K Larsson

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Dental health in smokers with and without COPD
    Jan Bergstrom
    Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e59492. 2013
  2. doi request reprint Combination of budesonide/formoterol more effective than fluticasone/salmeterol in preventing exacerbations in chronic obstructive pulmonary disease: the PATHOS study
    K Larsson
    Unit of Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 273:584-94. 2013
  3. pmc Adhesion molecules in subjects with COPD and healthy non-smokers: a cross sectional parallel group study
    Kristin Blidberg
    Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Respir Res 14:47. 2013
  4. pmc COPD diagnosis related to different guidelines and spirometry techniques
    Lennart Nathell
    Personal Injury Prevention Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Respir Res 8:89. 2007
  5. pmc Budesonide/formoterol as effective as prednisolone plus formoterol in acute exacerbations of COPD. A double-blind, randomised, non-inferiority, parallel-group, multicentre study
    Bjorn Stallberg
    Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology, Uppsala University, Sweden
    Respir Res 10:11. 2009
  6. ncbi request reprint Monitoring airway remodeling in asthma
    Kjell Larsson
    Unit of Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Respir J 4:35-40. 2010
  7. ncbi request reprint Aspects on pathophysiological mechanisms in COPD
    Kjell Larsson
    Unit of Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 262:311-40. 2007
  8. ncbi request reprint [Management of COPD]
    Kjell Larsson
    Institutet för miljömedicin, Karolinska Institutet, Stockholm
    Lakartidningen 104:1043-6. 2007
  9. doi request reprint Inflammatory markers in COPD
    K Larsson
    Unit of Lung and Allergy Research, Ntauional Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Respir J 2:84-7. 2008
  10. ncbi request reprint Sodium cromoglycate attenuates pulmonary inflammation without influencing bronchial responsiveness in healthy subjects exposed to organic dust
    K Larsson
    Program for Respiratory Health and Climate, National Institute for Working Life, Stockholm, Sweden
    Clin Exp Allergy 31:1356-68. 2001

Collaborators

Detail Information

Publications80

  1. pmc Dental health in smokers with and without COPD
    Jan Bergstrom
    Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e59492. 2013
    ....
  2. doi request reprint Combination of budesonide/formoterol more effective than fluticasone/salmeterol in preventing exacerbations in chronic obstructive pulmonary disease: the PATHOS study
    K Larsson
    Unit of Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 273:584-94. 2013
    ..The aim of this study was to investigate exacerbation rates in primary care patients with COPD treated with budesonide/formoterol compared with fluticasone/salmeterol...
  3. pmc Adhesion molecules in subjects with COPD and healthy non-smokers: a cross sectional parallel group study
    Kristin Blidberg
    Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Respir Res 14:47. 2013
    ..The aim of the study was to investigate how the expression of adhesion molecules changes as neutrophils migrate from the circulation to the lung and if these changes differ between non-smoking subjects and smokers with and without COPD...
  4. pmc COPD diagnosis related to different guidelines and spirometry techniques
    Lennart Nathell
    Personal Injury Prevention Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Respir Res 8:89. 2007
    ..The diagnosis of COPD is highly depending on which guidelines are used for defining the disease. If FVC and not the best of SVC and FVC is used when defining COPD the diagnosis will be missed in a substantial number of patients...
  5. pmc Budesonide/formoterol as effective as prednisolone plus formoterol in acute exacerbations of COPD. A double-blind, randomised, non-inferiority, parallel-group, multicentre study
    Bjorn Stallberg
    Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology, Uppsala University, Sweden
    Respir Res 10:11. 2009
    ....
  6. ncbi request reprint Monitoring airway remodeling in asthma
    Kjell Larsson
    Unit of Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Respir J 4:35-40. 2010
    ..Airway remodeling occurs in both mild and severe forms of asthma but, from a clinical point of view, airway remodeling in asthma is difficult to monitor...
  7. ncbi request reprint Aspects on pathophysiological mechanisms in COPD
    Kjell Larsson
    Unit of Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 262:311-40. 2007
    ....
  8. ncbi request reprint [Management of COPD]
    Kjell Larsson
    Institutet för miljömedicin, Karolinska Institutet, Stockholm
    Lakartidningen 104:1043-6. 2007
  9. doi request reprint Inflammatory markers in COPD
    K Larsson
    Unit of Lung and Allergy Research, Ntauional Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Respir J 2:84-7. 2008
    ....
  10. ncbi request reprint Sodium cromoglycate attenuates pulmonary inflammation without influencing bronchial responsiveness in healthy subjects exposed to organic dust
    K Larsson
    Program for Respiratory Health and Climate, National Institute for Working Life, Stockholm, Sweden
    Clin Exp Allergy 31:1356-68. 2001
    ..Inhalation of organic dust from a pig house induces airway inflammation and increases bronchial responsiveness to methacholine in healthy subjects...
  11. pmc Influence of fluticasone and salmeterol on airway effects of inhaled organic dust;an in vivo and ex vivo study
    A Ek
    Program for Respiratory Health and Climate, National Institute for Working Life, Stockholm, Sweden
    Clin Exp Immunol 121:11-6. 2000
    ..These findings suggest that drugs which are known to influence and control airway inflammation in asthma do not have major effects on airway inflammation induced by the inhalation of organic dust...
  12. ncbi request reprint Fluticasone and ibuprofen do not add to the effect of salmeterol on organic dust-induced airway inflammation and bronchial hyper-responsiveness
    K Strandberg
    Lung and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 264:83-94. 2008
    ..Exposure in a pig house causes airway inflammation and bronchial hyper-responsiveness which are not influenced by anti-asthma drugs, including a beta(2)-agonist (salmeterol)...
  13. ncbi request reprint Comparison of airway conductance and FEV(1) as measures of airway responsiveness to methacholine. Discrimination of small differences in bronchial responsiveness with Gaw and FEV(1)
    B M Sundblad
    Programme for Respiratory Health and Climate, National Institute for Working Life, Stockholm, Sweden
    Clin Physiol 21:673-81. 2001
    ..In conclusion, with our methacholine provocation method, FEV(1) and Gaw had similar sensitivity in detecting small differences in bronchial responsiveness in healthy subjects...
  14. doi request reprint Effect of formoterol with or without budesonide in repeated low-dose allergen challenge
    B Dahlen
    Division of Respiratory Medicine and Allergy, Dept of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Eur Respir J 33:747-53. 2009
    ..Signs of deteriorating asthma, provoked by low-dose allergen, are prevented by short-term use of budesonide/formoterol but not by temporary use of formoterol alone...
  15. ncbi request reprint Repeated exposure to organic material alters inflammatory and physiological airway responses
    B M Sundblad
    Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, PO Box 287, S 171 77 Stockholm, Sweden
    Eur Respir J 34:80-8. 2009
    ..We conclude that individuals who are repeatedly exposed to organic material develop an adaptation to the effects of acute exposure to inhaled organic material...
  16. ncbi request reprint Not 15 but 50% of smokers develop COPD?--Report from the Obstructive Lung Disease in Northern Sweden Studies
    B Lundback
    Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Respir Med 97:115-22. 2003
    ..The prevalence of chronic obstructive pulmonary disease (COPD) according to guidelines of today seems considerably higher than has been reported also in recent literature...
  17. ncbi request reprint Expression of TNFalpha and its receptors R1 and R2 in human alveolar epithelial cells exposed to organic dust and the effects of 8-bromo-cAMP and protein kinase A modulation
    K Burvall
    The National Institute of Environmental Medicine, Lung and Allergy Research, Karolinska Institutet, Box 287, 17177 Stockholm, Sweden
    Inflamm Res 54:281-8. 2005
    ..Additional objectives were to elucidate whether 8-bromocAMP affected TNF and TNF receptor mRNA expression by activation of protein kinase A (PKA) and whether it increased phosphorylation of cAMP-responsive element-binding protein (CREB)...
  18. ncbi request reprint Allergen avoidance does not alter airborne cat allergen levels in classrooms
    A S Karlsson
    Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Box 287, S 171 77 Stockholm, Sweden
    Allergy 59:661-7. 2004
    ....
  19. ncbi request reprint Different response to doubling and fourfold dose increases in methacholine provocation tests in healthy subjects
    B M Sundblad
    Programme for Respiratory Health and Climate, National Institute for Working Life, Stockholm, Sweden
    Chest 118:1371-7. 2000
    ..This modified methacholine provocation allows measurements of the provocative dose causing 20% decrease in FEV(1) (PD(20)) in a high proportion of a normal population...
  20. ncbi request reprint Incidence of physician-diagnosed asthma in adults--a real incidence or a result of increased awareness? Report from The Obstructive Lung Disease in Northern Sweden Studies
    B Lundback
    Department of Occupational Medicine, National Institute for Working Life, Stockholm, Sweden
    Respir Med 95:685-92. 2001
    ..Use of different methods when measuring incidence may in part explain the extremely diverging incidence rates of asthma found in different studies...
  21. ncbi request reprint Quality of life in primary care asthma
    P O Ehrs
    Family Medicine Stockholm, Department of Clinical Sciences, Karolinska Institutet, Huddinge, Sweden
    Respir Med 95:22-30. 2001
    ..Evaluation of quality of life enables a more careful grading of asthma status. Furthermore, this measure provides information concerning asthma control that is not revealed by spirometry and simple questions regarding symptoms...
  22. ncbi request reprint Worsening of asthma in children allergic to cats, after indirect exposure to cat at school
    C Almqvist
    Department of Environmental Health, Karolinska Hospital, Stockholm, Sweden
    Am J Respir Crit Care Med 163:694-8. 2001
    ..Thus, asthma symptoms, PEF, and the use of asthma medication in children with cat allergy may be affected by indirect cat exposure at school...
  23. ncbi request reprint Effectiveness of ganciclovir against human herpesvirus-6 excreted in saliva in stem cell transplant recipients
    P Ljungman
    Division of Hematology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Bone Marrow Transplant 39:497-9. 2007
    ..49 (s.e. 0.31) log(10)/week in patients receiving ganciclovir whereas it increased 0.15 (s.e. 0.17) log(10)/week in episodes without antiviral therapy (P=0.04). We conclude that ganciclovir can decrease the HHV-6 viral load in saliva...
  24. ncbi request reprint Influence of 8-bromo-cyclicAMP on interleukin -6 and -8 mRNA levels in A549 human lung epithelial cells exposed to organic dust: a time-kinetic study
    Karin Burvall
    The National Institute of Environmental Medicine, Lung and Allergy Research, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Life Sci 75:2733-49. 2004
    ..Thus, 8-bromo-cAMP exerted opposite action on dust-induced IL-6 and IL-8 mRNA expression with time...
  25. ncbi request reprint Chronic rhinosinusitis in asthma is a negative predictor of quality of life: results from the Swedish GA(2)LEN survey
    A Ek
    Experimental Asthma and Allergy Research Unit, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Allergy 68:1314-21. 2013
    ..The aim of this study was to evaluate the impact of CRS and other relevant factors on quality of life in asthmatic subjects...
  26. ncbi request reprint Exhaled nitric oxide and bronchial responsiveness in healthy subjects exposed to organic dust
    B M Sundblad
    Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Eur Respir J 20:426-31. 2002
    ..These results indicate that these two outcome measures reflect different aspects of airway inflammation induced by exposure to a farming environment...
  27. ncbi request reprint Impact on the cytomegalovirus (CMV) viral load by CMV-specific T-cell immunity in recipients of allogeneic stem cell transplantation
    G Avetisyan
    Department of Medicine, Division of Haematology, Karolinska Institutet, Karolinska University Hospital in Huddinge, Stockholm 14186, Sweden
    Bone Marrow Transplant 38:687-92. 2006
    ..Recovery of CMV-specific immunity might be delayed in patients with CMV disease. These observations suggest that detection of CMV-specific T-cells is useful in assessing the immunity against CMV...
  28. ncbi request reprint Albumin, transferrin and alpha2-macroglobulin in bronchoalveolar lavage fluid following exposure to organic dust in healthy subjects
    O Vesterberg
    Programme for Respiratory Health and Climate, National Institute for Working Life, Stockholm, Sweden
    Int Arch Occup Environ Health 74:249-54. 2001
    ..The aim of the study was to compare the concentration of three different proteins in bronchoalveolar lavage (BAL) fluid as markers for the inflammation...
  29. ncbi request reprint Organic dust activates NF-kappaB in lung epithelial cells
    Johan Liden
    Department of Medical Nutrition, Karolinska Institutet, Huddinge University Hospital Novum, Huddinge SE 141 86, Sweden
    Respir Med 97:882-92. 2003
    ..In conclusion, by interference at various levels we have shown that NF-kappaB plays a key role in the inflammatory response to organic dust...
  30. ncbi request reprint The effect of fluticasone on the airway inflammatory response to organic dust
    A Ek
    Lung and Allergy Research, Division of Physiology, Institute of Environmental Medicine, Karolinska Institutet, PO Box 287, SE 171 77, Stockholm, Sweden
    Eur Respir J 24:587-93. 2004
    ..In conclusion, glucocorticoid treatment attenuated the inflammatory response to inhaled organic dust without influencing the increased bronchial responsiveness to methacholine...
  31. ncbi request reprint Saliva is one likely source of leukotriene B4 in exhaled breath condensate
    F Gaber
    Unit for Experimental Asthma and Allergy Research, Division of Physiology, PO Box 287, The National Institute of Environmental Medicine, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Eur Respir J 28:1229-35. 2006
    ..As leukotriene B4 was consistently present in sputum supernatants, exhaled breath condensate may be inappropriate for monitoring airway leukotriene B4...
  32. ncbi request reprint Evidence for an involvement of 5-HT1B receptors in the inhibition of male rat ejaculatory behavior produced by 5-HTP
    S Ahlenius
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Psychopharmacology (Berl) 137:374-82. 1998
    ....
  33. ncbi request reprint Results of different strategies for reducing cytomegalovirus-associated mortality in allogeneic stem cell transplant recipients
    P Ljungman
    Department of Hematology, Huddinge University Hospital, Karolinska Institutet, Sweden
    Transplantation 66:1330-4. 1998
    ..Several preventive strategies against cytomegalovirus (CMV) disease have been developed during the last decade. These have frequently been used in combination, and it has been difficult to identify each strategy's contribution...
  34. ncbi request reprint Exposure to organic dust causes activation of human plasma complement factors C3 and B and the synthesis of factor C3 by lung epithelial cells in vitro
    Fernando Acevedo
    Lung and Allergy Research, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    Inflammation 29:39-45. 2005
    ..The activation of complement in vivo and induced C3 synthesis by epithelial cells suggests a role of complement in the airway reaction to organic dust exposure...
  35. ncbi request reprint Salmeterol does not alter increased bronchial responsiveness caused by organic dust exposure
    Alexandra Ek
    Lung and Allergy Research, Division of Pathology, Institute of Environmental Medicine, Karolinska Institutet, PO Box 287, SE 171 77 Stockholm, Sweden
    Chest 128:3038-47. 2005
    ..Exposure in a swine house induces airway inflammation and increases bronchial responsiveness to methacholine in healthy subjects...
  36. ncbi request reprint Effects of 5-lipoxygenase inhibitor zileuton on airway responses to inhaled swine house dust in healthy subjects
    Britt Marie Larsson
    Lung and Allergy Research, Division of Physiology, The National Institute of Environmental Medicine, Karolinska Institutet, P O Box 287, SE 171 77 Stockholm, Sweden
    Respir Med 100:226-37. 2006
    ..Inhalation of swine house dust induces acute airway inflammation and increased bronchial responsiveness in healthy subjects...
  37. doi request reprint Lung function testing influences the attitude toward smoking cessation
    Britt Marie Sundblad
    Lung and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, PO Box 287, S 171 77 Stockholm, Sweden
    Nicotine Tob Res 12:37-42. 2010
    ..The aim of the study was to explore whether performing a spirometry changes attitudes toward smoking cessation...
  38. doi request reprint Altered innate immune response in farmers and smokers
    Karin Sahlander
    Lung and Allergy Research, National Institute of Environmental Medicine Karolinska Institutet, Stockholm, Sweden
    Innate Immun 16:27-38. 2010
    ..This increased proportion of Th2 cells and reduced TLR2 expression may have health-related implications and may be related to the increased prevalence of respiratory disorders observed in these groups...
  39. ncbi request reprint Effect of formoterol and budesonide on chemokine release, chemokine receptor expression and chemotaxis in human neutrophils
    Karin Strandberg
    Lung and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Box 287, SE 171 77 Stockholm, Sweden
    Pulm Pharmacol Ther 23:316-23. 2010
    ..We conclude that a beta(2)-agonist and a glucocorticoid, commonly used in the treatment of obstructive lung diseases, influence chemokine release and receptor sensitivity but the functional consequences of these findings remain unclear...
  40. doi request reprint Increased serum levels of soluble ST2 in birch pollen atopics and individuals working in laboratory animal facilities
    Karin Sahlander
    Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Occup Environ Med 52:214-8. 2010
    ....
  41. doi request reprint Budesonide enhances Toll-like receptor 2 expression in activated bronchial epithelial cells
    Ida von Scheele
    Lung and Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Inhal Toxicol 22:493-9. 2010
    ..These findings contribute to our understanding of the beneficial effects of glucocorticosteroids during chronic obstructive pulmonary disease (COPD) exacerbations and asthma, which are frequently caused by microorganisms...
  42. doi request reprint Effect of budesonide and formoterol on IL-6 and IL-8 release from primary bronchial epithelial cells
    Karin Strandberg
    Lung and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Asthma 45:201-3. 2008
    ..Formoterol increased the IL-6 release but did not influence the IL-8 release. Budesonide attenuated the IL-6 and IL-8 release, an inhibiting effect that was sustained, but not reinforced, by formoterol...
  43. ncbi request reprint High rate of smoking abstinence in COPD patients: Smoking cessation by hospitalization
    Britt Marie Sundblad
    Lung and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Nicotine Tob Res 10:883-90. 2008
    ..Despite high costs for this aggressive smoking cessation program, beneficial economic effects are likely to be obtained in the long run...
  44. ncbi request reprint Effect of formoterol and salmeterol on IL-6 and IL-8 release in airway epithelial cells
    Karin Strandberg
    Lung and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Respir Med 101:1132-9. 2007
    ..The results indicate different mechanisms of beta(2)-agonist action in bronchial and alveolar epithelial cells. Furthermore, our results indicate that A549 cells do not possess functional beta(2)-adrenoceptors...
  45. ncbi request reprint Airways inflammation after exposure in a swine confinement building during cleaning procedure
    Britt Marie Larsson
    Lung and Allergy Research, The Institute of Environmental Medicine, Stockholm, Sweden
    Am J Ind Med 41:250-8. 2002
    ..The purpose of the present study was to investigate health effects from exposure during cleaning of the swine confinement building and to evaluate the effect of a respiratory protection device...
  46. doi request reprint Low awareness of COPD among physicians
    Britt Marie Sundblad
    Lung and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Respir J 2:11-6. 2008
    ....
  47. ncbi request reprint Bronchial responsiveness to eucapnic hyperventilation and methacholine following exposure to organic dust
    Britt Marie Sundblad
    Program for Respiratory Health and Climate, National Institute for Working Life, Stockholm, Sweden
    Chest 122:363-8. 2002
    ..The aims of the present study were to investigate whether exposure to organic dust also influences bronchial responsiveness to an indirect stimulus, and to assess the duration of increased postexposure bronchial responsiveness...
  48. ncbi request reprint Effects by 8-bromo-cyclicAMP on basal and organic dust-induced release of interleukin-6 and interleukin-8 in A549 human airway epithelial cells
    K Burvall
    National Institute for Working Life, Stockholm, Sweden
    Respir Med 97:46-50. 2003
    ..The results indicate that 8-Bromo-cAMP attenuated IL-8 release by affecting signaling transductions induced by the particulate fraction...
  49. ncbi request reprint Comparison of four allergen-sampling methods in conventional and allergy prevention classrooms
    A S Karlsson
    Lung and Allergy Research, National Institute of Environmental Medicine, Krolinska Institute, Stotcholm, Sweden
    Clin Exp Allergy 32:1776-81. 2002
    ..Several allergen-sampling methods are used to assess level of personal or indirect exposure to cat in homes, schools and other public buildings and working environments...
  50. pmc Ischaemic heart disease among livestock and agricultural workers
    B Sjogren
    Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE 171 77 Stockholm, Sweden
    Occup Environ Med 60:e1. 2003
    ..Agricultural workers are exposed to organic dust containing endotoxins, mites, and moulds...
  51. ncbi request reprint Covalent binding of proteins to grafted plastic surfaces suitable for immunoassays. II. Picograms of IgE detected in BAL fluid in sarcoidosis
    P H Larsson
    Department of Clinical Immunology and Transfusion Medicine, Karolinska Hospital, Stockholm, Sweden
    J Immunol Methods 210:41-9. 1997
    ..2 pg/ml). In contrast, none of the healthy controls (0/22) had detectable IgE as defined by the detection limit of the assay...
  52. ncbi request reprint Airway responses of healthy farmers and nonfarmers to exposure in a swine confinement building
    Lena Palmberg
    National Institute of Environmental Medicine, Lung and Allergy Research, Karolinska Institute, Stockholm, Sweden
    Scand J Work Environ Health 28:256-63. 2002
    ..The objective of the study was to determine whether swine farmers continuously exposed to the farming environment react differently to acute exposure than previously unexposed nonfarmers...
  53. ncbi request reprint Partial protection by respirators on airways responses following exposure in a swine house
    Lena Palmberg
    Lung and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, P O Box 287, S 17177 Stockholm, Sweden
    Am J Ind Med 46:363-70. 2004
    ..Exposure to swine dust leads to an intense airway inflammation and increased bronchial responsiveness. The purpose of the present study was to evaluate the effect of a respiratory protection device during exposure in a swine house...
  54. ncbi request reprint Organic dust-induced activation, adhesion to substrate and expression of intercellular adhesion molecules in THP-1 monocytes
    Karin Burvall
    The National Institute of Environmental Medicine, Lung and Allergy Research, Karolinska Institutet, Box 287, SE 171 77 Stockholm, Sweden
    Life Sci 80:1598-607. 2007
    ..The sustained adhesion to substrate indicates that organic dust from a swine confinement building may contain agents that prevent deactivation and detachment of the cells...
  55. doi request reprint Effect of fluticasone on markers of inflammation and quality of life in steroid-naive patients with mild asthma
    Per Olof Ehrs
    Unit of Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Respir J 4:51-8. 2010
    ..The aim was to find out if markers of asthma activity and quality of life are influenced by inhaled steroids in patients who regard themselves as free of symptoms...
  56. ncbi request reprint Quality of life and inflammatory markers in mild asthma
    Per Olof Ehrs
    Unit of Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Chest 129:624-31. 2006
    ..Spirometry was performed before and after bronchodilation, and bronchial challenges with methacholine and eucapnic dry air hyperventilation were conducted on separate days. NO in exhaled air and serum IgE were also analyzed...
  57. ncbi request reprint Effect of deep inhalations after a bronchial methacholine provocation in asthmatic and non-asthmatic subjects
    B M Sundblad
    National Institute of Environmental Medicine, Karolinska Institute, S 171 77 Stockholm, Sweden
    Respir Med 96:477-81. 2002
    ..In conclusion, deep inhalations attenuate the methacholine-induced bronchoconstriction in both asthmatic and non-asthmatic subjects. Thus, the effect of deep inhalations did not discriminate between asthmatic and non-asthmatic subjects...
  58. ncbi request reprint Organic dust-induced interleukin-12 production activates T- and natural killer cells
    C Muller-Suur
    Dept of Medicine, Karolinska Hospital, Stockholm, Sweden
    Eur Respir J 20:686-90. 2002
    ..In conclusion, this study indicates that swine dust can, at least in part, stimulate phagocytic cells to activate natural killer cells and T-lymphocytes through the production of interleukin-12...
  59. ncbi request reprint Human herpesvirus 6 infection and cytomegalovirus-specific lymphoproliferative responses in allogeneic stem cell transplant recipients
    F Z Wang
    Department of Hematology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    Bone Marrow Transplant 30:521-6. 2002
    ..001). Our data indicate the possibility that HHV-6 can suppress the development of CMV-specific immune responses and thereby could predispose to development of late CMV disease...
  60. ncbi request reprint Evaluation of respiratory effects related to high-pressure cleaning in a piggery with and without robot pre-cleaning
    Deline Hiel
    Lung and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Work Environ Health 35:376-83. 2009
    ..Exposure in connection with cleaning piggeries induces airway inflammation. The aim of this study was to compare the health effects related to two different cleaning processes in a piggery...
  61. ncbi request reprint Effect of respirators equipped with particle or particle-and-gas filters during exposure in a pig confinement building
    Britt Marie Sundblad
    Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, PO Box 287, S 17177 Stockholm, Sweden
    Scand J Work Environ Health 32:145-53. 2006
    ..This study compared the protective effect of two respiratory protection devices during exposure in a pig confinement building...
  62. doi request reprint Novel antigen design for the generation of antibodies to G-protein-coupled receptors
    K Larsson
    Division of Proteomics, School of Biotechnology, KTH AlbaNova University Center, Stockholm, Sweden
    J Immunol Methods 370:14-23. 2011
    ..Hence, the genetic combination of several different epitopes enables efficient generation of specific antibodies with potential use in several applications for the study of endogenous receptors...
  63. ncbi request reprint Synergistic actions of the 5-HT1A receptor antagonist WAY-100635 and citalopram on male rat ejaculatory behavior
    S Ahlenius
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Eur J Pharmacol 379:1-6. 1999
    ..It is suggested that blockade of inhibitory 5-HT1A autoreceptors discloses inhibitory effects of the selective serotonin re-uptake inhibitor citalopram on male rat ejaculatory behavior mediated via stimulation of 5-HT1B receptors...
  64. ncbi request reprint Underdiagnosis of chronic obstructive pulmonary disease in Northern Sweden
    M Lindstrom
    Respiratory Unit, Department of Occupational Medicine, National Institute for Working Life, Stockholm, Sweden
    Int J Tuberc Lung Dis 6:76-84. 2002
    ..To assess underdiagnosis of chronic obstructive pulmonary disease...
  65. doi request reprint Communication and self-management education at nurse-led COPD clinics in primary health care
    Eva Osterlund Efraimsson
    Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, Stockholm, Sweden
    Patient Educ Couns 77:209-17. 2009
    ..The aim of the study was to explore the structure, content in communication and self-management education in patients' first consultations at nurse-led chronic obstructive pulmonary disease (COPD) clinics in primary healthcare...
  66. ncbi request reprint Noneosinophilic CD4 lymphocytic airway inflammation in menopausal women with chronic dry cough
    Ester Mund
    The National Institute of Environmental Medicine, Division of Lung and Allergy Research, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    Chest 127:1714-21. 2005
    ..Chronic dry cough without dyspnea and wheezing is a well-known condition that is considered to be clinically overrepresented in women. The etiology and morphology remain unknown in many cases despite thorough investigations...
  67. ncbi request reprint Evaluation of Petri dish sampling for assessment of cat allergen in airborne dust
    A S Karlsson
    Department of Occupational Health, National Institute for Working Life, Stockholm, Sweden
    Allergy 57:164-8. 2002
    ..Because assessment of personal exposure using person-carried pumps is time-consuming and expensive we evaluated the Petri dish sampling method for measurement of airborne cat allergen in classrooms...
  68. ncbi request reprint Acute respiratory effects of exposure to ammonia on healthy persons
    Britt Marie Sundblad
    Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Work Environ Health 30:313-21. 2004
    ..This study investigated the acute respiratory effects of low ammonia exposure on healthy persons...
  69. ncbi request reprint The tyrosine kinase inhibitor genistein increases basal cAMP and potentiates forskolin-induced cAMP accumulation in A549 human airway epithelial cells
    Karin M Burvall
    National Institute for Working Life, Stockholm, Sweden
    Mol Cell Biochem 240:131-3. 2002
    ..Thus, the use of genistein in studies on signaling transductions may result in erroneous conclusions since increased cAMP may cause or contribute to the observed effects...
  70. ncbi request reprint Interval training compared with continuous training in patients with COPD
    Ragnheidur Harpa Arnardóttir
    Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden
    Respir Med 101:1196-204. 2007
    ..At isotime, the physiological response to training differed between the groups, in favour of the interval training...
  71. ncbi request reprint Two different training programmes for patients with COPD: a randomised study with 1-year follow-up
    R Harpa Arnardóttir
    Department of Medical sciences Respiratory Medicine and Allergology, Ing 40, 2 tr, Akademiska sjukhuset, Uppsala University, SE 751 85 Uppsala, Sweden
    Respir Med 100:130-9. 2006
    ..A second purpose was to find out whether the severity of chronic obstructive pulmonary disease (COPD) affected the training response and whether the interventions had a long-term effect...
  72. ncbi request reprint [All patients with COPD should be offered exercise therapy--no matter the severity of illness]
    Margareta Emtner
    Uppsala universitet, Akademiska sjukhuset, Uppsala
    Lakartidningen 102:766, 768, 770-1. 2005
  73. ncbi request reprint Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate
    Pär Gyllfors
    Division of Respiratory Medicine, Department of Medicine, Karolinska University Hospital Solna, Sweden
    J Allergy Clin Immunol 118:78-83. 2006
    ..Although the synthesis of leukotrienes is not affected by corticosteroid treatment, the influence of corticosteroids on the leukotriene pathway remains unresolved...
  74. ncbi request reprint [Post-exertional respiratory problems in asthma are reduced by exercise]
    Margareta Emtner
    Institutionen för Neurovetenskap, enheten för sjukgymnastik, Uppsala universitet och Akademiska sjukhuset, Uppsala
    Lakartidningen 102:654-5, 658-9. 2005
  75. ncbi request reprint [The cause of disease became less important than the symptoms--what went wrong?]
    Hans Gilljam
    Centrum för folkhälsa tobaksprevention, Stockholms läns landsting
    Lakartidningen 102:3246; discussion 3247. 2005
  76. ncbi request reprint Metabolic activation of A549 human airway epithelial cells by organic dust: a study based on microphysiometry
    Karin Burvall
    National Institute for Working Life, SE 112 79 Stockholm, Sweden
    Life Sci 71:299-309. 2002
    ..In summary, the organic dust induces PTX-sensitive (cAMP independent) signalling in near-confluent A549 epithelial cells and, depending on cell density opposing effects on NHE activity during exposure...
  77. ncbi request reprint [Can the society afford not to subsidize smoking cessation?]
    Matz Larsson
    Lungkliniken tobakspreventiva enheten, Universitetssjukhuset Orebro
    Lakartidningen 99:2665-6. 2002
  78. pmc Peak exercise capacity estimated from incremental shuttle walking test in patients with COPD: a methodological study
    Ragnheigur Harpa Arnardóttir
    Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden
    Respir Res 7:127. 2006
    ..The aim of the study was to investigate the relationship between an incremental shuttle walking test (ISWT) and two laboratory cycle tests in order to assess whether W peak could be estimated from an ISWT...
  79. pmc Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust
    Stefan Ivanov
    Department of Respiratory Medicine and Allergy, Institute for Internal Medicine, Goteborg University, Guldhedsgatan 10A, 413 46 Gothenburg, Sweden
    Respir Res 6:44. 2005
    ..We also assessed the expression of the elastinolytic protease MMP-9 in this airway compartment...
  80. ncbi request reprint Decline in FEV1 in relation to incident chronic obstructive pulmonary disease in a cohort with respiratory symptoms
    Anne Lindberg
    The OLIN Studies, Sunderby Central Hospital of Norrbotten, Lulea, Sweden
    COPD 4:5-13. 2007
    ..Among incident cases of COPD the decline was steeper and close to a quarter had a rapid decline...