Research Topics
Species | Johanna T LannerSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Detail Information
Publications
Effects of palmitate on Ca(2+) handling in adult control and ob/ob cardiomyocytes: impact of mitochondrial reactive oxygen speciesJeremy Fauconnier
Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Diabetes 56:1136-42. 2007..Conversely, high fatty acid levels may be vital to sustain cardiac Ca(2+) handling and contraction in obesity and insulin-resistant conditions...
Ryanodine receptor physiology and its role in diseaseJohanna T Lanner
Department of Physiology and Pharmacology, Karolinska Institutet, Von Eulersväg 8, 171 77 Stockholm, Sweden
Adv Exp Med Biol 740:217-34. 2012..This article discusses the physiological function of RyR and examines its role in disorders and diseases...
Ca(2+) and insulin-mediated glucose uptakeJohanna T Lanner
Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
Curr Opin Pharmacol 8:339-45. 2008..No Ca(2+) sensor in this process has yet been explicitly identified but recent studies point at synaptotagmin VII and the motor protein Myo1c as possible candidates...
Insulin potentiates TRPC3-mediated cation currents in normal but not in insulin-resistant mouse cardiomyocytesJeremy Fauconnier
Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Cardiovasc Res 73:376-85. 2007..In the present study we measured non-selective cation currents (NSCC) focusing on the interaction between insulin, the bioactive lipid diacylglycerol (DAG) and canonical transient receptor potential 3 (TRPC3) channels...
The role of Ca2+ influx for insulin-mediated glucose uptake in skeletal muscleJohanna T Lanner
Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77, Stockholm, Sweden
Diabetes 55:2077-83. 2006..Moreover, the present results indicate that Ca(2+) acts late in the insulin signaling pathway, for instance, in the GLUT4 translocation to the plasma membrane...
Activation of aconitase in mouse fast-twitch skeletal muscle during contraction-mediated oxidative stressShi Jin Zhang
Dept of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
Am J Physiol Cell Physiol 293:C1154-9. 2007..During contraction, a ROS-mediated inactivation of aconitase can be overcome, possibly by dephosphorylation of the enzyme. The dual-control system may be important in maintaining aerobic ATP production during muscle contraction...
Knockdown of TRPC3 with siRNA coupled to carbon nanotubes results in decreased insulin-mediated glucose uptake in adult skeletal muscle cellsJohanna T Lanner
Karolinska Institutet, Department of Physiology and Pharmacology, 171 77 Stockholm, Sweden
FASEB J 23:1728-38. 2009..Thus, TRPC3 is a potential target for treatment of insulin-resistant conditions...
Insulin and inositol 1,4,5-trisphosphate trigger abnormal cytosolic Ca2+ transients and reveal mitochondrial Ca2+ handling defects in cardiomyocytes of ob/ob miceJeremy Fauconnier
Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Diabetes 54:2375-81. 2005..This, together with an impaired mitochondrial Ca2+ handling, results in insulin-mediated extra Ca2+ transients in ob/ob cardiomyocytes that may predispose for arrhythmias in vivo...
