Research Topics
Species | M JaderstenSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
Erythropoietin and granulocyte-colony stimulating factor treatment associated with improved survival in myelodysplastic syndromeMartin Jadersten
Karolinska Institutet, Department of Medicine, Division of Hematology, Stockholm, Sweden
J Clin Oncol 26:3607-13. 2008..To assess the effect of erythropoietin (EPO) plus granulocyte-colony stimulating factor (G-CSF) treatment on survival and leukemic transformation in myelodysplastic syndrome (MDS)...
Myelodysplastic syndromes: biology and treatmentM Jadersten
Division of Hematology and Center of Experimental Hematology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
J Intern Med 265:307-28. 2009..We perform in depth analyses of two of the most widely used treatments, erythropoietin and lenalidomide, discussing mechanisms of action, reasons for treatment failure and influence on survival...
Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progressionMartin Jadersten
Karolinska Institutet, Department of Medicine, Center for Experimental Hematology, Karolinska University Hospital, Stockholm, Sweden
Haematologica 94:1762-6. 2009....
New clues to the molecular pathogenesis of myelodysplastic syndromesMartin Jadersten
Center for Experimental Hematology, Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
Exp Cell Res 316:1390-6. 2010..An improved understanding of the pathophysiology of MDS may lead to the identification of suitable targets for future drug development...
Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34+ blasts in myelodysplastic syndromeM Carlsten
Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Leukemia 24:1607-16. 2010..Thus, given the emerging evidence for NK cell-mediated immune surveillance of neoplastic cells, we speculate that reduced expression of DNAM-1 on bone marrow NK cells may facilitate disease progression in patients with MDS...
