Filip J Larsen

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Dietary inorganic nitrate improves mitochondrial efficiency in humans
    Filip J Larsen
    Department of Physiology and Pharmacology, Karolinska Institutet, 11486 Stockholm, Sweden
    Cell Metab 13:149-59. 2011
  2. doi request reprint Regulation of mitochondrial function and energetics by reactive nitrogen oxides
    Filip J Larsen
    Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Free Radic Biol Med 53:1919-28. 2012
  3. pmc A simple intravenous glucose tolerance test for assessment of insulin sensitivity
    Robert G Hahn
    Section for Anesthesia, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Theor Biol Med Model 8:12. 2011
  4. doi request reprint Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise
    Filip J Larsen
    Department of Physiology and Pharmacology, Swedish School of Sport and Health Sciences, Karolinska Institutet, 11486 Stockholm, Sweden
    Free Radic Biol Med 48:342-7. 2010
  5. doi request reprint Mitochondrial oxygen affinity predicts basal metabolic rate in humans
    Filip J Larsen
    1 Department of Physiology and Pharmacology, Karolinska Institutet, 11486 Stockholm, Sweden
    FASEB J 25:2843-52. 2011
  6. ncbi request reprint Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans
    Filip J Larsen
    Departments of Physiology and Pharmacology FJL, TAS, MPM, JOL, and EW, Medical Biochemistry and Biophysics, Division of Physiological Chemistry II AC and CEW, and Clinical Science and Education, Södersjukhuset TN, Karolinska Institutet, Stockholm, Sweden, and the Åstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Stockholm, Sweden BE
    Am J Clin Nutr 99:843-50. 2014
  7. ncbi request reprint Inorganic nitrite stimulates pancreatic islet blood flow and insulin secretion
    Thomas Nystrom
    Department of Clinical Science and Education, Karolinska Institutet, Sodersjukhuset, SE 118 83 Stockholm, Sweden
    Free Radic Biol Med 53:1017-23. 2012
  8. doi request reprint Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans
    Tomas A Schiffer
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Respir Physiol Neurobiol 185:339-48. 2013
  9. doi request reprint Cardiorespiratory fitness predicts insulin action and secretion in healthy individuals
    Filip J Larsen
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Metabolism 61:12-6. 2012
  10. doi request reprint Roles of dietary inorganic nitrate in cardiovascular health and disease
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Cardiovasc Res 89:525-32. 2011

Detail Information

Publications12

  1. doi request reprint Dietary inorganic nitrate improves mitochondrial efficiency in humans
    Filip J Larsen
    Department of Physiology and Pharmacology, Karolinska Institutet, 11486 Stockholm, Sweden
    Cell Metab 13:149-59. 2011
    ..We conclude that dietary nitrate has profound effects on basal mitochondrial function. These findings may have implications for exercise physiology- and lifestyle-related disorders that involve dysfunctional mitochondria...
  2. doi request reprint Regulation of mitochondrial function and energetics by reactive nitrogen oxides
    Filip J Larsen
    Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Free Radic Biol Med 53:1919-28. 2012
    ..Here we discuss the latest advances in our understanding of the roles of nitrate, nitrite, and NO in the modulation of mitochondrial function, with a particular focus on dietary nitrate and exercise...
  3. pmc A simple intravenous glucose tolerance test for assessment of insulin sensitivity
    Robert G Hahn
    Section for Anesthesia, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Theor Biol Med Model 8:12. 2011
    ..The aim of the study was to find a simple intravenous glucose tolerance test (IVGTT) that can be used to estimate insulin sensitivity...
  4. doi request reprint Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise
    Filip J Larsen
    Department of Physiology and Pharmacology, Swedish School of Sport and Health Sciences, Karolinska Institutet, 11486 Stockholm, Sweden
    Free Radic Biol Med 48:342-7. 2010
    ..This reduction occurred with a trend toward increased time to exhaustion implying that two separate mechanisms are involved: one that reduces VO(2max) and another that improves the energetic function of the working muscles...
  5. doi request reprint Mitochondrial oxygen affinity predicts basal metabolic rate in humans
    Filip J Larsen
    1 Department of Physiology and Pharmacology, Karolinska Institutet, 11486 Stockholm, Sweden
    FASEB J 25:2843-52. 2011
    ..The implications of these findings are discussed in terms of a trade-off between aerobic efficiency and power...
  6. ncbi request reprint Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans
    Filip J Larsen
    Departments of Physiology and Pharmacology FJL, TAS, MPM, JOL, and EW, Medical Biochemistry and Biophysics, Division of Physiological Chemistry II AC and CEW, and Clinical Science and Education, Södersjukhuset TN, Karolinska Institutet, Stockholm, Sweden, and the Åstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Stockholm, Sweden BE
    Am J Clin Nutr 99:843-50. 2014
    ..The bioactivation of nitrate involves its active accumulation in saliva followed by a sequential reduction to nitrite, nitric oxide, and other reactive nitrogen species...
  7. ncbi request reprint Inorganic nitrite stimulates pancreatic islet blood flow and insulin secretion
    Thomas Nystrom
    Department of Clinical Science and Education, Karolinska Institutet, Sodersjukhuset, SE 118 83 Stockholm, Sweden
    Free Radic Biol Med 53:1017-23. 2012
    ..The insulinotropic effect of nitrite is cGMP-dependent and involves formation of reactive nitrogen and oxygen species...
  8. doi request reprint Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans
    Tomas A Schiffer
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Respir Physiol Neurobiol 185:339-48. 2013
    ..During cycle ergometry nitrate had no effect on SaO(2), FETO(2) or maximum apnea duration. The negative effects of inorganic nitrate during static apnea may be explained by an attenuated diving response...
  9. doi request reprint Cardiorespiratory fitness predicts insulin action and secretion in healthy individuals
    Filip J Larsen
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Metabolism 61:12-6. 2012
    ..These findings highlight the importance of good CRF to maintaining normal insulin action...
  10. doi request reprint Roles of dietary inorganic nitrate in cardiovascular health and disease
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Cardiovasc Res 89:525-32. 2011
    ..A theory is now emerging suggesting nitrate as an active component in vegetables contributing to the beneficial health effects of this food group, including protection against cardiovascular disease and type-2 diabetes...
  11. pmc Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice
    Mattias Carlström
    Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:17716-20. 2010
    ..These findings may have implications for novel nutrition-based preventive and therapeutic strategies against cardiovascular disease and type 2 diabetes...
  12. doi request reprint Late cardiovascular drift observable during ultraendurance exercise
    C Mikael Mattsson
    Astrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
    Med Sci Sports Exerc 43:1162-8. 2011
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