J Lagergren

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Human papillomavirus infection and esophageal cancer: a nationwide seroepidemiologic case-control study in Sweden
    J Lagergren
    Department of Medical Epidemiology, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 91:156-62. 1999
  2. ncbi No increased risk of breast cancer after cholecystectomy
    J Lagergren
    Division of Surgery, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden
    Int J Cancer 88:679-81. 2000
  3. ncbi Heredity and risk of cancer of the esophagus and gastric cardia
    J Lagergren
    Division of Surgery, Karolinska Institutet, Danderyd Hospital, Sweden
    Cancer Epidemiol Biomarkers Prev 9:757-60. 2000
  4. ncbi Association between medications that relax the lower esophageal sphincter and risk for esophageal adenocarcinoma
    J Lagergren
    Karolinska Institutet and Danderyd Hospital, Stockholm, Sweden
    Ann Intern Med 133:165-75. 2000
  5. pmc No relation between body mass and gastro-oesophageal reflux symptoms in a Swedish population based study
    J Lagergren
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Gut 47:26-9. 2000
  6. ncbi [Increased incidence of adenocarcinoma of the esophagus and cardia. Reflux and obesity are strong and independent risk factors according to the SECC study]
    J Lagergren
    Karolinska Institutet, Danderyds sjukhus, Stockholm
    Lakartidningen 97:1950-3. 2000
  7. ncbi Association between body mass and adenocarcinoma of the esophagus and gastric cardia
    J Lagergren
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Ann Intern Med 130:883-90. 1999
  8. ncbi Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma
    J Lagergren
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 340:825-31. 1999
  9. ncbi Antioxidants and cancers of the esophagus and gastric cardia
    P Terry
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 87:750-4. 2000
  10. pmc Tamoxifen exposure and risk of oesophageal and gastric adenocarcinoma: a population-based cohort study of breast cancer patients in Sweden
    E Chandanos
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Br J Cancer 95:118-22. 2006

Detail Information

Publications52

  1. ncbi Human papillomavirus infection and esophageal cancer: a nationwide seroepidemiologic case-control study in Sweden
    J Lagergren
    Department of Medical Epidemiology, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 91:156-62. 1999
    ..We conducted a larger, population-based study to verify this association and to investigate possible confounding factors...
  2. ncbi No increased risk of breast cancer after cholecystectomy
    J Lagergren
    Division of Surgery, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden
    Int J Cancer 88:679-81. 2000
    ..Also, we did not find any evidence of an association between gall stone disease per se and the risk of breast cancer. We conclude that cholecystectomy and breast cancer are not likely to be associated...
  3. ncbi Heredity and risk of cancer of the esophagus and gastric cardia
    J Lagergren
    Division of Surgery, Karolinska Institutet, Danderyd Hospital, Sweden
    Cancer Epidemiol Biomarkers Prev 9:757-60. 2000
    ..A weak association between familial gastric cancer and the risk of cardia cancer may represent a genetic link...
  4. ncbi Association between medications that relax the lower esophageal sphincter and risk for esophageal adenocarcinoma
    J Lagergren
    Karolinska Institutet and Danderyd Hospital, Stockholm, Sweden
    Ann Intern Med 133:165-75. 2000
    ....
  5. pmc No relation between body mass and gastro-oesophageal reflux symptoms in a Swedish population based study
    J Lagergren
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Gut 47:26-9. 2000
    ..There is a widespread notion that obesity leads to gastro-oesophageal reflux but scientific evidence of an association is limited and inconsistent...
  6. ncbi [Increased incidence of adenocarcinoma of the esophagus and cardia. Reflux and obesity are strong and independent risk factors according to the SECC study]
    J Lagergren
    Karolinska Institutet, Danderyds sjukhus, Stockholm
    Lakartidningen 97:1950-3. 2000
    ..All of these hypotheses suffer from inconsistencies that need to be solved before any firm conclusions can be drawn concerning the reasons for the increasing incidence of esophageal adenocarcinoma...
  7. ncbi Association between body mass and adenocarcinoma of the esophagus and gastric cardia
    J Lagergren
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Ann Intern Med 130:883-90. 1999
    ..A weak and inconsistent association between body mass index (BMI) and adenocarcinoma of the esophagus and gastric cardia has been reported...
  8. ncbi Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma
    J Lagergren
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 340:825-31. 1999
    ..The causes of adenocarcinomas of the esophagus and gastric cardia are poorly understood. We conducted an epidemiologic investigation of the possible association between gastroesophageal reflux and these tumors...
  9. ncbi Antioxidants and cancers of the esophagus and gastric cardia
    P Terry
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 87:750-4. 2000
    ..Our results may be relevant for the implementation of focused, cost-effective preventive measures...
  10. pmc Tamoxifen exposure and risk of oesophageal and gastric adenocarcinoma: a population-based cohort study of breast cancer patients in Sweden
    E Chandanos
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Br J Cancer 95:118-22. 2006
    ..We concluded that there might be a link between tamoxifen and risk of non-cardia gastric adenocarcinoma...
  11. ncbi Association between cholecystectomy and adenocarcinoma of the esophagus
    J Freedman
    Division of Surgery, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 121:548-53. 2001
    ..Duodenogastric reflux is increased after cholecystectomy. This study aims to evaluate if cholecystectomy is associated with an increased risk of adenocarcinoma of the esophagus...
  12. ncbi Surgical prevention of reflux after esophagectomy for cancer
    Maartje van der Schaaf
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Ann Surg Oncol 20:3655-61. 2013
    ....
  13. ncbi Reflux-inducing dietary factors and risk of adenocarcinoma of the esophagus and gastric cardia
    P Terry
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Nutr Cancer 38:186-91. 2000
    ..Our findings indicate that dietary factors associated with LES relaxation and transient GER (but perhaps not severe chronic reflux) are not associated with any important risk of esophageal malignancy...
  14. ncbi Fruit and vegetable consumption in the prevention of oesophageal and cardia cancers
    P Terry
    Department of Medical Epidemiology, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden
    Eur J Cancer Prev 10:365-9. 2001
    ..Moderate relative risk reductions translate into weak absolute risk reductions for oesophageal cancers in Sweden...
  15. pmc Risk of adenocarcinomas of the oesophagus and gastric cardia in patients hospitalized for asthma
    W Ye
    Department of Medical Epidemiology, Karolinska Institute Box 281, Stockholm, SE, 171 77, Sweden
    Br J Cancer 85:1317-21. 2001
    ..Special clinical vigilance vis-à-vis gastro-esophageal cancers seems unwarranted in asthmatic patients, but may be appropriate in those with clinically manifest gastro-oesophageal reflux...
  16. pmc Sex-specific exposure prevalence of established risk factors for oesophageal adenocarcinoma
    M Rutegård
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Norra Stationsgatan 67, Second Floor, Stockholm 17176, Sweden
    Br J Cancer 103:735-40. 2010
    ..There is an unexplained male predominance in the incidence of oesophageal adenocarcinoma, and the sex-specific distribution of its risk factors in the general population is not known...
  17. ncbi Severe symptoms of gastro-oesophageal reflux disease are associated with cardiovascular disease and other gastrointestinal symptoms, but not diabetes: a population-based study
    C Jansson
    Unit of Esophageal and Gastric Research ESOGAR, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Aliment Pharmacol Ther 27:58-65. 2008
    ..Few population-based studies have examined comorbidity in relation to gastro-oesophageal reflux disease (GERD)...
  18. ncbi The influence of needle catheter jejunostomy on weight development after oesophageal cancer surgery in a population-based study
    L Martin
    Unit of Esophageal and Gastric Research ESOGAR, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Eur J Surg Oncol 33:713-7. 2007
    ..We aimed to assess whether needle catheter jejunostomy (NCJ) influences the weight development or discharge from hospital after oesophageal cancer surgery in an unselected and prospectively collected series of patients...
  19. pmc Risk of pancreatic cancer after cholecystectomy: a cohort study in Sweden
    W Ye
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Gut 49:678-81. 2001
    ..Although some experimental studies have indicated that cholecystectomy may increase the risk of pancreatic cancer, data from epidemiological studies are conflicting...
  20. doi Surgical complications and long-term survival after esophagectomy for cancer in a nationwide Swedish cohort study
    M Rutegård
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Eur J Surg Oncol 38:555-61. 2012
    ..Acute surgical complications after esophageal resection for cancer may decrease the long-term survival. Previous results on this topic are conflicting and no population-based studies are available...
  21. ncbi Body mass and reflux oesophagitis: an oestrogen-dependent association?
    M Nilsson
    Dept of Surgery, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Scand J Gastroenterol 37:626-30. 2002
    ..There is widespread belief that obesity is associated with gastro-oesophageal reflux disease, but the scientific evidence is weak and contradictory. Our aim is to evaluate the relation between body mass and reflux oesophagitis...
  22. pmc Drinking hot beverages is not associated with risk of oesophageal cancers in a Western population
    P Terry
    Department of Medical Epidemiology, Karolinska Institutet, Box 281, Stockholm, SE 171 77
    Br J Cancer 84:120-1. 2001
    ..Drinking beverages very hot did not increase the risk for oesophageal squamous cell carcinoma, oesophageal adenocarcinoma, or gastric cardia adenocarcinoma...
  23. ncbi Risk of adenocarcinomas of the esophagus and gastric cardia in patients with gastroesophageal reflux diseases and after antireflux surgery
    W Ye
    Department of Medical Epidemiology, Karolinska Institutet, Box 281, SE171 77, Stockholm, Sweden
    Gastroenterology 121:1286-93. 2001
    ..Furthermore, the effect of antireflux surgery has not yet been studied. We conducted a population-based retrospective cohort study to fill these gaps...
  24. doi Population-based study of the need for cholecystectomy after obesity surgery
    M Plecka Östlund
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Br J Surg 99:864-9. 2012
    ..The aim of this study was to clarify the need for cholecystectomy following obesity surgery...
  25. ncbi Malnutrition after oesophageal cancer surgery in Sweden
    L Martin
    Unit of Esophageal and Gastric Research ESOGAR, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Br J Surg 94:1496-500. 2007
    ..The aim of this study was to estimate weight change after surgery in a population-based setting and to identify nutritional problems that might correlate with weight loss...
  26. ncbi An antireflux stent versus conventional stents for palliation of distal esophageal or cardia cancer: a randomized clinical study
    U Wenger
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden
    Surg Endosc 20:1675-80. 2006
    ..This study compared the effects of a Dua antireflux stent with those of a conventional stent...
  27. pmc Airborne occupational exposures and risk of oesophageal and cardia adenocarcinoma
    C Jansson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Occup Environ Med 63:107-12. 2006
    ..The authors hypothesised that airborne occupational exposures in male dominated industries might contribute...
  28. ncbi Intestinal cancer after cholecystectomy: is bile involved in carcinogenesis?
    J Lagergren
    Department of Surgery, Karolinska Hospital, Stockholm, Sweden
    Gastroenterology 121:542-7. 2001
    ..Little is known about the relation between cholecystectomy and small bowel cancer. Therefore, we evaluated cholecystectomy and risk of bowel cancer...
  29. ncbi Surgical resection strategy and the influence of radicality on outcomes in oesophageal cancer
    A R Davies
    Department of Surgery, St Thomas Hospital, King s College London, London, UK Department of Surgery, Royal Marsden Hospital, King s College London, London, UK Gastrointestinal Cancer, Division of Cancer Studies, King s College London, London, UK Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Br J Surg 101:511-7. 2014
    ....
  30. pmc Reproductive factors and risk of oesophageal cancer, a population-based nested case-control study in Sweden
    Y Lu
    Department of Molecular Medicine and Surgery, Upper Gastrointestinal Research, Karolinska Institutet, Stockholm, Sweden
    Br J Cancer 107:564-9. 2012
    ..The role of sex hormonal influence in explaining the strong male predominance in oesophageal adenocarcinoma (EA) needs attention...
  31. doi Persisting symptoms after intrathoracic anastomotic leak following oesophagectomy for cancer
    M van der Schaaf
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Br J Surg 99:95-9. 2012
    ..In this Swedish nationwide cohort study, it was hypothesized that intrathoracic anastomotic leak makes patients more susceptible to persisting eating difficulties, odynophagia, dysphagia, trouble swallowing saliva and reflux...
  32. doi Population-based study of surgical factors in relation to health-related quality of life after oesophageal cancer resection
    M Rutegård
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Br J Surg 95:592-601. 2008
    ..This study explored how selected surgical factors affected HRQL 6 months after operation...
  33. ncbi Long-term health-related quality of life following surgery for oesophageal cancer
    T Djärv
    Unit of Oesophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Br J Surg 95:1121-6. 2008
    ..The aim of the study was to assess health-related quality of life (HRQL) in patients with surgically cured oesophageal cancer...
  34. ncbi A nationwide study of the use of self-expanding stents in patients with esophageal cancer in Sweden
    U Wenger
    Dept of Surgery, Karolinska University Hospital, Stockholm, Sweden
    Endoscopy 37:329-34. 2005
    ....
  35. doi Short-term outcome after gluteus maximus myocutaneous flap reconstruction of the pelvic floor following extra-levator abdominoperineal excision of the rectum
    C Anderin
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Colorectal Dis 14:1060-4. 2012
    ..This study reports short-term outcome of gluteus maximus myocutaneous flap reconstruction on perineal wound healing...
  36. pmc Gallstones and cholecystectomy in relation to risk of intra- and extrahepatic cholangiocarcinoma
    H Nordenstedt
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Br J Cancer 106:1011-5. 2012
    ..The aetiology is largely unknown, and the potential roles of gallstones and gall bladder removal (cholecystectomy) need to be addressed in a large study with a long follow-up...
  37. pmc Alcohol abuse and the risk of pancreatic cancer
    W Ye
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Gut 51:236-9. 2002
    ..Although most epidemiological studies do not support a role for alcohol in the aetiology of pancreatic cancer, an increased risk among heavy drinkers cannot be excluded...
  38. ncbi Three-year results of laparoscopic vertical banded gastroplasty
    E Naslund
    Division of Surgery, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Obes Surg 9:369-73. 1999
    ..Laparoscopic surgery appears to offer rapid recovery and low postoperative morbidity. The aim of the present study was to assess the outcome of laparoscopic vertical banded gastroplasty (lap VBG) in 60 obese patients...
  39. pmc Sex-specific risk factor profile in oesophageal adenocarcinoma
    H E Löfdahl
    Unit of Esophageal and Gastric Research ESOGAR, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Br J Cancer 99:1506-10. 2008
    ..1 vs OR=2.8, 95% CI=1.9-4.2), less harmed by low intake of fruit and vegetables (OR=0.9, 95% CI 0.3-2.4 vs OR=1.6, 95% CI=1.1-2.2) and less protected by Helicobacter pylori infection (OR=0.5, 95% CI=0.3-0.8 vs OR=1.6, 95% CI=0.5-5.4)...
  40. ncbi Severe gastro-oesophageal reflux symptoms in relation to anxiety, depression and coping in a population-based study
    C Jansson
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Aliment Pharmacol Ther 26:683-91. 2007
    ..The association between psychiatric disorders and gastro-oesophageal reflux symptoms is uncertain, and few population-based studies are available...
  41. pmc Hormone replacement therapy and risks of oesophageal and gastric adenocarcinomas
    M Lindblad
    Unit of Oesophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Br J Cancer 94:136-41. 2006
    ..34, 95% CI 0.14-0.78) and weaker for gastric cardia tumours (OR 0.68, 95% CI 0.23-2.01). There was no association between HRT and oesophageal adenocarcinoma (OR 1.17, 95% CI 0.41-3.32)...
  42. pmc Sex hormones and oesophageal adenocarcinoma: influence of childbearing?
    J Lagergren
    Unit of Esophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Br J Cancer 93:859-61. 2005
    ..82; 95% CI=0.25-2.72), as neither were women with 0-1 children compared to women with at least three children (OR=0.93; 95% CI=0.35-2.49). In conclusion, we found no inverse association between childbearing and oesophageal adenocarcinoma...
  43. ncbi Surgeon volume and postoperative mortality after oesophagectomy for cancer
    I Rouvelas
    Unit of Oesophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, SE 171 76 Stockholm, Sweden
    Eur J Surg Oncol 33:162-8. 2007
    ..Our aim was to assess the association between surgeon volume and postoperative mortality after oesophagectomy...
  44. pmc Adenocarcinoma of oesophagus: what exactly is the size of the problem and who is at risk?
    J Lagergren
    Department of Surgical Sciences, Karolinska Institutet, Karolinska University Hospital, SE 17176 Stockholm, Sweden
    Gut 54:i1-5. 2005
    ..Endoscopic surveillance for oesophageal adenocarcinoma among persons with reflux and obesity is discussed, but presently there is no evidence that strongly supports such a strategy...
  45. doi Cholecystectomy as a risk factor for oesophageal adenocarcinoma
    J Lagergren
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Br J Surg 98:1133-7. 2011
    ..There are some data in support of this hypothesis, and the aim of this study was to ascertain whether the association could be confirmed...
  46. ncbi A care pathway for patients with oesophageal cancer
    P Viklund
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm Department of Surgery, Karolinska University Hospital, Solna, Stockholm, Sweden
    Eur J Cancer Care (Engl) 16:533-8. 2007
    ..This pathway has therefore been established at our hospital, and we can recommend well-organized and nurse-led care pathways for oesophageal cancer patients...
  47. pmc Increased risk of laryngeal and pharyngeal cancer after gastrectomy for ulcer disease in a population-based cohort study
    J Lagergren
    Department of Molecular Medicine and Surgery, Upper Gastrointestinal Research, Karolinska Institutet, Norra Stationsgatan 67, Level 2, 17176 Stockholm, Sweden
    Br J Cancer 106:1342-5. 2012
    ..Gastrectomy has been indicated as a risk factor for laryngeal cancer, and possibly also for pharyngeal cancer, but few studies are available. The postulated mechanism is increased bile reflux following gastrectomy...
  48. pmc Increased risk of hepatocellular carcinoma after cholecystectomy
    J Lagergren
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Norra Stationsgatan 67, Level 2, 171 76 Stockholm, Sweden
    Br J Cancer 105:154-6. 2011
    ..An increased intrahepatic bile duct pressure following cholecystectomy might cause chronic inflammation in the surrounding liver tissue, which might induce cancer development...
  49. ncbi Re-adaptation of the esophageal mucosa of rats to protracted stress
    C A Rubio
    Gastrointestinal and Liver Research Laboratory, Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden
    In Vivo 15:413-6. 2001
    ..The model described may prove of value in studies aimed to abate the disparate fluctuations of DNA synthesis in the esophageal mucosa during the various phases of protracted stress...
  50. doi Morbidity and mortality before and after bariatric surgery for morbid obesity compared with the general population
    M Plecka Östlund
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Br J Surg 98:811-6. 2011
    ..The aim was to assess the risk of admission to hospital for obesity-related co-morbidities and overall mortality after bariatric surgery in relation to the general population...
  51. ncbi Gastric emptying and duodeno-gastro-oesophageal reflux in gastro-oesophageal reflux disease
    J Freedman
    Division of Surgery, Karolinska Institutet, Danderyd Hospital, Sweden
    Dig Liver Dis 34:477-83. 2002
    ..Previous studies present conflicting results regarding relationship between gastric emptying and gastro-oesophageal reflux disease. Reflux of duodenal content to oesophagus is generally considered to be associated with more severe disease...
  52. ncbi Extended abdominoperineal resection with gluteus maximus flap reconstruction of the pelvic floor for rectal cancer
    T Holm
    Department of Surgery, Karolinska University Hospital, Stockholm, Sweden
    Br J Surg 94:232-8. 2007
    ..The aim of this study was to report the technique and early experience of extended APR in a select cohort of patients...