Lars Klareskog

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis
    Yun Liu
    Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Biotechnol 31:142-7. 2013
  2. pmc Anti-type II collagen antibodies are associated with early radiographic destruction in rheumatoid arthritis
    Mohammed Mullazehi
    Clinical Immunology, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory C5, Uppsala University, Uppsala, SE 75185, Sweden
    Arthritis Res Ther 14:R100. 2012
  3. doi request reprint Autoimmunity in rheumatoid arthritis: citrulline immunity and beyond
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, Solna, Stockholm, Sweden
    Adv Immunol 118:129-58. 2013
  4. pmc Usage of skin care products and risk of rheumatoid arthritis: results from the Swedish EIRA study
    Berit M Sverdrup
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Arthritis Res Ther 14:R41. 2012
  5. pmc Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study
    Sudha Visvanathan
    Centocor Research and Development, Inc, 200 Great Valley Parkway, Malvern, PA 19355, USA
    Arthritis Res Ther 12:R211. 2010
  6. ncbi request reprint Genes, environment and immunity in the development of rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    Curr Opin Immunol 18:650-5. 2006
  7. doi request reprint Immunity to citrullinated proteins in rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, SE 171 76, Stockholm, Sweden
    Annu Rev Immunol 26:651-75. 2008
  8. ncbi request reprint Assessment of long-term safety and efficacy of etanercept in a 5-year extension study in patients with rheumatoid arthritis
    L Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Clin Exp Rheumatol 29:238-47. 2011
  9. doi request reprint Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis
    Lars Klareskog
    Department of Medicine, Karolinska Institutet Karolinska University Hospital, Solna, Stockholm, Sweden
    Semin Immunol 23:92-8. 2011
  10. ncbi request reprint Smoking as a trigger for inflammatory rheumatic diseases
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden
    Curr Opin Rheumatol 19:49-54. 2007

Detail Information

Publications117 found, 100 shown here

  1. pmc Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis
    Yun Liu
    Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Biotechnol 31:142-7. 2013
    ..01), with the rest showing suggestive association, in monocyte cell fractions in an independent cohort of 12 cases and 12 controls. Thus, DNA methylation is a potential mediator of genetic risk...
  2. pmc Anti-type II collagen antibodies are associated with early radiographic destruction in rheumatoid arthritis
    Mohammed Mullazehi
    Clinical Immunology, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory C5, Uppsala University, Uppsala, SE 75185, Sweden
    Arthritis Res Ther 14:R100. 2012
    ..We therefore hypothesized that anti-CII are also associated with early erosions...
  3. doi request reprint Autoimmunity in rheumatoid arthritis: citrulline immunity and beyond
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, Solna, Stockholm, Sweden
    Adv Immunol 118:129-58. 2013
    ....
  4. pmc Usage of skin care products and risk of rheumatoid arthritis: results from the Swedish EIRA study
    Berit M Sverdrup
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Arthritis Res Ther 14:R41. 2012
    ....
  5. pmc Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study
    Sudha Visvanathan
    Centocor Research and Development, Inc, 200 Great Valley Parkway, Malvern, PA 19355, USA
    Arthritis Res Ther 12:R211. 2010
    ..The goal of this study was to identify serum markers that are modulated by treatment with golimumab with or without methotrexate (MTX) and are associated with clinical response...
  6. ncbi request reprint Genes, environment and immunity in the development of rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    Curr Opin Immunol 18:650-5. 2006
    ....
  7. doi request reprint Immunity to citrullinated proteins in rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, SE 171 76, Stockholm, Sweden
    Annu Rev Immunol 26:651-75. 2008
    ..The model provides a new basis for molecular studies on the pathogenesis of ACPA-positive arthritis...
  8. ncbi request reprint Assessment of long-term safety and efficacy of etanercept in a 5-year extension study in patients with rheumatoid arthritis
    L Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Clin Exp Rheumatol 29:238-47. 2011
    ..To evaluate long-term safety and efficacy of etanercept (ETN) in patients with rheumatoid arthritis (RA) without concomitant disease-modifying antirheumatic drug therapy...
  9. doi request reprint Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis
    Lars Klareskog
    Department of Medicine, Karolinska Institutet Karolinska University Hospital, Solna, Stockholm, Sweden
    Semin Immunol 23:92-8. 2011
    ....
  10. ncbi request reprint Smoking as a trigger for inflammatory rheumatic diseases
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden
    Curr Opin Rheumatol 19:49-54. 2007
    ....
  11. doi request reprint Antibodies to citrullinated proteins in arthritis: pathology and promise
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    Curr Opin Rheumatol 20:300-5. 2008
    ....
  12. doi request reprint Prevention of autoimmune rheumatic disease: state of the art and future perspectives
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Solna, Stockholm, Sweden
    Ann Rheum Dis 69:2062-6. 2010
    ..Thus, the road map towards prevention of autoimmune rheumatic diseases includes increased understanding of how genes, environment and immunity interact...
  13. doi request reprint On the origins of complex immune-mediated disease: the example of rheumatoid arthritis
    Lars Klareskog
    Department of Medicine, Karolinska Institutet Karolinska University Hospital, Solna, Stockholm, Sweden
    J Mol Med (Berl) 87:357-62. 2009
    ....
  14. pmc Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis
    Maria Seddighzadeh
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Eur J Hum Genet 18:821-6. 2010
    ..This finding may lead to the development of treatment based on enhancing the protective features of 5-HT2A in individuals with a certain HLA genotype...
  15. doi request reprint Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile
    Karin Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm 171 76, Sweden
    Ann Rheum Dis 72:652-8. 2013
    ....
  16. doi request reprint Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor alpha therapies: does the risk change with the time since start of treatment?
    Johan Askling
    Department of Medicine Solna, Karolinska University Hospital at Solna and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:3180-9. 2009
    ..To determine the short-term and medium-term risks of cancer in patients receiving anti-tumor necrosis factor alpha (anti-TNFalpha) therapies that have proven effective in the treatment of chronic inflammatory conditions...
  17. ncbi request reprint Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis
    Dimitrios Makrygiannakis
    Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 54:1463-72. 2006
    ..We undertook this study to investigate the effect of intraarticular corticosteroids on the synovial expression of RANKL and osteoprotegerin (OPG)...
  18. pmc Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region
    Bo Ding
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:30-8. 2009
    ....
  19. pmc Time-dependent increase in risk of hospitalisation with infection among Swedish RA patients treated with TNF antagonists
    Johan Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 66:1339-44. 2007
    ..An observational cohort study was performed using prospectively collected data from the Swedish Biologics Register (ARTIS) and other national Swedish registers...
  20. pmc Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis
    Henrik Kallberg
    Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Hum Genet 80:867-75. 2007
    ..The data extend the basis for a pathogenetic hypothesis for RA involving genetic and environmental factors. The study also raises and illustrates principal questions concerning ways to define interactions in complex diseases...
  21. doi request reprint Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis
    Emeli Lundström
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:924-30. 2009
    ....
  22. doi request reprint Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis
    Hiba Mahdi
    Rheumatology Unit, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden
    Nat Genet 41:1319-24. 2009
    ..We conclude that citrullinated alpha-enolase is a specific citrullinated autoantigen that links smoking to genetic risk factors in the development of RA...
  23. ncbi request reprint A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Arthritis Rheum 54:38-46. 2006
    ..To investigate whether smoking and HLA-DR shared epitope (SE) genes may interact in triggering immune reactions to citrulline-modified proteins...
  24. pmc Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA)
    Chun Lai Too
    Rheumatology Unit, Department of Medicine, Center of Molecular Medicine L8 04, Karolinska University Hospital, 17176 Stockholm, Sweden
    Arthritis Res Ther 14:R89. 2012
    ....
  25. doi request reprint Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients
    Omri Snir
    Karolinska University Hospital, Karolinska Institutet at Solna, Stockholm, Sweden
    Arthritis Rheum 62:44-52. 2010
    ..Furthermore, we studied their relationships with mutated citrullinated vimentin (MCV), a newly identified RA-specific serum assay, and the classic cyclic citrullinated peptide (CCP) in the synovial fluid of well-defined HLA-DR groups...
  26. ncbi request reprint Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway
    Marina Korotkova
    Rheumatology Research Laboratory, CMM L8 04, Karolinska Institutet, Karolinska University Hospital, Stockholm S 17176, Sweden
    Arthritis Rheum 52:3439-47. 2005
    ..This study was carried out to determine the effects of tumor necrosis factor (TNF) blockers and glucocorticoids on mPGES-1 and cyclooxygenase (COX) expression, as well as biosynthesis of PGE(2) in rheumatoid joints...
  27. pmc Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis
    Mauro D'Amato
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e9315. 2010
    ..We sought to determine whether genetic variability at the NPSR1 locus influences the susceptibility and clinical manifestation of rheumatoid arthritis (RA)...
  28. ncbi request reprint Anti-tumor necrosis factor therapy increases synovial osteoprotegerin expression in rheumatoid arthritis
    Anca Irinel Catrina
    Rheumatology Research Laboratory, Karolinska University Hospital, Karolinska Institutet, S 17176 Stockholm, Sweden
    Arthritis Rheum 54:76-81. 2006
    ..In order to add to such knowledge, we investigated the effect of anti-TNF therapy on the expression of osteoprotegerin (OPG) and receptor activator of NF-kappaB ligand (RANKL) in synovial tissue...
  29. ncbi request reprint Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels
    Erik af Klint
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 52:3880-9. 2005
    ..To investigate whether intraarticular (IA) glucocorticoid (GC) therapy diminishes synovial cell infiltration, vascularity, expression of proinflammatory cytokines, and adhesion molecule levels in patients with chronic arthritides...
  30. doi request reprint Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritis
    Judit Laki
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 64:2078-84. 2012
    ....
  31. pmc Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis
    Marina Korotkova
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Eur J Hum Genet 19:908-14. 2011
    ..Genetically predisposed individuals may develop earlier and more active disease owing to this mechanism...
  32. ncbi request reprint Treatment with rituximab affects both the cellular and the humoral arm of the immune system in patients with SLE
    Therese Vallerskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden
    Clin Immunol 122:62-74. 2007
    ..In conclusion, both the humoral and the cellular immune systems were affected by treatment with rituximab...
  33. pmc Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important
    Emeli Lundström
    Karolinska Institutet, Rheumatology Unit, Department of Medicine, Stockholm, Sweden
    Arthritis Rheum 60:1597-603. 2009
    ..We aimed to further investigate this interaction between distinct SE alleles and smoking regarding the risk of developing RA with and without anti-citrullinated protein antibodies (ACPAs)...
  34. doi request reprint Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Reg
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheum 63:26-36. 2011
    ..To determine whether cigarette smoking influences the response to treatment in patients with early rheumatoid arthritis (RA)...
  35. ncbi request reprint Antitissue transglutaminase and antithyroid autoantibodies in children with Down syndrome and celiac disease
    Tony Hansson
    Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden
    J Pediatr Gastroenterol Nutr 40:170-4; discussion 125-7. 2005
    ..We measured circulating autoantibodies and evaluated the potential of circulating antitissue transglutaminase (tTG) antibodies to determine the presence of celiac disease (CD) in children with Down syndrome...
  36. doi request reprint Serial re-challenge with influenza vaccine as a tool to study individual immune responses
    Therese Vallerskog
    Rheumatology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    J Immunol Methods 339:165-74. 2008
    ..The method also allows humoral memory and immune competence per se to be studied on a cellular level in different patient groups...
  37. pmc Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis
    Wolfgang Hueber
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA
    Arthritis Res Ther 11:R76. 2009
    ..Since no clinical or laboratory tests are available to predict response to anti-TNF therapies, great need exists for predictive biomarkers...
  38. pmc Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor
    Sofia Ernestam
    Department of Rheumatology, Karolinska University Hospital, S 141 86 Stockholm, Sweden
    Arthritis Res Ther 8:R18. 2006
    ..Consequently, we propose that IL-15 should remain as a therapeutic target in RA, regardless of the response to TNF blockade...
  39. pmc Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients
    Johan Lindberg
    School of Biotechnology, Department of Gene Technology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden
    Arthritis Res Ther 8:R179. 2006
    ..In conclusion, this pilot study suggests that further investigation is warranted on the usefulness of gene expression profiling of synovial tissue to predict and monitor the outcome of rheumatoid arthritis therapies...
  40. ncbi request reprint No increased occurrence of ischemic heart disease prior to the onset of rheumatoid arthritis: results from two Swedish population-based rheumatoid arthritis cohorts
    Marie E Holmqvist
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:2861-9. 2009
    ....
  41. pmc Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case-control study
    Berit Sverdrup
    Department of Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Arthritis Res Ther 7:R1296-303. 2005
    ..The findings are of particular interest since the same mineral oils can induce polyarthritis in rats...
  42. pmc Etanercept versus etanercept plus methotrexate: a registry-based study suggesting that the combination is clinically more efficacious
    Ronald F van Vollenhoven
    Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden
    Arthritis Res Ther 5:R347-51. 2003
    ..Other disease outcomes showed non-significant trends in the same direction. These data suggest that the combination of etanercept plus MTX is clinically more efficacious than etanercept alone...
  43. doi request reprint Familial risks and heritability of rheumatoid arthritis: role of rheumatoid factor/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age
    Thomas Frisell
    Karolinska Institutet, Solna, Sweden
    Arthritis Rheum 65:2773-82. 2013
    ....
  44. pmc CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease
    Duojia Cao
    Rheumatology Unit, Department of Medicine at Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Arthritis Res Ther 6:R335-46. 2004
    ..Their capacity to suppress both proliferation and cytokine secretion might contribute to a dampening of local inflammatory processes...
  45. ncbi request reprint Evidence for immunostimulatory effects of intramuscular gold in patients with rheumatoid arthritis: correlation with skin reactions
    Sofia Ernestam
    Department of Rheumatology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
    J Rheumatol 30:1748-55. 2003
    ..In this prospective study we investigated cytokine production in peripheral blood from patients with RA during treatment with GSTM...
  46. pmc Sulphasalazine inhibits human antigen-specific immune responses in vivo
    Christina Trollmo
    Rheumatology Unit, Department of Medicine, S 171 76 Karolinska Hospital, Stockholm, Sweden, and the Blood Bank, National University Hospital, Reykjavik, Iceland
    Ann Rheum Dis 66:481-5. 2007
    ..To study the effects of the antirheumatic drug sulphasalazine (SASP) on the immune system by analysing systemic and gut-associated immune responses...
  47. ncbi request reprint Evidence that anti-tumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis joints: extended report
    Anca Irinel Catrina
    Rheumatology Research Laboratory, CMM L8 04, Karolinska University Hospital, S 171 76 Stockholm, Sweden
    Arthritis Rheum 52:61-72. 2005
    ....
  48. pmc The gene expression profile in the synovium as a predictor of the clinical response to infliximab treatment in rheumatoid arthritis
    Johan Lindberg
    Department of Gene Technology, School of Biotechnology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden
    PLoS ONE 5:e11310. 2010
    ..In this work we have investigated the transcriptional profile of synovial tissue sampled from RA patients before anti-TNF treatment with the aim to identify biomarkers predictive of response...
  49. pmc A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis
    Leonid Padyukov
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 70:259-65. 2011
    ..The aim of the current study is to provide and compare GWAS data for both subsets...
  50. ncbi request reprint Silica exposure is associated with an increased risk of developing ACPA-positive rheumatoid arthritis in an Asian population: evidence from the Malaysian MyEIRA case-control study
    Abqariyah Yahya
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Mod Rheumatol 24:271-4. 2014
    ..In this study, we aimed at examining the association between silica exposure (and its interaction with smoking) and the risk of RA in the Malaysian population...
  51. pmc Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
    Khaled Amara
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, SE 171 76 Solna, Stockholm, Sweden
    J Exp Med 210:445-55. 2013
    ....
  52. pmc Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, D2 01, 17176 Stockholm, Sweden
    Arthritis Res Ther 13:R65. 2011
    ....
  53. ncbi request reprint Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations
    Johan Frostegard
    Center for Infectious Medicine and Center for Metabolism and Endocrinology, Department of Medicine, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Arthritis Rheum 52:192-200. 2005
    ..Autoantibodies to OxLDL are common in SLE and cross-react with anticardiolipin antibodies (aCL). We therefore hypothesized that lipid peroxidation is enhanced in patients with SLE in general...
  54. ncbi request reprint Dietary fish and fish oil and the risk of rheumatoid arthritis
    Magdalena Rosell
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 20:896-901. 2009
    ..Whether the intake of oily fish and fish oil might also protect against the development of rheumatoid arthritis is not known...
  55. pmc Modulating co-stimulation: a rational strategy in the treatment of rheumatoid arthritis?
    Vivianne Malmstrom
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Arthritis Res Ther 7:S15-20. 2005
    ..This review explores the potential for a therapy targeting the adaptive immune system by modulating co-stimulation of T cells with a CTLA4-Ig fusion protein (abatacept)...
  56. pmc Shared epitope alleles remain a risk factor for anti-citrullinated proteins antibody (ACPA)--positive rheumatoid arthritis in three Asian ethnic groups
    Too Chun-Lai
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e21069. 2011
    ..To investigate the associations between HLA-DRB1 shared epitope (SE) alleles and rheumatoid arthritis in subsets of rheumatoid arthritis defined by autoantibodies in three Asian populations from Malaysia...
  57. pmc The inflammatory reflex and risk for rheumatoid arthritis: a case-control study of human vagotomy
    Cecilia Carlens
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institute, Stockholm, Sweden
    Ann Rheum Dis 66:414-6. 2007
    ..21, 95% 1.11 to 1.33). Vagotomy has no specific effect on the risk of developing rheumatoid arthritis in humans. Gastroduodenal ulcers occur more often than expected even before the occurrence of rheumatoid arthritis...
  58. ncbi request reprint Risk and case characteristics of tuberculosis in rheumatoid arthritis associated with tumor necrosis factor antagonists in Sweden
    Johan Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institute, Stockholm, Sweden
    Arthritis Rheum 52:1986-92. 2005
    ....
  59. doi request reprint A1.1 Characterisation of lung inflammation and identification of shared citrullinated targets in the lungs and joints of early rheumatoid arthritis
    Vijay Joshua
    Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 73:A4-5. 2014
    ..To investigate if changes in the lungs are present in rheumatoid arthritis (RA) patients early in the disease process and to address the contribution of these changes to the initiation of the disease...
  60. pmc Implementation of the CDC translational informatics platform--from genetic variants to the national Swedish Rheumatology Quality Register
    Imad Abugessaisa
    Department of Medicine, The Unit of Computational Medicine, Center for Molecular Medicine, Karolinska Institutet, Solna, Sweden
    J Transl Med 11:85. 2013
    ....
  61. ncbi request reprint A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis
    Leonid Padyukov
    Karolinska Institutet, Stockholm, Sweden, and Mechnikov Research Institute, Stockholm, Sweden
    Arthritis Rheum 50:3085-92. 2004
    ..We studied a potential gene-environment interaction between SE genes and smoking in the etiology of the 2 major subgroups of RA: rheumatoid factor (RF)-seropositive and RF-seronegative disease...
  62. doi request reprint Variants within STAT genes reveal association with anticitrullinated protein antibody-negative rheumatoid arthritis in 2 European populations
    Maria Seddighzadeh
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Rheumatol 39:1509-16. 2012
    ..We investigated the association of STAT3 and STAT4 polymorphisms with serologically distinct subgroups of rheumatoid arthritis (RA)...
  63. doi request reprint Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis
    Thierry Dervieux
    Exagen Diagnostics, Inc, Albuquerque, New Mexico, USA
    Pharmacogenet Genomics 22:1-9. 2012
    ..We sought to elucidate architecture of methotrexate response in three cohorts of patients with RA treated with methotrexate...
  64. ncbi request reprint Association of arthritis with a gene complex encoding C-type lectin-like receptors
    Johnny C Lorentzen
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, S 17176 Stockholm, Sweden
    Arthritis Rheum 56:2620-32. 2007
    ..To identify susceptibility genes in a rat model of rheumatoid arthritis (RA) and to determine whether the corresponding human genes are associated with RA...
  65. doi request reprint Ten years with biologics: to whom do data on effectiveness and safety apply?
    Julia F Simard
    Department of Medicine, Clinical Epidemiology Unit, T2, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Rheumatology (Oxford) 50:204-13. 2011
    ..The aim of this study was to assess the extent to which contemporary patients who start or switch biologic therapies are comparable with those patients who gave rise to the currently available data on effectiveness and safety...
  66. ncbi request reprint Mechanisms of disease: Genetic susceptibility and environmental triggers in the development of rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Nat Clin Pract Rheumatol 2:425-33. 2006
    ..Increased knowledge about these and other events involved in the development of RA should enable the design of new tools for suppressing RA pathogenesis before the onset of disease...
  67. ncbi request reprint Rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Lancet 373:659-72. 2009
    ..Understanding the cause and pathogenesis of different rheumatoid arthritis subsets will lead not only to individualised treatments during early phases of the illness but also, possibly, to disease prevention...
  68. ncbi request reprint Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with up-regulation of the tumor necrosis factor alpha/tumor necrosis factor receptor system in systemic lupus erythematosus
    Elisabet Svenungsson
    Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Arthritis Rheum 48:2533-40. 2003
    ....
  69. ncbi request reprint Cardiovascular disease a hazard despite improved prognosis in patients with systemic lupus erythematosus: results from a Swedish population based study 1964-95
    Lena Björnådal
    Rheumatology Unit, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden
    J Rheumatol 31:713-9. 2004
    ..Although short term prognosis has improved in patients with systemic lupus erythematosus (SLE) during the early disease course, less is known about the longterm prognosis...
  70. doi request reprint Does cancer that occurs during or after anti-tumor necrosis factor therapy have a worse prognosis? A national assessment of overall and site-specific cancer survival in rheumatoid arthritis patients treated with biologic agents
    Pauline Raaschou
    Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 63:1812-22. 2011
    ..While data on the incidence of cancer following anti-TNF therapy have been published, the purpose of this study was to examine the clinical presentation and outcome of cancers that develop during or after anti-TNF therapy...
  71. doi request reprint Association between body mass index and anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis: results from a population-based case-control study
    Annmarie Wesley
    Karolinska Institute, Stockholm, Sweden
    Arthritis Care Res (Hoboken) 65:107-12. 2013
    ..The aim of this study was to investigate the association between body mass index (BMI) and the risk of developing the 2 main subtypes of RA...
  72. doi request reprint Smoking is associated with an increased risk of developing ACPA-positive but not ACPA-negative rheumatoid arthritis in Asian populations: evidence from the Malaysian MyEIRA case-control study
    Abqariyah Yahya
    Institute of Environmental Medicine, Karolinska Institutet, Nobel väg 13, Box 210, 171 77, Stockholm, Sweden
    Mod Rheumatol 22:524-31. 2012
    ..1-9.8; at least 20 pack-years OR = 5.2, 95% CI 1.6-17.6). Hence, smoking is associated with an increased risk of ACPA-positive RA in the Malaysian population, in which the genetic context is similar to several other Asian countries...
  73. pmc Evaluation of arthroscopy and macroscopic scoring
    Erik af Klint
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, S 171 76 Stockholm, Sweden
    Arthritis Res Ther 11:R81. 2009
    ..For microscopic measurements scoring systems have been developed and validated, but for macroscopic evaluations there is a need for further comprehensive description and validation of equivalent scoring systems...
  74. doi request reprint MS analysis of rheumatoid arthritic synovial tissue identifies specific citrullination sites on fibrinogen
    Monika Hermansson
    Department of Medicine, Unit of Rheumatology Karolinska Biomics Center, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    Proteomics Clin Appl 4:511-8. 2010
    ..Induced expression of citrullinated proteins are frequently detected in various inflammatory states including arthritis; however, direct detection of citrullination in arthritic samples has not been successfully performed in the past...
  75. pmc Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity
    Karin Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Arthritis Res Ther 7:R458-67. 2005
    ..We also show that citrullinated proteins and the enzyme PAD4 are not detectable in healthy joints, and that the appearance and amounts in arthritic joints of experimental animals are correlated with the severity of inflammation...
  76. ncbi request reprint Risk of malignant lymphomas in patients with rheumatoid arthritis and in their first-degree relatives
    Karin Ekström
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 48:963-70. 2003
    ....
  77. ncbi request reprint Clinical responses to tumor necrosis factor alpha antagonists do not show a bimodal distribution: data from the Stockholm tumor necrosis factor alpha followup registry
    Ronald F van Vollenhoven
    Karolinska Hospital, Stockholm, Sweden
    Arthritis Rheum 48:1500-3. 2003
    ....
  78. ncbi request reprint Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institute Karolinska Hospital, Stockholm 17176, Sweden
    Lancet 363:675-81. 2004
    ..We aimed to assess combination treatment with etanercept and methotrexate versus the monotherapies in patients with rheumatoid arthritis...
  79. ncbi request reprint Corticosteroids--from an idea to clinical use
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine at Karolinska Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Best Pract Res Clin Rheumatol 18:7-19. 2004
    ..Perhaps the results in the first comparative studies would have been different if individual response criteria had been used. This is discussed in this chapter...
  80. doi request reprint A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis
    Maja Jagodic
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Sci Transl Med 1:10ra21. 2009
    ..We conclude that VAV1 plays a central role in controlling central nervous system immune-mediated disease and proinflammatory cytokine production critical for disease pathogenesis...
  81. ncbi request reprint How is clinical progress achieved?
    Lars Klareskog
    Department of Medicine, Rheumatology Unit, Karolinska Institutet Karolinska Hospital, S 171 76 Stockholm, Sweden
    Best Pract Res Clin Rheumatol 18:1-5. 2004
  82. doi request reprint Common vaccinations among adults do not increase the risk of developing rheumatoid arthritis: results from the Swedish EIRA study
    Camilla Bengtsson
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, S 171 77 Stockholm, Sweden
    Ann Rheum Dis 69:1831-3. 2010
    ..To investigate the association between vaccinations in adults and the risk of developing rheumatoid arthritis (RA)...
  83. ncbi request reprint The Swedish Twin Registry in the third millennium: an update
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Twin Res Hum Genet 9:875-82. 2006
    ..In particular, we describe recent efforts to screen all twins born between 1959 and 1985, and young twin pairs when they turn 9 and 12 years of age. For these studies, we present initial frequencies of common conditions and exposures...
  84. pmc Effects of GSTM1 in rheumatoid arthritis; results from the Swedish EIRA study
    Emeli Lundström
    Department of Rheumatology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e17880. 2011
    ....
  85. pmc GEIRA: gene-environment and gene-gene interaction research application
    Bo Ding
    Institute of Environmental Medicine, Karolinska Institutet, SE 171 77, Box 210, Stockholm, Sweden
    Eur J Epidemiol 26:557-61. 2011
    ..The algorithm is coded in both SAS and R. GEIRA is freely available to non-commercial users at http://www.epinet.se. Additional information, including user's manual and example datasets is available online at http://www.epinet.se...
  86. ncbi request reprint MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction
    Maria Swanberg
    Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden
    Nat Genet 37:486-94. 2005
    ..We conclude that polymorphisms in Mhc2ta and MHC2TA result in differential MHC molecule expression and are associated with susceptibility to common complex diseases with inflammatory components...
  87. pmc Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke
    Henrik Kallberg
    Correspondence to Dr Henrik Källberg, Institute of Environmental Medicine, Box 210, Karolinska Institutet, 171 77 Stockholm, Sweden
    Ann Rheum Dis 70:508-11. 2011
    ..Less is known on how smoking contributes to RA in the context of genetic variability, and what proportion of RA may be caused by smoking...
  88. ncbi request reprint Decreasing mortality in patients with rheumatoid arthritis: results from a large population based cohort in Sweden, 1964-95
    Lena Björnådal
    Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden
    J Rheumatol 29:906-12. 2002
    ..To assess changes in mortality in patients with rheumatoid arthritis (RA) from 1964 to 1995...
  89. ncbi request reprint Recombinant human tissue transglutaminase for diagnosis and follow-up of childhood coeliac disease
    Tony Hansson
    Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden
    Pediatr Res 51:700-5. 2002
    ..The human recombinant tTG-based ELISA can be used as a sensitive and specific test to support the diagnosis and may also be used in the follow-up of treatment in childhood celiac disease...
  90. ncbi request reprint Polymorphism in promoter region of IL10 gene is associated with rheumatoid arthritis in women
    Leonid Padyukov
    Rheumatology Unit, Institute of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Rheumatol 31:422-5. 2004
    ..We investigated IL10 and TNFA gene polymorphisms in a group of Swedish women and men with RA compared with healthy individuals to estimate combinations of alleles specific for the disease...
  91. doi request reprint Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice
    Lena Svelander
    Karolinska Institutet, Department of Medicine, Rheumatology Unit, Stockholm, Sweden
    Eur J Pharmacol 613:155-62. 2009
    ..05). Inhibition of cathepsin K activity exerts beneficial effects on collagen-induced arthritis in mice and thus warrants further investigation as a therapeutic intervention in human rheumatoid arthritis...
  92. pmc Genes and environment in arthritis: can RA be prevented?
    Lars Klareskog
    Rheumatology Unit, Department of Medicine at Karolinska Hospital, Stockholm, Sweden
    Arthritis Res 4:S31-6. 2002
    ..Taken together, our data support the notion that concepts and data on gene-environment interactions in arthritis can now be taken from induced animal models of arthritis to generate new etiological hypotheses for RA...
  93. ncbi request reprint Statins in rheumatoid arthritis--two birds with one stone?
    Lars Klareskog
    Rheumatology and Atherosclerosis Research Units, Department of Medicine, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Lancet 363:2011-2. 2004
  94. pmc A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis
    Ewa Berglin
    Department of Public Health and Clinical Medicine, Division of Rheumatology, University Hospital, Umea, Sweden
    Arthritis Res Ther 6:R303-8. 2004
    ..9, 95% confidence interval 0.9-4.2). This study showed that the presence of anti-CCP antibodies together with SE gene carriage is associated with a very high relative risk for future development of RA...
  95. ncbi request reprint [Antibodies against citrullinated proteins--a breakthrough in rheumatologic diagnostics]
    Johan Ronnelid
    Enheten för klinisk immunologi, klinisk immunologi och transfusionsmedicin, Uppsala universitet Akademiska sjukhuset
    Lakartidningen 101:4092-6. 2004
    ..Due to its considerably higher specificity, the authors recommend that anti-CP antibody analysis should replace the RF test in primary healthcare when investigating cases of clinically suspect RA...
  96. ncbi request reprint Presentation and analysis of data on radiographic outcome in clinical trials: experience from the TEMPO study
    Desiree van der Heijde
    Rheumatology Department, University Hospital, Maastricht, The Netherlands
    Arthritis Rheum 52:49-60. 2005
    ..To evaluate different methods of presentation and analysis of radiographic data in a rheumatoid arthritis (RA) randomized controlled trial...
  97. ncbi request reprint Rheumatoid arthritis and malignant lymphomas
    Eva Baecklund
    Department of Rheumatology, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Curr Opin Rheumatol 16:254-61. 2004
    ..This review summarizes data on possible associations between RA and lymphomas, including different treatments and RA disease related risk factors...
  98. pmc Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
    ..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23...
  99. ncbi request reprint Lymphoma subtypes in patients with rheumatoid arthritis: increased proportion of diffuse large B cell lymphoma
    Eva Baecklund
    Department of Rheumatology, University Hospital, Uppsala, Sweden
    Arthritis Rheum 48:1543-50. 2003
    ....
  100. ncbi request reprint Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope
    Ludmila Prokunina
    Uppsala University, Uppsala, Sweden
    Arthritis Rheum 50:1770-3. 2004
    ..To study the frequency of allele A of polymorphism PD-1.3 of the PDCD1 gene in patients with rheumatoid arthritis (RA) and its subsets, based on the presence of rheumatoid factor (RF) and the shared epitope (SE) alleles...
  101. pmc European population substructure: clustering of northern and southern populations
    Michael F Seldin
    Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California Davis, Davis, California, United States of America
    PLoS Genet 2:e143. 2006
    ..Based on this work, we have developed a core set of informative SNP markers that can control for this partition in European population structure in a variety of clinical and genetic studies...