Lars Klareskog

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity
    Lina M Olsson
    Medical Inflammation Research, Lund University, BMC I11, 221 84, Lund, Sweden
    Arthritis Res Ther 9:R98. 2007
  2. ncbi Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis
    Wolfgang Hueber
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA
    Arthritis Res Ther 11:R76. 2009
  3. ncbi Variability in synovial inflammation in rheumatoid arthritis investigated by microarray technology
    Johan Lindberg
    Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology, S-106 91 Stockholm, Sweden
    Arthritis Res Ther 8:R47. 2006
  4. ncbi [The proposal of the National Board of Health and Welfare counteracts knowledge development within health care]
    Lars Klareskog
    , Karolinska sjukhuset/Karolinska institutet, Stockholm
    Lakartidningen 100:631-2. 2003
  5. ncbi Statins in rheumatoid arthritis--two birds with one stone?
    Lars Klareskog
    Rheumatology and Atherosclerosis Research Units, Department of Medicine, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Lancet 363:2011-2. 2004
  6. ncbi What precedes development of rheumatoid arthritis?
    L Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Ann Rheum Dis 63:ii28-ii31. 2004
  7. ncbi Genes and environment in arthritis: can RA be prevented?
    Lars Klareskog
    Rheumatology Unit, Department of Medicine at Karolinska Hospital, Stockholm, Sweden
    Arthritis Res 4:S31-6. 2002
  8. ncbi A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Arthritis Rheum 54:38-46. 2006
  9. ncbi Mechanisms of disease: Genetic susceptibility and environmental triggers in the development of rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Nat Clin Pract Rheumatol 2:425-33. 2006
  10. ncbi Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institute Karolinska Hospital, Stockholm 17176, Sweden
    Lancet 363:675-81. 2004

Detail Information

Publications149 found, 100 shown here

  1. ncbi A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity
    Lina M Olsson
    Medical Inflammation Research, Lund University, BMC I11, 221 84, Lund, Sweden
    Arthritis Res Ther 9:R98. 2007
    ....
  2. ncbi Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis
    Wolfgang Hueber
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA
    Arthritis Res Ther 11:R76. 2009
    ..Since no clinical or laboratory tests are available to predict response to anti-TNF therapies, great need exists for predictive biomarkers...
  3. ncbi Variability in synovial inflammation in rheumatoid arthritis investigated by microarray technology
    Johan Lindberg
    Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology, S-106 91 Stockholm, Sweden
    Arthritis Res Ther 8:R47. 2006
    ..This revealed representative 'themes' likely to vary between synovial biopsies affected by inflammatory disease...
  4. ncbi [The proposal of the National Board of Health and Welfare counteracts knowledge development within health care]
    Lars Klareskog
    , Karolinska sjukhuset/Karolinska institutet, Stockholm
    Lakartidningen 100:631-2. 2003
  5. ncbi Statins in rheumatoid arthritis--two birds with one stone?
    Lars Klareskog
    Rheumatology and Atherosclerosis Research Units, Department of Medicine, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Lancet 363:2011-2. 2004
  6. ncbi What precedes development of rheumatoid arthritis?
    L Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Ann Rheum Dis 63:ii28-ii31. 2004
    ..We conclude that, in a certain genetic context, smoking is a potential trigger of RA, and a combination of the two factors is associated with the occurrence of immune reactions long before the onset of RA...
  7. ncbi Genes and environment in arthritis: can RA be prevented?
    Lars Klareskog
    Rheumatology Unit, Department of Medicine at Karolinska Hospital, Stockholm, Sweden
    Arthritis Res 4:S31-6. 2002
    ..Taken together, our data support the notion that concepts and data on gene-environment interactions in arthritis can now be taken from induced animal models of arthritis to generate new etiological hypotheses for RA...
  8. ncbi A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Arthritis Rheum 54:38-46. 2006
    ..To investigate whether smoking and HLA-DR shared epitope (SE) genes may interact in triggering immune reactions to citrulline-modified proteins...
  9. ncbi Mechanisms of disease: Genetic susceptibility and environmental triggers in the development of rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Nat Clin Pract Rheumatol 2:425-33. 2006
    ..Increased knowledge about these and other events involved in the development of RA should enable the design of new tools for suppressing RA pathogenesis before the onset of disease...
  10. ncbi Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institute Karolinska Hospital, Stockholm 17176, Sweden
    Lancet 363:675-81. 2004
    ..We aimed to assess combination treatment with etanercept and methotrexate versus the monotherapies in patients with rheumatoid arthritis...
  11. ncbi A long-term, open-label trial of the safety and efficacy of etanercept (Enbrel) in patients with rheumatoid arthritis not treated with other disease-modifying antirheumatic drugs
    L Klareskog
    Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm 17176, Sweden
    Ann Rheum Dis 65:1578-84. 2006
    ..To evaluate the long-term safety and efficacy of etanercept in patients with rheumatoid arthritis...
  12. ncbi Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis
    Maria Seddighzadeh
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Eur J Hum Genet 18:821-6. 2010
    ..This finding may lead to the development of treatment based on enhancing the protective features of 5-HT2A in individuals with a certain HLA genotype...
  13. ncbi Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor alpha therapies: does the risk change with the time since start of treatment?
    Johan Askling
    Department of Medicine Solna, Karolinska University Hospital at Solna and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:3180-9. 2009
    ..To determine the short-term and medium-term risks of cancer in patients receiving anti-tumor necrosis factor alpha (anti-TNFalpha) therapies that have proven effective in the treatment of chronic inflammatory conditions...
  14. ncbi Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis
    Dimitrios Makrygiannakis
    Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 54:1463-72. 2006
    ..These findings offer a rationale for the beneficial effect of corticosteroids on joint erosion in arthritis...
  15. ncbi Time-dependent increase in risk of hospitalisation with infection among Swedish RA patients treated with TNF antagonists
    Johan Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 66:1339-44. 2007
    ..An observational cohort study was performed using prospectively collected data from the Swedish Biologics Register (ARTIS) and other national Swedish registers...
  16. ncbi Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region
    Bo Ding
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:30-8. 2009
    ....
  17. ncbi Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis
    Hiba Mahdi
    Rheumatology Unit, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden
    Nat Genet 41:1319-24. 2009
    ..We conclude that citrullinated alpha-enolase is a specific citrullinated autoantigen that links smoking to genetic risk factors in the development of RA...
  18. ncbi Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis
    Emeli Lundström
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:924-30. 2009
    ....
  19. ncbi Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway
    Marina Korotkova
    Rheumatology Research Laboratory, CMM L8 04, Karolinska Institutet, Karolinska University Hospital, Stockholm S 17176, Sweden
    Arthritis Rheum 52:3439-47. 2005
    ..This study was carried out to determine the effects of tumor necrosis factor (TNF) blockers and glucocorticoids on mPGES-1 and cyclooxygenase (COX) expression, as well as biosynthesis of PGE(2) in rheumatoid joints...
  20. ncbi Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis
    Patrik Stolt
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, S 171 77 Stockholm, Sweden
    Ann Rheum Dis 69:1072-6. 2010
    ..To study the association between silica exposure, separately as well as combined with smoking, and the risk of developing rheumatoid arthritis (RA) with or without the presence of antibodies against citrullinated peptide antigens (ACPA)...
  21. ncbi Anti-tumor necrosis factor therapy increases synovial osteoprotegerin expression in rheumatoid arthritis
    Anca Irinel Catrina
    Rheumatology Research Laboratory, Karolinska University Hospital, Karolinska Institutet, S 17176 Stockholm, Sweden
    Arthritis Rheum 54:76-81. 2006
    ..In order to add to such knowledge, we investigated the effect of anti-TNF therapy on the expression of osteoprotegerin (OPG) and receptor activator of NF-kappaB ligand (RANKL) in synovial tissue...
  22. ncbi Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis
    Mauro D'Amato
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e9315. 2010
    ..We sought to determine whether genetic variability at the NPSR1 locus influences the susceptibility and clinical manifestation of rheumatoid arthritis (RA)...
  23. ncbi Common vaccinations among adults do not increase the risk of developing rheumatoid arthritis: results from the Swedish EIRA study
    Camilla Bengtsson
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, S 171 77 Stockholm, Sweden
    Ann Rheum Dis 69:1831-3. 2010
    ..To investigate the association between vaccinations in adults and the risk of developing rheumatoid arthritis (RA)...
  24. ncbi Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritis
    Judit Laki
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 64:2078-84. 2012
    ....
  25. ncbi Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case-control study
    Berit Sverdrup
    Department of Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Arthritis Res Ther 7:R1296-303. 2005
    ..The findings are of particular interest since the same mineral oils can induce polyarthritis in rats...
  26. ncbi Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients
    Omri Snir
    Karolinska University Hospital, Karolinska Institutet at Solna, Stockholm, Sweden
    Arthritis Rheum 62:44-52. 2010
    ..Furthermore, we studied their relationships with mutated citrullinated vimentin (MCV), a newly identified RA-specific serum assay, and the classic cyclic citrullinated peptide (CCP) in the synovial fluid of well-defined HLA-DR groups...
  27. ncbi Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis
    Marina Korotkova
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Eur J Hum Genet 19:908-14. 2011
    ..Genetically predisposed individuals may develop earlier and more active disease owing to this mechanism...
  28. ncbi Etanercept versus etanercept plus methotrexate: a registry-based study suggesting that the combination is clinically more efficacious
    Ronald F van Vollenhoven
    Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden
    Arthritis Res Ther 5:R347-51. 2003
    ..Other disease outcomes showed non-significant trends in the same direction. These data suggest that the combination of etanercept plus MTX is clinically more efficacious than etanercept alone...
  29. ncbi Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis
    Henrik Kallberg
    Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Hum Genet 80:867-75. 2007
    ..The data extend the basis for a pathogenetic hypothesis for RA involving genetic and environmental factors. The study also raises and illustrates principal questions concerning ways to define interactions in complex diseases...
  30. ncbi Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients
    Johan Lindberg
    School of Biotechnology, Department of Gene Technology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden
    Arthritis Res Ther 8:R179. 2006
    ..In conclusion, this pilot study suggests that further investigation is warranted on the usefulness of gene expression profiling of synovial tissue to predict and monitor the outcome of rheumatoid arthritis therapies...
  31. ncbi Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor
    Sofia Ernestam
    Department of Rheumatology, Karolinska University Hospital, S 141 86 Stockholm, Sweden
    Arthritis Res Ther 8:R18. 2006
    ..Consequently, we propose that IL-15 should remain as a therapeutic target in RA, regardless of the response to TNF blockade...
  32. ncbi Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels
    Erik af Klint
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 52:3880-9. 2005
    ..These findings may reflect mechanisms controlling the transiency of clinical improvement frequently observed after IA GC injection...
  33. ncbi Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important
    Emeli Lundström
    Karolinska Institutet, Rheumatology Unit, Department of Medicine, Stockholm, Sweden
    Arthritis Rheum 60:1597-603. 2009
    ..We aimed to further investigate this interaction between distinct SE alleles and smoking regarding the risk of developing RA with and without anti-citrullinated protein antibodies (ACPAs)...
  34. ncbi Serial re-challenge with influenza vaccine as a tool to study individual immune responses
    Therese Vallerskog
    Rheumatology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    J Immunol Methods 339:165-74. 2008
    ..The method also allows humoral memory and immune competence per se to be studied on a cellular level in different patient groups...
  35. ncbi Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke
    Henrik Kallberg
    Correspondence to Dr Henrik Källberg, Institute of Environmental Medicine, Box 210, Karolinska Institutet, 171 77 Stockholm, Sweden
    Ann Rheum Dis 70:508-11. 2011
    ..Less is known on how smoking contributes to RA in the context of genetic variability, and what proportion of RA may be caused by smoking...
  36. ncbi Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Reg
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheum 63:26-36. 2011
    ..To determine whether cigarette smoking influences the response to treatment in patients with early rheumatoid arthritis (RA)...
  37. ncbi Antitissue transglutaminase and antithyroid autoantibodies in children with Down syndrome and celiac disease
    Tony Hansson
    Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden
    J Pediatr Gastroenterol Nutr 40:170-4; discussion 125-7. 2005
    ..We measured circulating autoantibodies and evaluated the potential of circulating antitissue transglutaminase (tTG) antibodies to determine the presence of celiac disease (CD) in children with Down syndrome...
  38. ncbi Treatment with rituximab affects both the cellular and the humoral arm of the immune system in patients with SLE
    Therese Vallerskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden
    Clin Immunol 122:62-74. 2007
    ..In conclusion, both the humoral and the cellular immune systems were affected by treatment with rituximab...
  39. ncbi Clinical responses to tumor necrosis factor alpha antagonists do not show a bimodal distribution: data from the Stockholm tumor necrosis factor alpha followup registry
    Ronald F van Vollenhoven
    Karolinska Hospital, Stockholm, Sweden
    Arthritis Rheum 48:1500-3. 2003
    ....
  40. ncbi Risk and case characteristics of tuberculosis in rheumatoid arthritis associated with tumor necrosis factor antagonists in Sweden
    Johan Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institute, Stockholm, Sweden
    Arthritis Rheum 52:1986-92. 2005
    ....
  41. ncbi A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis
    Leonid Padyukov
    Karolinska Institutet, Stockholm, Sweden, and Mechnikov Research Institute, Stockholm, Sweden
    Arthritis Rheum 50:3085-92. 2004
    ..We studied a potential gene-environment interaction between SE genes and smoking in the etiology of the 2 major subgroups of RA: rheumatoid factor (RF)-seropositive and RF-seronegative disease...
  42. ncbi A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis
    Leonid Padyukov
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 70:259-65. 2011
    ..The aim of the current study is to provide and compare GWAS data for both subsets...
  43. ncbi The gene expression profile in the synovium as a predictor of the clinical response to infliximab treatment in rheumatoid arthritis
    Johan Lindberg
    Department of Gene Technology, School of Biotechnology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden
    PLoS ONE 5:e11310. 2010
    ..In this work we have investigated the transcriptional profile of synovial tissue sampled from RA patients before anti-TNF treatment with the aim to identify biomarkers predictive of response...
  44. ncbi Evidence for immunostimulatory effects of intramuscular gold in patients with rheumatoid arthritis: correlation with skin reactions
    Sofia Ernestam
    Department of Rheumatology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
    J Rheumatol 30:1748-55. 2003
    ..In this prospective study we investigated cytokine production in peripheral blood from patients with RA during treatment with GSTM...
  45. ncbi Sulphasalazine inhibits human antigen-specific immune responses in vivo
    Christina Trollmo
    Rheumatology Unit, Department of Medicine, S 171 76 Karolinska Hospital, Stockholm, Sweden, and the Blood Bank, National University Hospital, Reykjavik, Iceland
    Ann Rheum Dis 66:481-5. 2007
    ..To study the effects of the antirheumatic drug sulphasalazine (SASP) on the immune system by analysing systemic and gut-associated immune responses...
  46. ncbi No increased occurrence of ischemic heart disease prior to the onset of rheumatoid arthritis: results from two Swedish population-based rheumatoid arthritis cohorts
    Marie E Holmqvist
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:2861-9. 2009
    ....
  47. ncbi Evidence that anti-tumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis joints: extended report
    Anca Irinel Catrina
    Rheumatology Research Laboratory, CMM L8 04, Karolinska University Hospital, S 171 76 Stockholm, Sweden
    Arthritis Rheum 52:61-72. 2005
    ....
  48. ncbi Shared epitope alleles remain a risk factor for anti-citrullinated proteins antibody (ACPA)--positive rheumatoid arthritis in three Asian ethnic groups
    Too Chun-Lai
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e21069. 2011
    ..To investigate the associations between HLA-DRB1 shared epitope (SE) alleles and rheumatoid arthritis in subsets of rheumatoid arthritis defined by autoantibodies in three Asian populations from Malaysia...
  49. ncbi Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA)
    Chun Lai Too
    Rheumatology Unit, Department of Medicine, Center of Molecular Medicine L8 04, Karolinska University Hospital, 17176 Stockholm, Sweden
    Arthritis Res Ther 14:R89. 2012
    ....
  50. ncbi Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, D2 01, 17176 Stockholm, Sweden
    Arthritis Res Ther 13:R65. 2011
    ....
  51. ncbi CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease
    Duojia Cao
    Rheumatology Unit, Department of Medicine at Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Arthritis Res Ther 6:R335-46. 2004
    ..Their capacity to suppress both proliferation and cytokine secretion might contribute to a dampening of local inflammatory processes...
  52. ncbi Does cancer that occurs during or after anti-tumor necrosis factor therapy have a worse prognosis? A national assessment of overall and site-specific cancer survival in rheumatoid arthritis patients treated with biologic agents
    Pauline Raaschou
    Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 63:1812-22. 2011
    ..While data on the incidence of cancer following anti-TNF therapy have been published, the purpose of this study was to examine the clinical presentation and outcome of cancers that develop during or after anti-TNF therapy...
  53. ncbi The inflammatory reflex and risk for rheumatoid arthritis: a case-control study of human vagotomy
    Cecilia Carlens
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institute, Stockholm, Sweden
    Ann Rheum Dis 66:414-6. 2007
    ..21, 95% 1.11 to 1.33). Vagotomy has no specific effect on the risk of developing rheumatoid arthritis in humans. Gastroduodenal ulcers occur more often than expected even before the occurrence of rheumatoid arthritis...
  54. ncbi Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations
    Johan Frostegard
    Center for Infectious Medicine and Center for Metabolism and Endocrinology, Department of Medicine, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Arthritis Rheum 52:192-200. 2005
    ..Autoantibodies to OxLDL are common in SLE and cross-react with anticardiolipin antibodies (aCL). We therefore hypothesized that lipid peroxidation is enhanced in patients with SLE in general...
  55. ncbi Cardiovascular disease a hazard despite improved prognosis in patients with systemic lupus erythematosus: results from a Swedish population based study 1964-95
    Lena Björnådal
    Rheumatology Unit, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden
    J Rheumatol 31:713-9. 2004
    ..Although short term prognosis has improved in patients with systemic lupus erythematosus (SLE) during the early disease course, less is known about the longterm prognosis...
  56. ncbi Dietary fish and fish oil and the risk of rheumatoid arthritis
    Magdalena Rosell
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Epidemiology 20:896-901. 2009
    ..Whether the intake of oily fish and fish oil might also protect against the development of rheumatoid arthritis is not known...
  57. ncbi Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis
    Thierry Dervieux
    Exagen Diagnostics, Inc, Albuquerque, New Mexico, USA
    Pharmacogenet Genomics 22:1-9. 2012
    ..We sought to elucidate architecture of methotrexate response in three cohorts of patients with RA treated with methotrexate...
  58. ncbi Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity
    Karin Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Arthritis Res Ther 7:R458-67. 2005
    ..We also show that citrullinated proteins and the enzyme PAD4 are not detectable in healthy joints, and that the appearance and amounts in arthritic joints of experimental animals are correlated with the severity of inflammation...
  59. ncbi Antibodies to citrullinated proteins in arthritis: pathology and promise
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    Curr Opin Rheumatol 20:300-5. 2008
    ....
  60. ncbi Immunity to citrullinated proteins in rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, SE 171 76, Stockholm, Sweden
    Annu Rev Immunol 26:651-75. 2008
    ..The model provides a new basis for molecular studies on the pathogenesis of ACPA-positive arthritis...
  61. ncbi Ten years with biologics: to whom do data on effectiveness and safety apply?
    Julia F Simard
    Department of Medicine, Clinical Epidemiology Unit, T2, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Rheumatology (Oxford) 50:204-13. 2011
    ..The aim of this study was to assess the extent to which contemporary patients who start or switch biologic therapies are comparable with those patients who gave rise to the currently available data on effectiveness and safety...
  62. ncbi Modulating co-stimulation: a rational strategy in the treatment of rheumatoid arthritis?
    Vivianne Malmstrom
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Arthritis Res Ther 7:S15-20. 2005
    ..This review explores the potential for a therapy targeting the adaptive immune system by modulating co-stimulation of T cells with a CTLA4-Ig fusion protein (abatacept)...
  63. ncbi Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis
    Lars Klareskog
    Department of Medicine, Karolinska Institutet Karolinska University Hospital, Solna, Stockholm, Sweden
    Semin Immunol 23:92-8. 2011
    ....
  64. ncbi Association of arthritis with a gene complex encoding C-type lectin-like receptors
    Johnny C Lorentzen
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, S 17176 Stockholm, Sweden
    Arthritis Rheum 56:2620-32. 2007
    ..To identify susceptibility genes in a rat model of rheumatoid arthritis (RA) and to determine whether the corresponding human genes are associated with RA...
  65. ncbi Rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Lancet 373:659-72. 2009
    ..Understanding the cause and pathogenesis of different rheumatoid arthritis subsets will lead not only to individualised treatments during early phases of the illness but also, possibly, to disease prevention...
  66. ncbi Smoking as a trigger for inflammatory rheumatic diseases
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden
    Curr Opin Rheumatol 19:49-54. 2007
    ....
  67. ncbi Increased peripheral T cell reactivity to microbial antigens and collagen type II in rheumatoid arthritis after treatment with soluble TNFalpha receptors
    L Berg
    Department of Medicine, Unit of Rheumatology, Karolinska Institute, Stockholm, Sweden
    Ann Rheum Dis 60:133-9. 2001
    ..This study sought to find out if and how RA T cell reactivity is affected during treatment with etanercept (Enbrel), a soluble TNFalpha receptor...
  68. ncbi Evaluation of arthroscopy and macroscopic scoring
    Erik af Klint
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, S 171 76 Stockholm, Sweden
    Arthritis Res Ther 11:R81. 2009
    ..For microscopic measurements scoring systems have been developed and validated, but for macroscopic evaluations there is a need for further comprehensive description and validation of equivalent scoring systems...
  69. ncbi Risk of malignant lymphomas in patients with rheumatoid arthritis and in their first-degree relatives
    Karin Ekström
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 48:963-70. 2003
    ....
  70. ncbi On the origins of complex immune-mediated disease: the example of rheumatoid arthritis
    Lars Klareskog
    Department of Medicine, Karolinska Institutet Karolinska University Hospital, Solna, Stockholm, Sweden
    J Mol Med (Berl) 87:357-62. 2009
    ....
  71. ncbi Anti-tumour necrosis factor therapy in rheumatoid arthritis and risk of malignant lymphomas: relative risks and time trends in the Swedish Biologics Register
    J Askling
    Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 68:648-53. 2009
    ....
  72. ncbi How is clinical progress achieved?
    Lars Klareskog
    Department of Medicine, Rheumatology Unit, Karolinska Institutet Karolinska Hospital, S 171 76 Stockholm, Sweden
    Best Pract Res Clin Rheumatol 18:1-5. 2004
  73. ncbi Anti-tumour necrosis factor (TNF)-alpha therapy (etanercept) down-regulates serum matrix metalloproteinase (MMP)-3 and MMP-1 in rheumatoid arthritis
    A I Catrina
    Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden
    Rheumatology (Oxford) 41:484-9. 2002
    ..CONCLUSIONS: In RA patients, etanercept therapy down-regulates serum levels of MMP-3 and MMP-1 and the ratio between MMPs and TIMP-1. This may be an important mechanism for the prevention of future development of joint damage...
  74. ncbi Adalimumab (Humira) restores clinical response in patients with secondary loss of efficacy from infliximab (Remicade) or etanercept (Enbrel): results from the STURE registry at Karolinska University Hospital
    M C Wick
    Department of Rheumatology, Karolinska University Hospital, Solna, Sweden
    Scand J Rheumatol 34:353-8. 2005
    ..001). ACR20 responses with adalimumab in groups A, B, and C were similar (70-78%). CONCLUSIONS: For patients with secondary loss of efficacy from infliximab or etanercept, switching to adalimumab can restore a good clinical response...
  75. ncbi Decreasing mortality in patients with rheumatoid arthritis: results from a large population based cohort in Sweden, 1964-95
    Lena Björnådal
    Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden
    J Rheumatol 29:906-12. 2002
    ..To assess changes in mortality in patients with rheumatoid arthritis (RA) from 1964 to 1995...
  76. ncbi Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with up-regulation of the tumor necrosis factor alpha/tumor necrosis factor receptor system in systemic lupus erythematosus
    Elisabet Svenungsson
    Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Arthritis Rheum 48:2533-40. 2003
    ....
  77. ncbi Corticosteroids--from an idea to clinical use
    Ingrid E Lundberg
    Rheumatology Unit, Department of Medicine at Karolinska Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Best Pract Res Clin Rheumatol 18:7-19. 2004
    ..Perhaps the results in the first comparative studies would have been different if individual response criteria had been used. This is discussed in this chapter...
  78. ncbi Treatment with tumour necrosis factor alpha antagonists in patients with rheumatoid arthritis induces anticardiolipin antibodies
    T Jonsdottir
    Department of Rheumatology, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 63:1075-8. 2004
    ..To determine the frequency and clinical impact of anticardiolipin antibodies (aCL) in patients with rheumatoid arthritis treated with infliximab and etanercept...
  79. ncbi Infliximab dosage and infusion frequency in clinical practice: experiences in the Stockholm biologics registry STURE
    R F van Vollenhoven
    Department of Rheumatology, Karolinska University Hospital, Stockholm, Sweden
    Scand J Rheumatol 36:418-23. 2007
    ..To characterize dosages and frequencies of infliximab in a publicly financed health-care system without administrative restrictions on the use of biologics...
  80. ncbi Risks of solid cancers in patients with rheumatoid arthritis and after treatment with tumour necrosis factor antagonists
    J Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 64:1421-6. 2005
    ..Existing studies of solid cancers in rheumatoid arthritis (RA) reflect cancer morbidity up until the early 1990s in prevalent cohorts admitted to hospital during the 1980s...
  81. ncbi Haematopoietic malignancies in rheumatoid arthritis: lymphoma risk and characteristics after exposure to tumour necrosis factor antagonists
    J Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 64:1414-20. 2005
    ..Patients with rheumatoid arthritis (RA) are at increased risk of malignant lymphomas, and maybe also of leukaemia and multiple myeloma. The effect of tumour necrosis factor (TNF) antagonists on lymphoma risk and characteristics is unclear...
  82. ncbi Clinical and radiological disease-course in a Swedish DMARD-treated early RA-inception cohort: an observational study
    M C Wick
    Department of Medicine at Karolinska University Hospital, Stockholm, Sweden
    Scand J Rheumatol 33:380-4. 2004
    ..The objective of this study was to identify whether successful clinical disease-control in a Swedish early RA-inception cohort of patients led to an attenuation of radiological progression...
  83. ncbi Alcohol consumption is associated with decreased risk of rheumatoid arthritis: results from two Scandinavian case-control studies
    H Kallberg
    Institute of Environmental Medicine, Box 210, Karolinska Institutet, 17177 Stockholm, Sweden
    Ann Rheum Dis 68:222-7. 2009
    ..To determine the association between risk of rheumatoid arthritis (RA) and alcohol consumption in combination with smoking and HLA-DRB1 shared epitope (SE)...
  84. ncbi Increased levels of proinflammatory cytokines and nitric oxide metabolites in neuropsychiatric lupus erythematosus
    E Svenungsson
    Department of Medicine, Rheumatology Unit, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Ann Rheum Dis 60:372-9. 2001
    ..To investigate systemic and intrathecal production of proinflammatory cytokines in relation to cerebrospinal fluid (CSF) nitric oxide (NO) release in patients with neuropsychiatric lupus erythematosus (NPLE)...
  85. ncbi Do steroids increase lymphoma risk? A case-control study of lymphoma risk in polymyalgia rheumatica/giant cell arteritis
    J Askling
    Clinical Epidemiology Unit M9 01, Department of Medicine, Karolinska University Hospital Solna, SE 171 77 Stockholm, Sweden
    Ann Rheum Dis 64:1765-8. 2005
    ..Polymyalgia rheumatica (PMR) and temporal arteritis (giant cell arteritis, GCA) are common inflammatory conditions treated with steroids as single immunosuppressive therapy, but data on lymphoma risk in GCA/PMR are limited...
  86. ncbi Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis
    L Padyukov
    Unit of Rheumatology, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 62:526-9. 2003
    ..This is the case with the tumour necrosis factor (TNF) blocking agents, where 20-40% of patients have been described as non-responders. No predictive markers exist as yet for the prognosis of response...
  87. ncbi Risk for malignant lymphoma in ankylosing spondylitis: a nationwide Swedish case-control study
    J Askling
    Department of Medicine, Clinical Epidemiology Unit M9 01, Karolinska University Hospital Solna, SE 171 77, Stockholm, Sweden
    Ann Rheum Dis 65:1184-7. 2006
    ..Besides inflammation-lymphoma aetiology, information on risk of lymphoma in ankylosing spondylitis is particularly important as a benchmark in the evaluation of, for example, tumour necrosis factor inhibitors...
  88. ncbi Silica exposure is associated with increased risk of developing rheumatoid arthritis: results from the Swedish EIRA study
    P Stolt
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, S 171 77 Stockholm, Sweden
    Ann Rheum Dis 64:582-6. 2005
    ..To study the association between silica exposure and rheumatoid arthritis and how it is modified by cigarette smoking...
  89. ncbi Interindividual and intra-articular variation of proinflammatory cytokines in patients with rheumatoid arthritis: potential implications for treatment
    A K Ulfgren
    Department of Medicine Unit of Rheumatology, Karolinska Hospital, Stockholm, Sweden
    Ann Rheum Dis 59:439-47. 2000
    ....
  90. ncbi Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases
    P Stolt
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, S 171 77 Stockholm, Sweden
    Ann Rheum Dis 62:835-41. 2003
    ..To quantify the influence of cigarette smoking on the risk of developing rheumatoid arthritis (RA)...
  91. ncbi Genes, environment and immunity in the development of rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    Curr Opin Immunol 18:650-5. 2006
    ....
  92. ncbi The Swedish Twin Registry in the third millennium: an update
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Twin Res Hum Genet 9:875-82. 2006
    ..In particular, we describe recent efforts to screen all twins born between 1959 and 1985, and young twin pairs when they turn 9 and 12 years of age. For these studies, we present initial frequencies of common conditions and exposures...
  93. ncbi Effects of gold on cytokine production in vitro; increase of monocyte dependent interleukin 10 production and decrease of interferon-gamma levels
    Jon Lampa
    Department of Rheumatology, Karolinska Institute, Stockholm, Sweden
    J Rheumatol 29:21-8. 2002
    ..To investigate the effects of gold salt on the differential production of proinflammatory and antiinflammatory cytokines in vitro...
  94. ncbi Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles
    O Snir
    Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institute, Solna, Stockholm, Sweden
    Ann Rheum Dis 68:736-43. 2009
    ..Autoantibodies to cyclic citrullinated peptides (anti-CCP) are present in most patients with rheumatoid arthritis (RA), and associate with HLA-DRB1 shared epitope (SE) alleles...
  95. ncbi Suppressive effects of a quinoxaline-analogue (Rob 803) on pathogenic immune mechanisms in collagen-induced arthritis
    E Westman
    Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
    Clin Exp Immunol 152:192-9. 2008
    ..Rob 803 should be considered as a new candidate substance for anti-rheumatic treatment...
  96. ncbi Estimated prediagnosis radiological progression: an important tool for studying the effects of early disease modifying antirheumatic drug treatment in rheumatoid arthritis
    M C Wick
    Rheumatology Unit, Department of Medicine at Karolinska Hospital, Stockholm, Sweden
    Ann Rheum Dis 64:134-7. 2005
    ..To determine if intrapatient comparisons between prediagnosis and subsequent radiological progression could be used to assess effects of DMARDs in an RA inception cohort...
  97. ncbi On the organization of an early arthritis clinic
    L Klareskog
    Department of Rheumatology, Karolinska Hospital/Karolinska Institute, Stockholm, S.171 76, Sweden
    Best Pract Res Clin Rheumatol 15:1-15. 2001
    ....
  98. ncbi Citrullination is an inflammation-dependent process
    D Makrygiannakis
    Department of Medicine, Rheumatology Unit, CMM, L8-04, Karolinska University Hospital, Solna, S-17176 Stockholm, Sweden
    Ann Rheum Dis 65:1219-22. 2006
    ..CONCLUSION: Citrullination is present in a wide range of inflammatory tissues, suggesting that this process is inflammation dependent rather than disease dependent...
  99. ncbi Socioeconomic status and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study
    C Bengtsson
    Institute of Environmental Medicine, Box 210, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Ann Rheum Dis 64:1588-94. 2005
    ....
  100. ncbi Biopsy-verified response of severe lupus nephritis to treatment with rituximab (anti-CD20 monoclonal antibody) plus cyclophosphamide after biopsy-documented failure to respond to cyclophosphamide alone
    R F van Vollenhoven
    Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden
    Scand J Rheumatol 33:423-7. 2004
    ..The monoclonal anti-B cell antibody rituximab (Rituxin, Mabthera) may be of benefit in antibody-driven diseases, including systemic lupus erythematosus (SLE) nephritis...
  101. ncbi Swedish registers to examine drug safety and clinical issues in RA
    J Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 65:707-12. 2006
    ..The approach described is a possible prototype for long term surveillance systems needed for the safe introduction of new treatments...