Erik Melen

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc HTR4 gene structure and altered expression in the developing lung
    Emily Hodge
    Division of Respiratory Medicine, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Respir Res 14:77. 2013
  2. pmc Genome-wide association study of body mass index in 23 000 individuals with and without asthma
    E Melen
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Exp Allergy 43:463-74. 2013
  3. doi request reprint Pathophysiology of asthma: lessons from genetic research with particular focus on severe asthma
    E Melen
    Institute of Environmental Medicine and Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 272:108-20. 2012
  4. pmc Expression analysis of asthma candidate genes during human and murine lung development
    Erik Melen
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Respir Res 12:86. 2011
  5. pmc Analyses of shared genetic factors between asthma and obesity in children
    Erik Melen
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    J Allergy Clin Immunol 126:631-7.e1-8. 2010
  6. pmc Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease
    Erik Melen
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 116:1077-84. 2008
  7. ncbi request reprint Interaction between variants in the interleukin-4 receptor alpha and interleukin-9 receptor genes in childhood wheezing: evidence from a birth cohort study
    E Melen
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Exp Allergy 36:1391-8. 2006
  8. doi request reprint Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life
    Olena Gruzieva
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 129:240-6. 2012
  9. doi request reprint Exposure to air pollution from traffic and childhood asthma until 12 years of age
    Olena Gruzieva
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 24:54-61. 2013
  10. pmc Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma
    Nathalie Acevedo
    Translational Immunology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e60111. 2013

Collaborators

Detail Information

Publications24

  1. pmc HTR4 gene structure and altered expression in the developing lung
    Emily Hodge
    Division of Respiratory Medicine, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Respir Res 14:77. 2013
    ....
  2. pmc Genome-wide association study of body mass index in 23 000 individuals with and without asthma
    E Melen
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Exp Allergy 43:463-74. 2013
    ..Shared genetic factors between asthma and obesity have been proposed to partly explain epidemiological findings of co-morbidity between these conditions...
  3. doi request reprint Pathophysiology of asthma: lessons from genetic research with particular focus on severe asthma
    E Melen
    Institute of Environmental Medicine and Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 272:108-20. 2012
    ..Finally, we discuss how genetic and environmental factors jointly influence asthma susceptibility and summarize how the results may increase understanding of the pathophysiology of asthma-related diseases...
  4. pmc Expression analysis of asthma candidate genes during human and murine lung development
    Erik Melen
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Respir Res 12:86. 2011
    ..Little is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only important early in life, but also for later lung function...
  5. pmc Analyses of shared genetic factors between asthma and obesity in children
    Erik Melen
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    J Allergy Clin Immunol 126:631-7.e1-8. 2010
    ..Epidemiologic studies consistently show associations between asthma and obesity. Shared genetics might account for this association...
  6. pmc Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease
    Erik Melen
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 116:1077-84. 2008
    ..Air pollutants may induce airway inflammation and sensitization due to generation of reactive oxygen species. The genetic background to these mechanisms could be important effect modifiers...
  7. ncbi request reprint Interaction between variants in the interleukin-4 receptor alpha and interleukin-9 receptor genes in childhood wheezing: evidence from a birth cohort study
    E Melen
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Exp Allergy 36:1391-8. 2006
    ..Such interactions have been proposed to explain partly the difficulties in replicating association studies...
  8. doi request reprint Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life
    Olena Gruzieva
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 129:240-6. 2012
    ..The role of exposure to air pollution in the development of allergic sensitization remains unclear...
  9. doi request reprint Exposure to air pollution from traffic and childhood asthma until 12 years of age
    Olena Gruzieva
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 24:54-61. 2013
    ..We investigated the development of asthma and related symptoms longitudinally over the first 12 years of life in relation to air pollution from road traffic...
  10. pmc Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma
    Nathalie Acevedo
    Translational Immunology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e60111. 2013
    ..Combinations of common susceptibility alleles and less common functional polymorphisms may modify the joint risk effects on asthma susceptibility...
  11. doi request reprint Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildren
    Inger Kull
    Institute of Environmental Medicine, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    J Allergy Clin Immunol 125:1013-9. 2010
    ..The evidence from previous studies on beneficial effects of breast-feeding in relation to development of asthma is conflicting...
  12. doi request reprint Traffic-related air pollution and childhood respiratory symptoms, function and allergies
    Emma Nordling
    Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
    Epidemiology 19:401-8. 2008
    ..Urban air pollution can trigger asthma symptoms in children, but there is conflicting evidence on effects of long-term exposure on lung function, onset of airway disease and allergic sensitization...
  13. doi request reprint Biological and genetic interaction between tenascin C and neuropeptide S receptor 1 in allergic diseases
    Christina Orsmark-Pietras
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    Hum Mol Genet 17:1673-82. 2008
    ..These results suggest merging of previously independent pathways of importance in the development of asthma- and allergy-related traits...
  14. doi request reprint Traffic-related air pollution and lung function in children at 8 years of age: a birth cohort study
    Erica S Schultz
    Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    Am J Respir Crit Care Med 186:1286-91. 2012
    ..Objectives: To assess the role of long-term exposure to air pollution on lung function in school-age children...
  15. doi request reprint The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma
    Jon R Konradsen
    Astrid Lindgren Children s Hospital, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 132:328-35.e5. 2013
    ..The specific mechanisms involved are unknown, and novel biomarkers are required to facilitate treatment and diagnosis of therapy-resistant asthma. The chitinase-like protein YKL-40 has been related to asthma and airway remodeling...
  16. doi request reprint Fish consumption in infancy and development of allergic disease up to age 12 y
    Jessica Magnusson
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Clin Nutr 97:1324-30. 2013
    ..Fish intake in infancy has been associated with reduced risk of allergic disease in early childhood, but it is unknown whether this effect remains as children grow older...
  17. pmc DNA methylation in the Neuropeptide S Receptor 1 (NPSR1) promoter in relation to asthma and environmental factors
    Lovisa E Reinius
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e53877. 2013
    ..Both genetic variation and the methylated state of CpG sites seem to have an effect on the binding of nuclear proteins in the regulatory region of NPSR1 suggesting complex regulation of this gene in asthma and allergy...
  18. pmc MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    ..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups...
  19. doi request reprint Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics
    Christina Orsmark-Pietras
    Dept of Biosciences and Nutrition at NOVUM, Karolinska Institute, Stockholm, Sweden
    Eur Respir J 42:65-78. 2013
    ..In conclusion, specific gene expression patterns were observed in children with severe, therapy-resistant asthma. The increased expression of bronchodilatory TAS2Rs suggests a new target for the treatment of asthma. ..
  20. doi request reprint Investigation of novel genes for lung function in children and their interaction with tobacco smoke exposure: a preliminary report
    Sviatlana Panasevich
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Acta Paediatr 102:498-503. 2013
    ..To replicate newly reported single nucleotide polymorphism (SNP) associations with adult lung function in a cohort of children and to investigate interactions with tobacco smoke exposure on lung function...
  21. doi request reprint Selective IgA deficiency in early life: association to infections and allergic diseases during childhood
    Magdalena Janzi
    Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE 14186 Stockholm, Sweden
    Clin Immunol 133:78-85. 2009
    ..No increased risk was observed in the partial IgA deficiency group. The findings suggest that selective IgA deficiency may increase the risk of parentally reported pseudocroup and food hypersensitivity during early childhood...
  22. pmc Genome-wide association study of the age of onset of childhood asthma
    Erick Forno
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    J Allergy Clin Immunol 130:83-90.e4. 2012
    ..Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study of the age of onset of asthma in children...
  23. ncbi request reprint Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthma
    Erik Melen
    Institute of Environmental Medicine, Centre for Allergy Research, and Department of Biosciences, Karolinska Institutet, Box 210, Stockholm SE 171 77, Sweden
    Am J Respir Crit Care Med 171:1089-95. 2005
    ..A 70-kb haplotype block in the G protein-coupled receptor for asthma susceptibility gene (GPR154; alias GPRA) on chromosome 7p was recently identified to influence susceptibility to asthma and elevated total serum IgE levels in adults...
  24. ncbi request reprint Early-life supplementation of vitamins A and D, in water-soluble form or in peanut oil, and allergic diseases during childhood
    Inger Kull
    Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
    J Allergy Clin Immunol 118:1299-304. 2006
    ..Early vitamin supplementation is given routinely to infants in many countries, but it is unclear whether this affects the risk of allergic diseases...