Hugo Lagercrantz

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Behavioral stress is affected by the mode of tube feeding in very low birth weight infants
    Ann Dsilna
    Division of Reproductive and Perinatal Health Care, Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden
    Clin J Pain 24:447-55. 2008
  2. doi request reprint The birth of consciousness
    Hugo Lagercrantz
    Astrid Lindgren Children s Hospital Q2 07, Karolinska Institute, 171 76 Stockholm, Sweden
    Early Hum Dev 85:S57-8. 2009
  3. ncbi request reprint Basic consciousness of the newborn
    Hugo Lagercrantz
    Neonatal Research Unit, Karolinska Institute, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Semin Perinatol 34:201-6. 2010
  4. pmc Effects of preterm birth on cortical thickness measured in adolescence
    Zoltan Nagy
    Department of Woman and Child Health, Neonatal Unit, Karolinska University Hospital, Stockholm 171 76, Sweden
    Cereb Cortex 21:300-6. 2011
  5. doi request reprint The emergence of human consciousness: from fetal to neonatal life
    Hugo Lagercrantz
    Karolinska Institute, Neonatal Research Unit, Astrid Lindgren Children s Hospital, 171 76 Stockholm, Sweden
    Pediatr Res 65:255-60. 2009
  6. ncbi request reprint [The anatomy of the soul--does it exist?]
    Hugo Lagercrantz
    Karolinska Institutet, Astrid Lindgrens barnsjukhus, Stockholm
    Lakartidningen 105:387-8. 2008
  7. doi request reprint Structural correlates of preterm birth in the adolescent brain
    Zoltan Nagy
    Neonatal Units, Department of Woman andChild Health, Karolinska Institute, Stockholm, Sweden
    Pediatrics 124:e964-72. 2009
  8. doi request reprint Long-term reprogramming of cardiovascular function in infants of active smokers
    Gary Cohen
    Department of Women and Child Health, Neonatal Unit, Karolinska Institute, Elevhemmet H1 02, S 171 76 Stockholm, Sweden
    Hypertension 55:722-8. 2010
  9. pmc Positional circulatory control in the sleeping infant and toddler: role of the inner ear and arterial pulse pressure
    Gary Cohen
    Kvinnors och Barns H alsa, Karolinska Institute, Stockholm, Sweden
    J Physiol 590:3483-93. 2012
  10. doi request reprint The functional architecture of the infant brain as revealed by resting-state fMRI
    Peter Fransson
    Department of Clinical Neuroscience, Karolinska Institute, SE 171 76 Stockholm, Sweden
    Cereb Cortex 21:145-54. 2011

Collaborators

Detail Information

Publications52

  1. doi request reprint Behavioral stress is affected by the mode of tube feeding in very low birth weight infants
    Ann Dsilna
    Division of Reproductive and Perinatal Health Care, Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden
    Clin J Pain 24:447-55. 2008
    ..To compare the effect of continuous versus bolus feeding on behavioral responses of stress in very low birth weight infants during early postnatal life...
  2. doi request reprint The birth of consciousness
    Hugo Lagercrantz
    Astrid Lindgren Children s Hospital Q2 07, Karolinska Institute, 171 76 Stockholm, Sweden
    Early Hum Dev 85:S57-8. 2009
    ..The spontaneous resting activity discovered in the cortex of newborn infants may correspond to what William James called "the stream of consciousness"...
  3. ncbi request reprint Basic consciousness of the newborn
    Hugo Lagercrantz
    Neonatal Research Unit, Karolinska Institute, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Semin Perinatol 34:201-6. 2010
    ..Preterm infants may be conscious to a limited degree from about 25 weeks, when the thalamocortical connections are established...
  4. pmc Effects of preterm birth on cortical thickness measured in adolescence
    Zoltan Nagy
    Department of Woman and Child Health, Neonatal Unit, Karolinska University Hospital, Stockholm 171 76, Sweden
    Cereb Cortex 21:300-6. 2011
    ..These results support the notion that preterm birth is a risk factor for long-term development of cortical thickness...
  5. doi request reprint The emergence of human consciousness: from fetal to neonatal life
    Hugo Lagercrantz
    Karolinska Institute, Neonatal Research Unit, Astrid Lindgren Children s Hospital, 171 76 Stockholm, Sweden
    Pediatr Res 65:255-60. 2009
    ..It also shows avoidance reactions to harmful stimuli. However, the thalamocortical connections are not yet fully established, which is why it can only reach a minimal level of consciousness...
  6. ncbi request reprint [The anatomy of the soul--does it exist?]
    Hugo Lagercrantz
    Karolinska Institutet, Astrid Lindgrens barnsjukhus, Stockholm
    Lakartidningen 105:387-8. 2008
  7. doi request reprint Structural correlates of preterm birth in the adolescent brain
    Zoltan Nagy
    Neonatal Units, Department of Woman andChild Health, Karolinska Institute, Stockholm, Sweden
    Pediatrics 124:e964-72. 2009
    ....
  8. doi request reprint Long-term reprogramming of cardiovascular function in infants of active smokers
    Gary Cohen
    Department of Women and Child Health, Neonatal Unit, Karolinska Institute, Elevhemmet H1 02, S 171 76 Stockholm, Sweden
    Hypertension 55:722-8. 2010
    ..The underlying dysfunction in a smoker's infant could plausibly be a precursor or early marker of long-term susceptibility to complications, such as raised blood pressure...
  9. pmc Positional circulatory control in the sleeping infant and toddler: role of the inner ear and arterial pulse pressure
    Gary Cohen
    Kvinnors och Barns H alsa, Karolinska Institute, Stockholm, Sweden
    J Physiol 590:3483-93. 2012
    ..An anomaly in either or both mechanisms may weaken positional compensation in some sleeping infants...
  10. doi request reprint The functional architecture of the infant brain as revealed by resting-state fMRI
    Peter Fransson
    Department of Clinical Neuroscience, Karolinska Institute, SE 171 76 Stockholm, Sweden
    Cereb Cortex 21:145-54. 2011
    ..Our findings suggest that the functional network architecture in infants is linked to support tasks that are of a perception-action nature...
  11. doi request reprint Neonatal magnetic resonance imaging and outcome at age 30 months in extremely preterm infants
    Béatrice Skiöld
    Department of Women s and Children s Health, Karolinska Institute, Stockholm, Sweden
    J Pediatr 160:559-566.e1. 2012
    ..To examine associations between brain white matter abnormalities, including diffuse excessive high signal intensities, detected on neonatal magnetic resonance imaging (MRI) with neurodevelopmental outcome at age 30 months...
  12. doi request reprint Spontaneous brain activity in the newborn brain during natural sleep--an fMRI study in infants born at full term
    Peter Fransson
    Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, Stockholm, Sweden
    Pediatr Res 66:301-5. 2009
    ..In addition, we found evidence for a resting-state network that enclosed the bilateral basal ganglia...
  13. doi request reprint Early development of spatial patterns of power-law frequency scaling in FMRI resting-state and EEG data in the newborn brain
    Peter Fransson
    Department of Clinical Neuroscience, Karolinska Institute, SE 171 76 Stockholm, Sweden
    Cereb Cortex 23:638-46. 2013
    ....
  14. ncbi request reprint Lateral ventricular size in extremely premature infants: 3D MRI confirms 2D ultrasound measurements
    Sandra Horsch
    Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    Ultrasound Med Biol 35:360-6. 2009
    ..94, left 0.95). Our study underlines the value of cranial ultrasound measurements in neonatal care and follow-up...
  15. doi request reprint Cardiovascular stress hyperreactivity in babies of smokers and in babies born preterm
    Gary Cohen
    Department of Women and Child Health, Neonatal Unit, Karolinska Institute, Elevhemmet H1 02, S 171 76 Stockholm, Sweden
    Circulation 118:1848-53. 2008
    ..Here, we used 2 routine stress reactivity tests to identify incipient "silent" programming of cardiovascular dysfunction associated with adverse perinatal events...
  16. ncbi request reprint Hypoxic response in newborn rat is attenuated by neurokinin-1 receptor blockade
    H Ronny Wickström
    Department of Woman and Child Health, Karolinska Institutet, 17177 Stockholm, Sweden
    Respir Physiol Neurobiol 140:19-31. 2004
    ..It also represents a further example that neuropeptides are released under stressful conditions...
  17. ncbi request reprint Long-lasting adverse effects of prenatal hypoxia on developing autonomic nervous system and cardiovascular parameters in rats
    Julie Peyronnet
    Department of Woman and Child Health, Karolinska Institute, 171 76 Stockholm, Sweden
    Pflugers Arch 443:858-65. 2002
    ..The altered metabolic activity of the sympathoadrenal system and related central areas during development and at adulthood for most structures might be part of the potential mechanisms contributing to cardiovascular disorders in adults...
  18. pmc Novel alterations in the epigenetic signature of MeCP2-targeted promoters in lymphocytes of Rett syndrome patients
    Tobias Lilja
    Linnaeus Center in Developmental Biology for Regenerative Medicine DBRM, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Epigenetics 8:246-51. 2013
    ..Our results reveal an unexpected alteration of the chromatin state of established MeCP2 target genes in lymphocytes of human subjects with RTT...
  19. ncbi request reprint Disturbances in cardiorespiratory function during day and night in Rett syndrome
    Malin Rohdin
    Neonatal Unit Q2 09, Department of Woman and Child Health, Astrid Lindgren Children s Hospital, Karolinska Institutet, Stockholm, Sweden
    Pediatr Neurol 37:338-44. 2007
    ..We conclude that Rett syndrome is characterized by disturbed breathing and heart rate during sleep. The severity of cardiorespiratory dysfunction exhibited marked intra- and interindividual differences...
  20. ncbi request reprint Diffusion tensor imaging on teenagers, born at term with moderate hypoxic-ischemic encephalopathy
    Zoltan Nagy
    Department of Woman and Child Health, Neonatal Unit, Astrid Lindgren Children s Hospital Q2 07, Stockholm, Sweden
    Pediatr Res 58:936-40. 2005
    ..These results indicate that even in the absence of such major neurologic impairments as cerebral palsy, moderate HIE causes long term white matter disturbances which are not repaired by adolescence...
  21. ncbi request reprint Prenatal exposure to nicotine affects substance p and preprotachykinin-A mRNA levels in newborn rat
    Jonas Berner
    Department of Woman and Child Health, Karolinska Institutet, 171 77 Stockholm, Sweden
    Pediatr Res 64:621-4. 2008
    ..We conclude that nicotine causes alterations in the substance P-ergic system in the brainstem, possibly linked to the increased risk for SIDS after prenatal nicotine exposure...
  22. pmc Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice
    Elise Nsegbe
    Karolinska Institutet, Neonatal Unit, Astrid Lindgren Children s Hospital, S 171 76 Stockholm, Sweden
    J Physiol 556:43-59. 2004
    ....
  23. doi request reprint Acute morphine effects on respiratory activity in mice with target deletion of the tachykinin 1 gene (Tac1-/-)
    Yuri Shvarev
    Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    Adv Exp Med Biol 669:129-32. 2010
    ..The data suggest that hereditary deficiency in tachykinins, SP and NKA results in more robust hypoxic response in newborn Tac1-/- mice during respiratory depression induced by morphine...
  24. ncbi request reprint Perinatal nicotine attenuates the hypoxia-induced up-regulation of tyrosine hydroxylase and galanin mRNA in locus ceruleus of the newborn mouse
    H Ronny Wickström
    Department of Woman and Child Health, Karolinska Institutet, 171 77 Stockholm, Sweden
    Pediatr Res 52:763-9. 2002
    ..A deficient catecholamine synthesis in the adrenals may also contribute to the detrimental effect of prenatal exposure to nicotine on the response to hypoxia...
  25. ncbi request reprint Indications of improved cognitive development at one year of age among infants born very prematurely who received care based on the Newborn Individualized Developmental Care and Assessment Program (NIDCAP)
    Agneta Kleberg
    Neonatal Programme, Department of Woman and Child Health, Astrid Lindgren Children s Hospital, Karolinska Institute, SE 171 76 Stockholm, Sweden
    Early Hum Dev 68:83-91. 2002
    ..The aim of the present investigation was to determine the effect of such care on the 1-year development of infants born with a gestational age of less than 32 weeks...
  26. ncbi request reprint Preterm children have disturbances of white matter at 11 years of age as shown by diffusion tensor imaging
    Zoltan Nagy
    Neonatal Unit, Karolinska Institutet, Stockholm, Sweden
    Pediatr Res 54:672-9. 2003
    ....
  27. doi request reprint Comparison of three hypothermic target temperatures for the treatment of hypoxic ischemia: mRNA level responses of eight genes in the piglet brain
    Linus Olson
    Department of Women s and Children s Health, Astrid Lindgren Children s Hospital, Karolinska Institutet, 17176, Stockholm, Sweden
    Transl Stroke Res 4:248-57. 2013
    ..Comparing the three studied temperatures, cooling to 33.5 °C, appears to provide the best cooling temperature compromise. ..
  28. ncbi request reprint Nobel Prizes in paediatrics: Santiago Ramón y Cajal (1852-1934) and the founding of neuroembryology
    Hugo Lagercrantz
    Acta Paediatrica, Stockholm, Sweden
    Acta Paediatr 95:130-1. 2006
  29. ncbi request reprint Pain activates cortical areas in the preterm newborn brain
    Marco Bartocci
    Neonatal Research Unit, Astrid Lindgren s Children s Hospital, Karolinska University Hospital, Karolinska Institute, SE 17176 Stockholm, Sweden
    Pain 122:109-17. 2006
    ..Somatosensory cortical activation occurs bilaterally following unilateral stimulation and these changes are more pronounced in male neonates or preterm neonates at lower gestational ages...
  30. ncbi request reprint Hans Spemann (1869-1941): discoverer of the neuronal organizer
    Hugo Lagercrantz
    Karolinska University Hospital, Stockholm, Sweden
    Acta Paediatr 95:386-7. 2006
  31. ncbi request reprint J.F. Enders (1897-1985), T.H. Weller (1915-) and F.C. Robbins (1916-2003): a simplified method for the multiplication of poliomyelitis virus. Dreams of eradicating a terrifying disease
    Rolf Zetterström
    Acta Paediatrica, Karolinska University Hospital, Stockholm, Sweden
    Acta Paediatr 95:1026-8. 2006
  32. ncbi request reprint Developmental risks and protective factors for influencing cognitive outcome at 5 1/2 years of age in very-low-birthweight children
    Birgitta Bohm
    Karolinska Institute, Stockholm, Sweden
    Dev Med Child Neurol 44:508-16. 2002
    ..These two IQ measures were also negatively associated with intrauterine growth retardation late in pregnancy. We conclude that VLBW children, in the absence of these identified risk factors, have normal cognitive development...
  33. ncbi request reprint Development of CO(2)-response in the early newborn period in rat
    Ronny Wickström
    Department of Woman and Child Health, Neonatal Research Unit, Q2 07, Alb, Karolinska sjukhuset, 171 76 Stockholm, Sweden
    Respir Physiol Neurobiol 132:145-58. 2002
    ..We also speculate that differences in activation of chemosensitive brainstem neurons may be part of the maturation of the hypercapnic ventilatory response...
  34. ncbi request reprint IL-1 beta depresses respiration and anoxic survival via a prostaglandin-dependent pathway in neonatal rats
    Annika Olsson
    Karolinska Institutet, Neonatal Program, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Pediatr Res 54:326-31. 2003
    ..These findings suggest that IL-1 beta does not inhibit respiratory neurons directly but may depress breathing and hypoxic defense via a prostaglandin-mediated mechanism...
  35. ncbi request reprint Continuous feeding promotes gastrointestinal tolerance and growth in very low birth weight infants
    Ann Dsilna
    Division of Reproductive and Perinatal Health Care and Neonatal Research Unit, Department of Women and Child Health, Karolinska Institute, Stockholm, Sweden
    J Pediatr 147:43-9. 2005
    ..To compare the effects of continuous versus intermittent feeding on gastrointestinal tolerance and growth in very low birth weight (VLBW) infants...
  36. ncbi request reprint Perinatal respiratory control and its modulation by adenosine and caffeine in the rat
    Eric Herlenius
    Department of Woman and Child Health, Karolinska Hospital, Stockholm, Sweden
    Pediatr Res 51:4-12. 2002
    ....
  37. pmc Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function
    Gary Cohen
    Karolinska Institute, Neonatal Unit, Astrid Lindgren Children s Hospital, S 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:3817-21. 2005
    ..We propose that the underlying mechanisms of nicotine's detrimental side effects on a range of crucial defensive reflexes involve loss of function of nAChR subtypes, possibly via activity-dependent desensitization...
  38. pmc Lactose in human breast milk an inducer of innate immunity with implications for a role in intestinal homeostasis
    Andreas Cederlund
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e53876. 2013
    ..Together, these results suggest an additional function of lactose in innate immunity by upregulating gastrointestinal AMPs that may lead to protection of the neonatal gut against pathogens and regulation of the microbiota of the infant...
  39. ncbi request reprint Abnormal circulatory stress responses of preterm graduates
    Gary Cohen
    Department of Women and Child Health, Neonatal Unit, Karolinska Institute, S 171 76 Stockholm, Sweden
    Pediatr Res 61:329-34. 2007
    ..Most anomalies had not resolved by the time infants born preterm reached term age; some may be early signs of emerging long-term cardiovascular dysfunction...
  40. doi request reprint Activation of the right fronto-temporal cortex during maternal facial recognition in young infants
    Jakob Carlsson
    Neonatal Research Unit Q2 07, Astrid Lindgren Children s Hospital, Karolinska Institute, Stockholm, Sweden
    Acta Paediatr 97:1221-5. 2008
    ..Herein we report how the prefrontal cortices of healthy 6- to 9-month-old infants react to the sight of their mother's faces compared to that of an unknown female face...
  41. pmc Resting-state networks in the infant brain
    Peter Fransson
    Magnetic Resonance Research Center, Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:15531-6. 2007
    ..The potential link between the emergence of behavior and patterns of resting-state activity in the infant brain is discussed...
  42. ncbi request reprint Why do ALTE infants not die in SIDS?
    Ann Edner
    Department of Woman and Child, Astrid Lindgren Children s Hospital, SE 171 76 Stockholm, Sweden
    Acta Paediatr 96:191-4. 2007
    ..To compare known risk factors for sudden infant death syndrome (SIDS) amongst infants with apparent life threatening events (ALTE) with their matched controls, and ALTE infants who subsequently died of SIDS with infants surviving an ALTE...
  43. ncbi request reprint Developmental changes in HIF transcription factor in carotid body: relevance for O2 sensing by chemoreceptors
    Jean Christophe Roux
    Department of Woman and Child Health, Neonatal Research Unit, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Pediatr Res 58:53-7. 2005
    ..We suggest that this selective down-regulation of HIF-1alpha may be involved in the postnatal maturation of CB responsiveness to hypoxia...
  44. ncbi request reprint [Health insurance money can be used to increase medical research support]
    Sten Grillner
    Karolinska Institutet, Stockholm
    Lakartidningen 101:2124-6. 2004
  45. ncbi request reprint Neonatal individualized care in practice: a Swedish experience
    Björn Westrup
    Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    Semin Neonatol 7:447-57. 2002
    ..Furthermore, ethical issues and scientific obstacles concerning this concept of care are discussed...
  46. ncbi request reprint Aggravated brain damage after hypoxic ischemia in immature adenosine A2A knockout mice
    Ulrika Aden
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Stroke 34:739-44. 2003
    ..However, the roles of the different adenosine receptors are unclear, particularly in young animals. We examined the role of adenosine A2A receptors (A2AR) using 7-day-old A2A knockout (A2AR(-/-)) mice in a model of HI...
  47. pmc beta 2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure
    Gary Cohen
    Laboratoire de Neurologie et de Physiologie du Développement, Institut National de la Santé et de la Recherche Médicale E9935, Hopital Robert Debre, 75019 Paris, France
    Proc Natl Acad Sci U S A 99:13272-7. 2002
    ..We propose that nicotine impairs breathing (and possibly arousal) responses to stress by disrupting functions normally regulated by beta2-containing, high-affinity nAChRs...
  48. doi request reprint SIDS diagnosis should not be put to bed
    Bernt Alm
    Department of Paediatrics, University of Gothenburg, Queen Silvia Children s Hospital, Gothenburg, Sweden
    Acta Paediatr 97:695-6. 2008
    ..The finding that prone sleeping position and smoking are important risk factors for SIDS has considerably reduced the incidence. Although these risk factors can be found in many cases of SIDS, they cannot be regarded as causes of death...
  49. doi request reprint The hard problem
    Hugo Lagercrantz
    Acta Paediatr 97:142-3. 2008
  50. ncbi request reprint "One sometimes finds what one is not looking for" (Sir Alexander Fleming): the most important medical discovery of the 20th century
    Göran Wennergren
    Department of Pediatrics, Goteborg University, Queen Silvia Children s Hospital, Goteburg, Sweden
    Acta Paediatr 96:141-4. 2007
  51. ncbi request reprint Evaluating neonatal developmental care
    Björn Westrup
    J Pediatr 142:591-2. 2003
  52. ncbi request reprint [Sudden infant death needed as diagnosis. The BMJ idea not relevant--the diagnosis a basis for national SIDS registry]
    Bernt Alm
    Lakartidningen 105:988-9. 2008