification programme...
  6. ncbi GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans
    E Naslund
    Division of Surgery, Danderyd Hospital, Karolinska Institutet, SE 182 88, Stockholm, Sweden
    Am J Physiol 277:R910-6. 1999
    ..In addition, the release of PYY into the circulation is inhibited by GLP-1 infusion, suggesting a negative feedback of GLP-1 on the function of the L-cell...
  7. ncbi Three-year results of laparoscopic vertical banded gastroplasty
    E Naslund
    Division of Surgery, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Obes Surg 9:369-73. 1999
    ..Laparoscopic surgery appears to offer rapid recovery and low postoperative morbidity. The aim of the present study was to assess the outcome of laparoscopic vertical banded gastroplasty (lap VBG) in 60 obese patients...
  8. ncbi Glucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men
    E Naslund
    Department of Surgery, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden
    Am J Clin Nutr 68:525-30. 1998
    ..However, postprandial feelings of hunger decreased, suggesting that exogenous GLP-1 may influence feelings of hunger and satiety in humans...
  9. ncbi An adjustable vertical banded gastroplasty does not eliminate the risk of staple-line disruption
    E Naslund
    Division of Surgery, Karolinska Institute at Danderyd Hospital, Stockholm, Sweden
    Obes Surg 8:434-6. 1998
    ..The two main reasons for reoperation after vertical banded gastroplasty (VBG) in the treatment of obesity are staple-line disruption and stomal stenosis...
  10. ncbi Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity
    E Naslund
    Department of Surgery, Karolinska Institute, Stockholm, Sweden
    Obes Surg 8:253-60. 1998
    ..The aim of the present study was to examine the long-term effect of JIB on glucose metabolism...
  11. ncbi Prandial subcutaneous injections of glucagon-like peptide-1 cause weight loss in obese human subjects
    Erik Naslund
    Division of Surgery, Karolinska Institutet Danderyd Hospital, SE 182 88 Danderyd, Sweden
    Br J Nutr 91:439-46. 2004
    ....
  12. ncbi Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans
    Y Falkén
    Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, SE 182 88 Stockholm, Sweden
    Neurogastroenterol Motil 22:e192-200. 2010
    ..The aim of this study was to evaluate effects of intravenous ghrelin on gastrointestinal motility and glucose homeostasis during a 6-h infusion in humans...
  13. ncbi Ghrelin stimulates gastric emptying and hunger in normal-weight humans
    F Levin
    Department of Surgery, Danderyd Hospital, SE 182 88 Stockholm, Sweden
    J Clin Endocrinol Metab 91:3296-302. 2006
    ..Ghrelin is produced primarily by enteroendocrine cells in the gastric mucosa and increases gastric emptying in patients with gastroparesis...
  14. ncbi Inhibitory effect of exogenous orexin a on gastric emptying, plasma leptin, and the distribution of orexin and orexin receptors in the gut and pancreas in man
    M Ehrström
    Division of Surgery, Danderyd Hospital, SE 182 88 Stockholm, Sweden
    J Clin Endocrinol Metab 90:2370-7. 2005
    ..OXA decreased plasma levels of leptin, suggesting a possible interaction between leptin and OXA in the regulation of energy homeostasis...
  15. ncbi Pharmacokinetic profile of orexin A and effects on plasma insulin and glucagon in the rat
    M Ehrström
    Division of Surgery, Karolinska Institutet Danderyd Hospital, Stockholm SE182 88 Stockholm, Sweden
    Regul Pept 119:209-12. 2004
    ..Thus, OXA has a longer plasma half-life than many other peptides found in the gut. This needs to be taken into account when assessing effects of OXA on biological parameters after peripheral administration...
  16. doi Intravenous ghrelin accelerates postoperative gastric emptying and time to first bowel movement in humans
    Y Falkén
    Division of Surgery, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden
    Neurogastroenterol Motil 25:474-80. 2013
    ..Ghrelin has been shown to stimulate gastric emptying in healthy humans and patients with delayed gastric emptying. The aim of this study is to assess the effect of ghrelin on gastric emptying on day 2 after open colorectal surgery...
  17. ncbi Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety
    P T Schmidt
    Department of Gastroenterology and Hepatology, Karolinska Hospital, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Regul Pept 116:21-5. 2003
    ..0+/-7.0 min for saline, GLP-2 0.75 or 2.25 pmol kg(-1) min(-1), respectively). The change in hunger rating after the meal to 180 min was also unaffected by infusion of GLP-2. GLP-2 does not seem to mediate the ileal brake mechanism...
  18. doi Changes in glucose homeostasis after Roux-en-Y gastric bypass surgery for obesity at day three, two months, and one year after surgery: role of gut peptides
    Y Falkén
    Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, SE 182 88 Stockholm, Sweden
    J Clin Endocrinol Metab 96:2227-35. 2011
    ..Endocrine effects of gastric bypass (GBP) surgery for obesity on glucose homeostasis are not fully understood...
  19. ncbi Insulin signal transduction and glucose transport in human adipocytes: effects of obesity and low calorie diet
    M Björnholm
    Section of Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
    Diabetologia 45:1128-35. 2002
    ..We examined insulin signal transduction at the level of insulin receptor substrates (IRS) 1 and 2, phosphatidylinositol (PI) 3-kinase and glucose transport in isolated subcutaneous adipocytes from obese and lean women...
  20. ncbi The pancreatic polypeptide family and the migrating motor complex of the rat: differential effects in the duodenum and jejunum
    P T Schmidt
    Department of Medicine, Gastroenterology Unit, Karolinska University Hospital Solna, Karolinska Institutet, Sweden
    Regul Pept 139:59-64. 2007
    ..To investigate the effects of members of the pancreatic polypeptide family on migrating myoelectric complexes in rats in vivo...
  21. doi GLP-1 suppresses gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome
    P M Hellstrom
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Neurogastroenterol Motil 20:649-59. 2008
    ..Presence of the GLP-1 receptor in the gut was verified by reverse transcriptase PCR. In conclusion, the gut peptide GLP-1 decreases motility in the antro-duodeno-jejunal region and inhibits the MMC in healthy subjects and IBS patients...
  22. ncbi Interactions between gastric emptying and satiety, with special reference to glucagon-like peptide-1
    P M Hellstrom
    Department of Internal Medicine, Unit of Gastroenterology Karolinska Hospital, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Physiol Behav 74:735-41. 2001
    ..To conclude, after food intake, gut peptides may act in concert as neurohormonal satiety signals acting directly in the brain or indirectly via the vagus nerve, as well as through gastric sensory mechanisms to limit food intake...
  23. ncbi Effect of testosterone on lipolysis in human pre-adipocytes from different fat depots
    A Dicker
    Department of Medicine, M61, Huddinge University Hospital, Karolinska Institute, 14186, Stockholm, Sweden
    Diabetologia 47:420-8. 2004
    ..Regional differences in lipolysis, with higher lipolytic activity in visceral than subcutaneous fat, are important for the development of insulin resistance and might be influenced by testosterone...
  24. ncbi Information needs following a diagnosis of oesophageal cancer; self-perceived information needs of patients and family members compared with the perceptions of healthcare professionals: a pilot study
    S Andreassen
    Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Division of Surgery, and Sophiahemmet University College, Stockholm, Sweden
    Eur J Cancer Care (Engl) 16:277-85. 2007
    ..A qualitative study might be helpful to complete the description of patients' and family members' needs. If a questionnaire is employed, it ought to be less extensive...
  25. doi Nationwide cohort study of post-gastric bypass hypoglycaemia including 5,040 patients undergoing surgery for obesity in 1986-2006 in Sweden
    R Marsk
    Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, SE 182 88, Stockholm, Sweden
    Diabetologia 53:2307-11. 2010
    ..We therefore studied the incidence of post-gastric bypass hypoglycaemia and related symptoms in patients who have undergone gastric bypass and a reference cohort from the general population of Sweden...
  26. ncbi Physiological regulation and NO-dependent inhibition of migrating myoelectric complex in the rat small bowel by OXA
    M Ehrström
    Division of Surgery, Danderyd Hospital, Stockholm, Sweden
    Am J Physiol Gastrointest Liver Physiol 285:G688-95. 2003
    ..Endogenous OXA may have a physiological role in regulating the MMC...
  27. ncbi Gastric emptying and duodeno-gastro-oesophageal reflux in gastro-oesophageal reflux disease
    J Freedman
    Division of Surgery, Karolinska Institutet, Danderyd Hospital, Sweden
    Dig Liver Dis 34:477-83. 2002
    ..Previous studies present conflicting results regarding relationship between gastric emptying and gastro-oesophageal reflux disease. Reflux of duodenal content to oesophagus is generally considered to be associated with more severe disease...
  28. doi Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats
    T Rudholm
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden
    Regul Pept 152:8-12. 2009
    ..The inhibitory action of gastrazole, was in a similar range as that of SOM implying that physiological acid-induced inhibition of gastric acid may primarily be exerted through inhibition of gastrin endocrine secretion...
  29. doi Bariatric surgery reduces mortality in Swedish men
    R Marsk
    Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, SE 182 88 Stockholm, Sweden
    Br J Surg 97:877-83. 2010
    ..This cohort study compared mortality among operated obese patients, non-operated obese patients and a general control cohort of men...
  30. ncbi Characterization of obese individuals who claim to detect no relationship between their eating pattern and sensations of hunger or fullness
    B Barkeling
    Obesity Unit, Karolinska University Hospital Huddinge, Karolinska Insitutet, Stockholm, Sweden
    Int J Obes (Lond) 31:435-9. 2007
    ..To study the phenomenon that obese subjects show considerable individual variability in their reported relationships between eating and sensations of hunger and fullness...
  31. ncbi Association between cholecystectomy and adenocarcinoma of the esophagus
    J Freedman
    Division of Surgery, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 121:548-53. 2001
    ..Duodenogastric reflux is increased after cholecystectomy. This study aims to evaluate if cholecystectomy is associated with an increased risk of adenocarcinoma of the esophagus...
  32. ncbi Prospective and controlled studies of the actions of insulin and catecholamine in fat cells of obese women following weight reduction
    P Lofgren
    Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Diabetologia 48:2334-42. 2005
    ..The aim of the present study was to examine whether these aberrations return to normal following weight reduction...
  33. doi Morbidity and mortality before and after bariatric surgery for morbid obesity compared with the general population
    M Plecka Östlund
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Br J Surg 98:811-6. 2011
    ..The aim was to assess the risk of admission to hospital for obesity-related co-morbidities and overall mortality after bariatric surgery in relation to the general population...
  34. pmc Gd-EOB-DTPA-enhanced MRI for the assessment of liver function and volume in liver cirrhosis
    H Nilsson
    Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Br J Radiol 86:20120653. 2013
    ....
  35. doi Waist circumference to assess reversal of insulin resistance following weight reduction after bariatric surgery: cohort and cross-sectional studies
    D P Andersson
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital Clinic for Endocrinology and Metabolism, Stockholm, Sweden
    Int J Obes (Lond) 38:438-43. 2014
    ..To validate the use of waist circumference to assess reversal of insulin resistance after weight loss induced by bariatric surgery...
  36. doi Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery
    M Guldstrand
    Division of Internal Medicine, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Diabetes Obes Metab 11:1027-33. 2009
    ..Compare the response to oral glucose of the two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) at 1 year after restrictive vs. malabsorptive bariatric surgery...
  37. ncbi Family members' experiences, information needs and information seeking in relation to living with a patient with oesophageal cancer
    S Andreassen
    Division of Nursing, Karolinska Institutet Danderyd Hospital and Sophiahemmet University College, Stockholm, Sweden
    Eur J Cancer Care (Engl) 14:426-34. 2005
    ..Therefore, family members used different strategies for managing the uncertainty, whereof one was searching for information. The primary source of information was the physician...