Catharina Lavebratt

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Epigenetic regulation in obesity
    C Lavebratt
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Int J Obes (Lond) 36:757-65. 2012
  2. doi request reprint Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort
    Catharina Lavebratt
    Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden
    J Affect Disord 125:249-55. 2010
  3. pmc CRY2 is associated with depression
    Catharina Lavebratt
    Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden
    PLoS ONE 5:e9407. 2010
  4. doi request reprint PER2 variantion is associated with depression vulnerability
    Catharina Lavebratt
    Department of Molecular Medicine and Surgery, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden
    Am J Med Genet B Neuropsychiatr Genet 153:570-81. 2010
  5. ncbi request reprint Single nucleotide polymorphism (SNP) allele frequency estimation in DNA pools using Pyrosequencing
    Catharina Lavebratt
    Karolinska Institutet, Neurogenetics Unit, Center for Molecular Medicine CMM, Karolinska Hospital, 171 76 Stockholm, Sweden
    Nat Protoc 1:2573-82. 2006
  6. ncbi request reprint Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouse
    Catharina Lavebratt
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska Hospital L8 00, 171 76 Stockholm, Sweden
    Neurobiol Dis 24:374-83. 2006
  7. pmc A truncated Kv1.1 protein in the brain of the megencephaly mouse: expression and interaction
    Ann Sophie Persson
    Department of Molecular Medicine and Surgery, CMM, Karolinska Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
    BMC Neurosci 6:65. 2005
  8. doi request reprint PreproNPY Pro7 protects against depression despite exposure to environmental risk factors
    Louise K Sjöholm
    Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden
    J Affect Disord 118:124-30. 2009
  9. pmc Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes
    Dzana Sudic Hukic
    Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e67450. 2013
  10. pmc P2RX7: expression responds to sleep deprivation and associates with rapid cycling in bipolar disorder type 1
    Lena Backlund
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e43057. 2012

Detail Information

Publications40

  1. doi request reprint Epigenetic regulation in obesity
    C Lavebratt
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Int J Obes (Lond) 36:757-65. 2012
    ..Future more comprehensive knowledge on epigenetic regulation will complement genome sequence data for the understanding of the complex etiology of obesity and related disorder...
  2. doi request reprint Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort
    Catharina Lavebratt
    Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden
    J Affect Disord 125:249-55. 2010
    ..Genetic variations in FKBP5, BDNF, P2RX7 and CACNA1 are current candidates for involvement in depression...
  3. pmc CRY2 is associated with depression
    Catharina Lavebratt
    Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden
    PLoS ONE 5:e9407. 2010
    ..CRY2 is a circadian gene that participates in regulation of the evening oscillator. This is of interest in mood disorders where a lack of switch from evening to morning oscillators has been postulated...
  4. doi request reprint PER2 variantion is associated with depression vulnerability
    Catharina Lavebratt
    Department of Molecular Medicine and Surgery, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden
    Am J Med Genet B Neuropsychiatr Genet 153:570-81. 2010
    ..In conclusion, genetic variation in PER2 is associated with depression vulnerability a Swedish population-based sample. More studies are needed to determine if this is the case also for NPAS2, ARNTL, and RORA...
  5. ncbi request reprint Single nucleotide polymorphism (SNP) allele frequency estimation in DNA pools using Pyrosequencing
    Catharina Lavebratt
    Karolinska Institutet, Neurogenetics Unit, Center for Molecular Medicine CMM, Karolinska Hospital, 171 76 Stockholm, Sweden
    Nat Protoc 1:2573-82. 2006
    ..After PCR amplification, preparation and analysis of PCR amplicon by PSQ takes 1 h per plate...
  6. ncbi request reprint Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouse
    Catharina Lavebratt
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska Hospital L8 00, 171 76 Stockholm, Sweden
    Neurobiol Dis 24:374-83. 2006
    ..These observations and the effect of CBZ in utero suggest that CBZ treatment might be advantageous in some types of human idiopathic megalencephaly...
  7. pmc A truncated Kv1.1 protein in the brain of the megencephaly mouse: expression and interaction
    Ann Sophie Persson
    Department of Molecular Medicine and Surgery, CMM, Karolinska Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
    BMC Neurosci 6:65. 2005
    ..However, high Kv1.1 mRNA levels in mceph/mceph brain indicated that it escaped this control mechanism. Therefore, we hypothesized that the truncated Kv1.1 would be expressed and dysregulate other Kv1 subunits in the mceph/mceph mice...
  8. doi request reprint PreproNPY Pro7 protects against depression despite exposure to environmental risk factors
    Louise K Sjöholm
    Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden
    J Affect Disord 118:124-30. 2009
    ..Agren H., 2004. Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism. J. Psychiatr. Res. 38, 113-121)...
  9. pmc Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes
    Dzana Sudic Hukic
    Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e67450. 2013
    ..Dopamine and glutamate are important for cognitive processing, thus the COMT and DAOA genes that modulate the expression of these neurotransmitters are of interest for studies of cognitive function...
  10. pmc P2RX7: expression responds to sleep deprivation and associates with rapid cycling in bipolar disorder type 1
    Lena Backlund
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e43057. 2012
    ..We hypothesized that the P2RX7 gene would be affected by sleep deprivation and be implicated in rapid cycling...
  11. doi request reprint Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities
    Philippe A Melas
    Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden
    Int J Neuropsychopharmacol 16:1513-28. 2013
    ....
  12. ncbi request reprint Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly
    Susanna Petersson
    Neurogenetic Unit, Department of Molecular Medicine, CMM, L8 00, Karolinska Institutet, 171 76 Stockholm, Sweden
    Eur J Neurosci 18:3231-40. 2003
    ..However, in contrast to the commonly demonstrated epilepsy-induced neurodegeneration, we find that the mceph mutation leads to seizures with a concomitant increase in brain size, without overt neural atrophy...
  13. doi request reprint Carbamazepine protects against neuronal hyperplasia and abnormal gene expression in the megencephaly mouse
    Malin Almgren
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska Hospital L8 00, 171 76 Stockholm, Sweden
    Neurobiol Dis 32:364-76. 2008
    ..The results also support CBZ's effect on synaptic transmission through GABA A receptors, which could promote apoptotic neurodegeneration, affecting cell number...
  14. pmc Kv1.1 null mice have enlarged hippocampus and ventral cortex
    Ann Sophie Persson
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    BMC Neurosci 8:10. 2007
    ..1 are known to cause episodic ataxia type 1 and temporal lobe epilepsy. Mice that express a malfunctional, truncated Kv1.1 (BALB/cByJ-Kv1.1mceph/mceph) show a markedly enlarged hippocampus and ventral cortex in adulthood...
  15. pmc CLOCK is suggested to associate with comorbid alcohol use and depressive disorders
    Louise K Sjöholm
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Neurogenetics Unit CMM L8 00 Karolinska University Hospital, 171 76 Stockholm, Sweden
    J Circadian Rhythms 8:1. 2010
    ..Alcohol use influences the circadian rhythms generated by the central pacemaker in the suprachiasmatic nucleus, and circadian rhythm alterations in turn are common in depressive disorders as well as among persons addicted to alcohol...
  16. doi request reprint Influence of serotonin transporter promoter variation on the effects of separation from parent/partner on depression
    Andrés Fandiño-Losada
    Department of Public Health Science, Karolinsk Institute, 171 76 Stockholm, Sweden
    J Affect Disord 144:216-24. 2013
    ..Therefore, the effect of 5-HTT promoter variation on the relationship between the loss of parent or partner and depression was examined...
  17. ncbi request reprint Pyrosequencing-based SNP allele frequency estimation in DNA pools
    Catharina Lavebratt
    Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Hum Mutat 23:92-7. 2004
    ..Considering the ease of use, short run and analysis times, and little instrument maintenance requirements, Pyrosequencing may even be a preferred option...
  18. ncbi request reprint Lack of potassium channel induces proliferation and survival causing increased neurogenesis and two-fold hippocampus enlargement
    Malin Almgren
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Hippocampus 17:292-304. 2007
    ..This phenotype is a result, at least in DG, from increased proliferation, neurogenesis, and enhanced general hippocampal cell survival...
  19. doi request reprint The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with depression and motivation in men from a Swedish population-based study
    Elin Aberg
    Neurogenetics Unit, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    J Affect Disord 129:158-66. 2011
    ..Environmental risk factors together with genetic vulnerability create a complex background to develop depression...
  20. ncbi request reprint MRI and in situ hybridization reveal early disturbances in brain size and gene expression in the megencephalic (mceph/mceph) mouse
    Margarita Diez
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Eur J Neurosci 18:3218-30. 2003
    ..These results provide an objective description of the size changes in different brain regions of the mceph/mceph mouse, and suggest that certain molecules could be involved in the early processes underlying these changes...
  21. ncbi request reprint AHSG gene variant is associated with leanness among Swedish men
    Catharina Lavebratt
    Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital L8 00, Stockholm, Sweden
    Hum Genet 117:54-60. 2005
    ..A common variant of AHSG, previously associated with a lower AHSG protein level, is thus more common among lean than obese and overweight men, supporting the results from Ahsg knock-out mice, namely, that AHSG modulates body mass...
  22. ncbi request reprint Polymorphism of the AHSG gene is associated with increased adipocyte beta2-adrenoceptor function
    Catharina Lavebratt
    Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Lipid Res 46:2278-81. 2005
    ..We conclude that a common variation (Thr230Met) in the AHSG gene is associated with a marked increase in beta2-adrenoceptor sensitivity in subcutaneous fat cells, which may be of importance in body weight regulation...
  23. ncbi request reprint No linkage to obesity in candidate regions of chromosome 2 and 10 in a selected sample of Swedish twins
    Anastasia Iliadou
    Department of Medical Epidemiology, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden
    Twin Res 6:162-9. 2003
    ..However, the results were sensitive to issues related to power, minor effects of the genes, ethnic differences and the complex mechanism underlying obesity...
  24. doi request reprint Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset
    Philippe A Melas
    Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden
    FASEB J 26:2712-8. 2012
    ..In addition, blood DNA-methylation signatures show promise of serving as a schizophrenia biomarker in the future...
  25. doi request reprint Idiopathic megalencephaly-possible cause and treatment opportunities: from patient to lab
    Malin Almgren
    Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, L8 00, SE 171 76 Stockholm, Sweden
    Eur J Paediatr Neurol 12:438-45. 2008
    ..Carbamazepine's remarkable protective effects on the neuronal plasticity in the hyperexcitable state should be further studied, and maybe this drug should be considered more in treatment of temporal lobe epilepsy and megalencephaly...
  26. ncbi request reprint Large-scale genotyping of single nucleotide polymorphisms by Pyrosequencingtrade mark and validation against the 5'nuclease (Taqman((R))) assay
    Louise Nordfors
    Neurogenetics Unit, Karolinska Institutet, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Hum Mutat 19:395-401. 2002
    ..We conclude that Pyrosequencingtrade mark is highly efficient and accurate in the analysis of SNPs and represents a promising solution to high-throughput genotyping of large sample populations...
  27. doi request reprint Population-based study of antiepileptic drug exposure in utero--influence on head circumference in newborns
    Malin Almgren
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska Hospital L8 00, 171 76 Stockholm, Sweden
    Seizure 18:672-5. 2009
    ..To study the effect of AED exposure on head circumference in the newborn...
  28. doi request reprint Examining the public refusal to consent to DNA biobanking: empirical data from a Swedish population-based study
    Philippe A Melas
    Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden
    J Med Ethics 36:93-8. 2010
    ..To investigate empirically the motivations for not consenting to DNA biobanking in a Swedish population-based study and to discuss the implications...
  29. ncbi request reprint Carbamazepine treatment recovered low N-acetylaspartate+N-acetylaspartylglutamate (tNAA) levels in the megencephaly mouse BALB/cByJ-Kv1.1(mceph/mceph)
    Eric Westman
    Department of Neurobiology, Health Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Dis 26:221-8. 2007
    ..Furthermore, CBZ treatment recovered tCho and tNAA levels in mceph/mceph. Thus, distinct differences in MRS spectra between mceph/mceph and wt mice were depicted and treatment effects of CBZ were monitored using MRS...
  30. pmc Multigenic control of disease severity after virulent Mycobacterium tuberculosis infection in mice
    Fabio Sanchez
    Center for Molecular Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden
    Infect Immun 71:126-31. 2003
    ..Overall, linkage data reported here for F2 mice are in agreement with, and add to, our previous findings concerning the control of M. tuberculosis-triggered disease in the BC1 segregation...
  31. doi request reprint Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression
    Philippe A Melas
    Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institute, Stockholm, Sweden
    Int J Neuropsychopharmacol 15:669-79. 2012
    ..In conclusion, our data further support a role for P11 in depression-like states and suggest that this gene is controlled by epigenetic mechanisms that can be affected by antidepressant treatment...
  32. pmc CRY2 is associated with rapid cycling in bipolar disorder patients
    Louise K Sjöholm
    Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e12632. 2010
    ....
  33. doi request reprint Neuropeptide Y: identification of a novel rat mRNA splice-variant that is downregulated in the hippocampus and the prefrontal cortex of a depression-like model
    Philippe A Melas
    Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden
    Peptides 35:49-55. 2012
    ..These data add to the characterization of the rat Npy mRNA and demonstrate the presence of a novel transcript with a so far unknown function...
  34. doi request reprint Acoustic startle hypersensitivity in Mceph mice and its effect on hippocampal excitability
    André Fisahn
    Neuronal Oscillations Laboratory, KI Alzheimer s Disease Research Center, NVS, Karolinska Institutet, Stockholm, Sweden
    Eur J Neurosci 34:1121-30. 2011
    ..Our results provide novel insights into the mechanisms that underlie the spread of hypersensitivity and hypersynchrony across functionally different parts of the brain...
  35. pmc Evidence for presence and functional effects of Kv1.1 channels in β-cells: general survey and results from mceph/mceph mice
    Zuheng Ma
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 6:e18213. 2011
    ..1 in different species and tested for a functional role of Kv1.1 by assessing pancreatic islet function in BALB/cByJ (wild-type) and megencephaly (mceph/mceph) mice, the latter having a deletion in the Kv1.1 gene...
  36. doi request reprint A multifactorial developmental model for the etiology of major depression in a population-based sample
    Louise Sjöholm
    Department of Molecular Medicine and Surgery, Division of Neurogenetics, Karolinska Institutet, Stockholm, Sweden
    J Affect Disord 113:66-76. 2009
    ..To test depression specific prediction the sample was overrepresented for other psychiatric diagnoses...
  37. doi request reprint Working conditions, serotonin transporter gene polymorphism (5-HTTLPR) and anxiety disorders: a prospective cohort study
    Bojing Liu
    Division of Public Health Epidemiology, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden Electronic address
    J Affect Disord 151:652-9. 2013
    ..Therefore, we investigated the potential interplay between 5-HTTLPR and job-related risk factors in the prediction of the occurrence of anxiety...
  38. pmc Prenatal exposure to carbamazepine reduces hippocampal and cortical neuronal cell population in new-born and young mice without detectable effects on learning and memory
    Elin Aberg
    Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 8:e80497. 2013
    ..The challenge for future studies are to segment out what possible effects a reduction of neurons could have on different types of cognition, like intellectual ability and social interaction. ..
  39. pmc Genetic polymorphisms in monoamine systems and outcome of cognitive behavior therapy for social anxiety disorder
    Evelyn Andersson
    Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e79015. 2013
    ..The aim of the present study was to investigate if these three gene variants predicted response to CBT in a large sample of SAD patients...
  40. pmc Adenovirus-36 is associated with obesity in children and adults in Sweden as determined by rapid ELISA
    Malin Almgren
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e41652. 2012
    ..Adv36 infection has also been shown to reduce blood lipid levels, increase glucose uptake by adipose tissue and skeletal muscle biopsies, and to associate with improved glycemic control in non-diabetic individuals...