J Lagergren

..We conducted a larger, population-based study to verify this association and to investigate possible confounding factors...

..The causes of adenocarcinomas of the esophagus and gastric cardia are poorly understood. We conducted an epidemiologic investigation of the possible association between gastroesophageal reflux and these tumors...

..A weak and inconsistent association between body mass index (BMI) and adenocarcinoma of the esophagus and gastric cardia has been reported...

..Also, we did not find any evidence of an association between gall stone disease per se and the risk of breast cancer. We conclude that cholecystectomy and breast cancer are not likely to be associated...

..All of these hypotheses suffer from inconsistencies that need to be solved before any firm conclusions can be drawn concerning the reasons for the increasing incidence of esophageal adenocarcinoma...

..There is a widespread notion that obesity leads to gastro-oesophageal reflux but scientific evidence of an association is limited and inconsistent...

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..A weak association between familial gastric cancer and the risk of cardia cancer may represent a genetic link...

..Our results may be relevant for the implementation of focused, cost-effective preventive measures...

..We concluded that there might be a link between tamoxifen and risk of non-cardia gastric adenocarcinoma...

..Duodenogastric reflux is increased after cholecystectomy. This study aims to evaluate if cholecystectomy is associated with an increased risk of adenocarcinoma of the esophagus...

..Few population-based studies have examined comorbidity in relation to gastro-oesophageal reflux disease (GERD)...

..There is an unexplained male predominance in the incidence of oesophageal adenocarcinoma, and the sex-specific distribution of its risk factors in the general population is not known...

..Our findings indicate that dietary factors associated with LES relaxation and transient GER (but perhaps not severe chronic reflux) are not associated with any important risk of esophageal malignancy...

..Moderate relative risk reductions translate into weak absolute risk reductions for oesophageal cancers in Sweden...

..Special clinical vigilance vis-à-vis gastro-esophageal cancers seems unwarranted in asthmatic patients, but may be appropriate in those with clinically manifest gastro-oesophageal reflux...

..We aimed to assess whether needle catheter jejunostomy (NCJ) influences the weight development or discharge from hospital after oesophageal cancer surgery in an unselected and prospectively collected series of patients...

..Although some experimental studies have indicated that cholecystectomy may increase the risk of pancreatic cancer, data from epidemiological studies are conflicting...

..Acute surgical complications after esophageal resection for cancer may decrease the long-term survival. Previous results on this topic are conflicting and no population-based studies are available...

..Furthermore, the effect of antireflux surgery has not yet been studied. We conducted a population-based retrospective cohort study to fill these gaps...

..There is widespread belief that obesity is associated with gastro-oesophageal reflux disease, but the scientific evidence is weak and contradictory. Our aim is to evaluate the relation between body mass and reflux oesophagitis...

..Drinking beverages very hot did not increase the risk for oesophageal squamous cell carcinoma, oesophageal adenocarcinoma, or gastric cardia adenocarcinoma...

..The aim of this study was to clarify the need for cholecystectomy following obesity surgery...

..These results should encourage large-scale randomized trials that can establish potentially beneficial effects of antireflux stents...

..The authors hypothesised that airborne occupational exposures in male dominated industries might contribute...

..The aim of this study was to estimate weight change after surgery in a population-based setting and to identify nutritional problems that might correlate with weight loss...

..Little is known about the relation between cholecystectomy and small bowel cancer. Therefore, we evaluated cholecystectomy and risk of bowel cancer...

..The role of sex hormonal influence in explaining the strong male predominance in oesophageal adenocarcinoma (EA) needs attention...

..In this Swedish nationwide cohort study, it was hypothesized that intrathoracic anastomotic leak makes patients more susceptible to persisting eating difficulties, odynophagia, dysphagia, trouble swallowing saliva and reflux...

..This study explored how selected surgical factors affected HRQL 6 months after operation...

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..The aim of the study was to assess health-related quality of life (HRQL) in patients with surgically cured oesophageal cancer...

..This study reports short-term outcome of gluteus maximus myocutaneous flap reconstruction on perineal wound healing...

..The aetiology is largely unknown, and the potential roles of gallstones and gall bladder removal (cholecystectomy) need to be addressed in a large study with a long follow-up...

..The association between psychiatric disorders and gastro-oesophageal reflux symptoms is uncertain, and few population-based studies are available...

..Although most epidemiological studies do not support a role for alcohol in the aetiology of pancreatic cancer, an increased risk among heavy drinkers cannot be excluded...

..Laparoscopic surgery appears to offer rapid recovery and low postoperative morbidity. The aim of the present study was to assess the outcome of laparoscopic vertical banded gastroplasty (lap VBG) in 60 obese patients...

..1 vs OR=2.8, 95% CI=1.9-4.2), less harmed by low intake of fruit and vegetables (OR=0.9, 95% CI 0.3-2.4 vs OR=1.6, 95% CI=1.1-2.2) and less protected by Helicobacter pylori infection (OR=0.5, 95% CI=0.3-0.8 vs OR=1.6, 95% CI=0.5-5.4)...

..Our aim was to assess the association between surgeon volume and postoperative mortality after oesophagectomy...

..34, 95% CI 0.14-0.78) and weaker for gastric cardia tumours (OR 0.68, 95% CI 0.23-2.01). There was no association between HRT and oesophageal adenocarcinoma (OR 1.17, 95% CI 0.41-3.32)...

..Endoscopic surveillance for oesophageal adenocarcinoma among persons with reflux and obesity is discussed, but presently there is no evidence that strongly supports such a strategy...

..82; 95% CI=0.25-2.72), as neither were women with 0-1 children compared to women with at least three children (OR=0.93; 95% CI=0.35-2.49). In conclusion, we found no inverse association between childbearing and oesophageal adenocarcinoma...

..There are some data in support of this hypothesis, and the aim of this study was to ascertain whether the association could be confirmed...

..This pathway has therefore been established at our hospital, and we can recommend well-organized and nurse-led care pathways for oesophageal cancer patients...

..Gastrectomy has been indicated as a risk factor for laryngeal cancer, and possibly also for pharyngeal cancer, but few studies are available. The postulated mechanism is increased bile reflux following gastrectomy...

..The model described may prove of value in studies aimed to abate the disparate fluctuations of DNA synthesis in the esophageal mucosa during the various phases of protracted stress...

..An increased intrahepatic bile duct pressure following cholecystectomy might cause chronic inflammation in the surrounding liver tissue, which might induce cancer development...

..The aim was to assess the risk of admission to hospital for obesity-related co-morbidities and overall mortality after bariatric surgery in relation to the general population...

..Previous studies present conflicting results regarding relationship between gastric emptying and gastro-oesophageal reflux disease. Reflux of duodenal content to oesophagus is generally considered to be associated with more severe disease...

..The aim of this study was to report the technique and early experience of extended APR in a select cohort of patients...