Y L Hurd

Summary

Affiliation: Karolinska Hospital
Country: Sweden

Publications

  1. ncbi Subjects with major depression or bipolar disorder show reduction of prodynorphin mRNA expression in discrete nuclei of the amygdaloid complex
    Y L Hurd
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Mol Psychiatry 7:75-81. 2002
  2. ncbi D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain
    Y L Hurd
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, SE 171 76, Stockholm, Sweden
    J Chem Neuroanat 22:127-37. 2001
  3. ncbi Discrete opioid gene expression impairment in the human fetal brain associated with maternal marijuana use
    X Wang
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden
    Pharmacogenomics J 6:255-64. 2006
  4. ncbi Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects
    Y L Hurd
    Karolinska Institute, Dept of Clinical Neuroscience, Stockholm, Sweden
    Mol Psychiatry 2:495-500. 1997
  5. ncbi The role of dopamine, dynorphin, and CART systems in the ventral striatum and amygdala in cocaine abuse
    Y L Hurd
    Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sweden
    Ann N Y Acad Sci 877:499-506. 1999
  6. ncbi Blunted response to cocaine in the Flinders hypercholinergic animal model of depression
    P Fagergren
    Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, Stockholm, Sweden
    Neuroscience 132:1159-71. 2005
  7. ncbi Preprotachykinin-A mRNA expression in the human and monkey brain: An in situ hybridization study
    Y L Hurd
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institute, S 171 76 Stockholm, Sweden
    J Comp Neurol 411:56-72. 1999
  8. ncbi Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis
    Y L Hurd
    Karolinska Institute, Department Clinical Neuroscience, Psychiatry Section, S 171 76, Stockholm, Sweden
    Behav Brain Res 116:177-86. 2000
  9. ncbi Neuropeptide Y Y(1) and Y(2) receptor mRNA expression in the prefrontal cortex of psychiatric subjects. Relationship of Y(2) subtype to suicidal behavior
    L Caberlotto
    Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, Stockholm, Sweden
    Neuropsychopharmacology 25:91-7. 2001
  10. ncbi Human cocaine- and amphetamine-regulated transcript (CART) mRNA is highly expressed in limbic- and sensory-related brain regions
    Y L Hurd
    Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 171 76 Stockholm, Sweden
    J Comp Neurol 425:583-98. 2000

Collaborators

Detail Information

Publications18

  1. ncbi Subjects with major depression or bipolar disorder show reduction of prodynorphin mRNA expression in discrete nuclei of the amygdaloid complex
    Y L Hurd
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Mol Psychiatry 7:75-81. 2002
    ..These findings indicate specific prodynorphin amygdala impairment in association with mood disorder...
  2. ncbi D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain
    Y L Hurd
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, SE 171 76, Stockholm, Sweden
    J Chem Neuroanat 22:127-37. 2001
    ..The restricted expression of the D1 mRNA to the cortical mantle and to a few forebrain structures indicates a strong involvement of the D1 system in cognitive function...
  3. ncbi Discrete opioid gene expression impairment in the human fetal brain associated with maternal marijuana use
    X Wang
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden
    Pharmacogenomics J 6:255-64. 2006
    ..These results indicate that maternal cannabis and alcohol exposure during pregnancy differentially impair opioid-related genes in distinct brain circuits that may have long-term effects on cognitive and emotional behaviors...
  4. ncbi Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects
    Y L Hurd
    Karolinska Institute, Dept of Clinical Neuroscience, Stockholm, Sweden
    Mol Psychiatry 2:495-500. 1997
    ..Altogether the findings suggest that discrete dysfunction of the endogenous opioid dynorphin system might contribute to depression and the risk of suicide in nonschizophrenic subjects...
  5. ncbi The role of dopamine, dynorphin, and CART systems in the ventral striatum and amygdala in cocaine abuse
    Y L Hurd
    Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sweden
    Ann N Y Acad Sci 877:499-506. 1999
    ..We have noted differences between male and female rats in the mesolimbic mRNA expression of CART that might be relevant for gender differences apparent in drug abuse...
  6. ncbi Blunted response to cocaine in the Flinders hypercholinergic animal model of depression
    P Fagergren
    Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, Stockholm, Sweden
    Neuroscience 132:1159-71. 2005
    ..In conclusion, the FSL animal model of depression demonstrates marked blunting of the locomotor and dynorphin neuroadaptative responses to cocaine in accordance with its enhanced cholinergic sensitivity...
  7. ncbi Preprotachykinin-A mRNA expression in the human and monkey brain: An in situ hybridization study
    Y L Hurd
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institute, S 171 76 Stockholm, Sweden
    J Comp Neurol 411:56-72. 1999
    ..Overall, more similarities than differences are apparent between primate species in the expression pattern of the PPT-A gene. J. Comp. Neurol. 411;56-72, 1999...
  8. ncbi Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis
    Y L Hurd
    Karolinska Institute, Department Clinical Neuroscience, Psychiatry Section, S 171 76, Stockholm, Sweden
    Behav Brain Res 116:177-86. 2000
    ..Overall, these experiments show that elevated mesolimbic dopamine concentrations can differentially modulate cocaine self-administration behavior...
  9. ncbi Neuropeptide Y Y(1) and Y(2) receptor mRNA expression in the prefrontal cortex of psychiatric subjects. Relationship of Y(2) subtype to suicidal behavior
    L Caberlotto
    Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, Stockholm, Sweden
    Neuropsychopharmacology 25:91-7. 2001
    ..In summary, the current results suggest distinct alterations of the prefrontal Y(1) and Y(2) neuronal populations in aging and suicide...
  10. ncbi Human cocaine- and amphetamine-regulated transcript (CART) mRNA is highly expressed in limbic- and sensory-related brain regions
    Y L Hurd
    Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 171 76 Stockholm, Sweden
    J Comp Neurol 425:583-98. 2000
    ..Rat brain specimens were also studied and many similarities to the human CART mRNA expression were evident. However, the most marked species difference was the virtual absence of the CART mRNA in the rat thalamus...
  11. ncbi A heroin-, but not a cocaine-expecting, self-administration state preferentially alters endogenous brain peptides
    S L Cappendijk
    Karolinska Institute, Department of Clinical Neurosciences, Stockholm, Sweden
    Eur J Pharmacol 365:175-82. 1999
    ....
  12. ncbi Coadministration of (-)-OSU6162 with l-DOPA normalizes preproenkephalin mRNA expression in the sensorimotor striatum of primates with unilateral 6-OHDA lesions
    W Pirker
    Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, S-17176, Sweden
    Exp Neurol 169:122-34. 2001
    ..Coadministration of (-)-OSU6162 had no apparent influence on these l-DOPA-induced changes in PDyn mRNA expression. The present results suggest that (-)-OSU6162 acts primarily by modifying striatal output via the indirect pathway...
  13. ncbi Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects
    M Ellgren
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Eur Neuropsychopharmacol 18:826-34. 2008
    ..These findings emphasize the dynamic nature of the mesocorticolimbic endocannabinoid system during adolescence and the selective mesocorticolimbic disturbance as a consequence of adolescent cannabis exposure...
  14. ncbi Marijuana impairs growth in mid-gestation fetuses
    Y L Hurd
    Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, Karolinska University Hospital, Stockholm, Sweden
    Neurotoxicol Teratol 27:221-9. 2005
    ..These findings provide evidence of a negative impact of prenatal marijuana exposure on the mid-gestational fetal growth even when adjusting for maternal use of other substances well known to impair fetal development...
  15. ncbi Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self-administration
    P Fagergren
    Karolinska Institute, Department of Clinical Neuroscience, Karolinska Hospital, S-171 76 Stockholm, Sweden
    Eur J Neurosci 17:2212-8. 2003
    ..In addition, the temporal nature of the changes in PDYN gene expression within the striatal compartments could reflect a change in drug responsivity that occurs during the transition to drug dependence...
  16. ncbi Preferential limbic expression of the cannabinoid receptor mRNA in the human fetal brain
    X Wang
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Karolinska Hospital, S-171 76 Stockholm, Sweden
    Neuroscience 118:681-94. 2003
    ..Overall, the high CB1 mRNA expression in the fetal hippocampus and amygdala indicates that these limbic structures might be most vulnerable to prenatal cannabis exposure...
  17. ncbi Autoantigen Ku in the brain. Developmentally regulated expression and subcellular localization
    G Bakalkin
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuroreport 9:2147-51. 1998
    ..The abundant expression of Ku in the brain suggests the involvement of Ku autoantibodies in the pathogenesis of neuropsychiatric complications in connective tissue diseases...
  18. ncbi Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain
    L Caberlotto
    Karolinska Institute, Department of Neuroscience, Stockholm, Sweden
    Neuroscience 86:167-78. 1998
    ....