Lars Lundell

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..Bariatric surgery reduces the risk of global mortality, all-cause mortality and cardiovascular mortality when compared to obese control patients. Both gastric banding and gastric bypass seem to reduce mortality risk...

..Evaluation and management of failures after anti reflux surgery have to be centralised within each country...

..It is important to evaluate the long-term effects of therapies for gastroesophageal reflux disease (GERD). In a 12-year study, we compared the effects of therapy with omeprazole with those of antireflux surgery...

..This area, however, requires more research before preoperative oral intake of probiotics combined with postoperative treatment can be recommended for patients in need of gastrointestinal surgery...

..This randomized clinical trial compared long-term outcome after antireflux surgery with acid inhibition therapy in the treatment of chronic gastro-oesophageal reflux disease (GORD)...

..The 3-year interim results of a randomised study comparing both the efficacy and safety of LARS and esomeprazole (ESO) are reported...

..Accordingly, surgical repair has to be evaluated based on modern, evidence-based methodologies...

..The impact of long-term acid suppression on the gastric mucosa remains controversial...

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..Resection of the body and tail of the pancreas (distal pancreatectomy) is associated with high postoperative morbidity, most of which is due to leakage from the pancreatic transection surface...

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..CONCLUSION: After major surgery, specialized supportive enteral and parenteral nutrition are not superior to oral nutrition only when guided by a dietitian...

..To determine whether prophylactic pancreatic duct stenting reduces pancreatic fistula (PF) formation after distal pancreatectomy (DP)...

..Inflammation and tissue damage may be key pathogenetic pathways and we hypothesized that 1-lung ventilation may induce an inflammatory cascade reflected by markers for such a response...

..The aim of this prospective, randomized multicentre study was to compare stent placement and brachytherapy regarding health economy and clinical outcomes...

..The aim of the study was to compare the efficacy and mechanical consequences of 2 partial fundoplications performed laparoscopically under the framework of a randomized, controlled clinical trial...

..The other side of the coin is that antireflux surgery has some side effects that signify the importance of this surgery being performed in specialized centers...

..There seems to be no difference in short-term outcomes with either approach. The aim of the study was to determine whether there were the long-term differences (after 10 years)...

..Roux-en-Y gastric bypass (RYGBP) is the preferred operation for the treatment of morbid obesity by many surgeons. Hereby we present the process by which laparoscopic RYGBP (LRYGBP) developed at our institution...

..The incidence of acute cardiovascular and cerebrovascular events in patients treated for complicated or uncomplicated peptic ulcer disease (PUD) has not been ascertained completely...

..The benign character of these diseases further substantiates the importance of operating with greatest possible safety margins. We presently report our experiences with the use of perioperative leakage testing...

..The incidence of adenocarcinoma of the oesophagus is rising in many western countries including Sweden...

..But if the dose of omeprazole was adjusted in case of relapse, the two therapeutic strategies reached levels of efficacy that were not statistically different...

..Interestingly, we also found that radical splenectomy 7 days after stem cell transplantation did not lead to any significant loss of infused stem cells...

..However, the response rates have generally been moderate and there is no consensus on the optimal combination of cytotoxic agents and the potential role of more recently developed "targeted therapies"...

..With the introduction and development of self-expandable metal stents (SEMS), new therapeutic options have emerged for these severe complications...

..CONCLUSION: A posterior partial fundoplication can be done safely in a repeat operation for patients whose antireflux operation has failed...

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..Thus, the excellent safety record of these compounds seems not to be compromised by the presence of H. pylori...

..Dividing all short gastric vessels had no impact on the functional outcome during the first year of recovery after a total laparoscopic fundoplication...

..The efficacy of antireflux surgery (ARS) and omeprazole treatment in the control of gastrooesophageal reflux disease (GORD) are well established. We have compared these two therapeutic options in a randomized, clinical trial...

..Intraductal papillary mucinous neoplasm of the bile duct (IPMN-B) is a rare but increasingly diagnosed clinical entity. Typical cholangioscopic findings usually include intraductal protruding papillary tumors that secrete mucus...

..The critical question then formulated was whether a structured learning program and the level of experience would affect the clinical usefulness of this classification...

..The aim of this prospective, randomized study was to determine if health related quality of life is affected by the choice of surgical strategy in the management of acute cholecystitis...

..Vertical banded gastroplasty (VBG) has previously been documented as an effective treatment for morbid obesity. We have described a laparoscopic technique to perform this operation. Follow-up data are now presented...

..The best-documented preventive strategy presented so far is to carry out a posterior partial fundoplication and to ensure that the patient is operated on in a high-volume, specialised centre...

..The manometric mechanisms behind the inferior reflux control achieved by a Watson type of anterior partial wrap has now been further elucidated...

..Observational studies have, however, suggested that the clinical efficacy of PPI therapy may be reduced because of poor adherence...

..We designed a randomized clinical trial to compare the cavitron ultrasonic surgical aspirator (CUSA) and an endoscopic stapler device applied in routine clinical hepatic surgical practice...

..Little is known about how discontinuation of low-dose aspirin therapy after peptic ulcer bleeding affects patient mortality or acute cardiovascular events...

..Until now, no comparative and external evaluation of these systems in a clinical-like situation has been performed...

..The present case describes a less invasive method to provide adequate drainage of the obstructed jejunal limb by insertion of a 22-mm enteral Wallstent transhepatically. The patient became and stayed anicteric during 7 months' follow-up...

..Earlier observations demonstrating the advantages of a partial fundoplication, which included fewer complaints associated with gas-bloat, continue to be valid after more than 10 years of follow-up...

..This article also will address the issue of whether complete reflux control in patients with Barrett's esophagus can prevent the metaplastic mucosa from further progression to dysplasia and adenocarcinoma...

..This test may be helpful for the validation of new techniques of vagotomy...

..The aim of the study was to investigate whether neoadjuvant radiochemotherapy in patients scheduled for a thoracoabdominal resection impairs their working capacity and adds to the postoperative risk...

..Gastrointestinal symptom control seems important to minimize impairment in quality of life, body composition, and eating after gastrectomy...

..These results should encourage large-scale randomized trials that can establish potentially beneficial effects of antireflux stents...

..Both techniques offer low morbidity and rapid postoperative recovery...

..05). Despite a high conversion rate, early laparoscopic cholecystectomy offered significant advantages in the management of acute cholecystitis compared to a conservative strategy. The greatest advantage was a reduced total hospital stay...

..Few studies have been conducted with primary focus on patient acceptance and preferences in terms of quality of life for this practice compared with overnight stay...

..These findings suggest that the histamine containing endocrine cells in the human stomach are identical with the so called enterochromaffin like cells...

..However, after gastric distension with air, more TLESRs were recorded in the latter group suggesting a better maintained ability to vent air from the stomach...

..To evaluate the occurrence and changes over time of upper gastrointestinal symptoms in adult subjects randomly recruited from the general population...

..This study was designed to identify a methodology for standardization of surgical technique and to measure the effectiveness of this standardization...

..The long-term functional outcome after thoracoabdominal resection has to be better evaluated. A study was performed to evaluate patients after a similar operation both in terms of physical function and health-related quality of life (HRQL)...

..To examine the prevalence of gastrointestinal (GI) symptoms in patients with type 1 diabetes as compared to age- and sex-matched controls...

..The methodology, results and recommendations of the consensus are described in detail...

..The findings highlight the need for careful medical interviewing to enhance patient-physician communication about symptoms and signs of malignant diseases...

..Blood flow was lower among reflux patients but did not correlate with acid exposure or nitric oxide. Nitric oxide is formed following acid perfusion and predominantly in gastroesophageal reflux disease...

..i.d.) devoid of effects on important motor mechanisms involved in the pathogenesis of the disease...

..CONCLUSION: Reconstruction after radical resection for proximal oesophageal and hypopharyngeal cancer can be carried out with low mortality, acceptable morbidity and a promising functional outcome...

..The diagnosis and management of Barrett's esophagus (BE) are controversial. We conducted a critical review of the literature in BE to provide guidance on clinically relevant issues...

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..A protective effect of luminal nitric oxide on DIS development is suggested...