Francesca Mangialasche

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age
    Francesca Mangialasche
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 20:1029-37. 2010
  2. doi request reprint Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults
    Francesca Mangialasche
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy Electronic address
    Exp Gerontol 48:1428-35. 2013
  3. ncbi request reprint Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol
    F Mangialasche
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 273:602-21. 2013
  4. doi request reprint Tocopherols and tocotrienols plasma levels are associated with cognitive impairment
    Francesca Mangialasche
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 33:2282-90. 2012
  5. pmc Dementia prevention: current epidemiological evidence and future perspective
    Francesca Mangialasche
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet KI Stockholm University, Gävlegatan 16 9th floor SE 113 30, Stockholm, Sweden
    Alzheimers Res Ther 4:6. 2012
  6. doi request reprint Emotional and psychological distress of persons involved in the care of patients with Alzheimer disease predicts falls and fractures in their care recipients
    Dario Maggio
    Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Dement Geriatr Cogn Disord 30:33-8. 2010
  7. ncbi request reprint Practical lessons from amyloid immunotherapy trials in Alzheimer disease
    Alina Solomon
    Aging Research Center ARC, Department of Neurobiology, Care Sciences and Society Karolinska Institutet, Stockholm, Sweden
    Curr Alzheimer Res 9:1126-34. 2012
  8. doi request reprint Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment
    Francesca Mangialasche
    Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Ageing Res Rev 8:285-305. 2009
  9. doi request reprint Alzheimer's disease: clinical trials and drug development
    Francesca Mangialasche
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 9:702-16. 2010
  10. ncbi request reprint The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): study design and progress
    Miia Kivipelto
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland Aging Research Center, Karolinska Institutet, Stockholm, Sweden Alzheimer s Disease Research Center, Karolinska Institutet, Stockholm, Sweden Electronic address
    Alzheimers Dement 9:657-65. 2013

Detail Information

Publications14

  1. doi request reprint High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age
    Francesca Mangialasche
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 20:1029-37. 2010
    ..The neuroprotective effect of vitamin E seems to be related to the combination of different forms, rather than to alpha-tocopherol alone, whose efficacy in interventions against AD is currently debated...
  2. doi request reprint Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults
    Francesca Mangialasche
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy Electronic address
    Exp Gerontol 48:1428-35. 2013
    ..Vitamin E includes eight natural antioxidant compounds (four tocopherols and four tocotrienols), but α-tocopherol has been the main focus of investigation in studies of cognitive impairment and Alzheimer's disease...
  3. ncbi request reprint Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol
    F Mangialasche
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 273:602-21. 2013
    ....
  4. doi request reprint Tocopherols and tocotrienols plasma levels are associated with cognitive impairment
    Francesca Mangialasche
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 33:2282-90. 2012
    ..Further, both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD...
  5. pmc Dementia prevention: current epidemiological evidence and future perspective
    Francesca Mangialasche
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet KI Stockholm University, Gävlegatan 16 9th floor SE 113 30, Stockholm, Sweden
    Alzheimers Res Ther 4:6. 2012
    ..Taking a step in this direction, researchers involved in these European RCTs recently started the European Dementia Prevention Initiative, an international collaboration aiming to improve strategies for preventing dementia...
  6. doi request reprint Emotional and psychological distress of persons involved in the care of patients with Alzheimer disease predicts falls and fractures in their care recipients
    Dario Maggio
    Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Dement Geriatr Cogn Disord 30:33-8. 2010
    ..To investigate whether psychological distress of the caregiver might predispose older persons with Alzheimer disease (AD) to falls and fractures, we performed a prospective cohort study...
  7. ncbi request reprint Practical lessons from amyloid immunotherapy trials in Alzheimer disease
    Alina Solomon
    Aging Research Center ARC, Department of Neurobiology, Care Sciences and Society Karolinska Institutet, Stockholm, Sweden
    Curr Alzheimer Res 9:1126-34. 2012
    ..This study investigates practical experiences of staff and participants in immunotherapy RCTs...
  8. doi request reprint Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment
    Francesca Mangialasche
    Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Ageing Res Rev 8:285-305. 2009
    ..In this review we discuss the main results obtained in the field of biomarkers of oxidative/nitrosative stress in AD and MCI in humans, in addition to their potential role as a tool for diagnosis, prognosis and treatment efficacy in AD...
  9. doi request reprint Alzheimer's disease: clinical trials and drug development
    Francesca Mangialasche
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 9:702-16. 2010
    ....
  10. ncbi request reprint The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): study design and progress
    Miia Kivipelto
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland Aging Research Center, Karolinska Institutet, Stockholm, Sweden Alzheimer s Disease Research Center, Karolinska Institutet, Stockholm, Sweden Electronic address
    Alzheimers Dement 9:657-65. 2013
    ..Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland...
  11. doi request reprint Aging with multimorbidity: a systematic review of the literature
    Alessandra Marengoni
    Aging Research Center, NVS Department, Karolinska Institutet and Stockholm University, Sweden
    Ageing Res Rev 10:430-9. 2011
    ..New insights in this field can lead to the identification of preventive strategies and better treatment of multimorbid patients...
  12. doi request reprint Brain aging: lessons from community studies
    Laura Fratiglioni
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Nutr Rev 68:S119-27. 2010
    ..Presented here is an overview of the main findings of epidemiological studies on nutritional factors and nutrition-related pathological conditions, as related to dementia and Alzheimer's disease...
  13. doi request reprint Rethinking Alzheimer's disease therapy: are mitochondria the key?
    Maria Ankarcrona
    KI Alzheimer s Disease Research Center, Karolinska Institutet, Department of Neurobiology, Care Sciences and Society NVS, Huddinge, Sweden
    J Alzheimers Dis 20:S579-90. 2010
    ..In this review, we will discuss current available medications for AD, drugs under clinical testing, and mitochondria as a novel drug target...
  14. ncbi request reprint Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's disease
    Elena Mariani
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Neurol Sci 247:187-91. 2006
    ..Our data suggest that the CTSD-T allele of the CTSD-C/T polymorphism is associated with an increased relative risk for late-onset AD and, more interestingly, the combination of CTSD-T with the A2M-G allele seems to increase this risk...