Camilla Kappe

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cells
    Camilla Kappe
    Karolinska Institutet, Department of Clinical Science and Education, Unit for Diabetes Research, Sodersjukhuset, SE 118 83 Stockholm, Sweden
    Biochem Biophys Res Commun 427:91-5. 2012
  2. doi Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells
    Camilla Kappe
    Department of Clinical Science and Education, Unit for Diabetes Research, Karolinska Institutet, Sodersjukhuset, 118 83, Stockholm, Sweden
    J Gastroenterol 48:322-32. 2013
  3. doi Evidence for paracrine/autocrine regulation of GLP-1-producing cells
    Camilla Kappe
    Karolinska Institutet, Department of Clinical Science and Education, Unit for Diabetes Research, Sodersjukhuset, Stockholm, Sweden
    Am J Physiol Cell Physiol 305:C1041-9. 2013
  4. pmc Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats
    Vladimer Darsalia
    Diabetes Research Unit, Department of Clinical Science and Education, Sodersjukhuset, Karolinska Institutet, Stockholm, Sweden
    Clin Sci (Lond) 122:473-83. 2012
  5. pmc GLP-1 secretion by microglial cells and decreased CNS expression in obesity
    Camilla Kappe
    Karolinska Institutet, Department of Clinical Science and Education, Sodersjukhuset, Stockholm 11883, Sweden
    J Neuroinflammation 9:276. 2012
  6. doi Glucocorticoids suppress GLP-1 secretion: possible contribution to their diabetogenic effects
    Camilla Kappe
    Karolinska Institutet, Department of Clinical Science and Education, Unit for Diabetes Research, Sodersjukhuset, SE 118 83 Stockholm, Sweden Södertälje Hospital, Department of Internal Medicine, SE 152 86 Södertälje, Sweden
    Clin Sci (Lond) 129:405-14. 2015

Collaborators

Detail Information

Publications6

  1. doi Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cells
    Camilla Kappe
    Karolinska Institutet, Department of Clinical Science and Education, Unit for Diabetes Research, Sodersjukhuset, SE 118 83 Stockholm, Sweden
    Biochem Biophys Res Commun 427:91-5. 2012
    ..The present study may thus identify potential molecular targets for increasing endogenous GLP-1 secretion through enhanced viability of GLP-1 secreting cells in diabetic hyperlipidemia and obesity...
  2. doi Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells
    Camilla Kappe
    Department of Clinical Science and Education, Unit for Diabetes Research, Karolinska Institutet, Sodersjukhuset, 118 83, Stockholm, Sweden
    J Gastroenterol 48:322-32. 2013
    ..In addition, diabetic patients on metformin therapy have elevated levels of the insulinotropic hormone glucagon-like peptide-1 (GLP-1) and metformin has been shown to regulate the expression of the GLP-1R in the pancreas...
  3. doi Evidence for paracrine/autocrine regulation of GLP-1-producing cells
    Camilla Kappe
    Karolinska Institutet, Department of Clinical Science and Education, Unit for Diabetes Research, Sodersjukhuset, Stockholm, Sweden
    Am J Physiol Cell Physiol 305:C1041-9. 2013
    ..In addition, the effects of insulin indicate that not only is GLP-1 important for insulin secretion but altered insulin signaling may contribute to an altered GLP-1 secretion...
  4. pmc Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats
    Vladimer Darsalia
    Diabetes Research Unit, Department of Clinical Science and Education, Sodersjukhuset, Karolinska Institutet, Stockholm, Sweden
    Clin Sci (Lond) 122:473-83. 2012
    ..Our results should provide strong impetus to further investigate GLP-1R agonists for their neuroprotective action in diabetes, and for their possible use as anti-stroke medication in non-diabetic conditions...
  5. pmc GLP-1 secretion by microglial cells and decreased CNS expression in obesity
    Camilla Kappe
    Karolinska Institutet, Department of Clinical Science and Education, Sodersjukhuset, Stockholm 11883, Sweden
    J Neuroinflammation 9:276. 2012
    ..T2D patients have a deficiency in the intestinal incretin hormone GLP-1, which has been shown to exert neuroprotective and anti-inflammatory properties in the brain...
  6. doi Glucocorticoids suppress GLP-1 secretion: possible contribution to their diabetogenic effects
    Camilla Kappe
    Karolinska Institutet, Department of Clinical Science and Education, Unit for Diabetes Research, Sodersjukhuset, SE 118 83 Stockholm, Sweden Södertälje Hospital, Department of Internal Medicine, SE 152 86 Södertälje, Sweden
    Clin Sci (Lond) 129:405-14. 2015
    ..These effects may not only elucidate the pathogenesis of steroid diabetes, but could ultimately contribute to the identification of novel molecular targets for controlling incretin secretion. ..