Research Topics
| S G O JohanssonSummaryAffiliation: Karolinska Hospital Country: Sweden Publications
| Collaborators
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Detail Information
Publications
Omalizumab and the immune system: an overview of preclinical and clinical dataS G O Johansson
Department of Clinical Immunology, Karolinska Hospital, Stockholm, Sweden
Ann Allergy Asthma Immunol 89:132-8. 2002..This review discusses the role of immunoglobulin (Ig)E in allergic disease, inhibition of IgE with omalizumab, and the consequences of IgE inhibition (both clinically and in terms of the effect on the immune system)...- New diagnostic classification of allergic skin disordersS G O Johansson
Department of Clinical Immunology, Karolinska Hospital, Stockholm, Sweden
Curr Opin Allergy Clin Immunol 2:403-6. 2002..To highlight the importance of one common nomenclature for allergic skin disorders... - Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003S G O Johansson
Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska University Hospital, L2 04, S 171 76 Stockholm, Sweden
J Allergy Clin Immunol 113:832-6. 2004..It is assumed that as knowledge about basic causes and mechanisms improves, the nomenclature will need further review... 
The size of the disease relevant IgE antibody fraction in relation to 'total-IgE' predicts the efficacy of anti-IgE (Xolair) treatmentS G O Johansson
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden
Allergy 64:1472-7. 2009..e. the percentage of IgE antibody of total IgE, was evaluated in cat allergic patients treated with the recommended doses of Xolair. Results were measured as changes in basophil allergen threshold sensitivity (CD-sens)...- National pholcodine consumption and prevalence of IgE-sensitization: a multicentre studyS G O Johansson
Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden
Allergy 65:498-502. 2010..As a consequence the risk of anaphylaxis to neuromuscular blocking agents (NMBA) will be increased... - After 6 years with Xolair; a 3-year withdrawal follow-upAnna Nopp
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden
Allergy 65:56-60. 2010..This study reports the clinical and immunological state of patients 3 years after a 6-year period of Xolair treatment for severe allergic asthma... - High prevalence of IgE antibodies among blood donors in Sweden and NorwayS G O Johansson
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institutet, Stockholm, Sweden
Allergy 60:1312-5. 2005..Present routines to identify IgE sensitized, potential risk, donors are not satisfactory; the sensitivity of selection procedures is about 25%... - Cat IgA, representative of new carbohydrate cross-reactive allergensJustus Adedoyin
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institutet, University Hospital, Stockholm, Sweden
J Allergy Clin Immunol 119:640-5. 2007..Allergens from cat are among the most potent elicitors of allergic disease. Four cat allergens have been identified; however, evidence indicates the existence of additional allergens... - CD-sens and clinical changes during withdrawal of Xolair after 6 years of treatmentA Nopp
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden
Allergy 62:1175-81. 2007..e. <12 months. After withdrawal, the clinical symptoms tend to return. A group of patients who stopped treatment after approx. 6 years allowed studies of the long-term effects of Xolair... - Simultaneous exposure of several allergens has an additive effect on multisensitized basophilsA Nopp
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden
Allergy 61:1366-8. 2006..Even low concentrations of IgE antibodies could be of clinical relevance in such a situation... - Basophil allergen threshold sensitivity: a useful approach to anti-IgE treatment efficacy evaluationA Nopp
Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden
Allergy 61:298-302. 2006..CD-max, the conventional approach to basophil allergen challenge, which mirrors cell reactivity, gives incorrect information... - Xolair is effective in allergics with a low serum IgE levelJ Ankerst
Department of Medicine, Clinical Sciences, Lund, Sweden
Int Arch Allergy Immunol 152:71-4. 2010..Two atopic patients suffering from severe allergy difficult to handle by conventional medication were given Xolair despite an IgE level <30 kU/l... - CD-sens: a biological measure of immunological changes stimulated by ASITA Nopp
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden
Allergy 64:811-4. 2009..Basophil allergen threshold sensitivity, CD-sens, which is a valuable complement to resource-demanding clinical challenge tests, was used to monitor the initiation of ASIT induced allergen 'blocking activity'... - The importance of IgE antibody levels in anti-IgE treatmentS G O Johansson
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden
Allergy 61:1216-9. 2006..An increase of the anti-IgE dosage given to such patients should be considered, especially because IgE antibodies with different, relevant specificities have an additive effect in triggering inflammatory cells... - IgE-mediated anaphylactic reactions to neuromuscular blocking agents: can they be prevented?E Florvaag
Department of Clinical Immunology, Karolinska University Hospital, Solna, L2 04, S 171 76, Stockholm, Sweden
Curr Allergy Asthma Rep 8:375-6. 2008 - Basophil allergen threshold sensitivity, CD-sens, is a measure of allergen sensitivity in asthmaB Dahlen
Department of Medicine, Division of Respiratory Medicine and Allergy Research, Karolinska University Hospital, Huddinge, Sweden
Clin Exp Allergy 41:1091-7. 2011..The SPT and IgE-antibody values do not directly predict if the allergy clinically contributes to the asthma. There is therefore a need for new objective tests that may indicate the clinical importance of an IgE-sensitisation... - Anaphylaxis to Patent Blue V. II. A unique IgE-mediated reactionS G O Johansson
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden
Allergy 65:124-9. 2010..Anaphylactic reactions, allegedly IgE antibody mediated, have been reported. The aim of the study was to explore the immunological mechanism of anaphylaxis to PBV... - The discovery of immunoglobulin ES G O Johansson
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden
Allergy Asthma Proc 27:S3-6. 2006..The knowledge about IgE mediating allergy has greatly improved our understanding of allergic inflammation and diagnoses and treatment of allergic diseases... - Interference in immunoassays by human IgM with specificity for the carbohydrate moiety of animal proteinsJustus Adedoyin
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden
J Immunol Methods 310:117-25. 2006..The factor was further studied and shown to be human IgM. This IgM fits into the heterophile antibody classification and is directed against carbohydrates on animal immunoglobulins and on calf intestine alkaline phosphatase... - Antineutrophil cytoplasmic antibodies induce decreased CD62L expression and enhanced metabolic activity in monocytesA Wikman
Department of Medicine, Division of Clinical Immunology and Transfusion Medicine, Karolinska Hospital and Karolinska Institutet, Stockholm, Sweden
Scand J Immunol 57:179-84. 2003..These findings support the concept that the pathophysiological effect of ANCA is partly mediated through the action on crucial events in monocyte activation, such as CD62L downregulation and oxygen radical production... - Pet shop workers: exposure, sensitization, and work-related symptomsA Renström
National Institute of Environmental Medicine, Lung and Allergy Research, Karolinska Institutet, Stockholm, Sweden
Allergy 66:1081-7. 2011..Allergy to laboratory animals is a well-known occupational hazard. The aim was to investigate the frequency of allergic sensitization and respiratory symptoms among pet shop staff and to document their work environment... - ImmunoCAP Specific IgE test: an objective tool for research and routine allergy diagnosisS G O Johansson
Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska University Hospital, L2 04 SE 171 76 Stockholm, Sweden
Expert Rev Mol Diagn 4:273-9. 2004..It is a reliable diagnostic tool and particularly useful in primary care where the use of in vivo tests cannot be recommended if the personnel have insufficient opportunities to get the appropriate experience... - The History of IgE: From discovery to 2010S G O Johansson
Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Solna, L2 04, 171 76, Stockholm, Sweden
Curr Allergy Asthma Rep 11:173-7. 2011.... - Passive IgE-sensitization by blood transfusionS G O Johansson
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden
Allergy 60:1192-9. 2005..The recipients expressed 'slow' or 'rapid' CD-sens decline, indicating two different basophil populations. After transfusion of plasma with >10 kU(A)/l IgE antibody the recipient could have allergen reactive basophils for up to 7 weeks... - CD-Sens Can Be a Reliable and Easy-to-Use Complement in the Diagnosis of Allergic RhinitisA Nopp
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden
Int Arch Allergy Immunol 161:87-90. 2013..Conclusion: CD-sens appears to be a reproducible test for diagnosis of allergic rhinitis with great advantages also for follow-up of disease development and treatment effects... 
Oral peanut challenge identifies an allergy but the peanut allergen threshold sensitivity is not reproducibleSusanne Glaumann
Department of Clinical Science and Education, Sodersjukhuset, Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 8:e53465. 2013..A basophil allergen threshold sensitivity test, CD-sens, has shown promising results as a diagnostic tool in food allergy...- The Pholcodine Case. Cough Medicines, IgE-Sensitization, and Anaphylaxis: A Devious ConnectionE Florvaag
1Laboratory of Clinical Biochemistry and Section for Clinical Allergology, Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway 2Institute of Medicine, University of Bergen, Norway 3Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden 4Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden
World Allergy Organ J 5:73-8. 2012.... - The story of IgNDS G O Johansson
Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden
J Allergy Clin Immunol 115:644-8. 2005 - IgE-reactivity to seven Malassezia speciesA Zargari
Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, Sweden
Allergy 58:306-11. 2003..To obtain an optimal allergen preparation both common allergenic components as well as species-specific allergens have to be considered... - Pholcodine exposure raises serum IgE in patients with previous anaphylaxis to neuromuscular blocking agentsT Harboe
Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway
Allergy 62:1445-50. 2007..The present study explores the effect of pholcodine exposure on IgE in a population with previously diagnosed IgE-mediated anaphylaxis towards NMBAs... - [Revised terminology for allergies and related conditions]R Gerth van Wijk
Erasmus Medisch Centrum, afd Allergologie, Dr Molewaterplein 40, 3015 GD Rotterdam
Ned Tijdschr Geneeskd 146:2289-93. 2002.... - [Revised, global nomenclature for allergy. Unambiguous terms create clarity and prevent misunderstandings]S G O Johansson
, Karolinska Universitetssjukhuset Solna
Lakartidningen 103:379-83. 2006 - Pholcodine stimulates a dramatic increase of IgE in IgE-sensitized individuals. A pilot studyE Florvaag
Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway
Allergy 61:49-55. 2006..Household chemicals containing such allergenic epitopes seem capable of some, minor, stimulation... - No consumption of IgE antibody in serum during allergic drug anaphylaxisA B Guttormsen
Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway
Allergy 62:1326-30. 2007..As this is most unpractical, the changes in IgE antibody levels during anaphylaxis were studied to evaluate the possibility of using samples drawn at the time of the reaction... - Scandinavian Clinical Practice Guidelines on the diagnosis, management and follow-up of anaphylaxis during anaesthesiaM Kroigaard
Danish Anaesthesia Allergy Centre, Department of Anaesthesia, Section 4231 Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
Acta Anaesthesiol Scand 51:655-70. 2007..Lastly, Appendix 2 provides an overview of the incidence, mechanisms and possibilities for follow-up for some common drug groups... - [Latex caused two cases of anaphylactic shock during Cesarean section]Caroline Gillis-Haegerstrand
Danderyds sjukhus, Stockholm
Lakartidningen 104:1987-8. 2007 - IgE to Staphylococcus aureus enterotoxins in serum is related to severity of asthmaClaus Bachert
J Allergy Clin Immunol 111:1131-2. 2003 - Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissueP Gevaert
Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
Allergy 60:71-9. 2005..aureus, and tissue eosinophilia in a relevant subgroup of polyp patients... - World Allergy Organization guidelines for prevention of allergy and allergic asthmaInnes Asher
World Allergy Organization Project, 96 Vambrugh Park, Blackheath, London SE3 7AL, UK
Int Arch Allergy Immunol 135:83-92. 2004 - How atopic is atopic dermatitis?Carsten Flohr
Centre of Evidence Based Dermatology, University of Nottingham, United Kingdom
J Allergy Clin Immunol 114:150-8. 2004..The extent to which the phenotype of atopic dermatitis (AD) is truly atopic has been the subject of much debate... - Qualitative and quantitative evaluation of bird-specific IgG antibodiesAndreas L Lopata
Division of Immunology, Old Main Building H 43, Groote Schuur Hospital, National Health Laboratory Services, University of Cape Town, 7925 Cape Town, South Africa
Int Arch Allergy Immunol 134:173-8. 2004..The aim of this study was to establish the distribution of bird-specific IgG antibodies in exposed and nonexposed individuals and compare a nonquantitative and quantitative method in evaluating raised levels of IgG antibodies... - Prevalence of IgE antibodies to morphine. Relation to the high and low incidences of NMBA anaphylaxis in Norway and Sweden, respectivelyE Florvaag
Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway
Acta Anaesthesiol Scand 49:437-44. 2005..CONCLUSIONS: IgE-sensitization to SUX, MOR and PHO was detected in Norway but not in Sweden. One possible explanation is the unrestricted use of cough mixtures containing MOR derivatives in Norway...