Research Topics
Genomes and GenesSpecies | Eva KleinSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
Epstein-Barr virus infection in humans: from harmless to life endangering virus-lymphocyte interactionsE Klein
Microbiology, Tumor and Cell Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
Oncogene 26:1297-305. 2007..Certain combinations contribute to malignant transformation, but only in conjunction with additional cellular changes. These are induced by direct or cytokine-mediated interactions with normal cells of the immune system...
Activation of innate immunity by the leukotriene B 4 inhibits EBV induced B-cell transformation in cord-blood derived mononuclear culturesEva Klein
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, S 17177 Stockholm, Sweden
Immunol Lett 116:174-7. 2008..These results demonstrated thus that LTB4 can contribute to the activation of innate immunity...- Pathogenesis of Epstein-Barr virus (EBV)-carrying lymphomasEva Klein
Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, 17177, Sweden
Acta Microbiol Immunol Hung 53:441-57. 2006..The virus carrier state can lead to the evasion of apoptosis and can intensify the response to growth promoting signals, too... - Restricted expression of EBV encoded proteins in in vitro infected CLL cellsEva Klein
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Nobelsv 16, Stockholm, Sweden
Semin Cancer Biol 20:410-5. 2010..Moreover, they were shown in tissues of EBV infected "humanized" mice. The EBV encoded protein expression pattern may serve as a marker for the B cell differentiation stage from which CLL clones can develop... - Leukotriene B4 activates T cells that inhibit B-cell proliferation in EBV-infected cord blood-derived mononuclear cell culturesAnquan Liu
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels vag 16, Stockholm, Sweden
Blood 111:2693-703. 2008..Importantly, the results indicate that endogenous LTB(4) can induce T-cell activation that inhibits the EBV-induced proliferation of B lymphocytes... - Concomitant increase of LMP1 and CD25 (IL-2-receptor alpha) expression induced by IL-10 in the EBV-positive NK lines SNK6 and KAI3Miki Takahara
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Int J Cancer 119:2775-83. 2006..By this mechanism EBV could have an important role in the development of NK lymphoma since the inflammatory component in the tumor tissue can provide these cytokines... - IL-10 can induce the expression of EBV-encoded latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B lymphocytes and in Burkitt lymphoma- and NK lymphoma-derived cell linesLorand L Kis
Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
Blood 107:2928-35. 2006.... - Expression of SH2D1A in five classical Hodgkin's disease-derived cell linesLorand L Kis
Microbiology and Tumor Biology Center MTC, Karolinska Institutet, Stockholm, Sweden
Int J Cancer 104:658-61. 2003..It is likely therefore that in addition to the demonstrated functional defect of T and NK cells imposed by the SH2D1A mutation, the behavior of certain EBV-infected B lymphocytes is also modified... 
IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoterLorand L Kis
Department of Microbiology, Karolinska Institutet, S 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 107:872-7. 2010..In light of the fact that IL-21 is already in clinical trials for the treatment of multiple malignancies, the in vivo modulation of EBV gene expression by IL-21 might have therapeutic benefits for the EBV-carrying malignancies...- The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative diseaseNoemi Nagy
Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, SE 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 106:11966-71. 2009..We have shown that the anti-apoptotic protein VCP (valosin-containing protein) binds to SAP, suggesting that it could be instrumental in the enhanced apoptotic response modulated by SAP... - EBV infection induces expression of the transcription factors ATF-2/c-Jun in B lymphocytes but not in B-CLL cellsKentaro Bandobashi
Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77, Stockholm, Sweden
Virus Genes 30:323-30. 2005..Treatment with phorbol-12, 13-dibutyrate (PDB) induced LMP-1 expression in three of four clones. Neither the HDACi nor the PDB treated cells survived... - Simultaneous detection of the two main proliferation driving EBV encoded proteins, EBNA-2 and LMP-1 in single B cellsAbu E Rasul
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels vag 16, S 171 77 Stockholm, Sweden
J Immunol Methods 385:60-70. 2012..Consequently, Type IIa lines could not be established from Hodgkin's lymphoma in vitro. We propose that these experimental cultures can be exploited for study of the Type IIa cells... - STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphomaLorand L Kis
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Blood 117:165-74. 2011.... - The X-linked lymphoproliferative disease gene product SAP is expressed in activated T and NK cellsNoemi Nagy
Microbiology and Tumorbiology Center MTC, Karolinska Institute, Stockholm, Sweden
Immunol Lett 82:141-7. 2002..e. BL lines, activated T and NK cells express SAP, while BL blasts do not express SAP. This opposite relationship may be exploited for studies about the function of SAP... - SH2D1A expression in Burkitt lymphoma cells is restricted to EBV positive group I lines and is downregulated in parallel with immunoblastic transformationNoemi Nagy
Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
Int J Cancer 100:433-40. 2002..It is possible that SH2D1A is expressed in a narrow window of B cell development represented by germinal center cells... - Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I interferons in B cellsDaniel Salamon
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
J Virol 86:4701-7. 2012..Furthermore, our results may explain the expression of LMP-1 in memory B cells of systemic lupus erythematosus patients... - Cytokine mediated induction of the major Epstein-Barr virus (EBV)-encoded transforming protein, LMP-1Lorand L Kis
Microbiology and Tumor Biology Center, Karolinska Institute, S 17177 Stockholm, Sweden
Immunol Lett 104:83-8. 2006..Cytokine mediated induction of LMP-1 may also explain the heterogeneous expression of this viral gene seen in normal and malignant cells... - The apoptosis modulating role of SAP (SLAM associated protein) contributes to the symptomatology of the X linked lymphoproliferative diseaseNoemi Nagy
Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Stockholm, Sweden
Cell Cycle 8:3086-90. 2009..This mechanism is inefficient in XLP patients. In addition, in the absence of SAP, lymphoma development may be promoted by the illegitimate survival of lymphocytes with damaged DNA that would be normally eliminated by apoptosis... - In vitro EBV-infected subline of KMH2, derived from Hodgkin lymphoma, expresses only EBNA-1, while CD40 ligand and IL-4 induce LMP-1 but not EBNA-2Lorand L Kis
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Int J Cancer 113:937-45. 2005..The KMH2 EBV cells expressed LMP-2A, but not LMP-2B mRNAs. This result is highly relevant for the type II expression pattern of H/RS cells in vivo, since these stimuli can be provided by the surrounding activated T lymphocytes... - Soluble factors produced by activated CD4+ T cells modulate EBV latencyNoemi Nagy
Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden
Proc Natl Acad Sci U S A 109:1512-7. 2012..We detected similar regulatory functions of T cells in in vitro-infected lymphocyte populations. In conclusion, our results revealed an additional mechanism by which CD4(+) T cells can control the EBV-induced B-cell proliferation... - To the genesis of Burkitt lymphoma: regulation of apoptosis by EBNA-1 and SAP may determine the fate of Ig-myc translocation carrying B lymphocytesNoemi Nagy
Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Nobelsv 16, SE 171 77 Stockholm, Sweden
Semin Cancer Biol 19:407-10. 2009..However, their EBV positive counterparts are permissive for SAP expression, due to the anti-apoptotic function of EBNA-1... - PSK and Trx80 inhibit B-cell growth in EBV-infected cord blood mononuclear cells through T cells activated by the monocyte products IL-15 and IL-12Anquan Liu
Microbiology and Tumor Biology Center, Karolinska Institute, Box 280, 171 77 Stockholm, Sweden
Blood 105:1606-13. 2005..Phosphatidylinositol 3-(PI 3)-kinase and reactive oxygen species (ROSs) were involved in the PSK-induced activation of monocytes. Restimulation of the cultures with EBV-transformed B cells generated specific cytotoxic activity... - Upregulation of LMP1 expression by histone deacetylase inhibitors in an EBV carrying NPC cell lineJun Nishikawa
Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77 Stockholm, Sweden
Virus Genes 28:121-8. 2004..CONCLUSION: EBV carrying epithelial cells do not express EBNA-2. We showed that LMP1 expression was upregulated by histone deacetylase inhibitors in an in vitro infected, EBV carrier NPC cell line... - Interaction of Epstein-Barr virus (EBV) with human B-lymphocytesGeorge Klein
Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology MTC, Box 280, S17177 Stockholm, Sweden
Biochem Biophys Res Commun 396:67-73. 2010..We describe a possible growth promoting mechanism in the genesis of Burkitt lymphoma that depends on the presence of EBV... - Deficiency of the proapoptotic SAP function in X-linked lymphoproliferative disease aggravates Epstein-Barr virus (EBV) induced mononucleosis and promotes lymphoma developmentNoemi Nagy
Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Stockholm, Sweden
Immunol Lett 130:13-8. 2010..This is probably due to the antiapoptotic function of EBNA-1 and the proliferation induced by activated myc... - Type I interferons directly down-regulate BCL-6 in primary and transformed germinal center B cells: differential regulation in B cell lines derived from endemic or sporadic Burkitt's lymphomaDaniel Salamon
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels vag 16, SE 171 77 Stockholm, Sweden
Cytokine 57:360-71. 2012..Our results identify type I IFNs as the first group of cytokines that can down-regulate BCL-6 expression directly in GC B cells... - Chronic lymphoid leukemia cells are highly sensitive to the combination of prednisolone and daunorubicin, but much less to doxorubicin or epirubicinHenriette Skribek
Department of Microbiology, Tumor and Cell Biology and Center for Integrative Recognition in the Immune System, Karolinska Institute, Stockholm, Sweden
Exp Hematol 38:1219-30. 2010..To generate a comprehensive map of the drug sensitivity of chronic lymphoid leukemia cells (CLL) using a newly developed in vitro drug-sensitivity assay based on automated evaluation of cell viability on single-cell level... - Exosomes containing glycoprotein 350 released by EBV-transformed B cells selectively target B cells through CD21 and block EBV infection in vitroHelen Vallhov
Clinical Allergy Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
J Immunol 186:73-82. 2011..Our finding also suggests that exosome-based vaccines can be engineered for specific B cell targeting by inducing gp350 expression... - Leukotriene B4 plays a pivotal role in CD40-dependent activation of chronic B lymphocytic leukemia cellsGudmundur Runarsson
Department of Medicine, Microbiology and Tumor Biology Center, Karolinska Institutet, 17177 Stockholm, Sweden
Blood 105:1274-9. 2005..Taken together, the results of the present study suggest that leukotriene biosynthesis inhibitors may have a therapeutic role in B-CLL... - SH2D1A expression reflects activation of T and NK cells in cord blood lymphocytes infected with EBV and treated with the immunomodulator PSKAnquan Liu
Microbiology and Tumorbiology Center MTC, Karolinska Institute, Box 280, 171 77 Stockholm, Sweden
Immunol Lett 80:181-8. 2002..Its potentiation by immunomodulators may have practical significance... - p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAPHarsha S Madapura
Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
Cell Cycle 11:4563-9. 2012..Our result suggests that p53 contributes to T cell homeostasis through the induction of the pro-apoptotic SAP. A high level of SAP is necessary for the activation-induced cell death that is pivotal in termination of the T cell response... - Effect of frequently used chemotherapeutic drugs on the cytotoxic activity of human natural killer cellsLaszlo Markasz
Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, Box 280, SE 171 77 Stockholm, Sweden
Mol Cancer Ther 6:644-54. 2007.... - Surveillance against tumors--is it mainly immunological?George Klein
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
Immunol Lett 100:29-33. 2005..4) Intercellular surveillance. The tissue microenvironment influences the probability of disseminated tumor cell growth. Moreover, appropriate differentiation inducing signals may revert the tumor cell phenotype... - Torbjörn Caspersson, 15 October 1910 - 7 December 1997George Klein
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm
Proc Am Philos Soc 147:73-5. 2003 - Natural killer cells in cancerPetter Höglund
Semin Cancer Biol 16:331-2. 2006 - A spectrum of mutations in SH2D1A that causes X-linked lymphoproliferative disease and other Epstein-Barr virus-associated illnessesJanos Sumegi
Center of Human Genetics, University of Nebraska Medical Center, Omaha 68198 5454, USA
Leuk Lymphoma 43:1189-201. 2002..In due course, the manner by which this gene orchestrates an elegant response (akin to a Mozart divertimento) to EBV infection shall be defined... - Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tarJack L Arbiser
Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA
J Invest Dermatol 126:1396-402. 2006..Given its antiangiogenic and anti-inflammatory activities, carbazole is likely a major component of the antipsoriatic activity of coal tar. Carbazole and derivatives may be useful in the therapy of human psoriasis...