S Lehmann

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer
    Soren Lehmann
    Department of Hematology, M54, Karolinska University Hospital, 141 86 Stockholm, Sweden
    J Clin Oncol 30:3633-9. 2012
  2. ncbi request reprint Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice
    S Lehmann
    Division of Hematology Oncology, Cedars Sinai Medical Center, School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Leukemia 21:1931-6. 2007
  3. doi request reprint Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry
    S Lehmann
    Hematology Centre, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Leukemia 25:1128-34. 2011
  4. doi request reprint Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia
    S Deneberg
    Division of Hematology, Department of Medicine, Karolinska Institutet, Huddinge, Stockholm, Sweden
    Leukemia 24:932-41. 2010
  5. ncbi request reprint Retinoid receptor expression and its correlation to retinoid sensitivity in non-M3 acute myeloid leukemia blast cells
    S Lehmann
    Department of Hematology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden
    Clin Cancer Res 7:367-73. 2001
  6. ncbi request reprint Effects of arsenic trioxide (As2O3) on leukemic cells from patients with non-M3 acute myelogenous leukemia: studies of cytotoxicity, apoptosis and the pattern of resistance
    S Lehmann
    Department of Hematology, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden
    Eur J Haematol 66:357-64. 2001
  7. pmc Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells
    Tadayuki Akagi
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, Japan
    Haematologica 94:1301-6. 2009
  8. ncbi request reprint Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis
    M C Kastrinaki
    Department of Haematology, University of Crete School of Medicine, Heraklion, Crete, Greece
    Ann Rheum Dis 67:741-9. 2008
  9. ncbi request reprint Detection of prion after decontamination procedures: comparative study of standard Western blot, filter retention and scrapie-cell assay
    J Solassol
    Institut de Genetique Humaine, UPR 1142 du CNRS, 141 rue de la Cardonille, 34396 Montpellier Cedex 05, France
    J Hosp Infect 57:156-61. 2004

Collaborators

Detail Information

Publications9

  1. doi request reprint Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer
    Soren Lehmann
    Department of Hematology, M54, Karolinska University Hospital, 141 86 Stockholm, Sweden
    J Clin Oncol 30:3633-9. 2012
    ..The main aims of this first-in-human trial were to determine maximum-tolerated dose (MTD), safety, dose-limiting toxicities (DLTs), and pharmacokinetics (PK) of APR-246...
  2. ncbi request reprint Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice
    S Lehmann
    Division of Hematology Oncology, Cedars Sinai Medical Center, School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Leukemia 21:1931-6. 2007
    ..We conclude that many of the genes within the CDR associated with the 5q- syndrome exhibit significantly decreased expression and that SPARC, as a potential tumor suppressor gene, may play a role in the pathogenesis of this disease...
  3. doi request reprint Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry
    S Lehmann
    Hematology Centre, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Leukemia 25:1128-34. 2011
    ..Of non-ED patients, 97% achieved complete remission of which 16% subsequently relapsed. In total, 62% are still alive at 6.4 years median follow-up. We conclude that ED rates remain very high in an unselected APL population...
  4. doi request reprint Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia
    S Deneberg
    Division of Hematology, Department of Medicine, Karolinska Institutet, Huddinge, Stockholm, Sweden
    Leukemia 24:932-41. 2010
    ..We conclude that global and gene-specific methylation patterns are independently associated with the clinical outcome in AML patients...
  5. ncbi request reprint Retinoid receptor expression and its correlation to retinoid sensitivity in non-M3 acute myeloid leukemia blast cells
    S Lehmann
    Department of Hematology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden
    Clin Cancer Res 7:367-73. 2001
    ..03). We conclude that RAR alpha, RAR beta, RAR gamma, and RXR alpha are expressed in non-M3 AML blast cells and that ATRA-induced expression of RAR beta may be a marker for retinoid sensitivity...
  6. ncbi request reprint Effects of arsenic trioxide (As2O3) on leukemic cells from patients with non-M3 acute myelogenous leukemia: studies of cytotoxicity, apoptosis and the pattern of resistance
    S Lehmann
    Department of Hematology, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden
    Eur J Haematol 66:357-64. 2001
    ....
  7. pmc Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells
    Tadayuki Akagi
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, Japan
    Haematologica 94:1301-6. 2009
    ..Importantly, prognostic analysis revealed that overall survival and event-free survival of individuals in Group B were significantly worse than those in Group A...
  8. ncbi request reprint Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis
    M C Kastrinaki
    Department of Haematology, University of Crete School of Medicine, Heraklion, Crete, Greece
    Ann Rheum Dis 67:741-9. 2008
    ..This study investigates the reserves and function, the molecular and proteomic profile and the differentiation potential of BM MSCs in patients with active rheumatoid arthritis (RA)...
  9. ncbi request reprint Detection of prion after decontamination procedures: comparative study of standard Western blot, filter retention and scrapie-cell assay
    J Solassol
    Institut de Genetique Humaine, UPR 1142 du CNRS, 141 rue de la Cardonille, 34396 Montpellier Cedex 05, France
    J Hosp Infect 57:156-61. 2004
    ....