Karin Lore

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses
    Karin Lore
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:1721-9. 2007
  2. pmc HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates
    Ulrike Wille-Reece
    Cellular Immunology Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:15190-4. 2005
  3. pmc In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaques
    Karin Lore
    Immunology Laboratory, Research Center, National Institute of Allergy and Infectious Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 1202, USA
    Stem Cells 24:1539-48. 2006
  4. ncbi request reprint Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner
    Ruth Seggewiss
    Hematology Branch, National Heart, Lung, and Blood Institute NHLBI, the Immunology Laboratory, NIH DHHS, Bldg 10, CRC, Rm 4 5140, 10 Center Dr, MSC 1202, Bethesda, MD 20892, USA
    Blood 105:2473-9. 2005
  5. pmc Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates
    Ulrike Wille-Reece
    Cellular Immunology Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:1249-58. 2006
  6. ncbi request reprint HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters
    Makoto Sugaya
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, and Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 172:2219-24. 2004
  7. ncbi request reprint Isolation and immunophenotyping of human and rhesus macaque dendritic cells
    Karin Lore
    Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 20892 3022, USA
    Methods Cell Biol 75:623-42. 2004
  8. ncbi request reprint The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration
    Michael R Betts
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:6407-17. 2004
  9. ncbi request reprint Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses
    Karin Lore
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3022, USA
    J Immunol 171:4320-8. 2003
  10. pmc Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells
    Karin Lore
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:2023-33. 2005

Collaborators

Detail Information

Publications35

  1. pmc Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses
    Karin Lore
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:1721-9. 2007
    ..Thus, the ability of rAd35 to naturally target important DC subsets, induce their maturation, and appropriately present Ag to T cells may herald greater in vivo immunogenicity than has been observed with rAd5...
  2. pmc HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates
    Ulrike Wille-Reece
    Cellular Immunology Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:15190-4. 2005
    ..This type of vaccine formulation should have utility in preventive or therapeutic vaccines in which humoral and cellular immunity is required...
  3. pmc In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaques
    Karin Lore
    Immunology Laboratory, Research Center, National Institute of Allergy and Infectious Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 1202, USA
    Stem Cells 24:1539-48. 2006
    ..These results have implications for the design of gene therapy trials, as well as for the use of expanded PBPCs for improved T-cell immune reconstitution after transplantation...
  4. ncbi request reprint Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner
    Ruth Seggewiss
    Hematology Branch, National Heart, Lung, and Blood Institute NHLBI, the Immunology Laboratory, NIH DHHS, Bldg 10, CRC, Rm 4 5140, 10 Center Dr, MSC 1202, Bethesda, MD 20892, USA
    Blood 105:2473-9. 2005
    ....
  5. pmc Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates
    Ulrike Wille-Reece
    Cellular Immunology Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:1249-58. 2006
    ..These data provide insights for designing prime-boost immunization regimens to optimize Th1 and CD8+ T cell responses...
  6. ncbi request reprint HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters
    Makoto Sugaya
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, and Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 172:2219-24. 2004
    ..Disrupting cluster formation between LC and memory CD4(+) T cells may be a novel strategy to interfere with sexual transmission of HIV...
  7. ncbi request reprint Isolation and immunophenotyping of human and rhesus macaque dendritic cells
    Karin Lore
    Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 20892 3022, USA
    Methods Cell Biol 75:623-42. 2004
  8. ncbi request reprint The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration
    Michael R Betts
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:6407-17. 2004
    ..The inherent ability of viruses to induce high or low Ag states may be the primary determinant of the cytokine vs cytolytic nature of the virus-specific CD8(+) T cell response...
  9. ncbi request reprint Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses
    Karin Lore
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3022, USA
    J Immunol 171:4320-8. 2003
    ....
  10. pmc Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells
    Karin Lore
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:2023-33. 2005
    ..This suggests that the induction of antigen-specific T cell responses by DCs, a process crucial to immune defense, can lead to preferential HIV-1 infection and the deletion of responding CD4(+) T cells...
  11. ncbi request reprint Coadministration of polyinosinic:polycytidylic acid and immunostimulatory complexes modifies antigen processing in dendritic cell subsets and enhances HIV gag-specific T cell immunity
    Kylie M Quinn
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 191:5085-96. 2013
    ..These data illustrate how combining adjuvants, such as poly I:C and ISCOMs, that modulate Ag processing and have potent innate activity, can enhance the magnitude, quality, and phenotype of T cell immunity. ..
  12. pmc Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity
    Matthew J Johnson
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:6109-18. 2012
    ..Taken together, our results demonstrate that rAd-induced IFN-α production has multiple effects on T cell immunogenicity, the understanding of which should be considered in the design of rAd vaccine vectors...
  13. pmc IFN-α produced by human plasmacytoid dendritic cells enhances T cell-dependent naïve B cell differentiation
    Cornelia Gujer
    Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden
    J Leukoc Biol 89:811-21. 2011
    ..In summary, PDCs, via their production of IFN-α, may render B cells more responsive to T cell contact, which in turn, facilitates B cell proliferation and differentiation to antibody-producing cells...
  14. ncbi request reprint Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection
    Karin Lore
    Division of Clinical Virology, Department of Microbiology, Pathology and Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    AIDS 16:683-92. 2002
    ..Dendritic cells (DC) are target cells for HIV-1 and play a key role in antigen presentation and activation of T cells...
  15. pmc Type I interferon-dependent activation of NK cells by rAd28 or rAd35, but not rAd5, leads to loss of vector-insert expression
    Matthew J Johnson
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
    Vaccine 32:717-24. 2014
    ..This may be a possible mechanism that results in reduced immunogenicity of rAd28 and rAd35-based vectors. ..
  16. ncbi request reprint Dendritic cells at the interface of innate and adaptive immunity to HIV-1
    Anna Smed-Sorensen
    Department of Microbiology, Tumor and Cell Biology bCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Curr Opin HIV AIDS 6:405-10. 2011
    ..This review summarizes recent findings on how HIV-1 infection affects dendritic cells in their ability to elicit innate and adaptive immune responses...
  17. ncbi request reprint Abundant and superficial expression of C-type lectin receptors in ectocervix of women at risk of HIV infection
    Taha Hirbod
    Infectious Diseases Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
    J Acquir Immune Defic Syndr 51:239-47. 2009
    ..Here, we characterized the distribution of various DC subtypes and the density of the CLRs, DC-SIGN, langerin, and mannose receptor in the ectocervix of HIV-seronegative women with low- and high-risk behavior for acquiring HIV...
  18. doi request reprint Human B cell responses to TLR ligands are differentially modulated by myeloid and plasmacytoid dendritic cells
    Iyadh Douagi
    Swedish Institute for Infectious Disease Control, Stockholm, Sweden
    J Immunol 182:1991-2001. 2009
    ..These data help decipher the different roles of PDCs and MDCs for modulating human B cell responses and can contribute to selection of specific TLR ligands as vaccine adjuvants...
  19. doi request reprint Adenovirus serotype 5 infects human dendritic cells via a coxsackievirus-adenovirus receptor-independent receptor pathway mediated by lactoferrin and DC-SIGN
    William C Adams
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Gen Virol 90:1600-10. 2009
    ..A better understanding of the tropism and receptor mechanisms of Ad5 may help explain Ad5 pathogenesis and guide the engineering of improved rAd vectors...
  20. pmc Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies
    Lakshmanan Ganesh
    Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bldg 40, Rm 4502, MSC 3005, 40 Convent Dr, Bethesda, MD 20892 3005, USA
    J Virol 78:11980-7. 2004
    ..This property of DCs may enhance infection, contribute to immune evasion, and could provide a selective advantage for CCR5-tropic virus transmission...
  21. ncbi request reprint The role of dendritic cells in the pathogenesis of HIV-1 infection
    Karin Lore
    Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3022, USA
    APMIS 111:776-88. 2003
    ..In addition, we discuss the mechanisms through which HIV-1-DC interactions could be exploited to optimise the generation and maintenance of HIV-1-specific T cell immunity...
  22. ncbi request reprint HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation
    Anna Smed-Sorensen
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, F59 Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Blood 104:2810-7. 2004
    ..These observations suggest that HIV-1 infection disables DC function, a phenomenon that may be relevant for optimal induction of HIV-1-specific immune responses...
  23. pmc Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques
    Ruth Seggewiss
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Blood 110:441-9. 2007
    ..Thus, our findings suggest that KGF may be a useful adjuvant therapy to augment T-cell reconstitution after human PBPC transplantation...
  24. pmc IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcgammaRIIa
    Anna Smed-Sorensen
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Blood 111:5037-46. 2008
    ..Our data demonstrate an important role for FcgammaRIIa in regulating the CD1 antigen presentation machinery of human DCs...
  25. pmc Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates
    Christopher Sundling
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    J Exp Med 207:2003-17. 2010
    ..These data provide important information for the design and evaluation of vaccines aimed at stimulating protective HIV-1 immune responses in humans...
  26. pmc Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells
    Chuanfeng Wu
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Stem Cell 14:486-99. 2014
    ..Thus, in addition to providing insights into clonal behavior over time, our analysis suggests an unexpected paradigm for the relationship between NK cells and other hematopoietic lineages in primates...
  27. pmc Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants
    Yu Feng
    Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA IAVI Center for Neutralizing Antibodies, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 446:56-65. 2013
    ..These results have implications for the coupling of ligands to vaccine antigens where elicitation of humoral immune responses to specific neutralizing determinants is desired. ..
  28. ncbi request reprint Enhanced in vivo protein synthesis in circulating immune cells of ICU patients
    Anna Januszkiewicz
    Department of Anaesthesiology and Intensive Care, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden
    J Clin Immunol 27:589-97. 2007
    ..Determination of the in vivo protein synthesis rate may be used as a tool to obtain additional information on activation of the immune system...
  29. ncbi request reprint Dichotomy between CD1a+ and CD83+ dendritic cells in lymph nodes during SIV infection of macaques
    Johan Söderlund
    Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden
    J Med Primatol 33:16-24. 2004
    ..Thus, disease progression to sAIDS was associated with impaired maturation of DC, and lack of CD83, DC-LAMP and S100b expression...
  30. ncbi request reprint Determination of in vivo protein synthesis in human palatine tonsil
    Anna Januszkiewicz
    Department of Anaesthesiology and Intensive Care, Karolinska University Hospital at Huddinge, Karolinska Institutet, Stockholm 141 86, Sweden
    Clin Sci (Lond) 108:179-84. 2005
    ..This high metabolic rate may reflect the permanent immunological activity present in human tonsils, although cell phenotypes and activity markers do not explain the differences...
  31. pmc Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells
    Anna Smed-Sorensen
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, F59 Huddinge University Hospital, S 141 86 Stockholm, Sweden
    J Virol 79:8861-9. 2005
    ..The difference in susceptibility of PDCs and MDCs to HIV-1 may have implications for HIV-1 transmission and DC-mediated transfer of HIV-1 to T cells...
  32. pmc Influence of novel CD4 binding-defective HIV-1 envelope glycoprotein immunogens on neutralizing antibody and T-cell responses in nonhuman primates
    Iyadh Douagi
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Box 280, S 171 77 Stockholm, Sweden
    J Virol 84:1683-95. 2010
    ..Overall, our studies do not reveal any potential negative effects imparted by the in vivo interaction between WT Env and primate CD4 on the generation of functional T cells and antibodies in response to soluble Env vaccination...
  33. pmc The Toxoplasma gondii-shuttling function of dendritic cells is linked to the parasite genotype
    Henrik Lambert
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, SE 14186 Stockholm, Sweden
    Infect Immun 77:1679-88. 2009
    ....
  34. pmc Immunization with wild-type or CD4-binding-defective HIV-1 Env trimers reduces viremia equivalently following heterologous challenge with simian-human immunodeficiency virus
    Christopher Sundling
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Box 280, S 171 77 Stockholm, Sweden
    J Virol 84:9086-95. 2010
    ....
  35. doi request reprint Novel adjuvants for B cell immune responses
    Karin Lore
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Curr Opin HIV AIDS 4:441-6. 2009
    ..Both established and new experimental approaches are described and also briefly we discuss how adjuvants and virus-based vaccines interact with the immune system...