Jon O Lundberg

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Nitric oxide but not carbon monoxide is continuously released in the human nasal airways
    J O N Lundberg
    Dept Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Eur Respir J 20:100-3. 2002
  2. ncbi request reprint Increased nitric oxide production in collagenous and lymphocytic colitis
    J O Lundberg
    Department of Pharmacology, Karolinska Institute, Stockholm, Sweden
    Eur J Clin Invest 27:869-71. 1997
  3. ncbi request reprint Nitrate, bacteria and human health
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Stockholm, Sweden
    Nat Rev Microbiol 2:593-602. 2004
  4. ncbi request reprint Technology insight: calprotectin, lactoferrin and nitric oxide as novel markers of inflammatory bowel disease
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Nat Clin Pract Gastroenterol Hepatol 2:96-102. 2005
  5. ncbi request reprint NO generation from nitrite and its role in vascular control
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 25:915-22. 2005
  6. ncbi request reprint Inorganic nitrate is a possible source for systemic generation of nitric oxide
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Free Radic Biol Med 37:395-400. 2004
  7. pmc Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production
    Adrian T Gonon
    Divison of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 7:e42038. 2012
  8. ncbi request reprint Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate
    Emmelie A Jansson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 171 77, Sweden
    Free Radic Biol Med 42:510-8. 2007
  9. pmc Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity
    Jiangning Yang
    Divison of Cardiology, Department of Medicine, and Divison of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 110:15049-54. 2013
  10. doi request reprint Inhibition of cancer cell replication by inorganic nitrite
    Edward Morcos
    Karolinska University Hospital, Stockholm, Sweden
    Nutr Cancer 62:501-4. 2010

Detail Information

Publications84

  1. ncbi request reprint Nitric oxide but not carbon monoxide is continuously released in the human nasal airways
    J O N Lundberg
    Dept Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Eur Respir J 20:100-3. 2002
    ..Orally exhaled air contains both nitric oxide and carbon dioxide whereas nasal air contains nitric oxide only...
  2. ncbi request reprint Increased nitric oxide production in collagenous and lymphocytic colitis
    J O Lundberg
    Department of Pharmacology, Karolinska Institute, Stockholm, Sweden
    Eur J Clin Invest 27:869-71. 1997
    ..Moreover, it is tempting to speculate that these measurements could be clinically useful in the diagnosis and therapy monitoring of these two inflammatory bowel diseases...
  3. ncbi request reprint Nitrate, bacteria and human health
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Stockholm, Sweden
    Nat Rev Microbiol 2:593-602. 2004
  4. ncbi request reprint Technology insight: calprotectin, lactoferrin and nitric oxide as novel markers of inflammatory bowel disease
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Nat Clin Pract Gastroenterol Hepatol 2:96-102. 2005
    ..Here, we discuss what is known about these markers, how they could be used in clinical practice and how they can complement existing techniques used for the diagnosis and monitoring of inflammatory bowel disease...
  5. ncbi request reprint NO generation from nitrite and its role in vascular control
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 25:915-22. 2005
    ..With this new knowledge, nitrate and nitrite should probably be viewed as storage pools for NO rather than inert waste products. Here we discuss novel aspects of nitrite-dependent NO generation in vivo and its role in vascular control...
  6. ncbi request reprint Inorganic nitrate is a possible source for systemic generation of nitric oxide
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Free Radic Biol Med 37:395-400. 2004
    ..There are several pathways to further reduce this nitrite to NO. These results challenge the dogma that nitrate is biologically inert and instead suggest that a complete reverse pathway for generation of NO from nitrate exists...
  7. pmc Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production
    Adrian T Gonon
    Divison of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 7:e42038. 2012
    ..Local arginase inhibition during early reperfusion reduces infarct size via a mechanism that is dependent on increased bioavailability of NO...
  8. ncbi request reprint Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate
    Emmelie A Jansson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 171 77, Sweden
    Free Radic Biol Med 42:510-8. 2007
    ..Future studies will reveal if a diet rich in nitrate can offer an additional nutritional approach to preventing and treating peptic ulcer disease...
  9. pmc Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity
    Jiangning Yang
    Divison of Cardiology, Department of Medicine, and Divison of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 110:15049-54. 2013
    ..These results strongly support the notion that RBCs contain functional eNOS and release NO-like bioactivity. This process is under tight control by arginase 1 and is of functional importance during ischemia-reperfusion. ..
  10. doi request reprint Inhibition of cancer cell replication by inorganic nitrite
    Edward Morcos
    Karolinska University Hospital, Stockholm, Sweden
    Nutr Cancer 62:501-4. 2010
    ..The inhibitory effect is likely caused by nitric oxide and possibly other reactive nitrogen oxides formed from acidified nitrite...
  11. doi request reprint Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care
    Eddie Weitzberg
    Section of Anesthesiology and Intensive Care, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Anesthesiology 113:1460-75. 2010
    ..In this article, we present an overview of this field of research with emphasis on relevance in anesthesiology and intensive care...
  12. doi request reprint Decreased leukocyte recruitment by inorganic nitrate and nitrite in microvascular inflammation and NSAID-induced intestinal injury
    Cecilia Jädert
    Department of Physiology and Pharmacology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Free Radic Biol Med 52:683-92. 2012
    ..Bioactivation of dietary nitrate requires intermediate formation of nitrite by oral nitrate-reducing bacteria and then probably further reduction to NO and other bioactive nitrogen oxides in the tissues...
  13. doi request reprint The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash
    Mirco Govoni
    Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, S 17177 Stockholm, Sweden
    Nitric Oxide 19:333-7. 2008
    ..The removal of these bacteria with an antibacterial mouthwash will very likely attenuate the NO-dependent biological effects of dietary nitrate...
  14. ncbi request reprint Rectal nitric oxide and fecal calprotectin in inflammatory bowel disease
    Claudia A Reinders
    Department of Physiology and Pharmacology Karolinska Institutet, Stockholm, Sweden
    Scand J Gastroenterol 42:1151-7. 2007
    ..Both rectal nitric oxide (NO) and fecal calprotectin can be measured using non-invasive methods and are emerging as promising inflammatory markers in IBD. In this study the aim was to compare calprotectin and NO levels in IBD patients...
  15. doi request reprint Dietary inorganic nitrate improves mitochondrial efficiency in humans
    Filip J Larsen
    Department of Physiology and Pharmacology, Karolinska Institutet, 11486 Stockholm, Sweden
    Cell Metab 13:149-59. 2011
    ..We conclude that dietary nitrate has profound effects on basal mitochondrial function. These findings may have implications for exercise physiology- and lifestyle-related disorders that involve dysfunctional mitochondria...
  16. doi request reprint Regulation of mitochondrial function and energetics by reactive nitrogen oxides
    Filip J Larsen
    Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Free Radic Biol Med 53:1919-28. 2012
    ..Here we discuss the latest advances in our understanding of the roles of nitrate, nitrite, and NO in the modulation of mitochondrial function, with a particular focus on dietary nitrate and exercise...
  17. doi request reprint A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
    Emmelie A Jansson
    Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, SE 171 77 Stockholm, Sweden
    Nat Chem Biol 4:411-7. 2008
    ..Our findings suggest a role for mammalian nitrate reduction in regulation of nitrite and NO homeostasis...
  18. doi request reprint Mitochondrial oxygen affinity predicts basal metabolic rate in humans
    Filip J Larsen
    1 Department of Physiology and Pharmacology, Karolinska Institutet, 11486 Stockholm, Sweden
    FASEB J 25:2843-52. 2011
    ..The implications of these findings are discussed in terms of a trade-off between aerobic efficiency and power...
  19. ncbi request reprint Intragastric generation of antimicrobial nitrogen oxides from saliva--physiological and therapeutic considerations
    Håkan Björne
    Department of Physiology and Pharmacology, Karolinska Institute, 177 76 Stockholm, Sweden
    Free Radic Biol Med 41:1404-12. 2006
    ..Acidified nitrite inside a gas-permeable retention cuff may be useful for restoring gastric NO levels and host defense in critically ill patients...
  20. pmc Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice
    Mattias Carlström
    Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:17716-20. 2010
    ..These findings may have implications for novel nutrition-based preventive and therapeutic strategies against cardiovascular disease and type 2 diabetes...
  21. doi request reprint Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans
    Tomas A Schiffer
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Respir Physiol Neurobiol 185:339-48. 2013
    ..During cycle ergometry nitrate had no effect on SaO(2), FETO(2) or maximum apnea duration. The negative effects of inorganic nitrate during static apnea may be explained by an attenuated diving response...
  22. doi request reprint Arginase inhibition restores in vivo coronary microvascular function in type 2 diabetic rats
    Julia Grönros
    Department of Medicine, Division of Cardiology, Karolinska Institute, Stockholm, Sweden
    Am J Physiol Heart Circ Physiol 300:H1174-81. 2011
    ..Treatment with nor-NOHA restores the microvascular function by a mechanism related to increased utilization of arginine by NOS and increased NO availability...
  23. doi request reprint Measurement of luminal nitric oxide in the uterine cavity using a silicon balloon catheter
    Angelos Sioutas
    Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Nitric Oxide 24:213-6. 2011
    ..The levels of nitric oxide are increased in women diagnosed with pelvic inflammatory disease already after an incubation time of 2 min...
  24. doi request reprint Metabolism and pathways for denitration of organic nitrates in the human liver
    Mirco Govoni
    Department of Physiology and Pharmacology, Karolinska Institute, Nanna Svartz vag 2, S 177 76 Stockholm, Sweden
    J Pharmacol Exp Ther 346:96-104. 2013
    ....
  25. doi request reprint Inorganic nitrite stimulates pancreatic islet blood flow and insulin secretion
    Thomas Nystrom
    Department of Clinical Science and Education, Karolinska Institutet, Sodersjukhuset, SE 118 83 Stockholm, Sweden
    Free Radic Biol Med 53:1017-23. 2012
    ..The insulinotropic effect of nitrite is cGMP-dependent and involves formation of reactive nitrogen and oxygen species...
  26. doi request reprint The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Nat Rev Drug Discov 7:156-67. 2008
    ....
  27. ncbi request reprint Rectal nitric oxide as biomarker in the treatment of inflammatory bowel disease: responders versus nonresponders
    Tryggve Ljung
    Department of Gastroenterology and Hepatology, Karolinska University Hospital, Site Solna, Stockholm, Sweden
    World J Gastroenterol 12:3386-92. 2006
    ....
  28. doi request reprint Nitrate and nitrite in biology, nutrition and therapeutics
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Nat Chem Biol 5:865-9. 2009
    ..The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm...
  29. doi request reprint Enhanced xanthine oxidoreductase expression and tissue nitrate reduction in germ free mice
    Liyue Huang
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Nitric Oxide 22:191-5. 2010
    ..Future studies will reveal if this represents a compensatory functional response to uphold nitrite homeostasis in the absence of commensal bacteria...
  30. doi request reprint NO-synthase independent NO generation in mammals
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, S 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 396:39-45. 2010
    ..Moreover, an increasing number of studies suggest a therapeutic potential for nitrate and nitrite in diseases such as myocardial infarction, stroke, hypertension, renal failure and gastric ulcers...
  31. ncbi request reprint Intragastric nitric oxide is abolished in intubated patients and restored by nitrite
    Håkan Björne
    Department of Anesthesiology and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
    Crit Care Med 33:1722-7. 2005
    ..We studied intragastric NO levels in healthy controls and in intubated intensive care unit patients before and after supplementation with nitrite...
  32. doi request reprint Arginase inhibition mediates cardioprotection during ischaemia-reperfusion
    Christian Jung
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Cardiovasc Res 85:147-54. 2010
    ..The present study investigated whether arginase blockade protects from myocardial IR injury and whether such an effect is coupled to increased NO bioavailability...
  33. doi request reprint Biology of nitrogen oxides in the gastrointestinal tract
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Gut 62:616-29. 2013
    ..In addition, opportunities for nitric oxide-based pharmacological or dietary interventions are highlighted...
  34. doi request reprint Dietary conjugated linoleic acid activates PPARγ and the intestinal trefoil factor in SW480 cells and mice with dextran sulfate sodium-induced colitis
    Sara Borniquel
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Nutr 142:2135-40. 2012
    ..Altogether, these results indicate that dietary CLA protects against DSS-induced colitis in a process involving induction of PPARγ and TFF3...
  35. ncbi request reprint Cardioprotective effects of vegetables: is nitrate the answer?
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet 171 77, Stockholm, Sweden
    Nitric Oxide 15:359-62. 2006
    ....
  36. doi request reprint Roles of dietary inorganic nitrate in cardiovascular health and disease
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Cardiovasc Res 89:525-32. 2011
    ..A theory is now emerging suggesting nitrate as an active component in vegetables contributing to the beneficial health effects of this food group, including protection against cardiovascular disease and type-2 diabetes...
  37. ncbi request reprint Gastroprotective effects of salivary urate? A commentary on "Salivary uric acid at the acidic pH of the stomach is the principal defense against nitrite-derived reactive species: Sparing effects of chlorogenic acid and serum albumin"
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 171 77, Sweden
    Free Radic Biol Med 41:1747-9. 2006
  38. pmc Nitrated oleic acid up-regulates PPARgamma and attenuates experimental inflammatory bowel disease
    Sara Borniquel
    Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Free Radic Biol Med 48:499-505. 2010
    ..Altogether, these findings demonstrate that administration of OA-NO(2) attenuates colonic inflammation and improves clinical symptoms in experimental inflammatory bowel disease. This protection involves activation of colonic PPARgamma...
  39. doi request reprint NO generation from inorganic nitrate and nitrite: Role in physiology, nutrition and therapeutics
    Jon O Lundberg
    Department of Physiology and Pharmacology, Division of Pharmacology Karolinska Institutet, Stockholm, Sweden
    Arch Pharm Res 32:1119-26. 2009
    ..Finally, there is an intriguing nutritional aspect to this, since the major supply of nitrate and nitrite in our bodies comes from our everyday diet. Here we review recent advances in this exciting area of research...
  40. ncbi request reprint Rectal mucosal nitric oxide in differentiation of inflammatory bowel disease and irritable bowel syndrome
    Claudia I Reinders
    Division of Pharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Clin Gastroenterol Hepatol 3:777-83. 2005
    ..To further evaluate this disease marker, we compared NO in patients with irritable bowel syndrome (IBS) with those found in patients with active IBD and in healthy control subjects...
  41. ncbi request reprint Infliximab in clinical routine: experience with Crohn's disease and biomarkers of inflammation over 5 years
    Maria H Lönnkvist
    Department of Medicine, Gastroenterology and Hepatology Unit, Karolinska Institutet, Stockholm, Sweden
    Eur J Gastroenterol Hepatol 21:1168-76. 2009
    ..Infliximab was launched for the treatment of Crohn's disease (CD) in 1999. We set up a follow-up protocol to meticulously study disease development with repeated infusions of infliximab...
  42. ncbi request reprint Prolonged exposure to inhaled nitric oxide does not affect haemostasis in piglets
    Johanna Albert
    Danderyd University Hospital, Karolinska Institutet, Department of Clinical Sciences, Division of Anaesthesia and Intensive Care, SE 18288 Stockholm, Sweden
    Intensive Care Med 33:1594-601. 2007
    ..To examine possible adverse effects on haemostasis from prolonged exposure to inhaled nitric oxide (iNO)...
  43. pmc Dietary nitrate increases tetanic [Ca2+]i and contractile force in mouse fast-twitch muscle
    Andres Hernandez
    Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Physiol 590:3575-83. 2012
    ..A new mechanism is revealed by which nitrate can exert effects on muscle function with applications to performance and a potential therapeutic role in conditions with muscle weakness...
  44. doi request reprint Intestinal hydrogen and nitric oxide gases in preterm infants--effects of antibiotic therapy
    Tanja Sobko
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Neonatology 95:68-73. 2009
    ..The significance of preterm birth and antibiotic therapy for intestinal gas production is not known and was the subject of this study...
  45. pmc Nitrite in saliva increases gastric mucosal blood flow and mucus thickness
    HåKan Björne H
    Department of Anesthesiology and Intensive Care, Karolinska Hospital, Stockholm, Sweden
    J Clin Invest 113:106-14. 2004
    ..These effects are likely mediated through nonenzymatic generation of NO via activation of guanylyl cyclase. This supports a gastroprotective role of salivary nitrate/nitrite...
  46. ncbi request reprint Increased rectal nitric oxide in coeliac disease after local challenge with gluten
    M Herulf
    Dept of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Scand J Gastroenterol 36:169-73. 2001
    ..The aim of this study was to evaluate whether rectal challenge with gluten would trigger an increased local production of the gas nitric oxide (NO), a novel marker of intestinal inflammation...
  47. ncbi request reprint Nitric oxide inhibition of renal vasoconstrictor responses to sympathetic cotransmitters in the pig in vivo
    R E Malmstrom
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Nitric Oxide 5:98-104. 2001
    ..In contrast, NO seems not to modify vasoconstrictor responses to the sympathetic cotransmitter ATP, a discrepancy that may be due to differences in the types of receptors and intracellular effector mechanisms...
  48. ncbi request reprint Effect of intravenous L-NMMA on nitric oxide production in collagenous colitis
    C I Reinders
    Dept of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institute, Stockholm, Sweden
    Scand J Gastroenterol 39:32-6. 2004
    ..We investigated the effect of the NO synthase inhibitor L-NMMA on intestinal concentrations of NO in patients with clinically active collagenous colitis. In addition, we measured NO levels from the respiratory tract...
  49. ncbi request reprint Increased nitric oxide in infective gastroenteritis
    M Herulf
    Department of Physiology and Pharmacology Division of Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Infect Dis 180:542-5. 1999
    ..The high levels of NO are easily measurable by rectal sampling, and measurement of luminal NO seems to be useful for evaluating local NO production in the gut in health and disease...
  50. doi request reprint Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise
    Filip J Larsen
    Department of Physiology and Pharmacology, Swedish School of Sport and Health Sciences, Karolinska Institutet, 11486 Stockholm, Sweden
    Free Radic Biol Med 48:342-7. 2010
    ..This reduction occurred with a trend toward increased time to exhaustion implying that two separate mechanisms are involved: one that reduces VO(2max) and another that improves the energetic function of the working muscles...
  51. ncbi request reprint Endogenous nitric oxide release by vasoactive drugs monitored in exhaled air
    Rickard E Malmström
    Department of Surgical Sciences, Karolinska Institute, S 17176 Stockholm, Sweden
    Am J Respir Crit Care Med 168:114-20. 2003
    ..Moreover, the possibility of using exhaled NO as an indicator of pulmonary endothelial dysfunction merits further studies...
  52. doi request reprint Nitric oxide and the paranasal sinuses
    Jon O Lundberg
    Karolinska Institutet, Department of Physiology and Pharmacology, Stockholm, Sweden
    Anat Rec (Hoboken) 291:1479-84. 2008
    ..In this sense NO may be regarded as an "aerocrine" hormone that is produced in the nose and sinuses and transported to a distal site of action with every inhalation...
  53. pmc Intravesical nitric oxide delivery for prevention of catheter-associated urinary tract infections
    Stefan Carlsson
    Department of Surgery, Section of Urology, Karolinska Hospital, and Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Stockholm, Sweden
    Antimicrob Agents Chemother 49:2352-5. 2005
    ..Future clinical trials will reveal whether this novel approach for the intravesical delivery of an antibacterial gas could be used to prevent catheter-associated infections...
  54. ncbi request reprint Paranasal sinus ventilation by humming
    Svante Granqvist
    Department of Speech Music Hearing, KTH, Stockholm, Sweden
    J Acoust Soc Am 119:2611-7. 2006
    ....
  55. ncbi request reprint Intrauterine nitric oxide in pelvic inflammatory disease
    Angelos Sioutas
    Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    Fertil Steril 89:948-52. 2008
    ..To measure nitric oxide gas directly in the uterus of healthy women and patients with suspected pelvic inflammatory disease...
  56. ncbi request reprint Gastrointestinal nitric oxide generation in germ-free and conventional rats
    Tanja Sobko
    Centre for Allergy Research, Karolinska Institutet, S 17177 Stockholm, Sweden
    Am J Physiol Gastrointest Liver Physiol 287:G993-7. 2004
    ..Distinctly compartmentalized qualitative and quantitative NO levels in conventional and germ-free rats reflect complex host microbial cross talks, possibly making NO a regulator of the intestinal eco system...
  57. ncbi request reprint Sounding airflow enhances aerosol delivery into the paranasal sinuses
    M Maniscalco
    Department of Pharmacology and Physiology, Karolinska Institute, Stockholm, Sweden
    Eur J Clin Invest 36:509-13. 2006
    ..This is reflected by a high peak in nasally exhaled nitric oxide (NO) levels because NO accumulated in the sinuses is rapidly washed-out via the sinus ostia...
  58. ncbi request reprint Characterization of airway nitric oxide in allergic rhinitis: the effect of intranasal administration of L-NAME
    J P Palm
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Allergy 58:885-92. 2003
    ..hcl (l-name)...
  59. ncbi request reprint Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite
    T Sobko
    Department of Physiology and Pharmacology, Karolinska Institutet, S 17177 Stockholm, Sweden
    Nitric Oxide 13:272-8. 2005
    ..We conclude that NO can be generated by the anaerobic gut flora in the presence of nitrate or nitrite. Future studies will reveal its biological significance in regulation of gastrointestinal integrity...
  60. doi request reprint Control of pathogen growth and biofilm formation using a urinary catheter that releases antimicrobial nitrogen oxides
    Hiroaki Kishikawa
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Free Radic Biol Med 65:1257-64. 2013
    ..Although promising, future studies will reveal if this novel approach can be clinically useful for the prevention of catheter-associated urinary tract infections. ..
  61. doi request reprint Novel aspects of dietary nitrate and human health
    Eddie Weitzberg
    Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Annu Rev Nutr 33:129-59. 2013
    ..In our diet, vegetables are the major source of nitrate that can fuel a nitrate-nitrite-NO pathway. Herein we discuss the nutritional aspects of this pathway and what is presently known about the implications for human health. ..
  62. pmc Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish
    Lasse Dahl Ejby Jensen
    Department of Microbiology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:18408-13. 2009
    ..Our results might also imply that the hypoxia-induced NO pathway contributes to development of progression of pathologies, including promotion of lymphatic metastasis by modulating arterial-lymphatic conduits, in the mammalian system...
  63. ncbi request reprint Airborne nitric oxide: inflammatory marker and aerocrine messenger in man
    J O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Acta Physiol Scand Suppl 633:1-27. 1996
    ..Thus, airborne NO may be looked upon as a marker of inflammation and as an aerocrine messenger in humans...
  64. ncbi request reprint Birth-related increase in intracolonic hydrogen gas and nitric oxide as indicator of host-microbial interactions
    T Sobko
    Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    Allergy 60:396-400. 2005
    ..e. bacterial products, as well as of nitric oxide (NO), a marker of mucosal immune activation...
  65. ncbi request reprint Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation
    A Modin
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Acta Physiol Scand 171:9-16. 2001
    ..These results illustrate non-enzymatic release of NO from nitrite at physiological concentrations. This may be an important auto-regulated physiological mechanism involved in the regulation of vascular tone during hypoxia/ischaemia...
  66. ncbi request reprint Effects of pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation and bacterial growth in urine
    S Carlsson
    Department of Surgery, Section of Urology, Karolinska Hospital, Stockholm, Sweden
    Nitric Oxide 5:580-6. 2001
    ..These results may help to explain the well-known beneficial effects of urinary acidification with, e.g., vitamin C in treatment and prevention of urinary tract infection...
  67. pmc In vitro evaluation of a new treatment for urinary tract infections caused by nitrate-reducing bacteria
    S Carlsson
    Department of Surgery, Section of Urology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Antimicrob Agents Chemother 47:3713-8. 2003
    ..We speculate that ingestion of nitrate followed some hours later by acidification of urine could be a new therapeutic strategy for the treatment of urinary tract infections...
  68. ncbi request reprint Effects of dietary nitrate on oxygen cost during exercise
    F J Larsen
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 191:59-66. 2007
    ..The diet constitutes a major source of nitrate, and vegetables are particularly rich in this anion. The aim of this study was to investigate if dietary nitrate had any effect on metabolic and circulatory parameters during exercise...
  69. ncbi request reprint Early changes in rectal nitric oxide and mucosal inflammatory mediators in Crohn's colitis in response to infliximab treatment
    T Ljung
    Department of Gastroenterology and Hepatology, Karolinska University Hospital, Stockholm, Sweden
    Aliment Pharmacol Ther 25:925-32. 2007
    ..Treatment with tumor necrosis factor-alpha monoclonal antibody (infliximab) reduces clinical activity and intestinal inflammation in Crohn's disease...
  70. ncbi request reprint Humming-induced release of nasal nitric oxide for assessment of sinus obstruction in allergic rhinitis: pilot study
    M Maniscalco
    Karolinska Institutet, Stockholm, Sweden
    Eur J Clin Invest 34:555-60. 2004
    ..Humming greatly increases nasal nitric oxide (NO) in healthy people by causing a rapid washout of NO from the sinuses. This increase is abolished in patients with complete sinus ostial obstruction...
  71. ncbi request reprint Assessment of nasal and sinus nitric oxide output using single-breath humming exhalations
    M Maniscalco
    Dept of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Eur Respir J 22:323-9. 2003
    ..Combined nasal nitric oxide measurement with and without humming could be of use to estimate sinus ventilation and to better separate nasal mucosal nitric oxide output from sinus nitric oxide in health and disease...
  72. ncbi request reprint Dietary nitrate increases gastric mucosal blood flow and mucosal defense
    Joel Petersson
    Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Am J Physiol Gastrointest Liver Physiol 292:G718-24. 2007
    ..The gastroprotective effect likely involves a higher mucosal blood flow caused by nonenzymatic NO production. These data suggest an important physiological role of nitrate in the diet...
  73. doi request reprint Nitrite reduction to nitric oxide in the vasculature
    Jon O Lundberg
    Am J Physiol Heart Circ Physiol 295:H477-8. 2008
  74. ncbi request reprint Multiple single-breath measurements of nitric oxide in the intubated patient
    Daniel C Törnberg
    Department of Anesthesiology and Intensive Care, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Am J Respir Crit Care Med 168:1210-5. 2003
    ..Further studies will reveal whether this methodology will improve the value of exhaled NO analysis in intubated, mechanically ventilated patients with pulmonary disease...
  75. ncbi request reprint Nitric oxide metabolites and cardiovascular disease markers, mediators, or both?
    Jon O Lundberg
    J Am Coll Cardiol 47:580-1. 2006
  76. ncbi request reprint ATS workshop proceedings: exhaled nitric oxide and nitric oxide oxidative metabolism in exhaled breath condensate
    Philip E Silkoff
    Proc Am Thorac Soc 3:131-45. 2006
  77. ncbi request reprint The emerging biology of the nitrite anion
    Mark T Gladwin
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Chem Biol 1:308-14. 2005
    ..A recent two-day symposium at the US National Institutes of Health highlighted recent advances in the understanding of nitrite biochemistry, physiology and therapeutics...
  78. ncbi request reprint Acute purulent sinusitis triggered by topical nasal nitric oxide synthase inhibition
    Jon O Lundberg
    Am J Respir Crit Care Med 172:512-3. 2005
  79. pmc Extrapulmonary effects of nitric oxide inhalation therapy: time to consider new dosing regimes?
    Jon O Lundberg
    Crit Care 12:406. 2008
  80. doi request reprint The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions
    Bruno Gago
    Center for Neuroscience and Cell Biology and Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
    Free Radic Biol Med 45:404-12. 2008
    ..These findings reveal an alternative chemical reaction pathway for dietary nitrate and nitrite with possible impact on gastric physiology and pathophysiology...
  81. ncbi request reprint Humming, nitric oxide, and paranasal sinus obstruction
    Jon O Lundberg
    JAMA 289:302-3. 2003
  82. ncbi request reprint Red wine-dependent reduction of nitrite to nitric oxide in the stomach
    Bruno Gago
    Center for Neuroscience and Cell Biology and Faculty of Pharmacy, University of Coimbra, 3000 Coimbra, Portugal
    Free Radic Biol Med 43:1233-42. 2007
    ..The reduction of nitrite may reveal previously unrecognized physiologic effects of red wine in connection with *NO bioactivity...
  83. ncbi request reprint Effects of dietary nitrate on blood pressure in healthy volunteers
    Filip J Larsen
    N Engl J Med 355:2792-3. 2006
  84. ncbi request reprint Generation of NO by probiotic bacteria in the gastrointestinal tract
    Tanja Sobko
    Department Physiology and Pharmacology, Karolinska Institutet 171 77 Stockholm, Sweden
    Free Radic Biol Med 41:985-91. 2006
    ..The generation of NO by some probiotic bacteria can be counteracted by rapid NO consumption by other strains. Future studies will clarify the biological role of the bacteria-derived intestinal NO in health and disease...