Research Topics
Genomes and Genes | Erik MelenSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
Genome-wide association study of body mass index in 23 000 individuals with and without asthmaE Melen
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Clin Exp Allergy 43:463-74. 2013..Shared genetic factors between asthma and obesity have been proposed to partly explain epidemiological findings of co-morbidity between these conditions...
Pathophysiology of asthma: lessons from genetic research with particular focus on severe asthmaE Melen
Institute of Environmental Medicine and Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
J Intern Med 272:108-20. 2012..Finally, we discuss how genetic and environmental factors jointly influence asthma susceptibility and summarize how the results may increase understanding of the pathophysiology of asthma-related diseases...- Expression analysis of asthma candidate genes during human and murine lung developmentErik Melen
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Respir Res 12:86. 2011..Little is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only important early in life, but also for later lung function... 
Interaction between variants in the interleukin-4 receptor alpha and interleukin-9 receptor genes in childhood wheezing: evidence from a birth cohort studyE Melen
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Clin Exp Allergy 36:1391-8. 2006..Such interactions have been proposed to explain partly the difficulties in replicating association studies...- Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic diseaseErik Melen
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Environ Health Perspect 116:1077-84. 2008..Air pollutants may induce airway inflammation and sensitization due to generation of reactive oxygen species. The genetic background to these mechanisms could be important effect modifiers... - Analyses of shared genetic factors between asthma and obesity in childrenErik Melen
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
J Allergy Clin Immunol 126:631-7.e1-8. 2010..Epidemiologic studies consistently show associations between asthma and obesity. Shared genetics might account for this association... - Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of lifeOlena Gruzieva
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
J Allergy Clin Immunol 129:240-6. 2012..The role of exposure to air pollution in the development of allergic sensitization remains unclear... - Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildrenInger Kull
Institute of Environmental Medicine, Karolinska Institutet, SE 171 76 Stockholm, Sweden
J Allergy Clin Immunol 125:1013-9. 2010..The evidence from previous studies on beneficial effects of breast-feeding in relation to development of asthma is conflicting... - Traffic-related air pollution and childhood respiratory symptoms, function and allergiesEmma Nordling
Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
Epidemiology 19:401-8. 2008..Urban air pollution can trigger asthma symptoms in children, but there is conflicting evidence on effects of long-term exposure on lung function, onset of airway disease and allergic sensitization... - Traffic-related air pollution and lung function in children at 8 years of age: a birth cohort studyErica S Schultz
Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
Am J Respir Crit Care Med 186:1286-91. 2012..Objectives: To assess the role of long-term exposure to air pollution on lung function in school-age children... - Biological and genetic interaction between tenascin C and neuropeptide S receptor 1 in allergic diseasesChristina Orsmark-Pietras
Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
Hum Mol Genet 17:1673-82. 2008..These results suggest merging of previously independent pathways of importance in the development of asthma- and allergy-related traits... - Exposure to air pollution from traffic and childhood asthma until 12 years of ageOlena Gruzieva
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Epidemiology 24:54-61. 2013..We investigated the development of asthma and related symptoms longitudinally over the first 12 years of life in relation to air pollution from road traffic... - MMP12, lung function, and COPD in high-risk populationsGary M Hunninghake
Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
N Engl J Med 361:2599-608. 2009..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups... - Selective IgA deficiency in early life: association to infections and allergic diseases during childhoodMagdalena Janzi
Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE 14186 Stockholm, Sweden
Clin Immunol 133:78-85. 2009..No increased risk was observed in the partial IgA deficiency group. The findings suggest that selective IgA deficiency may increase the risk of parentally reported pseudocroup and food hypersensitivity during early childhood... - Investigation of novel genes for lung function in children and their interaction with tobacco smoke exposure: a preliminary reportSviatlana Panasevich
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Acta Paediatr 102:498-503. 2013..To replicate newly reported single nucleotide polymorphism (SNP) associations with adult lung function in a cohort of children and to investigate interactions with tobacco smoke exposure on lung function... - Genome-wide association study of the age of onset of childhood asthmaErick Forno
Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
J Allergy Clin Immunol 130:83-90.e4. 2012..Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study of the age of onset of asthma in children... - Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthmaErik Melen
Institute of Environmental Medicine, Centre for Allergy Research, and Department of Biosciences, Karolinska Institutet, Box 210, Stockholm SE 171 77, Sweden
Am J Respir Crit Care Med 171:1089-95. 2005..A 70-kb haplotype block in the G protein-coupled receptor for asthma susceptibility gene (GPR154; alias GPRA) on chromosome 7p was recently identified to influence susceptibility to asthma and elevated total serum IgE levels in adults... - Interaction between Retinoid Acid Receptor-Related Orphan Receptor Alpha (RORA) and Neuropeptide S Receptor 1 (NPSR1) in AsthmaNathalie Acevedo
Translational Immunology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 8:e60111. 2013..Combinations of common susceptibility alleles and less common functional polymorphisms may modify the joint risk effects on asthma susceptibility... - Early-life supplementation of vitamins A and D, in water-soluble form or in peanut oil, and allergic diseases during childhoodInger Kull
Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
J Allergy Clin Immunol 118:1299-304. 2006..Early vitamin supplementation is given routinely to infants in many countries, but it is unclear whether this affects the risk of allergic diseases... - DNA methylation in the Neuropeptide S Receptor 1 (NPSR1) promoter in relation to asthma and environmental factorsLovisa E Reinius
Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 8:e53877. 2013..Both genetic variation and the methylated state of CpG sites seem to have an effect on the binding of nuclear proteins in the regulatory region of NPSR1 suggesting complex regulation of this gene in asthma and allergy...