Research Topics
| Sigurdur Yngvi KristinssonSummaryAffiliation: Karolinska University Hospital Country: Sweden Publications
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Detail Information
Publications
Thrombosis is associated with inferior survival in multiple myelomaSigurdur Y Kristinsson
Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
Haematologica 97:1603-7. 2012..The prevention of thrombosis in multiple myeloma is an important goal in the management of these patients...- Monoclonal gammopathy of undetermined significance and risk of infections: a population-based studySigurdur Y Kristinsson
Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
Haematologica 97:854-8. 2012..Our findings provide novel insights into the mechanisms behind infections in patients with plasma cell dyscrasias, and may have clinical implications... - Familial aggregation of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia with solid tumors and myeloid malignanciesSigurdur Y Kristinsson
Division of Hematology, Department of Medicine, Karolinska University Hospital, Solna and Karolinska Institutet, Stockholm, Sweden
Acta Haematol 127:173-7. 2012..In this paper, we will review the current knowledge about familiality of LPL/WM and provide novel data on solid tumors and myeloid malignancies in first-degree relatives of LPL/WM patients... - Arterial and venous thrombosis in monoclonal gammopathy of undetermined significance and multiple myeloma: a population-based studySigurdur Y Kristinsson
Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
Blood 115:4991-8. 2010..0 g/L) at diagnosis. MGUS patients with (vs without) thrombosis had no excess risk of MM or Waldenström macroglobulinemia. Our findings are of relevance for future studies and for improvement of thrombosis prophylaxis strategies... 
What causes Waldenström's macroglobulinemia: genetic or immune-related factors, or a combination?Sigurdur Y Kristinsson
Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
Clin Lymphoma Myeloma Leuk 11:85-7. 2011..Further, we address clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up...- Thrombosis in multiple myelomaSigurdur Yngvi Kristinsson
Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden
Hematology Am Soc Hematol Educ Program 2010:437-44. 2010..Recommendations for thromboprophylaxis are described and treatment choices for venous thrombosis in MM patients are reviewed... - Hypercoagulability in multiple myeloma and its precursor state, monoclonal gammopathy of undetermined significanceSigurdur Yngvi Kristinsson
Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden
Semin Hematol 48:46-54. 2011..In this review, we discuss risk factors for thrombosis in multiple myeloma, as well as prophylactic strategies, the evidence for thrombosis among patients with MGUS, and proposed mechanisms for the hypercoagulability... - Monoclonal gammopathy of undetermined significance and risk of skeletal fractures: a population-based studySigurdur Y Kristinsson
Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
Blood 116:2651-5. 2010..Our findings may have implications for the development of better prophylaxis for bone disease in MGUS, and they provide novel clues on pathogenesis of MM bone disease... - Bone disease in multiple myeloma and precursor disease: novel diagnostic approaches and implications on clinical managementSigurdur Y Kristinsson
Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, SE 171 76, Stockholm, Sweden
Expert Rev Mol Diagn 11:593-603. 2011.... - Immune-related and inflammatory conditions and risk of lymphoplasmacytic lymphoma or Waldenstrom macroglobulinemiaSigurdur Y Kristinsson
Department of Medicine, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
J Natl Cancer Inst 102:557-67. 2010..We conducted, to our knowledge, the most comprehensive study to date to evaluate associations between a personal or family history of many immune-related and/or inflammatory disorders and the subsequent risk of LPL-WM... - Autoimmunity and the risk of myeloproliferative neoplasmsSigurdur Y Kristinsson
Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
Haematologica 95:1216-20. 2010..Future studies are needed to unravel the effects of these autoimmune diseases themselves, their treatment, or common genetic susceptibility... - Patterns of hematologic malignancies and solid tumors among 37,838 first-degree relatives of 13,896 patients with multiple myeloma in SwedenSigurdur Y Kristinsson
Department of Medicine, Division of Hematology, Karolinska University Hospital, Solna and Karolinska Institutet, Stockholm, Sweden
Int J Cancer 125:2147-50. 2009..0-1.5). No significantly increased risk was found for other hematologic or solid malignancies. Our findings support a role for a shared susceptibility (genetic, environmental or both) that predisposes to MM, MGUS, ALL and bladder cancer... - Genetics- and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/ Waldenström's macroglobulinemiaSigurdur Y Kristinsson
Department of Medicine, Division of Hematology, Karolinska University Hospital, Solna and Karolinska Institutet, Stockholm, Sweden
Clin Lymphoma Myeloma 9:23-6. 2009..Finally, based on novel insights on this topic, we discuss clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up... - Socioeconomic differences in patient survival are increasing for acute myeloid leukemia and multiple myeloma in swedenSigurdur Yngvi Kristinsson
Division of Hematology, Department of Medicine, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
J Clin Oncol 27:2073-80. 2009..We assessed the impact of SES on survival in two large population-based cohorts of AML and MM patients diagnosed in Sweden 1973 to 2005... - Risk of lymphoproliferative disorders among first-degree relatives of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia patients: a population-based study in SwedenSigurdur Y Kristinsson
Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
Blood 112:3052-6. 2008..Our findings of highly increased risks of developing LPL/WM, NHL, CLL, and MGUS support the operation of shared susceptibility genes that predispose to LPL/WM and other lymphoproliferative disorders... - Chronic immune stimulation might act as a trigger for the development of acute myeloid leukemia or myelodysplastic syndromesSigurdur Y Kristinsson
Dept of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
J Clin Oncol 29:2897-903. 2011.... - Patterns of survival among patients with myeloproliferative neoplasms diagnosed in Sweden from 1973 to 2008: a population-based studyMalin Hultcrantz
Karolinska University Hospital, Stockholm, Sweden
J Clin Oncol 30:2995-3001. 2012..We conducted a large population-based study to establish patterns of survival in more than 9,000 patients with MPNs... - Improved patient survival for acute myeloid leukemia: a population-based study of 9729 patients diagnosed in Sweden between 1973 and 2005Asa Rangert Derolf
Division of Hematology, Department of Medicine, Karolinska University Hospital, Solna and Karolinska Institutet, Stockholm, Sweden
Blood 113:3666-72. 2009..However, the majority of AML patients die of their disease and age remains an important predictor of prognosis. New effective agents with a more favorable toxicity profile are needed to improve survival, particularly in the elderly... - Temporal trends in the proportion cured among adults diagnosed with acute myeloid leukaemia in Sweden 1973-2001, a population-based studyTherese M L Andersson
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Br J Haematol 148:918-24. 2010..This novel approach of analysing survival data could be a valuable tool for physicians, patients, health care planners and health economists... 
Patterns of survival in multiple myeloma: a population-based study of patients diagnosed in Sweden from 1973 to 2003Sigurdur Yngvi Kristinsson
Division of Hematology, Department of Medicine, Karolinska Karolinska University Hospital and Institutet, Stockholm, Sweden
J Clin Oncol 25:1993-9. 2007..To define patterns of survival among all multiple myeloma (MM) patients diagnosed in Sweden during a 30-year period...- Novel therapies in multiple myeloma for newly diagnosed nontransplant candidatesSigurdur Yngvi Kristinsson
Division of Hematology, Department of Medicine, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
Cancer J 15:473-8. 2009..In this review, we discuss the role of novel therapies in multiple myeloma in elderly multiple myeloma patients. Important aspects, such as toxicity and the role of prognostic factors, are also addressed...