H Link

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Suppression of EAMG in Lewis rats by IL-10-exposed dendritic cells
    H Link
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    Ann N Y Acad Sci 998:537-8. 2003
  2. ncbi request reprint Interferon-beta induces the development of type 2 dendritic cells
    Y M Huang
    Neuroimmunology Unit, Division of Neurology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
    Cytokine 13:264-71. 2001
  3. ncbi request reprint Prevention of experimental autoimmune neuritis by nasal administration of P2 protein peptide 57-81
    J Zhu
    Karolinska Institute, Division of Neurology, Huddinge University Hospital, Stockholm, Sweden
    J Neuropathol Exp Neurol 57:291-301. 1998
  4. ncbi request reprint Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines
    Y M Huang
    Karolinska Institute, Division of Neurology, Unit of Neuroimmunology, Huddinge University Hospital, Stockholm, Sweden
    J Neuroimmunol 99:82-90. 1999
  5. pmc Altered phenotype and function of blood dendritic cells in multiple sclerosis are modulated by IFN-beta and IL-10
    Y M Huang
    Neuroimmunology Unit, Division of Neurology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
    Clin Exp Immunol 124:306-14. 2001
  6. ncbi request reprint Multiple sclerosis: pro- and anti-inflammatory cytokines and metalloproteinases are affected differentially by treatment with IFN-beta
    V Ozenci
    Division of Neurology, Unit of Neuroimmunology, Karolinska Institutet, Huddinge University Hospital, S 141 86 Huddinge, Stockholm, Sweden
    J Neuroimmunol 108:236-43. 2000
  7. ncbi request reprint Dendritic cells in the cerebrospinal fluid and peripheral nerves in Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy
    R Press
    Division of Neuroimmunology, Karolinska Institute, SE 141 86 Stockholm, Sweden
    J Neuroimmunol 159:165-76. 2005
  8. ncbi request reprint Altered expression of costimulatory molecules in myasthenia gravis
    N Teleshova
    Department of Neurology, Neuroimmunology Unit, Karolinska Institutet, Huddinge University Hospital, S 14186 Huddinge, Sweden
    Muscle Nerve 23:946-53. 2000
  9. ncbi request reprint SIN-1, a nitric oxide donor, ameliorates experimental allergic encephalomyelitis in Lewis rats in the incipient phase: the importance of the time window
    L Y Xu
    Experimental Neurobiology and Neuroimmunology Units, Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Immunol 166:5810-6. 2001
  10. pmc Bone marrow-derived dendritic cells from experimental allergic encephalomyelitis induce immune tolerance to EAE in Lewis rats
    B G Xiao
    Experimental Neurology and Neuroimmunology Units, Division of Neurology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
    Clin Exp Immunol 125:300-9. 2001

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Suppression of EAMG in Lewis rats by IL-10-exposed dendritic cells
    H Link
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    Ann N Y Acad Sci 998:537-8. 2003
  2. ncbi request reprint Interferon-beta induces the development of type 2 dendritic cells
    Y M Huang
    Neuroimmunology Unit, Division of Neurology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
    Cytokine 13:264-71. 2001
    ..Our data suggest that IFN-beta in vitro can induce the development of DC2, which provide a permissive environment for Th2 differentiation. This finding represents a novel mechanism for action of IFN-beta in MS...
  3. ncbi request reprint Prevention of experimental autoimmune neuritis by nasal administration of P2 protein peptide 57-81
    J Zhu
    Karolinska Institute, Division of Neurology, Huddinge University Hospital, Stockholm, Sweden
    J Neuropathol Exp Neurol 57:291-301. 1998
    ..This is the first study showing that mucosal tolerance is applicable to EAN and, as an extension, could be considered in GBS...
  4. ncbi request reprint Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines
    Y M Huang
    Karolinska Institute, Division of Neurology, Unit of Neuroimmunology, Huddinge University Hospital, Stockholm, Sweden
    J Neuroimmunol 99:82-90. 1999
    ..Circulating DC secreting pro-inflammatory cytokines may represent another focus for the study of both immuno-pathogenesis and therapeutic interventions in MS...
  5. pmc Altered phenotype and function of blood dendritic cells in multiple sclerosis are modulated by IFN-beta and IL-10
    Y M Huang
    Neuroimmunology Unit, Division of Neurology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
    Clin Exp Immunol 124:306-14. 2001
    ..In vitro modification of MS patients' DCs by IFN-beta and IL-10 could represent a novel way of immunomodulation and of possible usefulness for future immunotherapy of MS...
  6. ncbi request reprint Multiple sclerosis: pro- and anti-inflammatory cytokines and metalloproteinases are affected differentially by treatment with IFN-beta
    V Ozenci
    Division of Neurology, Unit of Neuroimmunology, Karolinska Institutet, Huddinge University Hospital, S 141 86 Huddinge, Stockholm, Sweden
    J Neuroimmunol 108:236-43. 2000
    ....
  7. ncbi request reprint Dendritic cells in the cerebrospinal fluid and peripheral nerves in Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy
    R Press
    Division of Neuroimmunology, Karolinska Institute, SE 141 86 Stockholm, Sweden
    J Neuroimmunol 159:165-76. 2005
    ....
  8. ncbi request reprint Altered expression of costimulatory molecules in myasthenia gravis
    N Teleshova
    Department of Neurology, Neuroimmunology Unit, Karolinska Institutet, Huddinge University Hospital, S 14186 Huddinge, Sweden
    Muscle Nerve 23:946-53. 2000
    ..These molecules could be the focus for new and improved immunomodulating therapies of MG...
  9. ncbi request reprint SIN-1, a nitric oxide donor, ameliorates experimental allergic encephalomyelitis in Lewis rats in the incipient phase: the importance of the time window
    L Y Xu
    Experimental Neurobiology and Neuroimmunology Units, Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Immunol 166:5810-6. 2001
    ..Enhanced NO production during the priming phase of EAE thus promotes apoptosis, down-regulates disease-promoting immune reactivities, and ameliorates clinical EAE, mainly through SIN-1-derived NO, without depending on NO synthase...
  10. pmc Bone marrow-derived dendritic cells from experimental allergic encephalomyelitis induce immune tolerance to EAE in Lewis rats
    B G Xiao
    Experimental Neurology and Neuroimmunology Units, Division of Neurology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
    Clin Exp Immunol 125:300-9. 2001
    ....
  11. pmc Enzyme-linked immunospot assays provide a sensitive tool for detection of cytokine secretion by monocytes
    M Kouwenhoven
    Neuroimmunology Unit, Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Clin Diagn Lab Immunol 8:1248-57. 2001
    ..In conclusion, ELISPOT assays constitute a valuable tool to enumerate monocytes secreting IL-6, TNF-alpha, IL-10, and IL-12 and probably to enumerate monocytes secreting other cytokines and proteins...
  12. ncbi request reprint Incidence of optic neuritis in Stockholm, Sweden, 1990-1995: II. Time and space patterns
    Y P Jin
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Sweden
    Arch Neurol 56:975-80. 1999
    ..To describe the time and space patterns of patients with monosymptomatic optic neuritis (MON) in Stockholm County, Sweden, and to explore the role of environmental factors in the etiology of MON and multiple sclerosis...
  13. ncbi request reprint Thalidomide suppresses T- and B-cell responses to myelin antigen in experimental allergic neuritis
    J Zhu
    Division of Neurology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden
    Clin Neuropharmacol 20:152-64. 1997
    ..The inhibitory effects of thalidomide on autoantigen-induced Th1-cell functions may warrant the use of this substance in T-cell-mediated autoimmune diseases...
  14. ncbi request reprint Monocytes in multiple sclerosis: phenotype and cytokine profile
    M Kouwenhoven
    Neuroimmunology Unit, Division of Neurology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Neuroimmunol 112:197-205. 2001
    ..In conclusion, monocyte aberrations occur in MS and may change over the disease course...
  15. ncbi request reprint Glatiramer acetate and IFN-beta act on dendritic cells in multiple sclerosis
    Y Hussien
    Neuroimmunology Unit, Division of Neurology, Karolinska Institute, Huddinge University Hospital, SE-141 86, Stockholm, Sweden
    J Neuroimmunol 121:102-10. 2001
    ..GA and IFN-beta synergistically suppressed CD1a and enhanced CD86 expression on MS DCs. These findings document novel mechanisms of action of GA and IFN-beta at the DC level in MS...
  16. ncbi request reprint Dendritic cells derived from patients with multiple sclerosis show high CD1a and low CD86 expression
    Y M Huang
    Neuroimmunology Unit, Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Mult Scler 7:95-9. 2001
    ..Production of IL-10 and IL-12 p40 by DC did not differ in MS patients and controls. These findings indicate that alterations of functionally important surface molecules on DC are associated with MS...
  17. ncbi request reprint IL-12 elispot assays to detect and enumerate IL-12 secreting cells
    V Ozenci
    Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Cytokine 12:1218-24. 2000
    ..IL-12 p40 ELISPOT assays represent a sensitive, specific and reliable tool for investigating the role of IL-12 in both health and disease...
  18. ncbi request reprint Chemokines and their receptors in whiplash injury: elevated RANTES and CCR-5
    J Kivioja
    Division of Orthopedics, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Clin Immunol 21:272-7. 2001
    ..In conclusion, WAD is associated with a systemic but transient dysregulation in percentages of RANTES and CCR-5 expressing MNC and T cells...
  19. ncbi request reprint Two subsets of dendritic cells are present in human cerebrospinal fluid
    M Pashenkov
    Division of Neurology, Karolinska Institutet, Huddinge University Hospital, R54, SE 14186 Huddinge, Sweden
    Brain 124:480-92. 2001
    ..Myeloid and plasmacytoid dendritic cells in CSF may contribute to orchestration of the local immune responses...
  20. pmc A new cell enzyme-linked immunosorbent assay demonstrates gamma interferon suppression by beta interferon in multiple sclerosis
    M Bakhiet
    Divisions of Infectious Diseases and Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Clin Diagn Lab Immunol 6:415-9. 1999
    ..The present work confirms in vivo the in vitro suppressive effects of IFN-beta-1b on IFN-gamma production in MS. Moreover, it provides a powerful new technique for detection of cytokines...
  21. ncbi request reprint Ischemic stroke is associated with a systemic increase of blood mononuclear cells expressing interleukin-8 mRNA
    N Kostulas
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Stroke 29:462-6. 1998
    ..We evaluated mRNA expression of the CXC chemokine interleukin (IL)-8, and the CC chemokines monocyte chemoattractant protein-1, macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta in blood MNC from patients with ischemic stroke...
  22. ncbi request reprint Differential requirements for CD28 and CD40 ligand in the induction of experimental autoimmune myasthenia gravis
    F D Shi
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Eur J Immunol 28:3587-93. 1998
    ..Thus, CD28 and CD40L are differentially required for induction of EAMG...
  23. pmc Interferon-gamma-modified dendritic cells suppress B cell function and ameliorate the development of experimental autoimmune myasthenia gravis
    S B Adikari
    Division of Neuroimmunology, Neurotec Department, Karolinska Institute, Stockholm, Sweden
    Clin Exp Immunol 138:230-6. 2004
    ..We conclude that IFN-gamma-DC reduced the number of plasma cells secreting nAChR antibodies in an IDO-dependent manner and ameliorated the development of EAMG in Lewis rats...
  24. ncbi request reprint IL-12/IL-12R system in multiple sclerosis
    V Ozenci
    Neuroimmunology Unit, Division of Neurology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Neuroimmunol 114:242-52. 2001
    ..Our data indicates a dysregulation of the IL-12/IL-12R system in MS. It is suggested that even in the absence of increased IL-12 levels, the net effect of IL-12 might be augmented in MS by elevated expression of its receptor...
  25. ncbi request reprint Interleukin-12 and perforin mRNA expression is augmented in blood mononuclear cells in multiple sclerosis
    D Matusevicius
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Scand J Immunol 47:582-90. 1998
    ..The augmentation of both IL-12 and perforin in MS might reflect ongoing inflammatory processes in MS and could represent targets for future treatments...
  26. ncbi request reprint Anti-CTLA-4 antibody treatment triggers determinant spreading and enhances murine myasthenia gravis
    H B Wang
    Experimental Neurology Unit, Division of Neurology, and Department of Medicine, Center for Infectious Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Immunol 166:6430-6. 2001
    ..Thus, treatment with anti-CTLA-4 Ab appears to induce determinant spreading, diversify the autoantibody repertoire, and enhance B cell-mediated autoimmune disease in this murine model of MG...
  27. ncbi request reprint Role for interferon-gamma in rat strains with different susceptibility to experimental autoimmune myasthenia gravis
    H B Wang
    Experimental Neurology Unit, Huddinge University Hospital, Stockholm, S 141 86, Sweden
    Clin Immunol 95:156-62. 2000
    ..We conclude that IFN-gamma plays a major role in the pathogenesis of EAMG in the Lewis rat, but fails to break disease resistance in the WF rat...
  28. pmc High numbers of autoantigen-reactive mononuclear cells expressing interferon-gamma (IFN-gamma), IL-4 and transforming growth factor-beta (TGF-beta) are present in cord blood
    M Yu
    Division of Neurology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden
    Clin Exp Immunol 101:190-6. 1995
    ..The results show a capacity of cord blood cells to react to several autoantigens by the up-regulation of cytokine mRNA expression...
  29. pmc Multiple sclerosis is associated with an imbalance between tumour necrosis factor-alpha (TNF-alpha)- and IL-10-secreting blood cells that is corrected by interferon-beta (IFN-beta) treatment
    V Ozenci
    Karolinska Institutet, Division of Neurology, Unit of Neuroimmunology, Huddinge University Hospital, Stockholm, Sweden
    Clin Exp Immunol 120:147-53. 2000
    ..Systemic aberrations of IL-6 and IFN-gamma and of IL-6 in CSF in MS versus controls were only minor, irrespective of treatment with IFN-beta...
  30. pmc Neutralization of macrophage inflammatory protein 2 (MIP-2) and MIP-1alpha attenuates neutrophil recruitment in the central nervous system during experimental bacterial meningitis
    A Diab
    Divisions of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Infect Immun 67:2590-601. 1999
    ..These data are also the first demonstration that the C-C chemokine MIP-1alpha is involved in neutrophil recruitment in vivo...
  31. ncbi request reprint Incidence of Guillain-Barré syndrome in Sweden 1996
    Q Cheng
    Unit of Neuroepidemiology, Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Eur J Neurol 7:11-6. 2000
    ..18-1.90) per 100 000 person-years in 1996, higher in males and increased with age. When compared with selected studies, the GBS incidence in Sweden is moderately high, and the variation of GBS incidence in Europe seems to be small...
  32. ncbi request reprint IL-17 and IFN-gamma mRNA expression is increased in the brain and systemically after permanent middle cerebral artery occlusion in the rat
    H L Li
    Neuro-Angiological Research Center, Division of Neurology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Neuroimmunol 116:5-14. 2001
    ..Altered levels of IL-17 and IFN-gamma after pMCAO may affect outcome of brain ischemia...
  33. ncbi request reprint Incidence of optic neuritis in Stockholm, Sweden 1990-1995: I. Age, sex, birth and ethnic-group related patterns
    Y P Jin
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Sweden
    J Neurol Sci 159:107-14. 1998
    ..In summary, MON occurred in Stockholm at a relatively low frequency, particularly among males. The presence of particular birth date and birth place related patterns might be etiologically relevant...
  34. ncbi request reprint Clomipramine and imipramine suppress clinical signs and T and B cell response to myelin proteins in experimental autoimmune neuritis in Lewis rats
    J Zhu
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Autoimmun 11:319-27. 1998
    ....
  35. ncbi request reprint No evidence for elevated numbers of mononuclear cells expressing MCP-1 and RANTES mRNA in blood and CSF in multiple sclerosis
    P Kivisakk
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Neuroimmunol 91:108-12. 1998
    ..We conclude that there is no evidence for a systemic dysregulation of the CC chemokines MCP-1 and RANTES in MS...
  36. ncbi request reprint Multiple sclerosis: deficient in vitro responses of blood mononuclear cells to IFN-beta
    Y M Huang
    Neuroimmunology Unit, Division of Neurology, Karolinska Institute, SE 141 86 Huddinge University Hospital, Stockholm, Sweden
    Acta Neurol Scand 104:249-56. 2001
    ....
  37. ncbi request reprint Metalloproteinases and their tissue inhibitors in multiple sclerosis
    V Ozenci
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Autoimmun 12:297-303. 1999
    ..A positive correlation was observed for MMP-9 and TIMP-1 mRNA expression in MS. These results demonstrate that MMPs and TIMPs are upregulated in MS and may contribute to the pathogenesis of the disease...
  38. ncbi request reprint Interleukin-10-modulated immature dendritic cells control the proinflammatory environment in multiple sclerosis
    S B Adikari
    Division of Neuroimmunology, Neurotec Department, Huddinge University Hospital, Stockholm, Sweden
    Scand J Immunol 59:600-6. 2004
    ..An exposure of imDC to IL-10 induced the production of IL-4 as well as IL-10 by autologous lymphocytes. We hypothesize that such imDC are important in controlling the proinflammatory environment in vivo in patients with MS...
  39. ncbi request reprint Antigen-specific T cells in autoimmune diseases with a focus on multiple sclerosis and experimental allergic encephalomyelitis
    B G Xiao
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Cell Mol Life Sci 56:5-21. 1999
    ..Therapeutic modalities have been established which selectively target the pathogenic T cells. leaving the remainder of the immune system intact...
  40. ncbi request reprint Systemic immune response in whiplash injury and ankle sprain: elevated IL-6 and IL-10
    J Kivioja
    Karolinska Institutet, Division of Orthopedics, Huddinge University Hospital, Stockholm, Sweden
    Clin Immunol 101:106-12. 2001
    ..Relatively minor trauma like WAD and ankle sprain are associated with a systemic dysregulation in numbers of cells secreting pro- as well as anti-inflammatory cytokines...
  41. ncbi request reprint IL-10 and IFN-gamma in Guillain-Barré syndrome. Network Members of the Swedish Epidemiological Study Group
    R Press
    Huddinge University Hospital, Karolinska Institutet, Department of Neurology, Neuroimmunology Unit, Huddinge University Hospital, SE 141 86, Huddinge, Sweden
    J Neuroimmunol 112:129-38. 2001
    ..The present data suggests that IFN-gamma is not involved in GBS pathogenesis, and IL-10 being up-regulated in the early phase of GBS and associated with axonal damage, may have a pathogenetic role in GBS...
  42. ncbi request reprint Interleukin 10 aggravates experimental autoimmune myasthenia gravis through inducing Th2 and B cell responses to AChR
    G X Zhang
    Experimental Neuroimmunology Unit, Division of Neurology, Karolinska Institute, Huddinge University Hospital, S-141 86 Huddinge, Sweden
    J Neuroimmunol 113:10-8. 2001
    ..This study implicates a critical precaution in planning immunotherapy of IL-10 in antibody-mediated autoimmune diseases, e.g. MG...
  43. ncbi request reprint Temporal profile of anti-ganglioside antibodies and their relation to clinical parameters and treatment in Guillain-Barré syndrome
    R Press
    Neuroimmunology Unit, Division of Neurology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Neurol Sci 190:41-7. 2001
    ....
  44. pmc Cerebrospinal fluid affects phenotype and functions of myeloid dendritic cells
    M Pashenkov
    Division of Neurology, Neuroimmunology Unit, Huddinge University, Stockholm, Sweden
    Clin Exp Immunol 128:379-87. 2002
    ..In summary, soluble factors present in the CSF may influence the phenotype and functions of meningeal, choroid plexus and CSF DC which, in turn, may have an impact on the character of intrathecal T cell responses...
  45. ncbi request reprint Influence of ion channel modulation on in vitro interferon-gamma induced MHC class I and II expression on macrophages
    J Zhu
    Department of Neurology, Karolinska Institute, Huddinge University Hospital, Sweden
    Immunopharmacol Immunotoxicol 17:109-36. 1995
    ....
  46. ncbi request reprint Neutralizing and binding anti-interferon-beta (IFN-beta) antibodies. A comparison between IFN-beta-1a and IFN-beta-1b treatment in multiple sclerosis
    P Kivisakk
    Division of Neurology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Eur J Neurol 7:27-34. 2000
    ..These data are the first using identical methodology to show that IFN-beta-1a gives rise to fewer NABs than IFN-beta-1b at recommended treatment schedules...
  47. ncbi request reprint Multiple sclerosis: elevated expression of matrix metalloproteinases in blood monocytes
    M Kouwenhoven
    Neuroimmunology Unit, Division of Neurology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Autoimmun 16:463-70. 2001
    ..We therefore conclude that MS is associated with elevated levels of MMP and TIMP expressing blood monocytes that may contribute to MS pathogenesis...
  48. ncbi request reprint Macrophage apoptosis in muscle tissue in experimental autoimmune myasthenia gravis
    F D Shi
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Muscle Nerve 21:1071-4. 1998
    ..These apoptotic macrophages were colocalized in the end-plate regions. Apoptosis is a major cause for elimination of infiltrating macrophages during the early phase of EAMG...
  49. ncbi request reprint Treatment with P2 protein peptide 57-81 by nasal route is effective in Lewis rat experimental autoimmune neuritis
    L P Zou
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Neuroimmunol 85:137-45. 1998
    ..Reduced CD4+ T cell and macrophage infiltrations within the PNS were also observed. Based on these observations, nasal autoantigen administration should be further evaluated, considering its possible future use in GBS...
  50. ncbi request reprint Increased IL-1beta, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study
    N Kostulas
    Neuro Angiological Research Center, Division of Neurology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Stroke 30:2174-9. 1999
    ..In this prospective study we evaluated numbers of peripheral blood mononuclear cells (PBMC) expressing mRNA for interleukin (IL)-1beta, IL-8, and IL-17 and macrophage inflammatory protein-1alpha (MIP-1alpha) after ischemic stroke...
  51. ncbi request reprint Multiple sclerosis: a study of chemokine receptors and regulatory T cells in relation to MRI variables
    P Putheti
    Division of Neuroimmunology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Eur J Neurol 10:529-35. 2003
    ....
  52. ncbi request reprint Cytokine production and the pathogenesis of experimental autoimmune neuritis and Guillain-Barré syndrome
    J Zhu
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Neuroimmunol 84:40-52. 1998
    ....
  53. ncbi request reprint Multiple MAG peptides are recognized by circulating T and B lymphocytes in polyneuropathy and multiple sclerosis
    M Andersson
    Department of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Eur J Neurol 9:243-51. 2002
    ....
  54. ncbi request reprint Vaccination with autologous dendritic cells: from experimental autoimmune encephalomyelitis to multiple sclerosis
    H Link
    Experimental Neurology and Neuroimmunology Units, Division of Neurology, Karolinska Institute, Huddinge University Hospital, S-141 86 Stockholm, Sweden
    J Neuroimmunol 114:1-7. 2001
    ..Molecular-biological approaches to tolerogenic DCs could provide a rationale for designing immunotherapeutic strategies in autoimmune diseases...
  55. ncbi request reprint Regression analysis of metabolite concentrations estimated from localized proton MR spectra of active and chronic multiple sclerosis lesions
    G Helms
    Division of Neurology, Huddinge University Hospital, Stockholm, Sweden
    Magn Reson Med 43:102-10. 2000
    ..Creatine and cholines correlated in chronic lesions, which may be the result of gliosis. The consequences of these findings for the interpretation of absolute concentrations and creatine ratios are discussed...
  56. ncbi request reprint Seasonal patterns in optic neuritis and multiple sclerosis: a meta-analysis
    Y Jin
    Neuroepidemiology Unit, Karolinska Institute, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    J Neurol Sci 181:56-64. 2000
    ..Random variation, misclassification and publication bias were less likely to account for the reported generalized seasonal patterns...
  57. ncbi request reprint Effect of stilbene-type anion channel blockers on the immune response during experimental allergic neuritis (EAN)
    E Mix
    Department of Neurology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Immunopharmacol Immunotoxicol 14:579-609. 1992
    ..Thus anion channel gating seems to regulate activities of immune cells, and drugs with anion channel blocking properties may have effects that enhance autoimmune disease...
  58. ncbi request reprint Clinical epidemiology of Guillain-Barré syndrome in adults in Sweden 1996-97: a prospective study
    Q Cheng
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Eur J Neurol 7:685-92. 2000
    ..In conclusion, GBS in Sweden is frequently preceded by a respiratory infection, is often treated with immunomodulatory therapies, and exhibits a high recovery rate and a low fatality rate...
  59. pmc Levels of gamma interferon and interleukin-4 are inversely related to the levels of their corresponding autoantibodies in patients with lower respiratory tract infection
    R Elkarim
    Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge University Hospital, S 141 86 Huddinge, Stockholm, Sweden
    Infect Immun 67:3051-4. 1999
    ..The levels of these cytokines were inversely related to the levels of their corresponding Aabs that exhibited regulatory effects on the cytokine biological function in vitro...
  60. ncbi request reprint Aberrated levels of cerebrospinal fluid chemokines in Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy
    R Press
    Neuroimmunology Unit, Neurotec Department, Karolinska Institutet and Department of Neurology, Huddinge University Hospital, Stockholm, Sweden
    J Clin Immunol 23:259-67. 2003
    ..In CIDP patients, CSF levels of MIP-3beta also correlated with the CSF:plasma albumin ratio. These data implicate MCP-1 and IP-10 in the pathogenesis of GBS, and IP-10 and MIP-3beta in the pathogenesis of CIDP...
  61. ncbi request reprint Cytokines in multiple sclerosis: methodological aspects and pathogenic implications
    V Ozenci
    Division of Neurology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Mult Scler 8:396-404. 2002
    ..Here we focus on possible reasons for the discrepancies of results reported on cytokines in MS and summarize findings obtained in particular by the application of enzyme-linked immunospot (ELISPOT) assays to cytokine studies in MS...
  62. ncbi request reprint Combination therapy with interferon-beta and glatiramer acetate in multiple sclerosis
    C Ytterberg
    Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Acta Neurol Scand 116:96-9. 2007
    ..To compare the effects of mono-therapy with interferon-beta (IFN-beta) or glatiramer acetate (GA) with IFN-beta + GA combination therapy for persons with multiple sclerosis (MS)...
  63. ncbi request reprint Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: identification of regulatory cells
    F D Shi
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    J Immunol 162:5757-63. 1999
    ..Thus, our results demonstrate that the suppression induced in the present model is independent of CD8+ T cells and suggest the involvement of Ag-specific CD4+ Th3 cells producing TGF-beta...
  64. ncbi request reprint Non-T(H)1 cytokines are augmented systematically early in Guillain-Barré syndrome
    Rayomand Press
    Division of Neurology, Neuroimmunology Unit, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Neurology 58:476-8. 2002
    ..Numbers of IL-12p70-secreting BMNC were not affected over the course of GBS. The non-T(H)1 cytokine profile observed early in GBS may explain the self-limited clinical course associated with GBS...
  65. ncbi request reprint Circulating CD4+CD25+ and CD4+CD25- T cells in myasthenia gravis
    Y Huang
    Immunological Laboratory, Center of Molecular Medicine, Stockholm, Sweden
    Ann N Y Acad Sci 998:318-9. 2003
  66. ncbi request reprint Circulating CD4+CD25+ and CD4+CD25+ T cells in myasthenia gravis and in relation to thymectomy
    Y M Huang
    Immunological Research Unit, Department of Medicine, Centre for Molecular Medicine CMM, Stockholm, Sweden
    Scand J Immunol 59:408-14. 2004
    ..The data thus show that there is no deficiency of CD4(+)CD25(+) cells in MG, nor is the proportion of CD4(+)CD25(+) cells influenced by thymectomy...
  67. pmc Elevated expression of CCR5 by myeloid (CD11c+) blood dendritic cells in multiple sclerosis and acute optic neuritis
    M Pashenkov
    Division of Neurology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    Clin Exp Immunol 127:519-26. 2002
    ..Thus, elevation of CCR5 may contribute to recruitment of myeloid DC to CSF in MS and ON. Recruitment of plasmacytoid DC to CSF appears to be CCR5-independent...
  68. pmc Glatiramer acetate reduces lymphocyte proliferation and enhances IL-5 and IL-13 production through modulation of monocyte-derived dendritic cells in multiple sclerosis
    A Sanna
    Institute of Clinical Neurology, University of Sassari, Italy
    Clin Exp Immunol 143:357-62. 2006
    ..05). In conclusion our in vitro study may provide new therapeutical mechanisms of GA on lymphocytes, antiproliferative and Th2-favouring effects, which are mediated by monocyte-derived DC...
  69. ncbi request reprint A putative mechanism on remission of multiple sclerosis during pregnancy: estrogen-induced indoleamine 2,3-dioxygenase by dendritic cells
    W H Zhu
    Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    Mult Scler 13:33-40. 2007
    ..Our data support the hypothesis that the change in the clinical course of MS observed in pregnancy may be related to the estrogen-DC-IDO axis, which could represent a novel target for MS therapy...
  70. ncbi request reprint Matrix metalloproteinase and cytokine profiles in monocytes over the course of stroke
    M Kouwenhoven
    J Clin Immunol 21:365-75. 2001
    ..Such changes may contribute to the influx of blood-borne cells into the ischemic lesions during the acute phase of stroke...
  71. pmc CD8alpha dendritic cells and immune protection from experimental allergic encephalomyelitis
    A Pettersson
    Division of Neuroimmunology, Neurotec Department, Fudan Univerity, Shanghai, China
    Clin Exp Immunol 137:486-95. 2004
    ....
  72. pmc Both CD4+ and CD8+ T cells are essential to induce experimental autoimmune myasthenia gravis
    G X Zhang
    Division of Neurology, Huddinge Hospital, Stockholm, Sweden
    J Exp Med 184:349-56. 1996
    ....
  73. ncbi request reprint Mice with IFN-gamma receptor deficiency are less susceptible to experimental autoimmune myasthenia gravis
    G X Zhang
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Immunol 162:3775-81. 1999
    ..These results indicate that IFN-gamma promotes systemic humoral responses in EAMG by up-regulating the production and the affinity of anti-AChR autoantibodies, thereby contributing to susceptibility to EAMG in C57BL/6-type mice...
  74. ncbi request reprint Natural killer cells determine the outcome of B cell-mediated autoimmunity
    F D Shi
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Nat Immunol 1:245-51. 2000
    ..1+ cell-depleted and NK cell-deficient IL-18-/- mice. These findings establish a previously unrecognized link between NK cells and autoreactive T and B cells...
  75. ncbi request reprint Immunophenotyping is an independent factor for risk stratification in AML
    R Repp
    Department of Medicine III, University of Erlangen Nuremberg, Erlangen, Germany
    Cytometry B Clin Cytom 53:11-9. 2003
    ..However, only a limited number of patients have such informative chromosomal abnormalities. The prognostic value of immunophenotyping in this disease is still unclear...
  76. ncbi request reprint Pretherapeutic identification of high-risk acute myeloid leukemia (AML) patients from immunophenotypic, cytogenetic, and clinical parameters
    G Valet
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Cytometry B Clin Cytom 53:4-10. 2003
    ..The goal of this study concerned the pretherapeutic identification of high-risk acute myeloid leukemia (AML) patients by data pattern analysis from flow cytometric immunophenotype, cytogenetic, and clinical data...
  77. ncbi request reprint Rat models as tool to develop new immunotherapies
    H Link
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Immunol Rev 184:117-28. 2001
    ....