Noemi Nagy

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint To the genesis of Burkitt lymphoma: regulation of apoptosis by EBNA-1 and SAP may determine the fate of Ig-myc translocation carrying B lymphocytes
    Noemi Nagy
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Nobelsv 16, SE 171 77 Stockholm, Sweden
    Semin Cancer Biol 19:407-10. 2009
  2. doi request reprint Deficiency of the proapoptotic SAP function in X-linked lymphoproliferative disease aggravates Epstein-Barr virus (EBV) induced mononucleosis and promotes lymphoma development
    Noemi Nagy
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Stockholm, Sweden
    Immunol Lett 130:13-8. 2010
  3. ncbi request reprint Concomitant increase of LMP1 and CD25 (IL-2-receptor alpha) expression induced by IL-10 in the EBV-positive NK lines SNK6 and KAI3
    Miki Takahara
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 119:2775-83. 2006
  4. ncbi request reprint EBV infection induces expression of the transcription factors ATF-2/c-Jun in B lymphocytes but not in B-CLL cells
    Kentaro Bandobashi
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
    Virus Genes 30:323-30. 2005
  5. ncbi request reprint The X-linked lymphoproliferative disease gene product SAP is expressed in activated T and NK cells
    Noemi Nagy
    Microbiology and Tumorbiology Center MTC, Karolinska Institute, Stockholm, Sweden
    Immunol Lett 82:141-7. 2002
  6. ncbi request reprint IL-10 can induce the expression of EBV-encoded latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B lymphocytes and in Burkitt lymphoma- and NK lymphoma-derived cell lines
    Lorand L Kis
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    Blood 107:2928-35. 2006
  7. pmc The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease
    Noemi Nagy
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:11966-71. 2009
  8. pmc IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter
    Lorand L Kis
    Department of Microbiology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:872-7. 2010
  9. ncbi request reprint Expression of SH2D1A in five classical Hodgkin's disease-derived cell lines
    Lorand L Kis
    Microbiology and Tumor Biology Center MTC, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 104:658-61. 2003
  10. ncbi request reprint SH2D1A expression in Burkitt lymphoma cells is restricted to EBV positive group I lines and is downregulated in parallel with immunoblastic transformation
    Noemi Nagy
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 100:433-40. 2002

Collaborators

Detail Information

Publications25

  1. doi request reprint To the genesis of Burkitt lymphoma: regulation of apoptosis by EBNA-1 and SAP may determine the fate of Ig-myc translocation carrying B lymphocytes
    Noemi Nagy
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Nobelsv 16, SE 171 77 Stockholm, Sweden
    Semin Cancer Biol 19:407-10. 2009
    ..However, their EBV positive counterparts are permissive for SAP expression, due to the anti-apoptotic function of EBNA-1...
  2. doi request reprint Deficiency of the proapoptotic SAP function in X-linked lymphoproliferative disease aggravates Epstein-Barr virus (EBV) induced mononucleosis and promotes lymphoma development
    Noemi Nagy
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Stockholm, Sweden
    Immunol Lett 130:13-8. 2010
    ..This is probably due to the antiapoptotic function of EBNA-1 and the proliferation induced by activated myc...
  3. ncbi request reprint Concomitant increase of LMP1 and CD25 (IL-2-receptor alpha) expression induced by IL-10 in the EBV-positive NK lines SNK6 and KAI3
    Miki Takahara
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 119:2775-83. 2006
    ..By this mechanism EBV could have an important role in the development of NK lymphoma since the inflammatory component in the tumor tissue can provide these cytokines...
  4. ncbi request reprint EBV infection induces expression of the transcription factors ATF-2/c-Jun in B lymphocytes but not in B-CLL cells
    Kentaro Bandobashi
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
    Virus Genes 30:323-30. 2005
    ..Treatment with phorbol-12, 13-dibutyrate (PDB) induced LMP-1 expression in three of four clones. Neither the HDACi nor the PDB treated cells survived...
  5. ncbi request reprint The X-linked lymphoproliferative disease gene product SAP is expressed in activated T and NK cells
    Noemi Nagy
    Microbiology and Tumorbiology Center MTC, Karolinska Institute, Stockholm, Sweden
    Immunol Lett 82:141-7. 2002
    ..e. BL lines, activated T and NK cells express SAP, while BL blasts do not express SAP. This opposite relationship may be exploited for studies about the function of SAP...
  6. ncbi request reprint IL-10 can induce the expression of EBV-encoded latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B lymphocytes and in Burkitt lymphoma- and NK lymphoma-derived cell lines
    Lorand L Kis
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    Blood 107:2928-35. 2006
    ....
  7. pmc The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease
    Noemi Nagy
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:11966-71. 2009
    ..We have shown that the anti-apoptotic protein VCP (valosin-containing protein) binds to SAP, suggesting that it could be instrumental in the enhanced apoptotic response modulated by SAP...
  8. pmc IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter
    Lorand L Kis
    Department of Microbiology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:872-7. 2010
    ..In light of the fact that IL-21 is already in clinical trials for the treatment of multiple malignancies, the in vivo modulation of EBV gene expression by IL-21 might have therapeutic benefits for the EBV-carrying malignancies...
  9. ncbi request reprint Expression of SH2D1A in five classical Hodgkin's disease-derived cell lines
    Lorand L Kis
    Microbiology and Tumor Biology Center MTC, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 104:658-61. 2003
    ..It is likely therefore that in addition to the demonstrated functional defect of T and NK cells imposed by the SH2D1A mutation, the behavior of certain EBV-infected B lymphocytes is also modified...
  10. ncbi request reprint SH2D1A expression in Burkitt lymphoma cells is restricted to EBV positive group I lines and is downregulated in parallel with immunoblastic transformation
    Noemi Nagy
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 100:433-40. 2002
    ..It is possible that SH2D1A is expressed in a narrow window of B cell development represented by germinal center cells...
  11. doi request reprint Simultaneous detection of the two main proliferation driving EBV encoded proteins, EBNA-2 and LMP-1 in single B cells
    Abu E Rasul
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels vag 16, S 171 77 Stockholm, Sweden
    J Immunol Methods 385:60-70. 2012
    ..Consequently, Type IIa lines could not be established from Hodgkin's lymphoma in vitro. We propose that these experimental cultures can be exploited for study of the Type IIa cells...
  12. pmc Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I interferons in B cells
    Daniel Salamon
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    J Virol 86:4701-7. 2012
    ..Furthermore, our results may explain the expression of LMP-1 in memory B cells of systemic lupus erythematosus patients...
  13. doi request reprint STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma
    Lorand L Kis
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Blood 117:165-74. 2011
    ....
  14. ncbi request reprint The apoptosis modulating role of SAP (SLAM associated protein) contributes to the symptomatology of the X linked lymphoproliferative disease
    Noemi Nagy
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Stockholm, Sweden
    Cell Cycle 8:3086-90. 2009
    ..This mechanism is inefficient in XLP patients. In addition, in the absence of SAP, lymphoma development may be promoted by the illegitimate survival of lymphocytes with damaged DNA that would be normally eliminated by apoptosis...
  15. ncbi request reprint Cytokine mediated induction of the major Epstein-Barr virus (EBV)-encoded transforming protein, LMP-1
    Lorand L Kis
    Microbiology and Tumor Biology Center, Karolinska Institute, S 17177 Stockholm, Sweden
    Immunol Lett 104:83-8. 2006
    ..Cytokine mediated induction of LMP-1 may also explain the heterogeneous expression of this viral gene seen in normal and malignant cells...
  16. ncbi request reprint In vitro EBV-infected subline of KMH2, derived from Hodgkin lymphoma, expresses only EBNA-1, while CD40 ligand and IL-4 induce LMP-1 but not EBNA-2
    Lorand L Kis
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 113:937-45. 2005
    ..The KMH2 EBV cells expressed LMP-2A, but not LMP-2B mRNAs. This result is highly relevant for the type II expression pattern of H/RS cells in vivo, since these stimuli can be provided by the surrounding activated T lymphocytes...
  17. pmc Soluble factors produced by activated CD4+ T cells modulate EBV latency
    Noemi Nagy
    Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 109:1512-7. 2012
    ..We detected similar regulatory functions of T cells in in vitro-infected lymphocyte populations. In conclusion, our results revealed an additional mechanism by which CD4(+) T cells can control the EBV-induced B-cell proliferation...
  18. ncbi request reprint Upregulation of LMP1 expression by histone deacetylase inhibitors in an EBV carrying NPC cell line
    Jun Nishikawa
    Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
    Virus Genes 28:121-8. 2004
    ..With this cell line it was thus possible to study the regulation of LMP1 expression by modification of chromatin acetylation state...
  19. pmc p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP
    Harsha S Madapura
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
    Cell Cycle 11:4563-9. 2012
    ..Our result suggests that p53 contributes to T cell homeostasis through the induction of the pro-apoptotic SAP. A high level of SAP is necessary for the activation-induced cell death that is pivotal in termination of the T cell response...
  20. doi request reprint Type I interferons directly down-regulate BCL-6 in primary and transformed germinal center B cells: differential regulation in B cell lines derived from endemic or sporadic Burkitt's lymphoma
    Daniel Salamon
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels vag 16, SE 171 77 Stockholm, Sweden
    Cytokine 57:360-71. 2012
    ..Our results identify type I IFNs as the first group of cytokines that can down-regulate BCL-6 expression directly in GC B cells...
  21. doi request reprint Exosomes containing glycoprotein 350 released by EBV-transformed B cells selectively target B cells through CD21 and block EBV infection in vitro
    Helen Vallhov
    Clinical Allergy Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    J Immunol 186:73-82. 2011
    ..Our finding also suggests that exosome-based vaccines can be engineered for specific B cell targeting by inducing gp350 expression...
  22. ncbi request reprint SH2D1A expression reflects activation of T and NK cells in cord blood lymphocytes infected with EBV and treated with the immunomodulator PSK
    Anquan Liu
    Microbiology and Tumorbiology Center MTC, Karolinska Institute, Box 280, 171 77 Stockholm, Sweden
    Immunol Lett 80:181-8. 2002
    ..Its potentiation by immunomodulators may have practical significance...
  23. doi request reprint Restricted expression of EBV encoded proteins in in vitro infected CLL cells
    Eva Klein
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Nobelsv 16, Stockholm, Sweden
    Semin Cancer Biol 20:410-5. 2010
    ..Moreover, they were shown in tissues of EBV infected "humanized" mice. The EBV encoded protein expression pattern may serve as a marker for the B cell differentiation stage from which CLL clones can develop...
  24. pmc Epstein-Barr virus coinfection in children boosts cytomegalovirus-induced differentiation of natural killer cells
    Shanie Saghafian-Hedengren
    Department of Molecular Biosciences, Wenner Gren Institute, Stockholm University, Stockholm, Sweden
    J Virol 87:13446-55. 2013
    ..This viral imprint may affect subsequent immune responses through altered distributions of effector cells. ..
  25. pmc Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis
    Gil Jin Shim
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 100:6694-9. 2003
    ..Furthermore, we suggest that ERbeta agonists might have clinical value in the treatment of leukemia...