George Klein


Affiliation: Karolinska Institutet
Country: Sweden


  1. Alkasalias T, Alexeyenko A, Hennig K, Danielsson F, Lebbink R, Fielden M, et al. RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo. Proc Natl Acad Sci U S A. 2017;114:E1413-E1421 pubmed publisher
    ..Taken together, our findings in vivo and in vitro indicate that Rho signaling governs the inhibitory effects by fibroblasts on tumor-cell growth. ..
  2. Klein G. Burkitt lymphoma--a stalking horse for cancer research?. Semin Cancer Biol. 2009;19:347-50 pubmed publisher
  3. Alkasalias T, Flaberg E, Kashuba V, Alexeyenko A, Pavlova T, Savchenko A, et al. Inhibition of tumor cell proliferation and motility by fibroblasts is both contact and soluble factor dependent. Proc Natl Acad Sci U S A. 2014;111:17188-93 pubmed publisher
  4. Darai Ramqvist E, Díaz de Ståhl T, Sandlund A, Mantripragada K, Klein G, Dumanski J, et al. Array-CGH and multipoint FISH to decode complex chromosomal rearrangements. BMC Genomics. 2006;7:330 pubmed
    ..Although our chr3 BAC/PAC array could identify single copy number changes even in pentaploid cells, mpFISH provided a more accurate analysis in the dissection of complex karyotypes at high ploidy levels. ..
  5. Klein G, Klein E, Kashuba E. Interaction of Epstein-Barr virus (EBV) with human B-lymphocytes. Biochem Biophys Res Commun. 2010;396:67-73 pubmed publisher
    ..We describe a possible growth promoting mechanism in the genesis of Burkitt lymphoma that depends on the presence of EBV. ..
  6. Alexeyenko A, Alkasalias T, Pavlova T, Szekely L, Kashuba V, Rundqvist H, et al. Confrontation of fibroblasts with cancer cells in vitro: gene network analysis of transcriptome changes and differential capacity to inhibit tumor growth. J Exp Clin Cancer Res. 2015;34:62 pubmed publisher
    ..We also demonstrated functional congruence between the in vitro and ex vivo models. The microarray data are made available via the Gene Expression Omnibus as GSE57199. ..