Genomes and Genes
Affiliation: Karolinska Institutet
- Childhood cognitive development as a skillTorkel Klingberg
Department of Neuroscience, Karolinska Institute, Retzius vag 8, 17176 Stockholm, Sweden Electronic address
Trends Cogn Sci 18:573-9. 2014..In this view, the development of WM capacity during childhood partly involves the same mechanisms as skill-learning. ..
- Development of a superior frontal-intraparietal network for visuo-spatial working memoryTorkel Klingberg
Paediatric Neurology, Karolinska Institute, Astrid Lindgren s Children s Hospital Q2 07, Stockholm, Sweden
Neuropsychologia 44:2171-7. 2006..These networks not only consist of cortical areas but also the white matter tracts connecting them. For visuo-spatial working memory, this network could consist of the superior frontal and intraparietal cortex...
- Training and plasticity of working memoryTorkel Klingberg
Department of Neuroscience, Karolinska Institute, Retzius vag 8, 171 77 Stockholm, Sweden
Trends Cogn Sci 14:317-24. 2010..The observed training effects suggest that WM training could be used as a remediating intervention for individuals for whom low WM capacity is a limiting factor for academic performance or in everyday life...
- Dopamine, working memory, and training induced plasticity: implications for developmental researchStina Soderqvist
Department of Neuroscience and Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
Dev Psychol 48:836-43. 2012..Our results emphasize the importance of the role of dopamine in determining cognitive plasticity...
- Visuo-spatial working memory span: a sensitive measure of cognitive deficits in children with ADHDHelena Westerberg
Department of Neuropediatrics, Karolinska Institute, Astrid Lindgrens Barnsjukhus Q2 07, 171 76 Stockholm, Sweden
Child Neuropsychol 10:155-61. 2004..01). Our results show that the VSWM test is a sensitive measure of cognitive deficits in ADHD and it supports the hypothesis that deficits in VSWM is a major component of ADHD...
- Stronger synaptic connectivity as a mechanism behind development of working memory-related brain activity during childhoodFredrik Edin
Karolinska Institutet, Stockholm, Sweden
J Cogn Neurosci 19:750-60. 2007....
- Trade-off between capacity and precision in visuospatial working memoryChantal Roggeman
Karolinska Institute, Stockholm, Sweden
J Cogn Neurosci 26:211-22. 2014..These results support a two-module model of WM where performance is determined both by storage capacity and by top-down influence, which can vary on a trial-by-trial basis, affecting both the capacity and precision of WM. ..
- Structural maturation and brain activity predict future working memory capacity during childhood developmentHenrik Ullman
Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
J Neurosci 34:1592-8. 2014..This gives a novel insight into the neural mechanisms of childhood development and supports the idea that neuroimaging can have a unique role in predicting children's cognitive development. ..
- Three dyslexia susceptibility genes, DYX1C1, DCDC2, and KIAA0319, affect temporo-parietal white matter structureFahimeh Darki
Neuroscience Department, Karolinska Institutet, Stockholm, Sweden
Biol Psychiatry 72:671-6. 2012..Volume and integrity of white matter correlate with reading ability, but the underlying factors contributing to this variability are unknown...
- Maturation of white matter is associated with the development of cognitive functions during childhoodZoltan Nagy
Karolinska Institute, Astrid Lindgren Children s Hospital, Stockholm, Sweden
J Cogn Neurosci 16:1227-33. 2004....
- Computerized training of working memory in children with ADHD--a randomized, controlled trialTorkel Klingberg
Unit of Neuropediatrics, Department Women and Children s Health, Karolinska Institute, 17176 Stockholm, Sweden
J Am Acad Child Adolesc Psychiatry 44:177-86. 2005..During 2002 to 2003, the authors conducted a multicenter, randomized, controlled, double-blind trial to investigate the effect of improving WM by computerized, systematic practice of WM tasks...
- Changes in cortical dopamine D1 receptor binding associated with cognitive trainingFiona McNab
Neuropediatric Unit, Department of Woman and Child Health, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
Science 323:800-2. 2009..This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo...
- Phonological working memory with auditory presentation of pseudo-words -- an event related fMRI StudyFredrik Strand
Neuropediatric Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
Brain Res 1212:48-54. 2008..Significant activation of the auditory cortex in the middle temporal gyrus was observed during the maintenance phase, which, together with the inferior frontal gyrus activation might underly the maintenance of phonological information...
- Brain activity related to working memory and distraction in children and adultsPernille J Olesen
Neuropediatric Research Unit, Department of Women and Child Health, Astrid Lindgren s Children s Hospital Q2 07, Karolinska Institutet, 171 76 Stockholm, Sweden
Cereb Cortex 17:1047-54. 2007..However, distraction activated frontal cortex only in children. The larger frontal activation in response to distracters presented during the delay may explain why children are more susceptible to interfering stimuli...
- Changes in cortical activity after training of working memory--a single-subject analysisHelena Westerberg
Karolinska Institutet, Department of Neuropediatrics, Stockholm, Sweden
Physiol Behav 92:186-92. 2007....
- The SNAP25 gene is linked to working memory capacity and maturation of the posterior cingulate cortex during childhoodStina Soderqvist
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Biol Psychiatry 68:1120-5. 2010..Although WM capacity is known to be highly heritable, most genes involved remain unidentified...
- Polymorphisms in the dopamine receptor 2 gene region influence improvements during working memory training in children and adolescentsStina Soderqvist
Karolinska Institutet, Stockholm, Sweden
J Cogn Neurosci 26:54-62. 2014..Moreover, they suggest that dopamine D2 transmission in the BG is a key factor for cognitive plasticity. ..
- Gains in fluid intelligence after training non-verbal reasoning in 4-year-old children: a controlled, randomized studySissela Bergman Nutley
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Dev Sci 14:591-601. 2011..This study shows that it is possible to improve Gf with training, which could have implications for early interventions in children...
- Influence of the COMT genotype on working memory and brain activity changes during developmentIroise Dumontheil
Neuroscience Department, Karolinska Institutet, Retzius vag 8, Stockholm, Sweden
Biol Psychiatry 70:222-9. 2011..Dopaminergic system changes during adolescence may lead to a reduction of basal dopamine levels, potentially affecting Met allele benefits during development...
- DCDC2 polymorphism is associated with left temporoparietal gray and white matter structures during developmentFahimeh Darki
Department of Neuroscience, Karolinska Institutet, 171 77 Solna, Sweden
J Neurosci 34:14455-62. 2014..Possibly, the variability of gray and white matter structures could both be related to the role of DCDC2 in ciliary function, which affects both neuronal migration and axonal outgrowth. ..
- Diffusion tensor imaging on teenagers, born at term with moderate hypoxic-ischemic encephalopathyZoltan Nagy
Department of Woman and Child Health, Neonatal Unit, Astrid Lindgren Children s Hospital Q2 07, Stockholm, Sweden
Pediatr Res 58:936-40. 2005..These results indicate that even in the absence of such major neurologic impairments as cerebral palsy, moderate HIE causes long term white matter disturbances which are not repaired by adolescence...
- Increased prefrontal and parietal activity after training of working memoryPernille J Olesen
Karolinska Institute, Department of Neuropediatrics, Astrid Lindgren s Children s Hospital Q2 07, 171 76 Stockholm, Sweden
Nat Neurosci 7:75-9. 2004..The changes in cortical activity could be evidence of training-induced plasticity in the neural systems that underlie working memory...
- Combined analysis of DTI and fMRI data reveals a joint maturation of white and grey matter in a fronto-parietal networkPernille J Olesen
Department of Neuropediatrics, Q2 07, Astrid Lindgren s Children s Hospital, Karolinska Institute, S 17176 Stockholm, Sweden
Brain Res Cogn Brain Res 18:48-57. 2003....
- Prefrontal cortex and basal ganglia control access to working memoryFiona McNab
Developmental Cognitive Neuroscience, Stockholm Brain Institute, Karolinska Institutet, MR Centrum, Stockholm, Sweden
Nat Neurosci 11:103-7. 2008....
- Measuring working memory capacity with greater precision in the lower capacity rangesSissela Bergman Nutley
Neuropaediatric Research Unit, Department of Women s and Children s Health, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
Dev Neuropsychol 35:81-95. 2010..Data showed a large variability of difficulty within each level and the factors contributing to this variability were identified. This variability can be used to provide a precise measure of working memory capacity in the lower ranges...
- Increased brain activity in frontal and parietal cortex underlies the development of visuospatial working memory capacity during childhoodTorkel Klingberg
Department of Neuropediatrics, Astrid Lindgrens Children s Hospital, Karolinska Institute, Stockholm, Sweden
J Cogn Neurosci 14:1-10. 2002..These frontal and parietal areas are known to be involved in the control of attention and spatial WM. The development of the functionality in these areas may play an important role in cognitive development during childhood...
- Fronto-parietal connection asymmetry regulates working memory distractibilityFredrik Edin
School of Computer Science and Communication, Kungliga Tekniska Högskolan, SE 100 44 Stockholm, Sweden
J Integr Neurosci 6:567-96. 2007..Our results therefore suggest that the previously demonstrated improvement of vsWM performance during development could be due to a shift in the control of the effective balance between the SFS-IPS networks...
- Mechanism for top-down control of working memory capacityFredrik Edin
Karolinska Institutet, 171 76 Stockholm, Sweden
Proc Natl Acad Sci U S A 106:6802-7. 2009..The model provides a mechanistic framework for understanding top-down control of working memory and specifies two different contributions of prefrontal and parietal cortex to working memory capacity...
- Training and transfer effects of executive functions in preschool childrenLisa B Thorell
Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institutet, Sweden
Dev Sci 12:106-13. 2009....
- Brain activity during a visuospatial working memory task predicts arithmetical performance 2 years laterIroise Dumontheil
Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Cereb Cortex 22:1078-85. 2012..These results demonstrate that neuroimaging data can provide useful information in addition to behavioral assessments and be used to improve the identification of individuals at risk of future low academic performance...
- Training of working memory in children with ADHDTorkel Klingberg
Department of Neuropediatrics, Karolinska Institute, Stockholm, Sweden
J Clin Exp Neuropsychol 24:781-91. 2002..The results thus suggest that WM training potentially could be of clinical use for ameliorating the symptoms in ADHD...
- CTNND2-a candidate gene for reading problems and mild intellectual disabilityWolfgang Hofmeister
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
J Med Genet 52:111-22. 2015..Cytogenetically visible chromosomal translocations are highly informative as they can pinpoint strong effect genes even in complex genetic disorders...
- Preterm children have disturbances of white matter at 11 years of age as shown by diffusion tensor imagingZoltan Nagy
Neonatal Unit, Karolinska Institutet, Stockholm, Sweden
Pediatr Res 54:672-9. 2003....
- Computerized training of non-verbal reasoning and working memory in children with intellectual disabilityStina Soderqvist
Department of Neuroscience, Karolinska Institutet Stockholm, Sweden Stockholm Brain Institute Stockholm, Sweden
Front Hum Neurosci 6:271. 2012..Future studies of cognitive training should take into consideration how inter-individual differences in training progress influence transfer effects and further investigate how baseline capacities predict training outcome...
- Common and unique components of inhibition and working memory: an fMRI, within-subjects investigationFiona McNab
Developmental Cognitive Neuroscience Group, Stockholm Brain Institute, Karolinska Institutet, Sweden
Neuropsychologia 46:2668-82. 2008..These results support the notion that inhibitory and working memory tasks involve common neural components, which may provide a neural basis for the interrelationship between the two systems...
- Neuronal firing rates account for distractor effects on mnemonic accuracy in a visuo-spatial working memory taskJulian Macoveanu
Computational Biology, Department of Physics, Linköping University of Technology, 581 83 Linkoping, Sweden
Biol Cybern 96:407-19. 2007....