Research Topics
Genomes and Genes | Lotus MallbrisSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
Psoriasis is associated with lipid abnormalities at the onset of skin diseaseLotus Mallbris
King Gustaf V Research Institute, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
J Am Acad Dermatol 54:614-21. 2006..However, previous studies consist of heterogeneous patient materials, including persons with highly varying disease duration and treatment...
The establishment and utility of Sweha-Reg: a Swedish population-based registry to understand hereditary angioedemaLotus Mallbris
Department of Medicine, Unit of Dermatology, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
BMC Dermatol 7:6. 2007..The low prevalence requires combined efforts to gain accurate epidemiological data on the disease and so give us tools to reduce morbidity and mortality, and improve quality of life of sufferers...- Metabolic disorders in patients with psoriasis and psoriatic arthritisLotus Mallbris
Department of Medicine, Dermatology Unit, Karolinska Institutet, 171 76 Stockholm, Sweden
Curr Rheumatol Rep 8:355-63. 2006.... - HLA-Cw*0602 associates with a twofold higher prevalence of positive streptococcal throat swab at the onset of psoriasis: a case control studyLotus Mallbris
Dermatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
BMC Dermatol 9:5. 2009..In the present study, we hypothesized that there is a statistical interaction between the result of streptococcal throat cultures and the presence of the HLA-Cw*0602 allele in psoriasis patients... - HLA-Cw*0602 associates more strongly to psoriasis in the Swedish population than variants of the novel 6p21.3 gene PSORS1C3Sofia J Holm
Department of Dermatology, Karolinska University Hospital, Stockholm, Sweden
Acta Derm Venereol 85:2-8. 2005..This association appeared to be HLA-Cw*0602-dependent due to linkage disequilibrium, thus HLA-C remains the strongest associating factor in the region... - STG does not associate with psoriasis in the Swedish populationFabio Sanchez
Department of Dermatology, Karolinska Institutet, Karolinska Hospital L8 02, SE 171 76 Stockholm, Sweden
Exp Dermatol 13:413-8. 2004..However, HLA-Cw*0602 status was strongly associated with disease. STG expression was investigated in human tissues and found not to be restricted to taste buds, with signals also being detected in skin and tonsils... - Distinct HLA-C/KIR genotype profile associates with guttate psoriasisSofia J Holm
Unit of Dermatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
J Invest Dermatol 125:721-30. 2005..In the guttate phenotype, balanced HLA-C/KIR interactions might be altered by the presence of concomitant streptococcal infections... 
IFN-regulatory factor 5 gene variants interact with the class I MHC locus in the Swedish psoriasis populationFabio O Sánchez
Department of Medicine, Molecular Unit of Dermatology and Venereology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
J Invest Dermatol 128:1704-9. 2008..Polymorphisms at IRF5 did not associate with psoriasis per se; however, an interaction with class I major histocompatibility complex (MHC) genes was found...- Excessive body weight and smoking associates with a high risk of onset of plaque psoriasisKatarina Wolk
Unit of Dermatology and Venereology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Acta Derm Venereol 89:492-7. 2009..Our results indicate that excessive body weight and smoking are risk factors for onset of psoriasis and that higher body mass index increases the PASI of plaque psoriasis at onset... - Injury downregulates the expression of the human cathelicidin protein hCAP18/LL-37 in atopic dermatitisLotus Mallbris
Unit of Dermatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Exp Dermatol 19:442-9. 2010..Itching is a hallmark of AD and scratching inevitably injures the skin. Failure to upregulate hCAP18 in eczema following injury is likely to affect antimicrobial protection and tissue repair in AD... - Increased risk for cardiovascular mortality in psoriasis inpatients but not in outpatientsLotus Mallbris
Dermatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden
Eur J Epidemiol 19:225-30. 2004..Severe psoriasis, however, here measured as repeated admissions, and early age at first admission, is associated with increased risk for cardiovascular death... - Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish populationSofia J Holm
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
Exp Dermatol 12:435-44. 2003..The second exon of SEEK1, containing the two Cw*0602-independent SNPs, showed the highest concentration of the psoriasis-associating SNPs, but did not appear to be translated... - Psoriasis phenotype at disease onset: clinical characterization of 400 adult casesLotus Mallbris
Dermatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
J Invest Dermatol 124:499-504. 2005..Longitudinal follow-up of the patients will provide robust information about disease development and response to treatment... - Progressive cutaneous sarcoidosis responding to anti-tumor necrosis factor-alpha therapyLotus Mallbris
Unit of Dermatology, Department of Medicine, Karolinska Institute, 171 76 Stockholm, Sweden
J Am Acad Dermatol 48:290-3. 2003....