T Hokfelt

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Galanin: a multitalented neuropeptide
    T Hokfelt
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    EXS 102:1-5. 2010
  2. ncbi Looking at neurotransmitters in the microscope
    Tomas Hokfelt
    Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Prog Neurobiol 90:101-18. 2010
  3. ncbi Galanin--25 years with a multitalented neuropeptide
    T Hokfelt
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Cell Mol Life Sci 65:1793-5. 2008
  4. ncbi NPY and its involvement in axon guidance, neurogenesis, and feeding
    Tomas Hokfelt
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Nutrition 24:860-8. 2008
  5. ncbi Deletion of the neuropeptide Y Y1 receptor affects pain sensitivity, neuropeptide transport and expression, and dorsal root ganglion neuron numbers
    T J S Shi
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Neuroscience 140:293-304. 2006
  6. ncbi Changes in the mRNA expression pattern, with special reference to calcitonin gene-related peptide, after axonal injuries in rat motoneurons depends on age and type of injury
    F Piehl
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Exp Brain Res 119:191-204. 1998
  7. ncbi Hypothalamic neurohistochemistry of the murine anorexia (anx/anx) mutation: altered processing of neuropeptide Y in the arcuate nucleus
    C Broberger
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Comp Neurol 387:124-35. 1997
  8. ncbi Galanin and NPY, two peptides with multiple putative roles in the nervous system
    T Hokfelt
    Dept of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Horm Metab Res 31:330-4. 1999
  9. ncbi Expression and regulation of cholecystokinin and cholecystokinin receptors in rat nodose and dorsal root ganglia
    C Broberger
    Department of Neuroscience, Berzelius Vag 1, Karolinska Institutet, 171 77 Stockholm, Sweden
    Brain Res 903:128-40. 2001
  10. ncbi Effects of antibodies against acetylcholinesterase on the expression of peptides and catecholamine synthesizing enzymes in the rat adrenal gland
    A Dagerlind
    Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden
    Neuroscience 54:1079-90. 1993

Collaborators

Detail Information

Publications133 found, 100 shown here

  1. ncbi Galanin: a multitalented neuropeptide
    T Hokfelt
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    EXS 102:1-5. 2010
    ..In this introduction, we provide some historical aspects on the galanin research and how the field has developed over three decades...
  2. ncbi Looking at neurotransmitters in the microscope
    Tomas Hokfelt
    Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Prog Neurobiol 90:101-18. 2010
    ....
  3. ncbi Galanin--25 years with a multitalented neuropeptide
    T Hokfelt
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Cell Mol Life Sci 65:1793-5. 2008
  4. ncbi NPY and its involvement in axon guidance, neurogenesis, and feeding
    Tomas Hokfelt
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Nutrition 24:860-8. 2008
    ..In the present study we examined a possible role of the 36-amino acid neuropeptide Y (NPY) with regard to three functions: axon guidance and attraction/repulsion, adult neurogenesis, and control of food intake...
  5. ncbi Deletion of the neuropeptide Y Y1 receptor affects pain sensitivity, neuropeptide transport and expression, and dorsal root ganglion neuron numbers
    T J S Shi
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Neuroscience 140:293-304. 2006
    ....
  6. ncbi Changes in the mRNA expression pattern, with special reference to calcitonin gene-related peptide, after axonal injuries in rat motoneurons depends on age and type of injury
    F Piehl
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Exp Brain Res 119:191-204. 1998
    ..Of the substances studied here, upregulation of alpha-CGRP and p75 mRNAs best correlated with a possibility of axon regeneration...
  7. ncbi Hypothalamic neurohistochemistry of the murine anorexia (anx/anx) mutation: altered processing of neuropeptide Y in the arcuate nucleus
    C Broberger
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Comp Neurol 387:124-35. 1997
    ..These data suggest that a defect in neuropeptide Y-ergic signalling in the arcuate neurons may contribute to the failure to thrive in anx/anx mice...
  8. ncbi Galanin and NPY, two peptides with multiple putative roles in the nervous system
    T Hokfelt
    Dept of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Horm Metab Res 31:330-4. 1999
    ..It may therefore be interesting to analyse to what extent drugs affecting galaninergic transmission also may be efficient in the treatment of, for example, depression...
  9. ncbi Expression and regulation of cholecystokinin and cholecystokinin receptors in rat nodose and dorsal root ganglia
    C Broberger
    Department of Neuroscience, Berzelius Vag 1, Karolinska Institutet, 171 77 Stockholm, Sweden
    Brain Res 903:128-40. 2001
    ..The stimulation of CCK and CCK(B)-R gene expression following vagotomy suggests a possible involvement in the response to injury for these molecules...
  10. ncbi Effects of antibodies against acetylcholinesterase on the expression of peptides and catecholamine synthesizing enzymes in the rat adrenal gland
    A Dagerlind
    Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden
    Neuroscience 54:1079-90. 1993
    ....
  11. ncbi Prominent expression of acidic fibroblast growth factor in motor and sensory neurons
    R Elde
    Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden
    Neuron 7:349-64. 1991
    ..Confocal and electron microscopic analysis suggested that a large portion of aFGF immunoreactivity was associated with the cytoplasmic face of neuronal membranes, consistent with the hypothesis that aFGF is a sequestered growth factor...
  12. ncbi Generation and phenotypic characterization of a galanin overexpressing mouse
    K Holmberg
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, B3 4, SE 171 77 Stockholm, Sweden
    Neuroscience 133:59-77. 2005
    ..These findings suggest that overexpressed galanin in some tissues of these mice can be released and via a receptor-mediated action influence pathophysiological processes...
  13. ncbi Neuropeptide Y: some viewpoints on a multifaceted peptide in the normal and diseased nervous system
    T Hokfelt
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Brain Res Brain Res Rev 26:154-66. 1998
    ..It is possible that these changes in NPY-ergic mechanisms may underlie some of the central symptoms associated with the prion disease. (ABSTRACT TRUNCATED)..
  14. ncbi Colocalization of neurotransmitters analyzed by in situ hybridization
    M Schalling
    Department of Histology, Karolinska Institutet, Stockholm, Sweden
    Eur Neuropsychopharmacol 1:173-6. 1991
    ..The results also suggest a novel way to define neuronal projections by visualizing increases in mRNA levels following electrical stimulation...
  15. ncbi Galanin-R1 receptor in anterior and mid-hypothalamus: distribution and regulation
    M Landry
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Comp Neurol 399:321-40. 1998
    ..The receptors are regulated in a specific fashion in the various nuclei, depending on the stimulus applied. The results suggest that the effect of galanin in the hypothalamus partly depends on the state of receptor expression...
  16. ncbi Immunologically induced sympathectomy of preganglionic nerves by antibodies against acetylcholinesterase: increased levels of peptides and their messenger RNAs in rat adrenal chromaffin cells
    A Dagerlind
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroscience 62:217-39. 1994
    ..The present results show that interruption of splanchnic transmission induces fast, marked, and selective increases in peptide expression in rat adrenal chromaffin cells...
  17. ncbi Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice. Focus on immunohistochemical localization
    J Kopp
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroscience 111:443-532. 2002
    ..Finally, the importance of using proper control experiments for immunohistochemical studies on seven-transmembrane receptors is stressed...
  18. ncbi Neuropeptides, nitric oxide synthase and GAP-43 in B4-binding and RT97 immunoreactive primary sensory neurons: normal distribution pattern and changes after peripheral nerve transection and aging
    E Bergman
    Department of Neuroscience, Division of Chemical Neurotransmission, Karolinska Institutet, Doktorsringen 17, 171 77, Stockholm, Sweden
    Brain Res 832:63-83. 1999
    ..The relative size of the DRG subpopulations was unaffected by aging, while the expression of neuropeptides was altered showing similarities with the changes induced by axotomy in young adult rats...
  19. ncbi Regulatory effects of trophic factors on expression and distribution of CGRP and GAP-43 in rat motoneurons
    F Piehl
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Neurosci Res 51:1-14. 1998
    ..The effect of a CGRP antagonist on GAP-43 in muscle indicates a role for CGRP in sprouting-related processes...
  20. ncbi Expression of acidic and basic fibroblast growth factors in the substantia nigra of rat, monkey, and human
    A J Bean
    Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden
    Proc Natl Acad Sci U S A 88:10237-41. 1991
    ..The distribution of aFGF mRNA in monkey brain was similar to that seen in the rat. RNA and immunoblot analysis confirmed the presence of both aFGF and bFGF mRNAs and proteins in the substantia nigra of rat, monkey, and human...
  21. ncbi Intraventricular injection of neurotensin reduces dopamine D2 agonist binding in rat forebrain and intermediate lobe of the pituitary gland. Relationship to serum hormone levels and nerve terminal coexistence
    G von Euler
    Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Brain Res 531:253-62. 1990
    ....
  22. ncbi An immunohistochemical marker for Wallerian degeneration of fibers in the central and peripheral nervous system
    P Pesini
    Department of Neuroscience, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Brain Res 828:41-59. 1999
    ....
  23. ncbi Effects of preganglionic sympathectomy on peptides in the rat superior cervical ganglion
    A Dagerlind
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuroreport 5:909-12. 1994
    ..g. GAL and GMAP, can be upregulated after deafferentation...
  24. ncbi The neuropeptide tyrosine Y1R is expressed in interneurons and projection neurons in the dorsal horn and area X of the rat spinal cord
    P Brumovsky
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, B2 5, S 171 77 Stockholm, Sweden
    Neuroscience 138:1361-76. 2006
    ..The present results show neuropeptide tyrosine-sensitive neuron populations virtually in all parts of the lumbar spinal cord, suggesting a role for neuropeptide tyrosine signaling in many spinal functions, including pain...
  25. ncbi Cocaine- and amphetamine-regulated transcript in the rat vagus nerve: A putative mediator of cholecystokinin-induced satiety
    C Broberger
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 96:13506-11. 1999
    ....
  26. ncbi Substance P: a pioneer amongst neuropeptides
    T Hokfelt
    Department of Neuroscience, and Department of Clinical Physiology, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Intern Med 249:27-40. 2001
    ....
  27. ncbi Effect of NGF, BDNF, bFGF, aFGF and cell density on NPY expression in cultured rat dorsal root ganglion neurones
    N Kerekes
    Department of Neuroscience, Karolinska Institutet, S 171 77, Stockholm
    J Auton Nerv Syst 81:128-38. 2000
    ..F., Hökfelt, T., 1996. aFGF, bFGF and NGF differentially regulate neuropeptide expression in dorsal root ganglia after axotomy and induce autotomy. Reg. Pept. 66, 179-189.]. Finally, NPY expression was also influenced by cell density...
  28. ncbi Transient prenatal expression of NPY-Y1 receptor in trigeminal axons innervating the mystacial vibrissae
    R Ubink
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Comp Neurol 429:183-91. 2001
    ..The transient expression of the Y1-R during prenatal mystacial pad development suggests a role for the Y1-R in the functional development of the vibrissae...
  29. ncbi Galanin in ascending systems. Focus on coexistence with 5-hydroxytryptamine and noradrenaline
    T Hokfelt
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Ann N Y Acad Sci 863:252-63. 1998
    ..Consequently, a galanin antagonist could attenuate an inhibitory tone on both dorsal raphe and locus coeruleus neurons and thus perhaps exert antidepressant activity...
  30. ncbi The distribution of cGMP in the adrenal gland in the rat, guinea pig and mouse after stimulation with sodium nitroprusside
    K Holmberg
    Department of Neuroscience, Karolinska Institute, S 17177 Stockholm, Sweden
    Cell Tissue Res 294:393-406. 1998
    ..These findings support the view that chromaffin cells, especially the noradrenergic ones and blood vessels, are targets for nitric oxide in the adrenal gland...
  31. ncbi Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus
    C Broberger
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroendocrinology 66:393-408. 1997
    ..Release of NPY, and possible coexisting messengers, may be controlled by presynaptic Y2-R expressed in NPY neurons. Taken together, the findings support the division of Y1-Rs and Y2-Rs into post- and presynaptic receptors, respectively...
  32. ncbi The NO-cGMP pathway in the rat locus coeruleus: electrophysiological, immunohistochemical and in situ hybridization studies
    Z Q Xu
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Eur J Neurosci 10:3508-16. 1998
    ..1994), a few neurons may influence a large population of noradrenergic LC neurons, which in turn may control activity in many regions of the central nervous system...
  33. ncbi Changes in neuropeptide Y receptors and pro-opiomelanocortin in the anorexia (anx/anx) mouse hypothalamus
    C Broberger
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Neurosci 19:7130-9. 1999
    ..The present data suggest that degeneration of the arcuate POMC system is a feature characteristic of the anx/anx mouse. The possible relationship to the NPYergic phenotype of this animal is discussed...
  34. ncbi Localization of choline acetyltransferase in rat peripheral sympathetic neurons and its coexistence with nitric oxide synthase and neuropeptides
    M A Morales
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Proc Natl Acad Sci U S A 92:11819-23. 1995
    ..Acetylcholine, VIP, and CGRP are coexisting messenger molecules in some postganglionic sympathetic neurons...
  35. ncbi Evidence for a cardiovascular role of central galanin neurons: focus on interactions with alpha 2-adrenergic and neuropeptide Y mechanisms
    A Harfstrand
    Department of Histology, Karolinska Institutet, Stockholm, Sweden
    J Cardiovasc Pharmacol 10:S199-204. 1987
    ..abstract truncated at 250 words)..
  36. ncbi Expression of galanin and nitric oxide synthase in subpopulations of serotonin neurons of the rat dorsal raphe nucleus
    Z Q Xu
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Chem Neuroanat 13:169-87. 1997
    ..It is possible that NO, and perhaps GAL, in 5-HT neurons exert their main actions at the somatic and dendritic level in the DR...
  37. ncbi Neuropeptides--an overview
    T Hokfelt
    Department of Neuroscience, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Neuropharmacology 39:1337-56. 2000
    ..Taken together it seems that peptides may play a role particularly when the nervous system is stressed, challenged or afflicted by disease, and that peptidergic systems may, therefore, be targets for novel therapeutic strategies...
  38. ncbi Expression of insulin-like growth factors and corresponding binding proteins (IGFBP 1-6) in rat spinal cord and peripheral nerve after axonal injuries
    H Hammarberg
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Comp Neurol 400:57-72. 1998
    ..The robust upregulation of IGFBP-6 mRNA in lesioned motoneurons suggests that this binding protein may be of special relevance for the severed cells...
  39. ncbi Differential effects of intrastriatally infused fully and endcap phosphorothioate antisense oligonucleotides on morphology, histochemistry and prodynorphin expression in rat brain
    C Broberger
    Department of Neuroscience, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Brain Res Mol Brain Res 75:25-45. 2000
    ....
  40. ncbi Birth-related expression of c-fos, c-jun and substance P mRNAs in the rat brainstem and pia mater: possible relationship to changes in central chemosensitivity
    H R Wickström
    Department of Women and Child Health, Karolinska Institute, S 171 77, Stockholm, Sweden
    Brain Res Dev Brain Res 112:255-66. 1999
    ....
  41. ncbi Expression of the vesicular glutamate transporters-1 and -2 in adult mouse dorsal root ganglia and spinal cord and their regulation by nerve injury
    P Brumovsky
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, B2 5, S 171 77 Stockholm, Sweden
    Neuroscience 147:469-90. 2007
    ..J Comp Neurol 483:1-16], we speculate that virtually all DRG neurons in adult mouse express VGLUTs and use glutamate as transmitter...
  42. ncbi Neuropeptide expression in rats exposed to chronic mild stresses
    Valeriy Sergeyev
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Psychopharmacology (Berl) 178:115-24. 2005
    ....
  43. ncbi Immunohistochemical studies on phosphorylation of tyrosine hydroxylase in central catecholamine neurons using site- and phosphorylation state-specific antibodies
    Z Q Xu
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuroscience 82:727-38. 1998
    ....
  44. ncbi Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cells
    B Meister
    Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden
    Proc Natl Acad Sci U S A 86:8068-72. 1989
    ..The results indicate that DA1 dopamine receptors and DARPP-32, an intracellular third messenger for dopamine, are part of the signal-transduction process for dopamine acting on renal tubule cells...
  45. ncbi Neuropeptide Y innervation and neuropeptide-Y-Y1-receptor-expressing neurons in the paraventricular hypothalamic nucleus of the mouse
    C Broberger
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroendocrinology 70:295-305. 1999
    ..This study further defines the link between NPY-induced feeding and the hypothalamus-pituitary-thyroid axis...
  46. ncbi Effect of peripheral nerve lesion and lumbar sympathectomy on peptide regulation in dorsal root ganglia in the NGF-overexpressing mouse
    K Holmberg
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Exp Neurol 167:290-303. 2001
    ..Finally, expression of NPY in sympathetic ganglia is differently regulated in NGFOE compared to wild-type mice...
  47. ncbi Effect of a graded single constriction of the rat sciatic nerve on pain behavior and expression of immunoreactive NPY and NPY Y1 receptor in DRG neurons and spinal cord
    P R Brumovsky
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, S 171 77 Stockholm, Sweden
    Brain Res 1006:87-99. 2004
    ....
  48. ncbi Neuropeptide y targets in the hypothalamus: nitric oxide synthesizing neurones express Y1 receptor
    S O Fetissov
    Department of Neuroscience B3 4, Karolinska Institutet, Stockholm, Sweden
    J Neuroendocrinol 15:754-60. 2003
    ..We observed several cGMP-positive cell bodies in the arcuate nucleus, cGMP-positive blood vessels and a cGMP-positive network of thin fibres, some of which colocalized with choline acetyltransferase...
  49. ncbi Expression of p75(NTR), trkB and trkC in nonmanipulated and axotomized motoneurons of aged rats
    H Johnson
    Department of Neuroscience, Karolinska Institutet, Division of Neuroanatomy and Neuronal Plasticity, S 171 77, Stockholm, Sweden
    Brain Res Mol Brain Res 69:21-34. 1999
    ..The lack of covariation between p75NTR and trkB and trkC regulation in aged rats indicates a changed role for p75NTR in senescent motoneurons...
  50. ncbi Alterations of arcuate nucleus neuropeptidergic development in contactin-deficient mice: comparison with anorexia and food-deprived mice
    Serguei O Fetissov
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Eur J Neurosci 22:3217-28. 2005
    ....
  51. ncbi Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse--possible implications for pain processing
    Pablo Brumovsky
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Chem Neuroanat 31:243-62. 2006
    ..Hao, J.X., Xu, X.J., Hökfelt, T., Crawley, J.N., Wiesenfeld-Hallin, Z., 2004. Galanin over-expression decreases the development of neuropathic pain-like behaviour in mice after partial sciatic nerve injury. Brain Res. 1025, 152-158]...
  52. ncbi Galanin receptor 2 overexpressing mice display an antidepressive-like phenotype: possible involvement of the subiculum
    T Wardi Le Maître
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, S 17177 Stockholm, Sweden
    Neuroscience 190:270-88. 2011
    ....
  53. ncbi CCK-ergic mechanisms in sensory systems
    T Hokfelt
    Department of Neuroscience, Retzius Laboratory, Karolinska Institutet, Stockholm, Sweden
    Scand J Clin Lab Invest Suppl 234:69-74. 2001
    ..In man and monkey the CCK1 receptor seems important in the dorsal horn under normal conditions, indicating distinct species differences...
  54. ncbi Galanin and spinal nociceptive mechanisms: recent advances and therapeutic implications
    X J Xu
    Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institutet, S 141 86 Huddinge, Sweden
    Neuropeptides 34:137-47. 2000
    ..Hence, the sensory effect of galanin may be increased under these conditions, raising the possibility that modulation of the activity of the galanin system may produce antinociception...
  55. ncbi Effect of peripheral axotomy on dorsal root ganglion neuron phenotype and autonomy behaviour in neuropeptide Y-deficient mice
    T J Shi
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Regul Pept 75:161-73. 1998
    ..Also, deletion of NPY does not seem to influence the expression of the partly coexisting peptide galanin...
  56. ncbi Perinatal distribution of galanin and galanin receptor-1 mRNA in the rat hindbrain
    R Wickstrom
    Department of Neuroscience, Karolinska Institutet, 171 76, Stockholm, Sweden
    Brain Res Dev Brain Res 123:53-65. 2000
    ....
  57. ncbi Galanin, galanin receptor subtypes and depression-like behaviour
    E Kuteeva
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, S 17177 Stockholm, Sweden
    Cell Mol Life Sci 65:1854-63. 2008
    ..These findings suggest that galanin receptor subtypes represent targets for development of novel antidepressant drugs...
  58. ncbi Neuropeptides in hippocampus and cortex in transgenic mice overexpressing V717F beta-amyloid precursor protein--initial observations
    M Diez
    Department of Neuroscience, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Neuroscience 100:259-86. 2000
    ..Further studies will be needed to establish to what extent these changes are typical for Alzheimer mouse models in general or are associated with the V717F mutation and/or the platelet-derived growth factor-beta promoter...
  59. ncbi Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems
    C Broberger
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Comp Neurol 402:460-74. 1998
    ..Furthermore, the results implicate hypocretin/orexin and melanin-concentrating hormone-expressing cells as downstream targets in neuropeptide Y-induced feeding...
  60. ncbi Multiple messengers in descending serotonin neurons: localization and functional implications
    T Hokfelt
    Department of Neuroscience, Karolinska Institutet, Box 60 400, 171 77, Stockholm, Sweden
    J Chem Neuroanat 18:75-86. 2000
    ....
  61. ncbi Altered hippocampal expression of neuropeptides in seizure-prone GALR1 knockout mice
    Serguei O Fetissov
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Epilepsia 44:1022-33. 2003
    ....
  62. ncbi Neuropeptide Y2 receptor protein is present in peptidergic and nonpeptidergic primary sensory neurons of the mouse
    Pablo Brumovsky
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Comp Neurol 489:328-48. 2005
    ..The results also support a role for this receptor and NPY in pain mechanisms...
  63. ncbi Altered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient mice
    Leah C Byrne
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177, Stockholm, Sweden
    Neuroreport 15:569-74. 2004
    ..Their altered subcellular distribution suggests that MT1-MMP is involved in postnatal development of the arcuate NPY/AgRP-system which may contribute to the generation of the wasting phenotype...
  64. ncbi Neuropeptide Y1 receptors in the rat genital tract
    J Kopp
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Regul Pept 70:149-60. 1997
    ..Fibers showing NPY-LI were found around blood vessels both in the ovary and oviduct. In the female genital tract also Y1-Rs may thus be involved in regulatory mechanisms mediating, for example, vasoconstriction...
  65. ncbi Hypothalamic and vagal neuropeptide circuitries regulating food intake
    C Broberger
    Department of Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden
    Physiol Behav 74:669-82. 2001
    ..Disturbances in the hypothalamic neuropeptide systems have been implicated in the phenotype of a genetic model of fatal hypophagia, the mouse anorexia (anx) mutation, which is also discussed...
  66. ncbi The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
    C Broberger
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 95:15043-8. 1998
    ..Our results show that arcuate NPY neurons, identified by the presence of AGRP, project more extensively in the brain than previously known and indicate that the feeding regulatory actions of NPY may extend beyond the hypothalamus...
  67. ncbi Microdialysis in freely moving mice: determination of acetylcholine, serotonin and noradrenaline release in galanin transgenic mice
    J Kehr
    Department of Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden
    J Neurosci Methods 109:71-80. 2001
    ..Furthermore, modulation by galanin and by behavioral activation, of NA and 5-HT neurotransmission in galanin over-expressing mice indicates its possible role in the aetiology of mood disorders...
  68. ncbi Expression of cholecystokinin, enkephalin, galanin and neuropeptide Y is markedly changed in the brain of the megencephaly mouse
    S Petersson
    Neurogenetic Unit, Center for Molecular Medicine, Karolinska Institutet, 171 76, Stockholm, Sweden
    Neuroscience 100:297-317. 2000
    ..Whether the mainly increased peptide levels contribute to the excessive growth of the brain or represent a consequence of this growth and/or of the neurological and motor disturbances remains to be elucidated...
  69. ncbi Novel antigen design for the generation of antibodies to G-protein-coupled receptors
    K Larsson
    Division of Proteomics, School of Biotechnology, KTH AlbaNova University Center, Stockholm, Sweden
    J Immunol Methods 370:14-23. 2011
    ..Hence, the genetic combination of several different epitopes enables efficient generation of specific antibodies with potential use in several applications for the study of endogenous receptors...
  70. ncbi Neuropeptide Y expression in Schwann cell precursors
    R Ubink
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Glia 32:71-83. 2000
    ..5. Based on its spatiotemporal expression, it is concluded that NPY is expressed by Schwann cell precursors. NPY expressed by Schwann cell precursors might have a role in axonal growth or axonal guidance, or both...
  71. ncbi Distribution of cGMP in guinea pig autonomic ganglia after stimulation with sodium nitroprusside
    K Holmberg
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Auton Neurosci 89:7-15. 2001
    ..possibly in satellite cells. We propose, as one alternative, that there is a functional, intraganglionic regulatory loop between the parasympathetic and sympathetic divisions of the APG, using the NO/cGMP pathway...
  72. ncbi Analysis of selected regulatory pathways for rat galanin gene transcription and their suitability as putative models for negative regulation by NGF
    J Corness
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Ann N Y Acad Sci 863:14-21. 1998
    ..From here we can carry out further experiments that may help to elucidate the possible mechanisms of NGF repression in vivo...
  73. ncbi Evidence of hypothalamic degeneration in the anorectic anx/anx mouse
    Ida A K Nilsson
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Glia 59:45-57. 2011
    ..These results support the hypothesis of degeneration of hypothalamic arcuate neuron populations in the anx/anx mice, whereby the AGRP system may be first affected, the changes in the POMC system being secondary in this process...
  74. ncbi Evidence for hypothalamic dysregulation in mouse models of anorexia as well as in humans
    Jeanette E Johansen
    Karolinska Institutet, Department of Molecular Medicine and Surgery, L8 00, Karolinska University Hospital, S 171 76 Stockholm, Sweden
    Physiol Behav 92:278-82. 2007
    ..These findings represent research avenues that may lead to a better understanding of eating disorders and development of targeted therapeutic approaches...
  75. ncbi Characterization of neuropeptide Y2 receptor protein expression in the mouse brain. I. Distribution in cell bodies and nerve terminals
    Davor Stanic
    Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Comp Neurol 499:357-90. 2006
    ..Localization of the Y2R suggests that it is mostly presynaptic, a view supported by its frequent absence in cell bodies in the normal mouse and its dramatic increase in cell bodies of colchicine-treated mice...
  76. ncbi Neuropeptides in learning and memory processes with focus on galanin
    Sven Ove Ogren
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Eur J Pharmacol 626:9-17. 2010
    ..It is concluded that compounds acting on neuropeptide receptor subtypes will represent novel targets for a number of disorders, which involve cognitive deficiencies...
  77. ncbi Aggressive behavior linked to corticotropin-reactive autoantibodies
    Serguei O Fetissov
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biol Psychiatry 60:799-802. 2006
    ..We hypothesized that autoantibodies (autoAbs) directed against several stress-related neurohormones may exist in aggressive subjects...
  78. ncbi Galanin receptor antagonists : a potential novel pharmacological treatment for mood disorders
    Sven Ove Ogren
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    CNS Drugs 20:633-54. 2006
    ..Taken together, the present evidence suggests that antidepressant efficacy may be associated with compounds acting as antagonists at the GAL3 and/or possibly GAL1 receptors, and/or agonists at the GAL2 receptor...
  79. ncbi Aberrant agouti-related protein system in the hypothalamus of the anx/anx mouse is associated with activation of microglia
    Ida Nilsson
    Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden
    J Comp Neurol 507:1128-40. 2008
    ..Thus, the aberrant appearance of the AgRP system in the anx/anx mouse in the early postnatal development could involve a microglia-associated process and the innate immune system...
  80. ncbi Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour
    Tie Jun Sten Shi
    Department of Neuroscience, Karolinska Institutet, S171 77 Stockholm, Sweden
    Eur J Neurosci 23:627-36. 2006
    ..These data are in line with earlier observations from the peripheral and central nervous system, suggesting that galanin actions mediated by GalR2 subtype are of importance in neurodevelopment and neuroprotection...
  81. ncbi Behavioural characterisation of young adult transgenic mice overexpressing galanin under the PDGF-B promoter
    Eugenia Kuteeva
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, Stockholm S 171 77, Sweden
    Regul Pept 125:67-78. 2005
    ..These data support the hypothesis that galanin may have a role in functions related to mood states including affective disorders...
  82. ncbi Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body level
    Eugenia Kuteeva
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, Stockholm S 171 77 corrected Sweden
    Neuropsychopharmacology 33:2573-85. 2008
    ..Galanin has a role in behavioral adaptation to stressful events involving changes of molecules important for noradrenaline and/or serotonin transmission...
  83. ncbi Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1
    Sophie Bensing
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:949-54. 2007
    ..Thus, we have identified TDRD6 as a major autoantigen in APS1 patients and shown that several sera from GH-deficient patients stain specific cell populations and nerves in the pituitary gland...
  84. ncbi Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test
    Takashi Yoshitake
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 101:354-9. 2004
    ..The present findings support a role of galanin in the regulation of release of NA and 5-HT, two neurotransmitters involved in mood control...
  85. ncbi Directional cues for arcuate NPY projections are present in the adult brain
    Serguei O Fetissov
    Department of Neuroscience, Karolinska Institutet, B3 4, Retzius vag 8, SE 171 77, Stockholm, Sweden
    Exp Neurol 183:116-23. 2003
    ....
  86. ncbi Prenatal exposure to nicotine affects substance p and preprotachykinin-A mRNA levels in newborn rat
    Jonas Berner
    Department of Woman and Child Health, Karolinska Institutet, 171 77 Stockholm, Sweden
    Pediatr Res 64:621-4. 2008
    ..We conclude that nicotine causes alterations in the substance P-ergic system in the brainstem, possibly linked to the increased risk for SIDS after prenatal nicotine exposure...
  87. ncbi Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain
    Davor Stanic
    Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:3610-5. 2008
    ..These findings suggest that both NPY and CCK through their receptors help to regulate the proliferation of precursor cells, the amount of neuroblast cells in the SVZ and RMS, and influence the differentiation of OB interneurons...
  88. ncbi Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain
    Wenyu Fu
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    J Comp Neurol 518:3464-94. 2010
    ..Thus, extrapolation of DRN physiology, and possibly pathology, from rat to mouse, and even human, should be made with caution...
  89. ncbi Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia
    Alexandre L R Oliveira
    Department of Neuroscience, The Retzius Laboratory, Karolinska Institutet, SE-171 77 Stockholm, Sweden
    Synapse 50:117-29. 2003
    ..VGLUT1 is mainly present in primary afferents from large, CGRP-negative DRG neurons, VGLUT2 has mainly a local origin, and VGLUT3 fibers probably have a supraspinal origin...
  90. ncbi Expression of neuropeptide Y in olfactory ensheathing cells during prenatal development
    R Ubink
    Department of Neuroscience, Karolinska Institutet, Berzelius v ag 1, 171 77 Stockholm, Sweden
    J Comp Neurol 423:13-25. 2000
    ..NPY might be involved in the guidance, growth, or both, of olfactory sensory axons toward their target glomeruli in the olfactory bulb or have a function in the maturation of the olfactory sensory neurons...
  91. ncbi Cholecystokinin/opioid interactions
    Z Wiesenfeld-Hallin
    Karolinska Institutet, Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    Brain Res 848:78-89. 1999
    ..While the effect of morphine on CCK-LI can be interpreted as the result of increased CCK release, the effect on MOR-LI may be related to changes in the microenvironment of the dorsal horn induced by nerve injury...
  92. ncbi Potent and nontoxic antisense oligonucleotides containing locked nucleic acids
    C Wahlestedt
    Center for Genomics Research and Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 97:5633-8. 2000
    ..LNA-containing oligonucleotides will likely be useful for many antisense applications...
  93. ncbi Galanin expression in adult human dorsal root ganglion neurons: initial observations
    M Landry
    Department of Neuroscience, Retzius vag 8, B3 4, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Neuroscience 117:795-809. 2003
    ..However, to what extent a similarly dramatic upregulation of galanin expression can be seen after peripheral nerve lesion in man, as has been reported for rat, mouse and monkey, remains to be analysed...
  94. ncbi Excitatory amino acids, monoamine, and nitric oxide synthase systems in organotypic cultures: biochemical and immunohistochemical analysis
    M Herrera-Marschitz
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Amino Acids 19:33-43. 2000
    ..Thus, the organotypic model appears to capture many of the neurochemical and morphological features seen in vivo, providing a valuable model for studying in detail the neurocircuitries of the brain...
  95. ncbi Systematically generated antibodies against human gene products: high throughput screening on sections from the rat nervous system
    J Mulder
    Department of Neuroscience, Karolinska Institutet, Retzius v 8, S171 77 Stockholm, Sweden
    Neuroscience 146:1689-703. 2007
    ....
  96. ncbi Galanin decreases proliferation of PC12 cells and induces apoptosis via its subtype 2 receptor (GalR2)
    R Tofighi
    Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:2717-22. 2008
    ..These findings point to GalR2 as a possible target for therapeuthic interventions in pheochromocytoma...
  97. ncbi Developmental exposure to methylmercury alters learning and induces depression-like behavior in male mice
    Natalia Onishchenko
    Division of Toxicology and Neurotoxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Toxicol Sci 97:428-37. 2007
    ..This study provides novel evidence that the developmental exposure to MeHg can affect not only cognitive functions but also motivation-driven behaviors...
  98. ncbi An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function
    Jenny U Johansson
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    PLoS Genet 4:e1000278. 2008
    ..We conclude that the ancient exon duplication in the Snap25 gene provides additional SNAP-25-function required for complex neuronal processes in higher eukaryotes...
  99. ncbi Differential distribution and regulation of galanin receptors- 1 and -2 in the rat lumbar spinal cord
    Pablo Brumovsky
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain Res 1085:111-20. 2006
    ..Furthermore, the nerve injury-induced Gal(2) upregulation in motor neurons suggests a role for galanin in survival/regeneration mechanisms...
  100. ncbi Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain
    Tie Jun Sten Shi
    Department of Neuroscience, and Department of Clinical Science and Education, Section of Hand Surgery, Sodersjukhuset, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:20004-8. 2008
    ..Thus, inhibition of PLC may provide a way to treat neuropathic pain...
  101. ncbi Tissue profiling of the mammalian central nervous system using human antibody-based proteomics
    Jan Mulder
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Mol Cell Proteomics 8:1612-22. 2009
    ..Furthermore optimized tissue processing and colchicine treatment allow a high quality, more extended annotation and detailed analysis of subcellular distributions and protein dynamics...