Per Karlsson

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi PET study of D(1) dopamine receptor binding in neuroleptic-naive patients with schizophrenia
    Per Karlsson
    Department of Clinical Neuroscience, Karlinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Am J Psychiatry 159:761-7. 2002
  2. doi Dopamine D(1) receptors and age differences in brain activation during working memory
    Lars Backman
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, SE 113 30 Stockholm, Sweden
    Neurobiol Aging 32:1849-56. 2011
  3. ncbi Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
    Hristina Jovanovic
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Neuroimage 39:1408-19. 2008
  4. doi Simulating neurocognitive aging: effects of a dopaminergic antagonist on brain activity during working memory
    Hakan Fischer
    Aging Research Center, Karolinska Institute, Stockholm, Sweden
    Biol Psychiatry 67:575-80. 2010
  5. doi 5-HT(1A) receptor and 5-HTT binding during the menstrual cycle in healthy women examined with [(11)C] WAY100635 and [(11)C] MADAM PET
    Hristina Jovanovic
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Psychiatry Res 172:31-7. 2009
  6. doi Dose-dependent binding of AZD3783 to brain 5-HT1B receptors in non-human primates and human subjects: a positron emission tomography study with [11C]AZ10419369
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden
    Psychopharmacology (Berl) 213:533-45. 2011
  7. ncbi Imaging the norepinephrine transporter with positron emission tomography: initial human studies with (S,S)-[18F]FMeNER-D2
    Akihiro Takano
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, 171 76, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 35:153-7. 2008
  8. doi Mapping of the norepinephrine transporter in the human brain using PET with (S,S)-[18F]FMeNER-D2
    Akihiro Takano
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Neuroimage 42:474-82. 2008
  9. ncbi PET analysis of the 5-HT2A receptor inverse agonist ACP-103 in human brain
    Anna Lena Nordstrom
    Karolinska University Hospital, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Int J Neuropsychopharmacol 11:163-71. 2008
  10. doi Extrastriatal dopamine D(2) receptor binding in Huntington's disease
    Mouna Esmaeilzadeh
    PET Centre, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
    Hum Brain Mapp 32:1626-36. 2011

Detail Information

Publications20

  1. ncbi PET study of D(1) dopamine receptor binding in neuroleptic-naive patients with schizophrenia
    Per Karlsson
    Department of Clinical Neuroscience, Karlinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Am J Psychiatry 159:761-7. 2002
    ..The objective of the present PET study was to compare D(1) receptor binding in first-admission, neuroleptic-naive patients with schizophrenia and in healthy subjects...
  2. doi Dopamine D(1) receptors and age differences in brain activation during working memory
    Lars Backman
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, SE 113 30 Stockholm, Sweden
    Neurobiol Aging 32:1849-56. 2011
    ..These findings suggest that age-related alterations in dopaminergic neurotransmission may contribute to underrecruitment of task-relevant brain regions during working-memory performance in old age...
  3. ncbi Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
    Hristina Jovanovic
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Neuroimage 39:1408-19. 2008
    ..The result of the present study may help in understanding sex differences in drug treatment responses to drugs affecting the serotonin system...
  4. doi Simulating neurocognitive aging: effects of a dopaminergic antagonist on brain activity during working memory
    Hakan Fischer
    Aging Research Center, Karolinska Institute, Stockholm, Sweden
    Biol Psychiatry 67:575-80. 2010
    ..Previous correlational studies have indirectly linked dysfunctional dopaminergic neurotransmission to age-related cognitive deficits and associated reductions in task-induced functional brain activity...
  5. doi 5-HT(1A) receptor and 5-HTT binding during the menstrual cycle in healthy women examined with [(11)C] WAY100635 and [(11)C] MADAM PET
    Hristina Jovanovic
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Psychiatry Res 172:31-7. 2009
    ..The finding however does not preclude that gonadal hormones differentially influence central serotonin system inwomen and men, which might contribute to gender differences in serotonin-associated disorders...
  6. doi Dose-dependent binding of AZD3783 to brain 5-HT1B receptors in non-human primates and human subjects: a positron emission tomography study with [11C]AZ10419369
    Katarina Varnas
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden
    Psychopharmacology (Berl) 213:533-45. 2011
    ..AZD3783 is a recently developed, orally bioavailable 5-HT(1B) receptor antagonist with potential antidepressant properties...
  7. ncbi Imaging the norepinephrine transporter with positron emission tomography: initial human studies with (S,S)-[18F]FMeNER-D2
    Akihiro Takano
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, 171 76, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 35:153-7. 2008
    ..A monkey occupancy study with the radioligand indicated that (S,S)-[(18)F]FMeNER-D(2) can be useful for quantitative PET analysis. In this preliminary study, regional distributions in the living human brain were evaluated...
  8. doi Mapping of the norepinephrine transporter in the human brain using PET with (S,S)-[18F]FMeNER-D2
    Akihiro Takano
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Neuroimage 42:474-82. 2008
    ..This study indicated that (S,S)-[(18)F]FMeNER-D(2) combined with a template method provides detailed information on the distribution of NET in vivo and that functional ROIs on the template would be useful in further clinical studies...
  9. ncbi PET analysis of the 5-HT2A receptor inverse agonist ACP-103 in human brain
    Anna Lena Nordstrom
    Karolinska University Hospital, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Int J Neuropsychopharmacol 11:163-71. 2008
    ..In conclusion, administration of ACP-103 to healthy volunteers was found to be safe and well tolerated, and single oral doses as low as 10 mg were found to fully saturate 5-HT2A receptors in human brain as determined by PET...
  10. doi Extrastriatal dopamine D(2) receptor binding in Huntington's disease
    Mouna Esmaeilzadeh
    PET Centre, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
    Hum Brain Mapp 32:1626-36. 2011
    ..Hence, the present study demonstrates that dopamine D(2) receptors extrinsic to the striatum are well preserved in early to mid stage patients with HD. This observation may have implication for the development of therapy for HD...
  11. doi Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [18F]FEDAA1106: a human whole-body PET study
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, 171 76, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 38:2058-65. 2011
    ..TSPO imaging is expected to be useful for the clinical evaluation of neuroinflammatory diseases. The aim of this study was to provide dosimetry estimates for [(18)F]FEDAA1106 based on human whole-body PET measurements...
  12. doi Quantitative PET analyses of regional [11C]PE2I binding to the dopamine transporter--application to juvenile myoclonic epilepsy
    Ikuo Odano
    Psychiatric Section, Department of Clinical Neuroscience Karolinska Institutet, Stockholm, Sweden
    Neuroimage 59:3582-93. 2012
    ..The reference tissue models should be applied with better understanding of the biochemical nature of the radioligand and the reliability of these approaches...
  13. doi [18F]flumazenil binding to central benzodiazepine receptor studies by PET--quantitative analysis and comparisons with [11C]flumazenil
    Ikuo Odano
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuroimage 45:891-902. 2009
    ..The present analysis supports the use of pons as reference region in simplified protocols without arterial blood sampling. [(18)F]flumazenil should thus be an excellent choice for applied studies at centers not having a cyclotron...
  14. pmc Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain
    Katarina Varnas
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Cereb Blood Flow Metab 31:113-23. 2011
    ..The findings support the use of reference tissue models in applied clinical studies with [(11)C]AZ10419369...
  15. doi Modulation of striatal dopamine D1 binding by cognitive processing
    Sari Karlsson
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, SE 113 30 Stockholm, Sweden
    Neuroimage 48:398-404. 2009
    ....
  16. ncbi Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[18F]FMeNER-D2: a human whole-body PET study
    Akihiro Takano
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 35:630-6. 2008
    ..The aim of this study was to provide dosimetry estimates for (S,S)-[(18)F]FMeNER-D(2) based on human whole-body PET measurements...
  17. ncbi [(11)C]PE2I: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain
    Christer Halldin
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska Hospital, 17176 Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 30:1220-30. 2003
    ..The present characterisation of binding in monkey and man suggests that [(11)C]PE2I is a suitable PET radioligand for quantitative regional examination of DAT in man...
  18. ncbi A PET study of 5-HT1A receptors at different phases of the menstrual cycle in women with premenstrual dysphoria
    Hristina Jovanovic
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Psychiatry Res 148:185-93. 2006
    ..The study principally provides new support, in vivo, for a serotonergic dysregulation in women with PMDD...
  19. ncbi [Cerebral uptake and regional distribution of [11C]-vinpocetin after intravenous administration to healthy men: a PET study]
    Adám Vas
    Richter Gedeon Vegyészeti Gyár Rt, Budapest
    Orv Hetil 143:2631-6. 2002
    ..Three healthy persons were examined with positron emission tomography (PET) and [11C]-vinpocetine...
  20. doi [11C]AZ10419369: a selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET). Characterization in the primate brain
    M Edward Pierson
    AstraZeneca Pharmaceuticals CNS Discovery, 1800 Concord Pike, PO Box 15437, Wilmington, DE 19850 5437, USA
    Neuroimage 41:1075-85. 2008
    ..This radioligand may be useful in future studies evaluating drug-induced receptor occupancy and measurement of brain 5-HT1B receptor levels in patients with psychiatric disorders...