M Kivipelto

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Statin therapy in Alzheimer's disease
    Miia Kivipelto
    Lancet Neurol 4:521-2. 2005
  2. ncbi Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
    Miia Kivipelto
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Arch Neurol 62:1556-60. 2005
  3. ncbi Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study
    Miia Kivipelto
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 5:735-41. 2006
  4. doi Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study
    Miia Kivipelto
    Aging Research Center, NVS, Karolinska Institutet, Stockholm, Sweden
    J Cell Mol Med 12:2762-71. 2008
  5. pmc Association between mid-life marital status and cognitive function in later life: population based cohort study
    Krister Håkansson
    School of Social Sciences, Department of Psychology, Vaxjo University, Sweden
    BMJ 339:b2462. 2009
  6. ncbi The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): study design and progress
    Miia Kivipelto
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland Aging Research Center, Karolinska Institutet, Stockholm, Sweden Alzheimer s Disease Research Center, Karolinska Institutet, Stockholm, Sweden Electronic address
    Alzheimers Dement 9:657-65. 2013
  7. pmc Dementia prevention: current epidemiological evidence and future perspective
    Francesca Mangialasche
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet KI Stockholm University, Gävlegatan 16 9th floor SE 113 30, Stockholm, Sweden
    Alzheimers Res Ther 4:6. 2012
  8. ncbi Cholesterol as a risk factor for Alzheimer's disease - epidemiological evidence
    M Kivipelto
    Department of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden
    Acta Neurol Scand Suppl 185:50-7. 2006
  9. ncbi Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study
    M Kivipelto
    Aging Research Center, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Eur J Neurol 16:808-13. 2009
  10. ncbi Alzheimer's disease - the ways of prevention
    M Kivipelto
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, S 113 30 Stockholm, Sweden
    J Nutr Health Aging 12:89S-94S. 2008

Collaborators

Detail Information

Publications61

  1. ncbi Statin therapy in Alzheimer's disease
    Miia Kivipelto
    Lancet Neurol 4:521-2. 2005
  2. ncbi Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
    Miia Kivipelto
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Arch Neurol 62:1556-60. 2005
    ..Vascular risk factors play a role in the development of dementia, including Alzheimer disease (AD). However, little is known about the effect of body mass index and clustering of vascular risk factors on the development of dementia...
  3. ncbi Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study
    Miia Kivipelto
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 5:735-41. 2006
    ..Several vascular risk factors are associated with dementia. We sought to develop a simple method for the prediction of the risk of late-life dementia in people of middle age on the basis of their risk profiles...
  4. doi Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study
    Miia Kivipelto
    Aging Research Center, NVS, Karolinska Institutet, Stockholm, Sweden
    J Cell Mol Med 12:2762-71. 2008
    ..The apoE epsilon4 carriers may be more vulnerable to environmental factors, and thus, lifestyle interventions may greatly modify dementia risk particularly among the genetically susceptible individuals...
  5. pmc Association between mid-life marital status and cognitive function in later life: population based cohort study
    Krister Håkansson
    School of Social Sciences, Department of Psychology, Vaxjo University, Sweden
    BMJ 339:b2462. 2009
    ..To evaluate whether mid-life marital status is related to cognitive function in later life...
  6. ncbi The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): study design and progress
    Miia Kivipelto
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland Aging Research Center, Karolinska Institutet, Stockholm, Sweden Alzheimer s Disease Research Center, Karolinska Institutet, Stockholm, Sweden Electronic address
    Alzheimers Dement 9:657-65. 2013
    ..Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland...
  7. pmc Dementia prevention: current epidemiological evidence and future perspective
    Francesca Mangialasche
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet KI Stockholm University, Gävlegatan 16 9th floor SE 113 30, Stockholm, Sweden
    Alzheimers Res Ther 4:6. 2012
    ..Taking a step in this direction, researchers involved in these European RCTs recently started the European Dementia Prevention Initiative, an international collaboration aiming to improve strategies for preventing dementia...
  8. ncbi Cholesterol as a risk factor for Alzheimer's disease - epidemiological evidence
    M Kivipelto
    Department of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden
    Acta Neurol Scand Suppl 185:50-7. 2006
    ....
  9. ncbi Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study
    M Kivipelto
    Aging Research Center, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Eur J Neurol 16:808-13. 2009
    ..Another marker of vitamin B12 deficiency, holo-transcobalamin (holo-TC), has not been studied in a prospective setting...
  10. ncbi Alzheimer's disease - the ways of prevention
    M Kivipelto
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, S 113 30 Stockholm, Sweden
    J Nutr Health Aging 12:89S-94S. 2008
    ..The interplay of genes and environment in the aetiology of AD needs to be further investigated as well as the role of lifestyle and pharmacological interventions for the prevention of dementia...
  11. doi Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study
    B Hooshmand
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet, Gavlegatan 16, S 113 30, Stockholm, Sweden
    Neurology 75:1408-14. 2010
    ..To examine the relation between serum levels of homocysteine (tHcy) and holotranscobalamin (holoTC), the active fraction of vitamin B12, and risk of incident Alzheimer disease (AD) in a sample of Finnish community-dwelling elderly...
  12. doi Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: a population-based cardiovascular risk factors, aging and dementia study
    M Rusanen
    Department of Neurology, University of Eastern Finland, Kuopio, Finland
    Dement Geriatr Cogn Disord 30:277-84. 2010
    ..To elucidate the effect of midlife smoking on the risk of dementia and Alzheimer's disease (AD), and the possible modification of this relation by the apolipoprotein E (APOE) ε4...
  13. ncbi Education and dementia: what lies behind the association?
    T Ngandu
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, 11330 Stockholm, Sweden
    Neurology 69:1442-50. 2007
    ..People with low education have unhealthier lifestyles and more cardiovascular risk factors, but it is unclear how this affects the association between education and dementia...
  14. doi Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study
    B Hooshmand
    Aging Research Center, KarolinskaInstitutet, Stockholm, Sweden
    J Intern Med 271:204-12. 2012
    ....
  15. ncbi Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study
    M H Laitinen
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 22:99-107. 2006
    ..Lifestyle and vascular factors have been linked to dementia and Alzheimer's disease (AD), but the role of dietary fats in the development of dementia is less clear...
  16. ncbi Advances in the prevention of Alzheimer's disease and dementia
    A Solomon
    Karolinska Institutet Alzheimer Disease Research Center KI ADRC, Stockholm, Sweden Department of Neurology, University of Eastern Finland, Kuopio, Finland
    J Intern Med 275:229-50. 2014
    ..The shift towards presymptomatic and pre-dementia stages of AD has brought prevention and treatment trials much closer to each other than before...
  17. doi Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study
    S Ahtiluoto
    Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    Neurology 75:1195-202. 2010
    ..To investigate the relation of diabetes to dementia, Alzheimer disease (AD), and vascular dementia (VaD), through analyses of incidence, mortality, and neuropathologic outcomes in a prospective population-based study of the oldest old...
  18. ncbi Serum total cholesterol, statins and cognition in non-demented elderly
    A Solomon
    Department of Neurology, University of Kuopio, P O Box 1627 FIN 70211, Kuopio, Finland
    Neurobiol Aging 30:1006-9. 2009
    ..The association between serum total cholesterol (TC), lipid-lowering drugs and cognition in the elderly is currently controversial...
  19. ncbi Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease
    Suvi Rovio
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 4:705-11. 2005
    ..The aim of our study was to investigate the association between leisure-time physical activity at midlife and the subsequent development of dementia and Alzheimer's disease (AD)...
  20. pmc Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex
    C Qiu
    Ageing Research Centre, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and the Stockholm Gerontology Research Centre, Stockholm, Sweden
    J Neurol Neurosurg Psychiatry 75:828-33. 2004
    ..The risk effect of APOE epsilon 4 allele for Alzheimer's disease is acknowledged, whereas the putative protective effect of epsilon 2 allele remains in debate...
  21. ncbi Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol
    F Mangialasche
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 273:602-21. 2013
    ....
  22. pmc Clinical trials in mild cognitive impairment: lessons for the future
    V Jelic
    Karolinska Institutet, Neurotec Department, Division of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Neurol Neurosurg Psychiatry 77:429-38. 2006
    ....
  23. ncbi Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
    ....
  24. ncbi The new cholesterol controversy - a little bit of history repeating?
    M Kivipelto
    Department of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden
    Acta Neurol Scand Suppl 185:1-2. 2006
  25. ncbi Alzheimer's Disease: back to the future
    M Kivipelto
    Department of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden
    Acta Neurol Scand Suppl 185:119-20. 2006
  26. doi High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age
    Francesca Mangialasche
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 20:1029-37. 2010
    ..The neuroprotective effect of vitamin E seems to be related to the combination of different forms, rather than to alpha-tocopherol alone, whose efficacy in interventions against AD is currently debated...
  27. doi A prospective study on the development of Alzheimer's disease with regard to thyroid-stimulating hormone and homocysteine
    Sylvia Annerbo
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 28:275-80. 2009
    ..Our objective was to prospectively investigate the association between tHcy and TSH and the subsequent development of AD...
  28. ncbi Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders
    Marjan Shafaati
    Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Neurosci Lett 425:78-82. 2007
    ..The levels of apoE in cerebrospinal fluid were also correlated to the levels of Tau and the possibility is discussed that the level of apoE in cerebrospinal fluid may be used as a marker of neurodegeneration...
  29. ncbi Work-related physical activity and the risk of dementia and Alzheimer's disease
    Suvi Rovio
    Aging Research Center, NVS, Karolinska Institutet, Stockholm, Sweden
    Int J Geriatr Psychiatry 22:874-82. 2007
    ..This study aimed to clarify the association between work-related physical activity and dementia/AD...
  30. pmc Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention
    Chengxuan Qiu
    Aging Research Center, Karolinska Institutet Stockholm, Sweden
    Dialogues Clin Neurosci 11:111-28. 2009
    ....
  31. ncbi Alcohol drinking and cognitive functions: findings from the Cardiovascular Risk Factors Aging and Dementia (CAIDE) Study
    Tiia Ngandu
    Aging Research Center ARC, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 23:140-9. 2007
    ..Little is known about the effects of midlife alcohol drinking on the cognitive functions later in life...
  32. doi The effect of midlife physical activity on structural brain changes in the elderly
    Suvi Rovio
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, 11330 Stockholm, Sweden
    Neurobiol Aging 31:1927-36. 2010
    ..The differences in the GM density localized mainly in frontal lobes. There was no significant association between midlife physical activity and severe WML later in life after full adjustments (OR 4.20, 95% CI 0.26-69.13, p=0.32)...
  33. ncbi Rethinking the dementia diagnoses in a population-based study: what is Alzheimer's disease and what is vascular dementia?. A study from the kungsholmen project
    Hedda Aguero-Torres
    Aging Research Center ARC, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 22:244-9. 2006
    ..To explore the hypothesis that older adults often are affected by more than one disease, making the differential diagnosis between Alzheimer's disease (AD) and vascular dementia (VaD) difficult...
  34. pmc Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study
    Tiia Anttila
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Box 6401, 11382 Stockholm, Sweden
    BMJ 329:539. 2004
    ..To evaluate the relation between midlife alcohol consumption and mild cognitive impairment and dementia in old age, and the possible modification of this relation by apolipoprotein E...
  35. ncbi Decreased brain creatine levels in elderly apolipoprotein E epsilon 4 carriers
    M P Laakso
    Department of Neurology, Clinical Radiology, Kuopio University Hospital, Kuopio, Finland
    J Neural Transm 110:267-75. 2003
    ..These findings may be of significant clinical interest as potential indicator of incipient AD, and also from therapeutical point of view given the potential neuroprotective effects of creatine...
  36. ncbi Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment?
    Valerio Leoni
    Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Karolinska University Hospital in Huddinge, Stockholm, Sweden
    Neurosci Lett 397:83-7. 2006
    ..In patients with AD, the percentages of those with increased levels of 24OHC, tau and phospho tau were similar (55-67%). In this pilot study, we discuss the possibility that 24OHC may be a sensitive test for MCI...
  37. doi Cholesterol-modifying strategies for Alzheimer's disease
    Alina Solomon
    Aging Research Center, Karolinska Institutet, Sweden
    Expert Rev Neurother 9:695-709. 2009
    ....
  38. doi Alzheimer's disease: clinical trials and drug development
    Francesca Mangialasche
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 9:702-16. 2010
    ....
  39. ncbi High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice
    Atiqur Rahman
    Karolinska Institutet, Neurotec Department, Division of Experimental Geriatrics, Novum, Karolinska University Hospital, SE 14186 Huddinge, Sweden
    FEBS Lett 579:6411-6. 2005
    ..Our results suggest an interaction between dietary and genetic factors in the development of tauopathies, which can be relevant in humans, where the apoE4 isoform could have a lack of function as compared to other isoforms...
  40. doi The International Network on Public Health and Aging (INOPA): introducing a life course perspective to the public health agenda
    Ake Wahlin
    Department of Psychology, Stockholm University, 106 91, Stockholm, Sweden
    J Cross Cult Gerontol 23:97-105. 2008
    ....
  41. ncbi Memantine offers new possibilities for the treatment of VaD
    Bengt Winblad
    Karolinska Institutet, Neurotec, Division of Geriatric Medicine and Geriatric Epidemiology, Huddinge University Hospital, 141 86 Stockholm, Sweden
    Lancet Neurol 1:469. 2002
  42. ncbi Hypertension and hypercholesterolaemia as risk factors for Alzheimer's disease: potential for pharmacological intervention
    Miia Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    CNS Drugs 16:435-44. 2002
    ..Based on these data, we propose that proper, early interventions aimed at reducing these cardiovascular risk factors may have an impact on the future incidence and prevalence of Alzheimer's disease...
  43. ncbi Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
    Corina Pennanen
    Department of Neuroscience and Neurology, University of Kuopio and Brain Research Unit, Clinical Research Center, Mediteknia, P O Box 1627, FIN 70 211 Kuopio, Finland
    Neurobiol Aging 25:303-10. 2004
    ..Our results suggest that the ERC atrophy precedes hippocampal atrophy in AD. The ERC volume loss is dominant over the hippocampal volume loss in MCI, whereas more pronounced hippocampal volume loss appears in mild AD...
  44. ncbi Incidence and risk factors for mild cognitive impairment: a population-based three-year follow-up study of cognitively healthy elderly subjects
    Susanna Tervo
    Department of Neuroscience and Neurology, Brain Research Unit, Clinical Research Centre, Mediteknia, University of Kuopio, Kuopio, Finland
    Dement Geriatr Cogn Disord 17:196-203. 2004
    ..Both the apolipoprotein E (ApoE) epsilon4 allele and vascular factors have been associated with a higher risk for AD, recently they have also been linked to the risk of MCI...
  45. ncbi Utilization of cognitive support in episodic free recall as a function of apolipoprotein E and vitamin B12 or folate among adults aged 75 years and older
    David Bunce
    Department of Psychology, Goldsmiths College, University of London, London, United Kingdom
    Neuropsychology 18:362-70. 2004
    ..A similar, but nonsignificant, trend was evident in relation to folate. The research is discussed with reference to vulnerability models and genetic influences on brain reserves...
  46. ncbi Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease
    Miia Kivipelto
    University of Kuopio, Department of Neuroscience and Neurology, PO Box 1627, 70211 Kuopio, Finland
    Ann Intern Med 137:149-55. 2002
    ..Elevated midlife values for total cholesterol level and blood pressure have been implicated recently as risk factors for Alzheimer disease...
  47. ncbi The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study
    Corina Pennanen
    Department of Neuroscience and Neurology, University of Kuopio, Canthia, Kuopio, Finland
    Dement Geriatr Cogn Disord 22:60-6. 2006
    ..In cases homozygous for the epsilon4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus...
  48. ncbi [Genetics of Alzheimer's disease]
    Mikko Hiltunen
    Kuopion yliopisto, Neurologian klinikka, Mediteknia
    Duodecim 120:2425-31. 2004
  49. pmc Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 7:812-26. 2008
    ..Dementia costs in developing countries are estimated to be US$73 billion yearly, but care demands social protection, which seems scarce in these regions...
  50. ncbi Metabolic syndrome and cognitive function: a population-based follow-up study in elderly women
    Pirjo Komulainen
    Kuopio Research Institute of Exercise Medicine, Department of Physiology, University of Kuopio, Kuopio, Finland
    Dement Geriatr Cogn Disord 23:29-34. 2007
    ..To test the hypothesis that metabolic syndrome predicts cognitive impairment, and to examine the association of single metabolic risk factors with cognitive functioning...
  51. pmc Cerebral embolism and Alzheimer's disease
    Miia Kivipelto
    BMJ 332:1104-5. 2006
  52. ncbi Apolipoprotein E, B vitamins, and cognitive function in older adults
    David Bunce
    Department of Psychology, Goldsmiths College, University of London, London, SE14 6NW, UK
    J Gerontol B Psychol Sci Soc Sci 60:P41-8. 2005
    ..This finding was unrelated to incipient dementia up to 6 years following testing. The results are discussed with reference to the neuroanatomical reserves that epsilon4 carriers may possess...
  53. ncbi Serum lipids and hippocampal volume: the link to Alzheimer's disease?
    Henrike Wolf
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Ann Neurol 56:745-8. 2004
    ..This is compatible with protective effects of high-density lipoprotein cholesterol on hippocampal atrophy and Alzheimer's disease...
  54. ncbi Serum high sensitivity C-reactive protein and cognitive function in elderly women
    Pirjo Komulainen
    Kuopio Research Institute of Exercise Medicine, Finland
    Age Ageing 36:443-8. 2007
    ..Inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function...
  55. ncbi Hypertension and white matter lesions of the brain
    Miia Kivipelto
    J Hypertens 20:387-9. 2002
  56. ncbi Carotid intima-media thickness and cognitive function in elderly women: a population-based study
    Pirjo Komulainen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Neuroepidemiology 28:207-13. 2007
    ..We investigated whether carotid intima-media thickness (IMT) predicts the risk of cognitive impairment and whether the putative impairment is specific for some cognitive domains...
  57. ncbi MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study
    Tero Tapiola
    Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
    Neurobiol Aging 29:31-8. 2008
    ..The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD...
  58. ncbi Acetylcholinesterase and its inhibition in Alzheimer disease
    Roger M Lane
    Novartis Neuroscience, Novartis Pharmaceuticals Corp, East Hanover, NJ 07936 1080, USA
    Clin Neuropharmacol 27:141-9. 2004
    ..If such differences between ChE-Is are shown to have clinical correlates, this may prompt reconsideration of the rationale and expectations of some agents in the long-term management of AD...
  59. doi The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics
    Roy W Jones
    RICE The Research Institute for the Care of Older People, Royal United Hospital, Bath, United Kingdom
    Alzheimers Dement 4:145-53. 2008
    ....
  60. ncbi Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment
    Anne Hämäläinen
    Department of Neurology, University of Kuopio and Brain Research Unit, Clinical Research Center, Mediteknia, and Kuopio University Hospital, Finland
    Neuroimage 37:1122-31. 2007
    ..We conclude that widespread cortical atrophy is present already two and a half years before a clinical diagnosis of dementia can be set...
  61. doi A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease
    Taru Tukiainen
    Computational Medicine Research Group, Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, P O Box 9203, FI 02015 HUT, Finland
    Biochem Biophys Res Commun 375:356-61. 2008
    ..The analyses also feature the role of elevated glycoproteins in the risk for AD, supporting the view that coexistence of inflammation and the MetS forms a high risk condition for cognitive decline...