Hans Link

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness
    Hans Link
    Karolinska Institute, 14185 Stockholm, Sweden
    J Neuroimmunol 180:17-28. 2006
  2. ncbi request reprint Protective potential of experimental autoimmune myasthenia gravis in Lewis rats by IL-10-modified dendritic cells
    Rui Sheng Duan
    Division of Neuroimmunology, Neurotec, Karolinska Institute, Stockholm, Sweden
    Neurobiol Dis 16:461-7. 2004
  3. ncbi request reprint Anti-inflammatory nuclear receptor superfamily in multiple sclerosis patients from Sardinia and Sweden
    Xuan Liu
    Neurotec Department, Division of Neuroimmunology, Karolinska Institute, 141 86 Stockholm, Sweden
    Neurobiol Dis 20:961-8. 2005
  4. ncbi request reprint Antigen-specific T cell functions are suppressed over the estrogen-dendritic cell-indoleamine 2,3-dioxygenase axis
    Bao guo Xiao
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, Alfred Nobels Alle 10, 141 83 Stockholm, Sweden
    Steroids 69:653-9. 2004
  5. ncbi request reprint Long-term effects of IFN-gamma, IL-10, and TGF-beta-modulated dendritic cells on immune response in Lewis rats
    Rui Sheng Duan
    Division of Neuroimmunology Neurotec, Karolinska Institute, Stockholm, Sweden
    J Clin Immunol 25:50-6. 2005
  6. ncbi request reprint Circulating CD4+CD25+ T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs
    Prabhakar Putheti
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, Stockholm, Sweden
    J Clin Immunol 24:155-61. 2004
  7. ncbi request reprint Immunological heterogeneity of multiple sclerosis in Sardinia and Sweden
    Yu Min Huang
    Neurotec Department, Karolinska Institute, Stockholm, Sweden
    Mult Scler 11:16-23. 2005
  8. ncbi request reprint CD24 and myosin light polypeptide 2 are involved in prevention of experimental autoimmune encephalomyelitis by myelin basic protein-pulsed dendritic cells
    Xuan Liu
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, 14183 Stockholm, Sweden
    J Neuroimmunol 172:137-44. 2006
  9. ncbi request reprint Multiple sclerosis: expression of CD1a and production of IL-12p70 and IFN-gamma by blood mononuclear cells in patients on combination therapy with IFN-beta and glatiramer acetate compared to monotherapy with IFN-beta
    Yassir Hussien
    Neurotec Department, Division of Neuroimmunology, Karolinska Institute, Alfred Nobels Alle 10, Stockholm, Sweden
    Mult Scler 10:16-25. 2004
  10. ncbi request reprint Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis
    Xuan Liu
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, 14183 Huddinge, Stockholm, Sweden
    Mult Scler 11:381-9. 2005

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness
    Hans Link
    Karolinska Institute, 14185 Stockholm, Sweden
    J Neuroimmunol 180:17-28. 2006
    ..systemic B-cell responses in patients with MS or CIS vs. patients with other inflammatory neurological diseases should shed new light on the role of CSF OB, which remains enigmatic...
  2. ncbi request reprint Protective potential of experimental autoimmune myasthenia gravis in Lewis rats by IL-10-modified dendritic cells
    Rui Sheng Duan
    Division of Neuroimmunology, Neurotec, Karolinska Institute, Stockholm, Sweden
    Neurobiol Dis 16:461-7. 2004
    ..Importantly, this procedure that autologous DC from EAMG were adopted to treat ongoing EAMG is more close to clinical trial in human, encouraging future evaluation in human myasthenia gravis...
  3. ncbi request reprint Anti-inflammatory nuclear receptor superfamily in multiple sclerosis patients from Sardinia and Sweden
    Xuan Liu
    Neurotec Department, Division of Neuroimmunology, Karolinska Institute, 141 86 Stockholm, Sweden
    Neurobiol Dis 20:961-8. 2005
    ..Higher levels of AR mRNA are present in HC from Sassari. The findings indicate that the expression levels of anti-inflammatory nuclear receptor superfamily genes in MS appear to reflect both ethnic and environmental influences...
  4. ncbi request reprint Antigen-specific T cell functions are suppressed over the estrogen-dendritic cell-indoleamine 2,3-dioxygenase axis
    Bao guo Xiao
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, Alfred Nobels Alle 10, 141 83 Stockholm, Sweden
    Steroids 69:653-9. 2004
    ..This observation could open up a novel therapeutic target for influencing the course of MS and other diseases with an autoimmune diseases background...
  5. ncbi request reprint Long-term effects of IFN-gamma, IL-10, and TGF-beta-modulated dendritic cells on immune response in Lewis rats
    Rui Sheng Duan
    Division of Neuroimmunology Neurotec, Karolinska Institute, Stockholm, Sweden
    J Clin Immunol 25:50-6. 2005
    ..These results suggest that IFN-gamma-DC seems to be a more ideal candidate in the treatment of autoimmune diseases without suppressing immune response...
  6. ncbi request reprint Circulating CD4+CD25+ T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs
    Prabhakar Putheti
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, Stockholm, Sweden
    J Clin Immunol 24:155-61. 2004
    ..This study suggests that levels of circulating CD4(+)CD25(+) Tr cells and CD4(+)CD25(high) Tr cells are not altered in MS, and are unaffected by substances currently used to modulate the disease...
  7. ncbi request reprint Immunological heterogeneity of multiple sclerosis in Sardinia and Sweden
    Yu Min Huang
    Neurotec Department, Karolinska Institute, Stockholm, Sweden
    Mult Scler 11:16-23. 2005
    ..The changes of pro-inflammatory and other immune response-related variables differ however between the two MS populations. This may be attributed to the genetic and/or environmental background...
  8. ncbi request reprint CD24 and myosin light polypeptide 2 are involved in prevention of experimental autoimmune encephalomyelitis by myelin basic protein-pulsed dendritic cells
    Xuan Liu
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, 14183 Stockholm, Sweden
    J Neuroimmunol 172:137-44. 2006
    ..These two genes could be targeted to treat EAE and, possibly, multiple sclerosis...
  9. ncbi request reprint Multiple sclerosis: expression of CD1a and production of IL-12p70 and IFN-gamma by blood mononuclear cells in patients on combination therapy with IFN-beta and glatiramer acetate compared to monotherapy with IFN-beta
    Yassir Hussien
    Neurotec Department, Division of Neuroimmunology, Karolinska Institute, Alfred Nobels Alle 10, Stockholm, Sweden
    Mult Scler 10:16-25. 2004
    ..It remains to be shown whether these immunological changes imply a clinical benefit. Follow up studies of immune variables versus clinical effects during combined therapy of MS with IFN-beta+GA are ongoing...
  10. ncbi request reprint Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis
    Xuan Liu
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, 14183 Huddinge, Stockholm, Sweden
    Mult Scler 11:381-9. 2005
    ..In line with the suppression of EAE induced by MBP-pulsed DC, the dynamic change of cytokines and growth factors in spinal cords should constitute a beneficial microenvironment against EAE...
  11. ncbi request reprint Dendritic cells exposed to estrogen in vitro exhibit therapeutic effects in ongoing experimental allergic encephalomyelitis
    Asa Pettersson
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, Alfred Nobels Alle 10, SE 141 83, Stockholm, Sweden
    J Neuroimmunol 156:58-65. 2004
    ..The results suggest that in vitro exposure of DC to estrogen modulates DC functions and results in a therapeutic effect of DC...
  12. ncbi request reprint Efficacy of peripheral tolerance induced by dendritic cells is dependent on route of delivery
    Qing Hong Zhang
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, Stockholm, Sweden
    J Autoimmun 23:37-43. 2004
    ..These results suggest that the administration route of DC should be considered as an important factor for DC-based immunotherapy in autoimmune diseases...
  13. ncbi request reprint Therapeutic potential of IFN-gamma-modified dendritic cells in acute and chronic experimental allergic encephalomyelitis
    Bao guo Xiao
    Division of Neuroimmunology, Neurotec and MRC, Department of Clinical Neuroscience, Karolinska Institute, 14183 Stockholm, Sweden
    Int Immunol 16:13-22. 2004
    ..This approach may represent a novel possibility of individualized immunotherapy using autologous, in vitro modified DC as a complement to conventional therapy in multiple sclerosis and other diseases with an autoimmune background...
  14. ncbi request reprint Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats
    Jian She Yang
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, Stockholm, Sweden
    J Neuroimmunol 156:3-9. 2004
    ..Laquinimod therefore represents a new orally active immunoregulatory drug without general immunosuppressive properties with a potential for the treatment of severe autoimmune diseases like MS...
  15. ncbi request reprint Decreased levels of CD95 and caspase-8 mRNA in multiple sclerosis patients with gadolinium-enhancing lesions on MRI
    Andreia C Gomes
    Division of Neurology, Neurotec Department, Karolinska Institute, Huddinge University Hospital R54, SE 141 86 Stockholm, Sweden
    Neurosci Lett 352:101-4. 2003
    ..05). These results support the notion that the CD95-dependent pathway plays a complex role in the regulation of survival of activated immune cells in MS...
  16. ncbi request reprint Effect of glatiramer acetate (Copaxone) on CD4+CD25high T regulatory cells and their IL-10 production in multiple sclerosis
    Prabhakar Putheti
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, Alfred Nobels Alle 10, SE 141 83 Stockholm, Sweden
    J Neuroimmunol 144:125-31. 2003
    ..We conclude that GA induces elevated IL-10 production by Tr cells that is uniform and independent of ongoing MS treatment with IFN-beta or GA or IFN-beta+GA...
  17. ncbi request reprint Dehydroepiandrosterone therapy ameliorates experimental autoimmune myasthenia gravis in Lewis rats
    Rui Sheng Duan
    Division of Neurology, Unit of Experimental Neurology R54, Karolinska Institute, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    J Clin Immunol 23:100-6. 2003
    ..These results obtained from EAMG in Lewis rats further encourage us to study DHEA treatment in human MG...
  18. ncbi request reprint Induction of peripheral tolerance to experimental autoimmune myasthenia gravis by acetylcholine receptor-pulsed dendritic cells
    Bao guo Xiao
    Neurotec Department, Karolinska Institute, Alfred Nobels Alle 10, SE 141 83, Stockholm, Sweden
    Cell Immunol 223:63-9. 2003
    ....
  19. ncbi request reprint Birth cohort effects in multiple sclerosis
    Ya Ping Jin
    Neuroepidemiology Unit, Division of Neurology, Karolinska Institute, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    Ann Epidemiol 13:252-60. 2003
    ..To identify potential birth cohort effects in multiple sclerosis in Sweden and particularly in Stockholm county...
  20. ncbi request reprint Dendritic cell vaccine design: strategies for eliciting peripheral tolerance as therapy of autoimmune diseases
    Bao guo Xiao
    Experimental Neurology and Neuroimmunology Units, Department of Neurotec, Karolinska Institute, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    BioDrugs 17:103-11. 2003
    ....
  21. ncbi request reprint Monocyte-derived dendritic cells express and secrete matrix-degrading metalloproteinases and their inhibitors and are imbalanced in multiple sclerosis
    Mathilde Kouwenhoven
    Neuroimmunology Unit, Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Neuroimmunol 126:161-71. 2002
    ..In conclusion, blood monocyte-derived iDC and mDC express, produce and secrete several MMP and TIMP. Alterations in these molecules as observed in MS may be functionally important for DC functioning...
  22. ncbi request reprint Secondary lymphoid organ chemokines are elevated in the cerebrospinal fluid during central nervous system inflammation
    Mikhail Pashenkov
    Division of Neuroimmunology, Karolinska Institute, Bipontus Building, Box 4, Alfred Nobels Alle 10, SE 14183, Stockholm, Sweden
    J Neuroimmunol 135:154-60. 2003
    ..The role of elevated CCL19 and CCL21 in MS could be retention of mature dendritic cells (DC) in the CNS, recruitment of nai;ve T cells and activated B cells, as well as de novo formation of secondary lymphoid structures in MS plaques...
  23. ncbi request reprint Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid
    Natalia Teleshova
    Department of Neurology, Karolinska Institutet, Huddinge University Hospital, 14186 Stockholm, Sweden
    J Neurol 249:723-9. 2002
    ..High chemokine receptor expression may be one prerequisite for Th1 cells to migrate to the CNS. Inhibition of chemokine receptor expression may constitute a potentially important therapeutic effect of IFN-beta...
  24. doi request reprint Bedside to bench: betting on B cells in multiple sclerosis
    Hans Link
    Nat Med 14:615-6. 2008