Amelia Marutle

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine
    Amelia Marutle
    Biomolecular Sciences Center, Burnett College of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA
    Proc Natl Acad Sci U S A 104:12506-11. 2007
  2. pmc Β-amyloid 1-42 oligomers impair function of human embryonic stem cell-derived forebrain cholinergic neurons
    Linn Wicklund
    Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e15600. 2010
  3. pmc Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels
    Anna M Lilja
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e58752. 2013
  4. pmc ³H-deprenyl and ³H-PIB autoradiography show different laminar distributions of astroglia and fibrillar β-amyloid in Alzheimer brain
    Amelia Marutle
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum floor 5, Stockholm S 14186, Sweden
    J Neuroinflammation 10:90. 2013
  5. ncbi request reprint Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue
    Ruiqing Ni
    Alzheimer Neurobiology Centre, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Brain 136:2217-27. 2013
  6. ncbi request reprint Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice
    Ewa Hellström-Lindahl
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge B84, S 141 86 Stockholm, Sweden
    Eur J Neurosci 19:2703-10. 2004
  7. pmc Neurotrophic and neuroprotective actions of (-)- and (+)-phenserine, candidate drugs for Alzheimer's disease
    Anna M Lilja
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    PLoS ONE 8:e54887. 2013
  8. doi request reprint Modulation of α7 nicotinic acetylcholine receptor and fibrillar amyloid-β interactions in Alzheimer's disease brain
    Ruiqing Ni
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 33:841-51. 2013
  9. ncbi request reprint Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons
    Mats Nilbratt
    Karolinska Institutet, Karolinska University Hospital Huddinge, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
    J Cell Mol Med 14:1476-84. 2010
  10. doi request reprint Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity
    Fuxiang Bao
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 33:825.e1-13. 2012

Collaborators

Detail Information

Publications17

  1. pmc Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine
    Amelia Marutle
    Biomolecular Sciences Center, Burnett College of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA
    Proc Natl Acad Sci U S A 104:12506-11. 2007
    ....
  2. pmc Β-amyloid 1-42 oligomers impair function of human embryonic stem cell-derived forebrain cholinergic neurons
    Linn Wicklund
    Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e15600. 2010
    ..We propose that it may be possible for future AD therapies to promote the maturation of functional stem cell-derived neurons by altering the brain microenvironment with trophic support and by targeting different aggregation forms of Aβ...
  3. pmc Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels
    Anna M Lilja
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e58752. 2013
    ..In contrast, lowering Aβ levels in Tg2576 mice when Aβ plaque pathology is prominent mainly alters the levels of proinflammatory cytokines and chemokines...
  4. pmc ³H-deprenyl and ³H-PIB autoradiography show different laminar distributions of astroglia and fibrillar β-amyloid in Alzheimer brain
    Amelia Marutle
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum floor 5, Stockholm S 14186, Sweden
    J Neuroinflammation 10:90. 2013
    ..This information could aid the development of specific biomarkers to accurately chart disease progression...
  5. ncbi request reprint Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue
    Ruiqing Ni
    Alzheimer Neurobiology Centre, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Brain 136:2217-27. 2013
    ..BF-227 shows mainly binding to site 3 and FDDNP shows only some binding to site 2. Different amyloid tracers may provide new insight into the pathophysiological mechanisms in the progression of Alzheimer's disease...
  6. ncbi request reprint Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice
    Ewa Hellström-Lindahl
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge B84, S 141 86 Stockholm, Sweden
    Eur J Neurosci 19:2703-10. 2004
    ..Further studies are required to identify potential mechanisms of the nicotine's amyloid-reducing effect...
  7. pmc Neurotrophic and neuroprotective actions of (-)- and (+)-phenserine, candidate drugs for Alzheimer's disease
    Anna M Lilja
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    PLoS ONE 8:e54887. 2013
    ....
  8. doi request reprint Modulation of α7 nicotinic acetylcholine receptor and fibrillar amyloid-β interactions in Alzheimer's disease brain
    Ruiqing Ni
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 33:841-51. 2013
    ....
  9. ncbi request reprint Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons
    Mats Nilbratt
    Karolinska Institutet, Karolinska University Hospital Huddinge, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
    J Cell Mol Med 14:1476-84. 2010
    ....
  10. doi request reprint Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity
    Fuxiang Bao
    Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 33:825.e1-13. 2012
    ..These novel findings suggest that distinct Aβ oligomers induce impairment of cholinergic neurotransmission in AD pathogenesis...
  11. pmc Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease
    Ahmadul Kadir
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Brain 134:301-17. 2011
    ....
  12. pmc Involvement of notch signaling pathway in amyloid precursor protein induced glial differentiation
    Young Don Kwak
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA
    Eur J Pharmacol 650:18-27. 2011
    ..These results indicate APP induces glial differentiation of NPCs through Notch signaling...
  13. doi request reprint Functional interactions of fibrillar and oligomeric amyloid-β with alpha7 nicotinic receptors in Alzheimer's disease
    Anna M Lilja
    Karolinska Institutet, Division of Alzheimer Neurobiology, Department of Neurobiology, Care Sciences and Society, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Alzheimers Dis 23:335-47. 2011
    ..Our findings demonstrate that fibrillar Aβ exerts neurotoxic effects mediated partly through a blockade of α7 nAChRs, whilst oligomeric Aβ may act as a ligand activating α7 nAChRs, thereby stimulating downstream signaling pathways...
  14. ncbi request reprint Retinoic acid and nerve growth factor induce differential regulation of nicotinic acetylcholine receptor subunit expression in SN56 cells
    Mats Nilbratt
    Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Neurosci Res 85:504-14. 2007
    ..The present results show that RA and NGF have different effects on the expression of ChAT and the morphology and the expression pattern of different nAChR subunits in cholinergic SN56 cells...
  15. pmc Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation
    Marjan Shafaati
    Department of Laboratory Medicine Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Huddinge, Sweden
    J Lipid Res 52:1004-10. 2011
    ..We discuss the possibility of a vicious circle in the brains of the patients with familial AD whereby neurodegenerative changes cause an accumulation of 27OHC that further accelerates neurodegeneration...
  16. ncbi request reprint Elevated levels of Abeta1-40 and Abeta1-42 do not alter the binding sites of nicotinic receptor subtypes in the brain of APPswe and PS1 double transgenic mice
    Amelia Marutle
    Division of Molecular Neuropharmacology, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Karolinska Institutet, Huddinge University Hospital, B84, 141 86, Stockholm, Sweden
    Neurosci Lett 328:269-72. 2002
    ..The findings indicate that elevated Abeta levels in the brains of APPswe/PS1 mice do not alter the number of alpha4beta2 and alpha7 receptors, the two major brain nAChR subtypes...
  17. ncbi request reprint Selective nicotinic receptor consequences in APP(SWE) transgenic mice
    Ivan Bednar
    Divisions of Molecular Neuropharmacology, Occupational Therapy and Elderly Care Research NEUROTEC, S 141 86 Stockholm, Sweden
    Mol Cell Neurosci 20:354-65. 2002
    ..The upregulation of the nAChRs probably reflects compensatory mechanisms in response to Abeta burden in the brains of Tg+ mice...