Jesper Lagergren

Summary

Affiliation: Karolinska Hospital
Country: Sweden

Publications

  1. doi request reprint Tamoxifen exposure in relation to gastric adenocarcinoma development
    Evangelos Chandanos
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Eur J Cancer 44:1007-14. 2008
  2. ncbi request reprint Controversies surrounding body mass, reflux, and risk of oesophageal adenocarcinoma
    Jesper Lagergren
    Unit of Oesophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
    Lancet Oncol 7:347-9. 2006
  3. pmc A population-based study of gastroesophageal reflux disease and sleep problems in elderly twins
    Anna Lindam
    Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e48602. 2012
  4. doi request reprint Endogenous estrogen exposure in relation to distribution of histological type and estrogen receptors in gastric adenocarcinoma
    Evangelos Chandanos
    Unit of Esophageal and Gastric Research, Section of Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Gastric Cancer 11:168-74. 2008
  5. ncbi request reprint Carbonated soft drinks and risk of esophageal adenocarcinoma: a population-based case-control study
    Jesper Lagergren
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 98:1158-61. 2006
  6. ncbi request reprint Impact of hospital volume on long-term survival after esophageal cancer surgery
    Ioannis Rouvelas
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Arch Surg 142:113-7; discussion 118. 2007
  7. doi request reprint Hospital and surgeon volume in relation to survival after esophageal cancer surgery in a population-based study
    Maryam Derogar
    Unit of Upper Gastrointestinal Research, Karolinska Institutet, NS 67, Level 2, SE 171 76 Stockholm, Sweden
    J Clin Oncol 31:551-7. 2013
  8. doi request reprint Aspects of esophageal atresia in a population-based setting: incidence, mortality, and cancer risk
    Jenny Oddsberg
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden
    Pediatr Surg Int 28:249-57. 2012
  9. ncbi request reprint Relation between gastroesophageal reflux symptoms and socioeconomic factors: a population-based study (the HUNT Study)
    Catarina Jansson
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Clin Gastroenterol Hepatol 5:1029-34. 2007
  10. pmc Postmenopausal hormone therapy as a risk factor for gastroesophageal reflux symptoms among female twins
    Helena Nordenstedt
    Unit of Esophageal and Gastric Research ESOGAR, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 134:921-8. 2008

Detail Information

Publications86

  1. doi request reprint Tamoxifen exposure in relation to gastric adenocarcinoma development
    Evangelos Chandanos
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Eur J Cancer 44:1007-14. 2008
    ....
  2. ncbi request reprint Controversies surrounding body mass, reflux, and risk of oesophageal adenocarcinoma
    Jesper Lagergren
    Unit of Oesophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
    Lancet Oncol 7:347-9. 2006
    ..Moreover, none of these factors contribute strongly to the striking predominance of oesophageal adenocarcinoma in men. Thus, several factors that can explain the development of oesophageal adenocarcinoma need to be addressed...
  3. pmc A population-based study of gastroesophageal reflux disease and sleep problems in elderly twins
    Anna Lindam
    Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e48602. 2012
    ..This study aimed to reveal the association between sleep problems and GERD, while adjusting for heredity and other potential confounding factors...
  4. doi request reprint Endogenous estrogen exposure in relation to distribution of histological type and estrogen receptors in gastric adenocarcinoma
    Evangelos Chandanos
    Unit of Esophageal and Gastric Research, Section of Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Gastric Cancer 11:168-74. 2008
    ..Estrogen might protect women against gastric adenocarcinoma of the intestinal histological type. We addressed this hypothesis and proposed that gastric estrogen receptors (ERs) are involved...
  5. ncbi request reprint Carbonated soft drinks and risk of esophageal adenocarcinoma: a population-based case-control study
    Jesper Lagergren
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 98:1158-61. 2006
    ..No association between intake of carbonated soft drinks or low-alcohol beer and risk of cardia adenocarcinoma was observed...
  6. ncbi request reprint Impact of hospital volume on long-term survival after esophageal cancer surgery
    Ioannis Rouvelas
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Arch Surg 142:113-7; discussion 118. 2007
    ..The improved survival after esophageal cancer surgery in Sweden during recent years may be attributable to the increased centralization of such surgery...
  7. doi request reprint Hospital and surgeon volume in relation to survival after esophageal cancer surgery in a population-based study
    Maryam Derogar
    Unit of Upper Gastrointestinal Research, Karolinska Institutet, NS 67, Level 2, SE 171 76 Stockholm, Sweden
    J Clin Oncol 31:551-7. 2013
    ..CONCLUSION Because surgeon volume rather than hospital volume independently influences the prognosis after esophageal cancer surgery, centralization of this surgery to fewer surgeons seems warranted...
  8. doi request reprint Aspects of esophageal atresia in a population-based setting: incidence, mortality, and cancer risk
    Jenny Oddsberg
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden
    Pediatr Surg Int 28:249-57. 2012
    ..To estimate the incidence, mortality and cancer risk of the congenital malformation esophageal atresia (EA) in a population-based investigation...
  9. ncbi request reprint Relation between gastroesophageal reflux symptoms and socioeconomic factors: a population-based study (the HUNT Study)
    Catarina Jansson
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Clin Gastroenterol Hepatol 5:1029-34. 2007
    ..Gastroesophageal reflux constitutes a major public health problem in the Western world. Few population-based studies have addressed socioeconomic factors in relation to reflux...
  10. pmc Postmenopausal hormone therapy as a risk factor for gastroesophageal reflux symptoms among female twins
    Helena Nordenstedt
    Unit of Esophageal and Gastric Research ESOGAR, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 134:921-8. 2008
    ..We investigated the relationship of oral contraceptives and postmenopausal hormone therapy (HT) to risk of reflux symptoms, controlling for genetic factors and body mass...
  11. doi request reprint Salt and gastric adenocarcinoma: a population-based cohort study in Norway
    Krister Sjödahl
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, P9 03, SE 171 76 Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 17:1997-2001. 2008
    ..It has been suggested that consumption of salted foods is associated with increased risk of this cancer, but the results of the few available prospective studies are contradictory...
  12. doi request reprint Albumin and C-reactive protein levels predict short-term mortality after percutaneous endoscopic gastrostomy in a prospective cohort study
    John Blomberg
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Gastrointest Endosc 73:29-36. 2011
    ..Percutaneous endoscopic gastrostomy (PEG) is a procedure with many complications that sometimes can be devastating. To give better advice to patients referred for PEG regarding risk of complications, important risk factors should be known...
  13. doi request reprint Association of oral glucocorticoid use with an increased risk of acute pancreatitis: a population-based nested case-control study
    Omid Sadr-Azodi
    Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Norra Stationsgatan 67, SE 171 76 Stockholm, Sweden
    JAMA Intern Med 173:444-9. 2013
    ..Oral glucocorticoid use has been suggested to cause acute pancreatitis in several case reports. However, no epidemiological study has investigated this association...
  14. doi request reprint Increased population prevalence of reflux and obesity in the United Kingdom compared with Sweden: a potential explanation for the difference in incidence of esophageal adenocarcinoma
    Hedvig E Löfdahl
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Eur J Gastroenterol Hepatol 23:128-32. 2011
    ..The incidence of esophageal adenocarcinoma is five times higher in the UK than in Sweden. We examined the prevalence of established risk factors for esophageal adenocarcinoma in both populations...
  15. ncbi request reprint Survival after neoadjuvant therapy compared with surgery alone for resectable esophageal cancer in a population-based study
    Ioannis Rouvelas
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    World J Surg 30:2182-90; discussion 2191-2. 2006
    ..The aim of this study was to assess the surgical outcomes with and without neoadjuvant treatment for resectable esophageal cancer in a population-based setting...
  16. ncbi request reprint Helicobacter pylori infection and gastroesophageal reflux in a population-based study (The HUNT Study)
    Helena Nordenstedt
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Helicobacter 12:16-22. 2007
    ..pylori and reflux remains uncertain. The aim of this study was to investigate this relationship in a population-based, nested, case-control study...
  17. ncbi request reprint Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study
    Mats Lindblad
    Department of Surgical Sciences, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Cancer Causes Control 16:285-94. 2005
    ....
  18. doi request reprint Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction
    Yulan Lin
    Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Norra Stationsgatan 67, Stockholm, Sweden
    Cancer Causes Control 23:837-44. 2012
    ..The strong male predominance in esophageal and gastroesophageal junctional adenocarcinoma remains unexplained. Sex hormonal influence has been suggested, but not proven. A protective role of dietary phytoestrogen lignans was hypothesized...
  19. doi request reprint Selective serotonin reuptake inhibitors and the risk of acute pancreatitis: a Swedish population-based case-control study
    Rickard Ljung
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Clin Psychopharmacol 32:336-40. 2012
    ..0 (95% CI, 0.9-1.1). The OR for antidepressant use other than SSRI showed a similar pattern. In conclusion, no increased risk of acute pancreatitis remained among users of SSRI after adjusting for confounding factors...
  20. doi request reprint Motor vehicle exposure and risk of oesophageal adenocarcinoma
    Jesper Lagergren
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Eur J Cancer 47:1446-9. 2011
    ..The aim of the study was to test this new hypothesis in a large case-control study...
  21. doi request reprint Body mass and physical activity and risk of gastric cancer in a population-based cohort study in Norway
    Krister Sjödahl
    Unit of Esophageal and Gastric Research, P9 03, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 17:135-40. 2008
    ..It is concluded that recreational physical activity might have a protective effect against gastric cancer. The sedentary lifestyle gaining ground in western societies might counteract the ongoing decrease in incidence of gastric cancer...
  22. ncbi request reprint Smoking and alcohol drinking in relation to risk of gastric cancer: a population-based, prospective cohort study
    Krister Sjödahl
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 120:128-32. 2007
    ..Combined high exposure to smoking and alcohol further increases the risk. Successful preventive measures could considerably reduce the incidence of gastric cancer...
  23. doi request reprint Oral disease and risk of oesophageal and gastric cancer in a nationwide nested case-control study in Sweden
    Rickard Ljung
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Eur J Cancer 47:2128-32. 2011
    ..7-1.1). In conclusion, this study supports the hypothesis that oral disease increases the risk of oesophageal adenocarcinoma, but not for oesophageal squamous cell carcinoma or gastric cancer. Further investigations are warranted...
  24. doi request reprint The risk of esophageal adenocarcinoma after antireflux surgery
    Jesper Lagergren
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 138:1297-301. 2010
    ..We aimed to clarify whether antireflux surgery prevents later development of esophageal adenocarcinoma...
  25. doi request reprint The mystery of male dominance in oesophageal cancer and the potential protective role of oestrogen
    Evangelos Chandanos
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Eur J Cancer 45:3149-55. 2009
    ..More evidence from valid and large human studies is needed before any conclusions can be drawn...
  26. pmc Risk factors for complications after esophageal cancer resection: a prospective population-based study in Sweden
    Pernilla Viklund
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Ann Surg 243:204-11. 2006
    ..To identify risk factors for complications after resection for esophageal or cardia cancer...
  27. ncbi request reprint Perinatal risk factors for cancer of the esophagus and gastric cardia: a nested case-control study
    Olof Akre
    Clinical Epidemiology Unit, Karolinska University Hospital, Solna, M9 01, SE 171 76 Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 15:867-71. 2006
    ..In this study, we aimed to test if there is an association between gestational duration and birth weight on the one hand, and risk of esophageal and cardia adenocarcinoma on the other...
  28. doi request reprint Antireflux stent versus conventional stent in the palliation of distal esophageal cancer. A randomized, multicenter clinical trial
    John Blomberg
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Scand J Gastroenterol 45:208-16. 2010
    ..This study addressed the hypothesis that antireflux stenting improves HRQL compared to conventional stenting...
  29. doi request reprint Validation of FFQ-based assessment of dietary lignans compared with serum enterolactone in Swedish women
    Yulan Lin
    Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Norra Stationsgatan 67, 2nd Floor, SE 171 76 Stockholm, Sweden
    Br J Nutr 109:1873-80. 2013
    ..No significant correlation was observed for the FFQ-87 (r 0·09, P= 0·30). The present study indicates that the FFQ-97 might be better than the FFQ-87 for assessing dietary intake of lignans, although the correlation was low...
  30. doi request reprint Dietary intake of lignans and risk of esophageal and gastric adenocarcinoma: a cohort study in Sweden
    Yulan Lin
    Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 22:308-12. 2013
    ..89 (95% CI, 0.52-1.55: P(trend) = 0.78) for gastric adenocarcinoma. No clear support for a protective role of dietary intake of lignans in the development of esophageal or gastric adenocarcinoma was found...
  31. pmc Physical activity, obesity and gastroesophageal reflux disease in the general population
    Therese Djärv
    Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 17176 Stockholm, Sweden
    World J Gastroenterol 18:3710-4. 2012
    ..To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in non-obese and obese people...
  32. doi request reprint Complications after percutaneous endoscopic gastrostomy in a prospective study
    John Blomberg
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Upper Gastrointestinal Research, Stockholm, Sweden
    Scand J Gastroenterol 47:737-42. 2012
    ..Better knowledge of rates and patterns of complications after PEG might influence decision-making...
  33. ncbi request reprint Is esophageal adenocarcinoma occurring late after antireflux surgery due to persistent postoperative reflux?
    Jesper Lagergren
    Unit of Esophageal and Gastric Research ESOGAR, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    World J Surg 31:465-9. 2007
    ..We tested the hypothesis that esophageal adenocarcinoma that develops with long latency after antireflux surgery might be due to persistent postoperative reflux...
  34. doi request reprint Oestrogen and the enigmatic male predominance of gastric cancer
    Evangelos Chandanos
    Unit of Esophageal and Gastric Research ESOGAR, Section of Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Eur J Cancer 44:2397-403. 2008
    ..There are indications that oestrogen may lead to an increased expression of trefoil factor proteins, which protect mucous epithelia or inhibit the expression of c-erb-2 oncogene...
  35. ncbi request reprint Use of tight belts and risk of esophageal adenocarcinoma
    Jesper Lagergren
    Department of Molecular Medicine and Surgery, Unit of Esophageal and Gastric Research, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 119:2464-6. 2006
    ..In conclusion, this study provided no support for the hypothesis that use of tight belts is associated with an increased risk of developing esophageal or cardia adenocarcinoma...
  36. doi request reprint Maternal tobacco smoking, obesity, and low socioeconomic status during early pregnancy in the etiology of esophageal atresia
    Jenny Oddsberg
    Unit of Esophageal and Gastric Research ESOGAR, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Pediatr Surg 43:1791-5. 2008
    ..We hypothesized that maternal tobacco smoking, obesity, and low socioeconomic status (SES) during early pregnancy might increase the risk of the fetus developing EA...
  37. doi request reprint Oesophageal adenocarcinoma: the new epidemic in men?
    Martin Rutegård
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Maturitas 69:244-8. 2011
    ..Moreover, the association with breastfeeding indicates a need for extensive epidemiological studies to clarify a possible role of sex hormonal influence in the aetiology of oesophageal adenocarcinoma...
  38. ncbi request reprint Etiology and risk factors for oesophageal adenocarcinoma: possibilities for chemoprophylaxis?
    Jesper Lagergren
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, SE 171 76 Stockholm, Sweden
    Best Pract Res Clin Gastroenterol 20:803-12. 2006
    ..Oesophageal adenocarcinoma is a highly deadly cancer, but the overall prognosis and the prognosis after oesophageal cancer surgery has improved during recent years...
  39. ncbi request reprint Quality of life and persisting symptoms after oesophageal cancer surgery
    Pernilla Viklund
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery P9 03, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur J Cancer 42:1407-14. 2006
    ..Thus, patients who undergo oesophageal cancer resection suffer greatly from reduced QoL and several general and oesophageal-specific symptoms six months postoperatively...
  40. doi request reprint Influence of maternal parity, age, and ethnicity on risk of esophageal atresia in the infant in a population-based study
    Jenny Oddsberg
    Unit of Esophageal and Gastric Research ESOGAR, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Pediatr Surg 43:1660-5. 2008
    ..The etiology of esophageal atresia (EA) is virtually unknown. We hypothesized that the maternal factors low parity, high age, and white ethnicity are involved...
  41. pmc Disparities in the classification of esophageal and cardia adenocarcinomas and their influence on reported incidence rates
    Mats Lindblad
    Department of Surgical Sciences, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
    Ann Surg 243:479-85. 2006
    ..To evaluate the diagnostic accuracy of esophageal and cardia adenocarcinoma in the Swedish Cancer Register...
  42. doi request reprint Maternal diabetes and risk of esophageal atresia
    Jenny Oddsberg
    Department of Molecular Medicine and Surgery, Upper Gastrointestinal Research, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    J Pediatr Surg 45:2004-8. 2010
    ..We hypothesized that maternal diabetes increases the risk of esophageal atresia in the infant...
  43. doi request reprint Intrathoracic anastomotic leakage and mortality after esophageal cancer resection: a population-based study
    Martin Rutegård
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Ann Surg Oncol 19:99-103. 2012
    ..The current study addressed the unselected and independent fatality rate of intrathoracic esophageal anastomotic leaks after resection for cancer...
  44. doi request reprint Job strain and risk of esophageal and cardia cancers
    Catarina Jansson
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol 33:473-5. 2009
    ..Few studies have investigated work-related stress in relation to esophageal or cardia cancers...
  45. doi request reprint No further increase in the incidence of esophageal adenocarcinoma in Sweden
    Jesper Lagergren
    Department of Molecular Medicine and Surgery, Upper Gastrointestinal Research, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 129:513-6. 2011
    ....
  46. ncbi request reprint Influence of surgery-related factors on quality of life after esophageal or cardia cancer resection
    Pernilla Viklund
    Department of Surgical Science, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    World J Surg 29:841-8. 2005
    ..In conclusion, any measures that can reduce the risk of major surgery-related complications can decrease the negative impact on quality of life after esophageal cancer surgery. More population-based studies are warranted, however...
  47. pmc Diverging trends in recent population-based survival rates in oesophageal and gastric cancer
    Jesper Lagergren
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e41352. 2012
    ..Survival trends in oesophageal and gastric cancer need to be updated. A nationwide Swedish population-based study in 1961-2009 was based on registry data...
  48. pmc Prevalence of human papillomavirus (HPV) in oesophageal squamous cell carcinoma in relation to anatomical site of the tumour
    Hedvig E Löfdahl
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e46538. 2012
    ....
  49. doi request reprint Reproductive history and risk of small bowel cancer by histologic type: a population-based study
    Yunxia Lu
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden
    Cancer Causes Control 23:2041-6. 2012
    ..The male predominance of the two main histologic malignancies of the small bowel cancer may reflect a role of sex hormones which will be examined in this study...
  50. doi request reprint Validation of the reflux scale in the European Organisation for Research and Treatment of Cancer QLQ-OES18
    Pernilla Lagergren
    Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Eur J Cancer 49:1097-103. 2013
    ..This study validated such assessment of GORD...
  51. doi request reprint Incidence patterns of small bowel cancer in a population-based study in Sweden: increase in duodenal adenocarcinoma
    Yunxia Lu
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol 36:e158-63. 2012
    ..Increasing incidences of malignant small bowel tumours have been reported, but data from European populations are limited. This study aimed to clarify the incidence patterns of malignant small bowel tumours in Sweden...
  52. doi request reprint Increased risk of acute pancreatitis among tetracycline users in a Swedish population-based case-control study
    Rickard Ljung
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Norra Stationsgatan 67, 2nd Floor, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Gut 61:873-6. 2012
    ..To evaluate the suggested association between tetracycline and acute pancreatitis in a large pharmacoepidemiological study...
  53. ncbi request reprint Chewing gum and risk of oesophageal adenocarcinoma: a new hypothesis tested in a population-based study
    Jesper Lagergren
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, P9 03, 17176 Stockholm, Sweden
    Eur J Cancer 42:2359-62. 2006
    ..0, 95% CI 0.6-1.7), irrespective of duration of use (P = 0.56). In conclusion, with regard to risk of oesophageal or cardia adenocarcinoma, gum chewing seems harmless...
  54. ncbi request reprint Survival after surgery for oesophageal cancer: a population-based study
    Ioannis Rouvelas
    Unit of Oesophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Lancet Oncol 6:864-70. 2005
    ..However, few population-based studies of survival after surgery have been done. We aimed to assess whether survival after surgery for oesophageal cancer has improved since 1987...
  55. doi request reprint Influence of obesity on the risk of esophageal disorders
    Jesper Lagergren
    Karolinska Institutet, Department of Molecular Medicine and Surgery, Upper Gastrointestinal Research, Norra Stationsgatan 67, 2nd Floor, SE 171 76 Stockholm, Sweden
    Nat Rev Gastroenterol Hepatol 8:340-7. 2011
    ..These findings are summarized in this Review, but more research remains to be carried out before these mechanisms are established...
  56. pmc Dietary proportions of carbohydrates, fat, and protein and risk of oesophageal cancer by histological type
    Katarina Lagergren
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e54913. 2013
    ..Dietary habits influence the risk of cancer of the oesophagus and oesophago-gastric junction, but the role of proportions of the main dietary macronutrients carbohydrates, fats and proteins is uncertain...
  57. doi request reprint The risk of oesophageal adenocarcinoma after gastrectomy for peptic ulcer disease
    Jesper Lagergren
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Eur J Cancer 48:749-52. 2012
    ..The influence of bile reflux in the development of oesophageal adenocarcinoma remains controversial. This was tested in a cohort of patients who had undergone gastrectomy, a procedure often entailed by substantial bile reflux...
  58. doi request reprint Twelve tips for conducting a postgraduate course on study design and study protocol writing for the medical profession
    Rickard Ljung
    Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Med Teach 34:25-9. 2012
    ..However, several studies have shown that the biostatistical and epidemiological knowledge of academically active health care professionals is far below the desired level...
  59. doi request reprint Dietary acrylamide intake and risk of esophageal cancer in a population-based case-control study in Sweden
    Yulan Lin
    Department of Molecular Medicine and Surgery, Upper Gastrointestinal Research, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 128:676-81. 2011
    ..01). Dietary intake of acrylamide might be a risk exposure for esophageal cancer, a stronger association among overweight or obese persons was indicated...
  60. doi request reprint Surgeon volume is a poor proxy for skill in esophageal cancer surgery
    Martin Rutegård
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Ann Surg 249:256-61. 2009
    ..To evaluate the impact of surgeon volume on the risk of technical surgical complications after esophageal cancer resection...
  61. ncbi request reprint Airborne exposures and risk of gastric cancer: a prospective cohort study
    Krister Sjödahl
    Unit of Esophageal and Gastric Research ESOGAR, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 120:2013-8. 2007
    ..In conclusion, this study provides some support to the hypothesis that specific airborne exposures increase the risk of noncardia gastric cancer...
  62. pmc Losartan to prevent hyperenzymemia after endoscopic retrograde cholangiopan-creatography: A randomized clinical trial
    Tomas Sjöberg Bexelius
    Tomas Sjöberg Bexelius, John Blomberg, Yun Xia Lu, Jesper Lagergren, Mats Lindblad, Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, 176 70 Stockholm, Sweden
    World J Gastrointest Endosc 4:506-12. 2012
    ..To study if the angiotensin II receptor blockers (ARB) losartan counteracts pancreatic hyperenzymemia as measured 24 h after endoscopic retrograde cholangiopancreatography (ERCP)...
  63. doi request reprint The impact of volume on outcomes after oesophageal cancer surgery
    Ioannis Rouvelas
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    ANZ J Surg 80:634-41. 2010
    ..In conclusion, the available literature supports the centralization of oesophagectomy for cancer to dedicated centres with a multidisciplinary approach and a good track record of valid clinical research...
  64. ncbi request reprint The relation between gastroesophageal reflux and respiratory symptoms in a population-based study: the Nord-Trøndelag health survey
    Helena Nordenstedt
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
    Chest 129:1051-6. 2006
    ..In spite of numerous investigations, the relation between respiratory symptoms and reflux symptoms in the general population remains unclear, since population-based studies are few...
  65. ncbi request reprint Supportive care for patients with oesophageal and other upper gastrointestinal cancers: The role of a specialist nurse in the team
    Pernilla Viklund
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Eur J Oncol Nurs 10:353-63. 2006
    ..Thus, specialist nurses can be recommended as leaders of the care pathway of patients with upper gastrointestinal cancers...
  66. doi request reprint Risk of obesity-related cancer after obesity surgery in a population-based cohort study
    Magdalena Plecka Ostlund
    Department of Molecular Medicine and Surgery, Upper Gastrointestinal Research, Karolinska Institutet, Stockholm, Sweden
    Ann Surg 252:972-6. 2010
    ..We hypothesized that risk of obesity-related cancer decreases with time after obesity surgery...
  67. ncbi request reprint The relation between body mass and gastro-oesophageal reflux
    Magnus Nilsson
    Department of Surgery, Karolinska Intitutet, Karolinska University Hospital, Stockholm, Sweden
    Best Pract Res Clin Gastroenterol 18:1117-23. 2004
    ..Weight-reduction seems to reduce the risk of symptomatic gastro-oesophageal reflux disease, indicating that such strategy might be a useful tool in the treatment of reflux...
  68. ncbi request reprint Nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer
    Mats Lindblad
    Department of Surgery, P9 03, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 14:444-50. 2005
    ..Nonsteroidal anti-inflammatory drugs (NSAID) might reduce risks of esophageal and gastric cancer, but previous studies are limited and provide somewhat conflicting results...
  69. ncbi request reprint Health economic evaluation of stent or endoluminal brachytherapy as a palliative strategy in patients with incurable cancer of the oesophagus or gastro-oesophageal junction: results of a randomized clinical trial
    Urs Wenger
    Department of Surgery, Karolinska University Hospital, Stockholm, Sweden
    Eur J Gastroenterol Hepatol 17:1369-77. 2005
    ..The aim of this prospective, randomized multicentre study was to compare stent placement and brachytherapy regarding health economy and clinical outcomes...
  70. ncbi request reprint Estrogen and risk of gastric cancer: a protective effect in a nationwide cohort study of patients with prostate cancer in Sweden
    Mats Lindblad
    Department of Surgical Sciences, Karolinska University Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 13:2203-7. 2004
    ..The global pattern of male predominance in gastric cancer incidence remains unexplained. We tested the hypothesis that estrogen prevents gastric cancer in a cohort of men heavily exposed to estrogen...
  71. pmc Novel approach to antibiotic prophylaxis in percutaneous endoscopic gastrostomy (PEG): randomised controlled trial
    John Blomberg
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    BMJ 341:c3115. 2010
    ..To evaluate a new and simpler strategy of antibiotic prophylaxis in percutaneous endoscopic gastrostomy (PEG)...
  72. pmc Body measures in relation to gastro-oesophageal reflux
    Jesper Lagergren
    Unit of Esophageal and Gastric Research ESOGAR, Department of Molecular Medicine and Surgery, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Gut 56:741-2. 2007
  73. doi request reprint Environmental factors in the etiology of gastroesophageal reflux disease
    Helena Nordenstedt
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, P9 03, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Expert Rev Gastroenterol Hepatol 2:93-103. 2008
    ..This review discusses the current knowledge on risk factors and potential protective factors in the development of GERD...
  74. doi request reprint High concomitant use of interacting drugs and low use of gastroprotective drugs among NSAID users in an unselected elderly population: a nationwide register-based study
    Rickard Ljung
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Drugs Aging 28:469-76. 2011
    ..NSAIDs are commonly used in the elderly and carry significant risks of adverse events when used concomitantly with potentially interacting drugs...
  75. ncbi request reprint Dietary intake of heterocyclic amines and cancers of the esophagus and gastric cardia
    Paul D Terry
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 12:940-4. 2003
    ..Given the dearth of epidemiological data regarding these cancers and the lack of established biological mechanisms, confirmatory data are needed...
  76. ncbi request reprint Screening and surveillance for Barrett esophagus in high-risk groups: a cost-utility analysis
    John M Inadomi
    Veterans Affairs Ann Arbor Health Systems, 2215 Fuller Road, Ann Arbor, MI 48105, USA
    Ann Intern Med 138:176-86. 2003
    ..Once-in-a-lifetime screening for Barrett esophagus has been proposed for patients with gastroesophageal reflux disease (GERD), but there is little evidence of its cost-effectiveness...
  77. ncbi request reprint Helicobacter pylori infection and gastric atrophy: risk of adenocarcinoma and squamous-cell carcinoma of the esophagus and adenocarcinoma of the gastric cardia
    Weimin Ye
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 96:388-96. 2004
    ..pylori infection, gastric atrophy, and the risk of esophageal adenocarcinoma, esophageal squamous-cell carcinoma, and gastric cardia adenocarcinoma in a large population-based case-control study in Sweden...
  78. ncbi request reprint Improved survival in both histologic types of oesophageal cancer in Sweden
    Martin Sundelöf
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 99:751-4. 2002
    ..9% during the study period. In conclusion, the survival rates for both oesophageal adenocarcinoma and squamous cell carcinoma have increased significantly during the 1990s compared to those in the previous 3 decades (p < 0.001)...
  79. ncbi request reprint Occupational exposures and risk of esophageal and gastric cardia cancers among male Swedish construction workers
    Catarina Jansson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE 171 77 Stockholm, Sweden
    Cancer Causes Control 16:755-64. 2005
    ..We hypothesized that occupational airborne exposures in a traditional male dominated industry might contribute to these observations...
  80. ncbi request reprint [Esophageal cancer surgery should be centralized. Big surgical volume benefits the patients]
    Jesper Lagergren
    Karolinska Institutet, Karolinska Universitetssjukhuset Solna, Stockholm
    Lakartidningen 104:2782. 2007
  81. ncbi request reprint Psychosocial working conditions and the risk of esophageal and gastric cardia cancers
    Catarina Jansson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Eur J Epidemiol 19:631-41. 2004
    ..These tumors occur predominantly among males. We hypothesized that stressful psychosocial working conditions might be involved in the etiology of these cancers...
  82. ncbi request reprint Socioeconomic factors and risk of esophageal adenocarcinoma: a nationwide Swedish case-control study
    Catarina Jansson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, P O Box 281, SE 171 77 Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 14:1754-61. 2005
    ..Although low socioeconomic status (SES) is linked to an increased risk of esophageal squamous cell carcinoma (SCC), the relation with adenocarcinoma is uncertain...
  83. pmc Lifestyle factors and risk for symptomatic gastroesophageal reflux in monozygotic twins
    Zongli Zheng
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels vag 12a, SE 171 77 Stockholm, Sweden
    Gastroenterology 132:87-95. 2007
    ..We investigated associations between lifestyle factors and gastroesophageal reflux (GER) symptoms, with and without controlling for genetic predisposition...
  84. ncbi request reprint Obesity and estrogen as risk factors for gastroesophageal reflux symptoms
    Magnus Nilsson
    Department of Surgery, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    JAMA 290:66-72. 2003
    ..Gastroesophageal reflux and obesity are both increasing in prevalence. The scientific evidence for an association between these conditions is sparse and contradictory. A difference between sexes concerning this relation has been proposed...
  85. ncbi request reprint The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study in Sweden
    Weimin Ye
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE 171 77, Sweden
    Carcinogenesis 27:1835-41. 2006
    ..Other studied variants were not found to be related to the three tumors. Our study suggests that XPD 751Gln allele is a potential genetic marker for susceptibility to esophageal adenocarcinoma...
  86. ncbi request reprint Gastroesophageal reflux disease in monozygotic and dizygotic twins
    Alan J Cameron
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 122:55-9. 2002
    ..Gastroesophageal reflux disease (GERD) interferes with the quality of life and carries an increased risk for esophageal adenocarcinoma. We investigated genetic influence in the development of reflux...