Paul Lichtenstein

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Remembered parental bonding in adult twins: genetic and environmental influences
    Paul Lichtenstein
    Department of Medical Epidemiology, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    Behav Genet 33:397-408. 2003
  2. ncbi request reprint [Swedish twin study surveys how antisocial behavior is developed. Hereditary factors are more important in girls, in older children and in aggressive behavior]
    P Lichtenstein
    Institutionen for medicinsk epidemiologi, Karolinska Institutet, Stockholm
    Lakartidningen 98:1888-91. 2001
  3. ncbi request reprint Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 343:78-85. 2000
  4. ncbi request reprint Heritability and prevalence of specific fears and phobias in childhood
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    J Child Psychol Psychiatry 41:927-37. 2000
  5. doi request reprint Familial factors do not confound the association between birth weight and childhood asthma
    Anne Kristina Ortqvist
    Department of Medical Epidemiology and Biostatistics, Astrid Lindgren Children s Hospital, Karolinska Institute, Stockholm, Sweden
    Pediatrics 124:e737-43. 2009
  6. doi request reprint Maternal effects for preterm birth: a genetic epidemiologic study of 630,000 families
    Anna C Svensson
    Division of Public Health Epidemiology, Department of Public Health Sciences, Karolinska Institutet, Norrbacka, Fifth Floor, SE 171 76 Stockholm, Sweden
    Am J Epidemiol 170:1365-72. 2009
  7. doi request reprint Schizophrenia and offspring's risk for adverse pregnancy outcomes and infant death
    Emma Nilsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Br J Psychiatry 193:311-5. 2008
  8. ncbi request reprint Importance of familial factors in associations between offspring birth weight and parental risk of type-2 diabetes
    Niklas Bergvall
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Epidemiol 37:185-92. 2008
  9. pmc Advancing paternal age and offspring violent offending: a sibling-comparison study
    Ralf Kuja-Halkola
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, P O Box 281, Stockholm 171 77, Sweden
    Dev Psychopathol 24:739-53. 2012
  10. ncbi request reprint The association between low birth weight and type 2 diabetes: contribution of genetic factors
    Stefan Johansson
    Departments of Medical Epidemiology, and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 19:659-65. 2008

Collaborators

Detail Information

Publications129 found, 100 shown here

  1. ncbi request reprint Remembered parental bonding in adult twins: genetic and environmental influences
    Paul Lichtenstein
    Department of Medical Epidemiology, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    Behav Genet 33:397-408. 2003
    ..However, other explanations such as personality characteristics influencing how experiences with parents are interpreted or circumstances in adult life that affect the recall of experiences could not be ruled out...
  2. ncbi request reprint [Swedish twin study surveys how antisocial behavior is developed. Hereditary factors are more important in girls, in older children and in aggressive behavior]
    P Lichtenstein
    Institutionen for medicinsk epidemiologi, Karolinska Institutet, Stockholm
    Lakartidningen 98:1888-91. 2001
    ..Further, genes and environmental factors of importance in childhood were important also in early adolescence...
  3. ncbi request reprint Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 343:78-85. 2000
    ..The contribution of hereditary factors to the causation of sporadic cancer is unclear. Studies of twins make it possible to estimate the overall contribution of inherited genes to the development of malignant diseases...
  4. ncbi request reprint Heritability and prevalence of specific fears and phobias in childhood
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    J Child Psychol Psychiatry 41:927-37. 2000
    ..These results indicate that both heritable factors as well as environmental factors such as trauma, vicarious learning, and/or negative information are important for differences in fearfulness and phobias--at least in children...
  5. doi request reprint Familial factors do not confound the association between birth weight and childhood asthma
    Anne Kristina Ortqvist
    Department of Medical Epidemiology and Biostatistics, Astrid Lindgren Children s Hospital, Karolinska Institute, Stockholm, Sweden
    Pediatrics 124:e737-43. 2009
    ..Our objective was to investigate whether fetal growth and birth weight affect the risk of asthma in childhood, controlling for gestational age (GA), and shared (familial) environment and genetic factors...
  6. doi request reprint Maternal effects for preterm birth: a genetic epidemiologic study of 630,000 families
    Anna C Svensson
    Division of Public Health Epidemiology, Department of Public Health Sciences, Karolinska Institutet, Norrbacka, Fifth Floor, SE 171 76 Stockholm, Sweden
    Am J Epidemiol 170:1365-72. 2009
    ..The increased odds ratio between offspring of sisters was independent of maternal risk factors for preterm birth, suggesting that the relative importance of maternal effects is not explained by these well-known risk factors...
  7. doi request reprint Schizophrenia and offspring's risk for adverse pregnancy outcomes and infant death
    Emma Nilsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Br J Psychiatry 193:311-5. 2008
    ..Women with schizophrenia are at increased risk for adverse pregnancy outcomes. It is not known whether offspring born to fathers with schizophrenia also have an increased risk...
  8. ncbi request reprint Importance of familial factors in associations between offspring birth weight and parental risk of type-2 diabetes
    Niklas Bergvall
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Epidemiol 37:185-92. 2008
    ..It is hypothesized that associations found between birth weight and subsequent risk of type-2 diabetes are due to inherited genes affecting both fetal growth and metabolism of insulin...
  9. pmc Advancing paternal age and offspring violent offending: a sibling-comparison study
    Ralf Kuja-Halkola
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, P O Box 281, Stockholm 171 77, Sweden
    Dev Psychopathol 24:739-53. 2012
    ..Life-course persistent criminality has been proposed to have a partly biological etiology; our results agree with a stronger biological effect (i.e., de novo mutations) on persistent violent offending...
  10. ncbi request reprint The association between low birth weight and type 2 diabetes: contribution of genetic factors
    Stefan Johansson
    Departments of Medical Epidemiology, and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 19:659-65. 2008
    ..Poor fetal nutrition has been suggested to explain this association. Our objective was to determine whether genetic factors contribute to the association between low birth weight and subsequent risk of type 2 diabetes...
  11. ncbi request reprint Genetic effects on women's positive mental health: do marital relationships and social support matter?
    Erica L Spotts
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Fam Psychol 19:339-49. 2005
    ..Together, these findings emphasize the importance of genetically informed studies in family research and the role of the environment and interpersonal relationships in promoting and improving mental health...
  12. ncbi request reprint Genetic and shared environmental factors do not confound the association between birth weight and hypertension: a study among Swedish twins
    Niklas Bergvall
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE 171 77 Stockholm, Sweden
    Circulation 115:2931-8. 2007
    ..Studies have found associations between low birth weight and increased risks of cardiovascular diseases in adulthood. However, these associations could be due to confounding by genetic or socioeconomic factors...
  13. pmc The observed association between maternal anxiety and adolescent asthma: children of twin design suggest familial effects
    Ida Havland
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e66040. 2013
    ..Previous studies indicate that maternal anxiety is associated with asthma in the adolescent child, but mechanisms are unclear...
  14. pmc Risk of bipolar disorder and schizophrenia in relatives of people with attention-deficit hyperactivity disorder
    Henrik Larsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Br J Psychiatry 203:103-6. 2013
    ..Attention-deficit hyperactivity disorder (ADHD) is associated with bipolar disorder and schizophrenia, and it has been suggested that combined bipolar disorder and ADHD is aetiologically distinct from the pure disorders...
  15. doi request reprint Twinship influence on morbidity and mortality across the lifespan
    Sara Oberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Epidemiol 41:1002-9. 2012
    ..To better understand the influence twinning may have on health, we investigated long-term health outcomes of twins, their singleton siblings and singletons from the population...
  16. pmc Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior
    Hasse Walum
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Biol Psychiatry 71:419-26. 2012
    ..Here we investigate the extent to which genetic variants in the oxytocin receptor gene (OXTR) are associated with pair-bonding and related social behaviors in humans...
  17. ncbi request reprint Physical activity and mortality: is the association explained by genetic selection?
    Sofia Carlsson
    Division of Epidemiology, Stockholm Centre of Public Health, Stockholm, Sweden
    Am J Epidemiol 166:255-9. 2007
    ..Results indicate that physical activity is associated with a reduced risk of mortality not due to genetic selection. This finding supports a causal link between physical activity and mortality...
  18. doi request reprint Breast cancer onset in twins and women with bilateral disease
    Mikael Hartman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Clin Oncol 26:4086-91. 2008
    ..Little is known of the onset of breast cancer in high-risk populations. We investigated the risk of breast cancer in twin sisters and in the contralateral breast taking family history into consideration...
  19. pmc Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Lancet 373:234-9. 2009
    ..We aimed to assess genetic and environmental contributions to liability for schizophrenia, bipolar disorder, and their comorbidity...
  20. pmc Testing different types of genotype-environment correlation: an extended children-of-twins model
    Jurgita Narusyte
    Department of Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Dev Psychol 44:1591-603. 2008
    ..The results showed that this association was best explained by evocative genotype-environment correlation...
  21. pmc Autism risk across generations: a population-based study of advancing grandpaternal and paternal age
    Emma M Frans
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    JAMA Psychiatry 70:516-21. 2013
    ..Advancing paternal age has been linked to autism...
  22. doi request reprint Familial aggregation of schizophrenia: the moderating effect of age at onset, parental immigration, paternal age and season of birth
    Anna C Svensson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Scand J Public Health 40:43-50. 2012
    ..An abundance of evidence has firmly established the familial aggregation of schizophrenia. The aim of this study was to examine how age at onset, parental characteristics and season of birth modify the familiality in schizophrenia...
  23. doi request reprint Heritability, assortative mating and gender differences in violent crime: results from a total population sample using twin, adoption, and sibling models
    Thomas Frisell
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, PO Box 281, 171 77, Stockholm, Sweden
    Behav Genet 42:3-18. 2012
    ..4), appeared to result from both phenotypic assortment and social homogamy, but had only minor effect on variance components. Finally, we found significant gender differences in the etiology of violent crime...
  24. doi request reprint The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Am J Psychiatry 167:1357-63. 2010
    ..Population-based studies of the heritability of other neuropsychiatric disorders and comorbidities among them have also been sparse. The authors sought to address both of these issues...
  25. pmc Advanced paternal and grandpaternal age and schizophrenia: a three-generation perspective
    Emma M Frans
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Schizophr Res 133:120-4. 2011
    ..The aim of the current study was to explore the links between both paternal and grandpaternal age with respect to the risk of schizophrenia in a large, national register-based cohort...
  26. pmc Parental criticism and externalizing behavior problems in adolescents: the role of environment and genotype-environment correlation
    Jurgita Narusyte
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Abnorm Psychol 120:365-76. 2011
    ..This suggests that previously reported differences in caretaking between mothers and fathers also are reflected in differences in why parenting is associated with externalizing behavior in offspring...
  27. doi request reprint Advancing paternal age and bipolar disorder
    Emma M Frans
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE 171 77 Stockholm, Sweden
    Arch Gen Psychiatry 65:1034-40. 2008
    ..Advancing paternal age has been reported as a risk factor for neurodevelopmental disorders...
  28. ncbi request reprint Obesity and hormone-dependent tumors: cohort and co-twin control studies based on the Swedish Twin Registry
    Fredrik Jonsson
    Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 106:594-9. 2003
    ..78). No association was found for prostate cancer. We conclude that age is an important effect modifier of cancer risk associated with obesity and that obesity and overweight in young adult life may affect cancer risk also later in life...
  29. ncbi request reprint Covariance component models for multivariate binary traits in family data analysis
    Benjamin H Yip
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobelvgen 12, Stockholm, Sweden
    Stat Med 27:1086-105. 2008
    ..We motivate our problem with real questions from psychiatric epidemiology and demonstrate how different substantive issues of comorbidity between two diseases can be put into the analytical framework...
  30. ncbi request reprint The Swedish Twin Registry in the third millennium: an update
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Twin Res Hum Genet 9:875-82. 2006
    ..In particular, we describe recent efforts to screen all twins born between 1959 and 1985, and young twin pairs when they turn 9 and 12 years of age. For these studies, we present initial frequencies of common conditions and exposures...
  31. doi request reprint Mental illness, suicide and creativity: 40-year prospective total population study
    Simon Kyaga
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden
    J Psychiatr Res 47:83-90. 2013
    ..We discuss the findings in relationship to some of the major components of creativity...
  32. doi request reprint Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs
    Henrik Larsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Child Psychol Psychiatry 53:73-80. 2012
    ..The aim of this study was to assess genetic links between the extreme and the subthreshold range of ADHD symptoms...
  33. ncbi request reprint Genetic influence on dystocia
    Michael Algovik
    Department of Obstetrics and Gynecology, Huddinge University Hospital, Stockholm, Sweden
    Acta Obstet Gynecol Scand 83:832-7. 2004
    ..Epidemiological studies have suggested a familial aggregation. This study aimed to quantify the genetic influence (i.e. the heritability) on dystocia...
  34. ncbi request reprint Accounting for depressive symptoms in women: a twin study of associations with interpersonal relationships
    Erica L Spotts
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    J Affect Disord 82:101-11. 2004
    ..This study examined how interpersonal relationships, specifically marital quality and adequacy of social support, are associated with depressive symptoms among women...
  35. ncbi request reprint Birth weight and attention-deficit/hyperactivity symptoms in childhood and early adolescence: a prospective Swedish twin study
    Christina M Hultman
    Dr Hultman is with the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77, Stockholm, Sweden
    J Am Acad Child Adolesc Psychiatry 46:370-7. 2007
    ..To determine whether low birth weight increases the risk of attention-deficit/hyperactivity disorder (ADHD) in childhood and early adolescence...
  36. doi request reprint Developmental twin study of attention problems: high heritabilities throughout development
    Zheng Chang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    JAMA Psychiatry 70:311-8. 2013
    ..The genetic and environmental link between attention-deficit/hyperactivity disorder in childhood and the adult manifestation of the disorder is poorly understood because of a lack of longitudinal studies with cross-informant data...
  37. pmc Maternal bereavement and childhood asthma-analyses in two large samples of Swedish children
    Fang Fang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e27202. 2011
    ..Prenatal factors such as prenatal psychological stress might influence the development of childhood asthma...
  38. doi request reprint Disability pension among Swedish twins--prevalence over 16 years and associations with sociodemographic factors in 1992
    Asa Samuelsson
    Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Occup Environ Med 54:10-6. 2012
    ..To investigate annual prevalence of disability pension (DP) from 1992 to 2007 and associations with sociodemographic factors in 1992...
  39. ncbi request reprint Familial aggregation of small-for-gestational-age births: the importance of fetal genetic effects
    Anna C Svensson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Am J Obstet Gynecol 194:475-9. 2006
    ..This study was undertaken to disentangle the maternal genetic, fetal genetic, and environmental effects for the risk of having small-for-gestational-age (SGA) offspring...
  40. ncbi request reprint The development of antisocial behaviour from childhood to adolescence. A longitudinal twin study
    Catherine Tuvblad
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, P O Box 281, 17177 Stockholm, Sweden
    Eur Child Adolesc Psychiatry 14:216-25. 2005
    ..The hypothesis that the aggressive pathway is genetically mediated was supported in girls, whereas the hypothesis that the nonaggressive pathway is environmentally dependent was supported in boys...
  41. ncbi request reprint Aggression as a mediator of genetic contributions to the association between negative parent-child relationships and adolescent antisocial behavior
    Jurgita Narusyte
    Dept of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden
    Eur Child Adolesc Psychiatry 16:128-37. 2007
    ..It suggests that aggression in children evokes negative parenting, which in turn influences adolescent antisocial behavior. The mechanism proposed by these findings is consistent with evocative gene-environment correlation...
  42. ncbi request reprint Fertility of first-degree relatives of patients with schizophrenia: a three generation perspective
    Anna C Svensson
    Department of Medical Epidemiology and Biostatistics, PO Box 281, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Schizophr Res 91:238-45. 2007
    ..94, 95% CI 0.84-1.05). In conclusion, we found reduced fertility in patients with schizophrenia and among their offspring that was not compensated by higher parental or sibling fertility...
  43. ncbi request reprint Self-rated health in a longitudinal perspective: a 9-year follow-up twin study
    Pia Svedberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77 Stockholm, Sweden
    J Gerontol B Psychol Sci Soc Sci 60:S331-S340. 2005
    ..This study first considers age and cohort explanations for age-related changes in mean values and variance in self-rated health. Second, it evaluates the contributions of genes and environments to self-rated health measured longitudinally...
  44. doi request reprint Body mass index and mortality: is the association explained by genetic factors?
    Sofia Carlsson
    Department of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 22:98-103. 2011
    ..Numerous studies have shown that higher body mass index (BMI) is associated with higher mortality. We investigated the extent to which this association might be explained by genetic factors...
  45. ncbi request reprint No linkage to obesity in candidate regions of chromosome 2 and 10 in a selected sample of Swedish twins
    Anastasia Iliadou
    Department of Medical Epidemiology, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden
    Twin Res 6:162-9. 2003
    ..However, the results were sensitive to issues related to power, minor effects of the genes, ethnic differences and the complex mechanism underlying obesity...
  46. ncbi request reprint Etiology of familial aggregation in melanoma and squamous cell carcinoma of the skin
    Linda S Lindström
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, P O Box 281, Stockholm 17177, Sweden
    Cancer Epidemiol Biomarkers Prev 16:1639-43. 2007
    ..Because the malignancies are dependent on UV radiation, we did separate analyses for sun-covered and sun-exposed sites...
  47. doi request reprint Creativity and mental disorder: family study of 300,000 people with severe mental disorder
    Simon Kyaga
    Department of Epidemiology and Biostatistics, Karolinska Institutet, POB 281, SE 171 77 Stockholm, Sweden
    Br J Psychiatry 199:373-9. 2011
    ..There is a long-standing belief that creativity is coupled with psychopathology...
  48. doi request reprint The Swedish Twin Registry: establishment of a biobank and other recent developments
    Patrik K E Magnusson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Twin Res Hum Genet 16:317-29. 2013
    ..Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described...
  49. doi request reprint Genetic susceptibility to sickness absence is similar among women and men: findings from a Swedish twin cohort
    Pia Svedberg
    Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Twin Res Hum Genet 15:642-8. 2012
    ..As SA seem to be influenced by genetic factors, future studies of associations between risk factors and SA should consider this potentially confounding effect...
  50. doi request reprint The effects of childhood ADHD symptoms on early-onset substance use: a Swedish twin study
    Zheng Chang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, P O Box 281, 171 77 Stockholm, Sweden
    J Abnorm Child Psychol 40:425-35. 2012
    ..Our results indicated that hyperactivity/impulsivity, but not inattention, is an important early predictor for early-onset substance use, and a shared genetic susceptibility is suggested to explain this association...
  51. doi request reprint Developmental trajectories of DSM-IV symptoms of attention-deficit/hyperactivity disorder: genetic effects, family risk and associated psychopathology
    Henrik Larsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Child Psychol Psychiatry 52:954-63. 2011
    ....
  52. doi request reprint Genetic and environmental effects on same-sex sexual behavior: a population study of twins in Sweden
    Niklas Långström
    Centre for Violence Prevention, Karolinska Institutet, P O Box 23000, 104 35, Stockholm, Sweden
    Arch Sex Behav 39:75-80. 2010
    ....
  53. pmc Familial aggregation of amyotrophic lateral sclerosis
    Fang Fang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Ann Neurol 66:94-9. 2009
    ..To assess the relative risk for amyotrophic lateral sclerosis (ALS) in families of ALS patients...
  54. ncbi request reprint Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairs
    Despina Katsika
    Department of Medicine at Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Hepatology 41:1138-43. 2005
    ..In conclusion, our results show heritability to be a major susceptibility factor for symptomatic gallstone disease, consistent with results from previous, much smaller studies...
  55. ncbi request reprint Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study
    Sven Cnattingius
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Am J Med Genet A 130:365-71. 2004
    ..4-0.9). Genetic factors account for more than half of the liability of preeclampsia, and maternal genes contribute more than fetal genes. We suggest that the couple effect is due to a genetic interaction between mother and father...
  56. ncbi request reprint The Swedish Twin study of CHild and Adolescent Development: the TCHAD-study
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden
    Twin Res Hum Genet 10:67-73. 2007
    ..In this article we describe the sample, data collections, and measures used. In addition, we provide some key findings from the study, focusing on antisocial behavior, criminality, and psychopathic personality...
  57. doi request reprint A longitudinal twin study of the direction of effects between psychopathic personality and antisocial behaviour
    Mats Forsman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Child Psychol Psychiatry 51:39-47. 2010
    ..The aim in this study was to investigate the direction of effects between psychopathic personality and antisocial behaviour, and to investigate the genetic and environmental contribution to this association...
  58. doi request reprint Genetic effects explain the stability of psychopathic personality from mid- to late adolescence
    Mats Forsman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Abnorm Psychol 117:606-17. 2008
    ..Thus, the model provides evidence for etiologic generality and etiologic specificity for the stability of psychopathic personality between mid- and late adolescence...
  59. ncbi request reprint Genetic and environmental influences on marital relationships
    Erica L Spotts
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Fam Psychol 18:107-19. 2004
    ..Finally, nonshared environmental influences were the primary contributor to both individual reports and the overlap of spouse reports, an interesting deviation from findings of behavior genetic studies of other types of relationships...
  60. ncbi request reprint Body mass index, alcohol, tobacco and symptomatic gallstone disease: a Swedish twin study
    D Katsika
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Intern Med 262:581-7. 2007
    ..We aimed to examine the association between symptomatic GD and overweight (body mass index, BMI, 25-30 kg m(-2)), obesity (BMI > 30 kg m(-2)), alcohol, smoking and smoke-free tobacco by analysing a large twin population...
  61. ncbi request reprint The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 252:184-205. 2002
    ..In the following, we will summarize the content of the database, describe for the first time recent data collection efforts and review some of the principal findings that have come from the Registry...
  62. ncbi request reprint Low birthweight and Type 2 diabetes: a study on 11 162 Swedish twins
    A Iliadou
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Epidemiol 33:948-53; discussion 953-4. 2004
    ..Method A cohort of 11 162 same-sexed Swedish twins born between 1906 and 1958 was used in order to investigate the risk of developing Type 2 diabetes between and within twin pairs by utilizing random effects linear models...
  63. pmc Medication for attention deficit-hyperactivity disorder and criminality
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    N Engl J Med 367:2006-14. 2012
    ..Attention deficit-hyperactivity disorder (ADHD) is a common disorder that has been associated with criminal behavior in some studies. Pharmacologic treatment is available for ADHD and may reduce the risk of criminality...
  64. pmc Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans
    Hasse Walum
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:14153-6. 2008
    ..These results suggest an association between a single gene and pair-bonding behavior in humans, and indicate that the well characterized influence of AVP on pair-bonding in voles may be of relevance also for humans...
  65. ncbi request reprint Fetal growth restriction and schizophrenia: a Swedish twin study
    Emma Nilsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Twin Res Hum Genet 8:402-8. 2005
    ..The association between low birthweight and schizophrenia is partly a function of reduced fetal growth. Fetal growth restriction seems to be associated with risk of schizophrenia independently of familial factors...
  66. pmc ADHD and Disruptive Behavior scores - associations with MAO-A and 5-HTT genes and with platelet MAO-B activity in adolescents
    Kerstin Malmberg
    Karolinska Institutet, Department of Woman and Child Health, Child and Adolescent Psychiatric Unit Q3 04, Astrid Lindgren Children s Hospital, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    BMC Psychiatry 8:28. 2008
    ....
  67. pmc Method of attempted suicide as predictor of subsequent successful suicide: national long term cohort study
    Bo Runeson
    Department of Clinical Neuroscience, Karolinska Institutet, Division of Psychiatry, St Göran, SE 112 81 Stockholm, Sweden
    BMJ 341:c3222. 2010
    ..To study the association between method of attempted suicide and risk of subsequent successful suicide...
  68. doi request reprint Internalizing behavior in adolescent girls affects parental emotional overinvolvement: a cross-lagged twin study
    Therese Moberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Behav Genet 41:223-33. 2011
    ....
  69. ncbi request reprint Recurrence risks for schizophrenia in a Swedish national cohort
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Psychol Med 36:1417-25. 2006
    ..Widely cited estimates are from small/older samples. If these estimates are biased upwards, then the rationale for molecular genetic studies of schizophrenia may not be as solid...
  70. ncbi request reprint The Swedish Twin Registry in the third millennium
    Nancy L Pedersen
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Twin Res 5:427-32. 2002
    ....
  71. ncbi request reprint Physical and mental health related to dental amalgam fillings in Swedish twins
    L Björkman
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Community Dent Oral Epidemiol 24:260-7. 1996
    ..This study does not indicate any negative effects from dental amalgam on physical or mental health or memory functions in the general population over 50 years of age...
  72. ncbi request reprint Genetic contributions to the development of ADHD subtypes from childhood to adolescence
    Henrik Larsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm
    J Am Acad Child Adolesc Psychiatry 45:973-81. 2006
    ..The aim of this study was to examine genetic influences contributing to the development of hyperactive-impulsive symptoms and inattentive symptoms of ADHD from childhood to adolescence...
  73. doi request reprint Birth weight predicts risk of cardiovascular disease within dizygotic but not monozygotic twin pairs: a large population-based co-twin-control study
    Sara Oberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE 171 77, Sweden
    Circulation 123:2792-8. 2011
    ..Within-twin-pair analysis provides a unique opportunity to investigate whether factors shared within twin pairs influence the association...
  74. ncbi request reprint The importance of genetic and environmental effects for pre-eclampsia and gestational hypertension: a family study
    Emma Nilsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    BJOG 111:200-6. 2004
    ..To determine the importance of genetic effects in the aetiology of pre-eclampsia and gestational hypertension and to investigate whether pre-eclampsia and gestational hypertension share genetic aetiology...
  75. ncbi request reprint Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin-angiotensin-aldosterone system
    Anastasia Iliadou
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    J Hypertens 20:1543-50. 2002
    ..However, many studies have not been able to replicate findings of association between specific polymorphisms and diastolic and systolic blood pressure...
  76. ncbi request reprint Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database
    Kamila Czene
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 99:260-6. 2002
    ....
  77. pmc Long-term follow-up of transsexual persons undergoing sex reassignment surgery: cohort study in Sweden
    Cecilia Dhejne
    Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e16885. 2011
    ..There is a dearth of long term, follow-up studies after sex reassignment...
  78. ncbi request reprint Heritability for adolescent antisocial behavior differs with socioeconomic status: gene-environment interaction
    Catherine Tuvblad
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden
    J Child Psychol Psychiatry 47:734-43. 2006
    ..One explanation for this paradox could be that socioeconomic status moderates the influence of genetic and environmental effects on antisocial behavior...
  79. ncbi request reprint Genetic and environmental contributions to stability and change of ADHD symptoms between 8 and 13 years of age: a longitudinal twin study
    Jan Olov Larsson
    Department of Child and Adolescent Psychiatry, The Karolinska Hospital, Stockholm, Sweden
    J Am Acad Child Adolesc Psychiatry 43:1267-75. 2004
    ..To study the genetic and environmental contributions to stability and change of attention-deficit/hyperactivity disorder (ADHD) symptoms between 8 and 9 and 13 and 14 years of age...
  80. pmc Prenatal smoking exposure and offspring stress coping in late adolescence: no causal link
    Ralf Kuja-Halkola
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Epidemiol 39:1531-40. 2010
    ..We examined if mothers' smoking during pregnancy (SDP) is associated with long-term impairment in offspring stress coping and the causal mechanism behind a possible link...
  81. ncbi request reprint Physical activity and risk for breast cancer a prospective cohort study among Swedish twins
    Tahereh Moradi
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 100:76-81. 2002
    ..The importance of physical activity for breast cancer risk seems to depend on birth cohort. The association may be limited to normal-weight postmenopausal women and overweight premenopausal women...
  82. ncbi request reprint A genetic factor explains most of the variation in the psychopathic personality
    Henrik Larsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Abnorm Psychol 115:221-30. 2006
    ..The authors propose that this latent psychopathic personality factor is a meaningful target for future etiological research...
  83. ncbi request reprint Pulmonary embolism and stroke in relation to pregnancy: how can high-risk women be identified?
    Helena Salonen Ros
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Am J Obstet Gynecol 186:198-203. 2002
    ....
  84. ncbi request reprint Serum insulin-like growth factors in normal pregnancy and in pregnancies complicated by preeclampsia
    Anna Hübinette
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Acta Obstet Gynecol Scand 82:1004-9. 2003
    ..We have prospectively investigated maternal serum levels of IGF-I, IGF-II, and the main binding protein insulin-like growth factor binding protein 3 (IGFBP-3) in women with and without preeclampsia...
  85. ncbi request reprint Variation in genetic and environmental influences in serum lipid and apolipoprotein levels across the lifespan in Swedish male and female twins
    A Iliadou
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    Am J Med Genet 102:48-58. 2001
    ....
  86. ncbi request reprint Genetic and environmental influences on recurrent headaches in eight to nine-year-old twins
    D A Svensson
    Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    Cephalalgia 19:866-72. 1999
    ..We conclude that genetic and individual specific effects are important for recurrent headaches of migrainous and nonmigrainous types in prepubescent children, and that different genetic etiologies might exist for boys and girls...
  87. ncbi request reprint Lifestyle and endometrial cancer risk: a cohort study from the Swedish Twin Registry
    P Terry
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 82:38-42. 1999
    ..We did not find a genetic component to endometrial cancer. Our results confirm that environmental factors are the most important, especially physical activity, parity, and weight in young and middle age...
  88. ncbi request reprint Estimation of genetic and environmental factors for binary traits using family data
    Y Pawitan
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, P O Box 281, 17177 Stockholm, Sweden
    Stat Med 23:449-65. 2004
    ..In our illustration the models will account for maternal or foetal genetic effects, environmental effects, or a combination of these and we show how these effects can be readily estimated using family data...
  89. ncbi request reprint No paternal effect on monozygotic twinning in the Swedish Twin Registry
    P Lichtenstein
    Institute for Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    Twin Res 1:212-5. 1998
    ..Thus, there is no evidence for a paternal effect on monozygotic twinning, suggesting that the gene(s) increasing the liability for division of the embryo are expressed in the mother and not in the fertilised egg...
  90. ncbi request reprint Birth weight and risk of angina pectoris: analysis in Swedish twins
    A Hubinette
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Eur J Epidemiol 18:539-44. 2003
    ..By investigating the association within twin pairs discordant for disease, the influence of genetic and early environmental factors is substantially reduced...
  91. ncbi request reprint Aetiology of teenage childbearing: reasons for familial effects
    P O Olausson
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    Twin Res 3:23-7. 2000
    ..When studying risk factors for teenage childbearing, it is recommended to include life style and socio-economic variables as well as information about family history of teenage childbearing. Twin Research (2000) 3, 23-27...
  92. ncbi request reprint Genetic effects on the liability of developing pre-eclampsia and gestational hypertension
    H Salonen Ros
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    Am J Med Genet 91:256-60. 2000
    ..In efforts to identify women with elevated risk of developing pre-eclampsia during pregnancy, a question about family history of pre-eclampsia should be included...
  93. ncbi request reprint Long-term tobacco smoking and colorectal cancer in a prospective cohort study
    P Terry
    Department of Medical Epidemiology, Karolinska Institutet, Box 281, SE 171 77 Stockholm, Sweden
    Int J Cancer 91:585-7. 2001
    ..Further elucidation of this association would be valuable from both etiologic and public health perspectives...
  94. ncbi request reprint Birth characteristics and breast cancer risk: a study among like-sexed twins
    A Hubinette
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 91:248-51. 2001
    ..5; 95% CI 0.7-18.5). The results give some support to the hypothesis that the fetal environment influences adult breast cancer risk...
  95. ncbi request reprint Parents' perception of mental development and behavioural problems in 8 to 9-year-old children
    J O Larsson
    Department of Child and Adolescent Psychiatry, Astrid Lindgren s Children s Hospital, Karolinska Hospital, Stockholm, Sweden
    Acta Paediatr 89:1469-73. 2000
    ..There was also a statistically significant relationship between the maturity factor and the CBCL grouping of syndromes (internalizing, externalizing, total behaviour problems score) as well as between the maturity factor and ADHD...
  96. ncbi request reprint Physical activity and risk of renal cell cancer
    A Bergstrom
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 92:155-7. 2001
    ..We found no evidence of an inverse association between either occupational or leisure time physical activity and risk of renal cell cancer in this prospective cohort...
  97. ncbi request reprint Age and sex differences in genetic and environmental factors for self-rated health: a twin study
    P Svedberg
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    J Gerontol B Psychol Sci Soc Sci 56:S171-8. 2001
    ..Self-rated health has been shown to be a predictor for future health status and mortality. The purpose of this study was to investigate age-group and sex differences in genetic and environmental sources of variation for self-rated health...
  98. ncbi request reprint Tall or short? Twenty years after preeclampsia exposure in utero: comparisons of final height, body mass index, waist-to-hip ratio, and age at menarche among women, exposed and unexposed to preeclampsia during fetal life
    H S Ros
    Department of Medical Epidemiology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Pediatr Res 49:763-9. 2001
    ..These data indicate that neither adult anthropometry nor age at menarche is in the causal pathway between intrauterine preeclampsia exposure and the reduced risk of breast cancer...
  99. ncbi request reprint Birthweight, early environment, and genetics: a study of twins discordant for acute myocardial infarction
    A Hubinette
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Lancet 357:1997-2001. 2001
    ..We undertook a case-control study in twins discordant for acute myocardial infarction (AMI)...
  100. ncbi request reprint Women with schizophrenia: pregnancy outcome and infant death among their offspring
    Emma Nilsson
    Department of Medical Epidemiology, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    Schizophr Res 58:221-9. 2002
    ....
  101. ncbi request reprint Genetic and environmental influences on problematic masturbatory behavior in children: a study of same-sex twins
    Niklas Långström
    Division of Forensic Psychiatry, Karolinska Institutet, P O Box 4044, S 141 04 Huddinge, Sweden
    Arch Sex Behav 31:343-50. 2002
    ..When interpreting the findings, the very brief measure of sexual problem behavior and low statistical power, precluding the analysis of possible coinheritance with other symptoms or disorders, should be borne in mind...