Paul Hjemdahl

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint [More evidence against COX-2 inhibitors. The risk of severe cardiovascular complications more and more obvious]
    Paul Hjemdahl
    Institutionen för medicin, enheten för kliniskfarmakologi, Karolinska institutet och Karolinska Universitetssjukhuset Solna, Stockholm
    Lakartidningen 104:310-1. 2007
  2. pmc Postprandial platelet activation is related to postprandial plasma insulin rather than glucose in patients with type 2 diabetes
    Galia Spectre
    Department of Medicine Solna, Clinical Pharmacology Unit, Karolinska University Hospital Solna, Stockholm, Sweden
    Diabetes 61:2380-4. 2012
  3. pmc Validation of the clinical COPD Questionnaire (CCQ) in primary care
    Bjorn Stallberg
    Department of Public Health and Caring Sciences, Section of Family Medicine and Clinical Epidemiology, Uppsala University, Uppsala, Sweden
    Health Qual Life Outcomes 7:26. 2009
  4. ncbi request reprint Effect of clopidogrel treatment on stress-induced platelet activation and myocardial ischemia in aspirin-treated patients with stable coronary artery disease
    Christina Perneby
    Karolinska Institutet Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital, Stockholm, Sweden
    Thromb Haemost 98:1316-22. 2007
  5. doi request reprint Platelets selectively enhance lymphocyte adhesion on subendothelial matrix under arterial flow conditions
    Galia Spectre
    Department of Medicine Solna, Clinical Pharmacology Unit, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, Sweden
    Thromb Haemost 108:328-37. 2012
  6. doi request reprint Risk prediction in stable angina pectoris
    Thomas Kahan
    Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, SE 182 88, Stockholm, Sweden
    Eur J Clin Invest 43:141-51. 2013
  7. ncbi request reprint High glucose levels enhance platelet activation: involvement of multiple mechanisms
    Dzana Sudic
    Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital Solna, Stockholm, Sweden
    Br J Haematol 133:315-22. 2006
  8. ncbi request reprint No effect of lipid lowering on platelet activity in patients with coronary artery disease and type 2 diabetes or impaired glucose tolerance
    Rickard E Malmström
    Department of Medicine Solna, Clinical Pharmacology Unit, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Thromb Haemost 101:157-64. 2009
  9. doi request reprint Long-term stability of heart rate variability in chronic stable angina pectoris, and the impact of an acute myocardial infarction
    Inge Bjorkander
    Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Clin Physiol Funct Imaging 29:201-8. 2009
  10. ncbi request reprint Contrast medium attenuates platelet activation and platelet-leukocyte cross-talk
    Qiushang Ji
    Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital Solna, Stockholm, Sweden
    Thromb Haemost 93:922-6. 2005

Collaborators

Detail Information

Publications41

  1. ncbi request reprint [More evidence against COX-2 inhibitors. The risk of severe cardiovascular complications more and more obvious]
    Paul Hjemdahl
    Institutionen för medicin, enheten för kliniskfarmakologi, Karolinska institutet och Karolinska Universitetssjukhuset Solna, Stockholm
    Lakartidningen 104:310-1. 2007
  2. pmc Postprandial platelet activation is related to postprandial plasma insulin rather than glucose in patients with type 2 diabetes
    Galia Spectre
    Department of Medicine Solna, Clinical Pharmacology Unit, Karolinska University Hospital Solna, Stockholm, Sweden
    Diabetes 61:2380-4. 2012
    ..Premeal insulin infusion was also associated with platelet activation. Our results suggest that postprandial insulin rather than glucose accounts for postprandial platelet activation in T2DM patients...
  3. pmc Validation of the clinical COPD Questionnaire (CCQ) in primary care
    Bjorn Stallberg
    Department of Public Health and Caring Sciences, Section of Family Medicine and Clinical Epidemiology, Uppsala University, Uppsala, Sweden
    Health Qual Life Outcomes 7:26. 2009
    ..The newly developed, short Clinical COPD Questionnaire, CCQ, was therefore validated against the St George's Respiratory Questionnaire (SGRQ)...
  4. ncbi request reprint Effect of clopidogrel treatment on stress-induced platelet activation and myocardial ischemia in aspirin-treated patients with stable coronary artery disease
    Christina Perneby
    Karolinska Institutet Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital, Stockholm, Sweden
    Thromb Haemost 98:1316-22. 2007
    ..Intensified antiplatelet treatment did not reduce ECG signs of either exercise-induced or ambulatory myocardial ischemia...
  5. doi request reprint Platelets selectively enhance lymphocyte adhesion on subendothelial matrix under arterial flow conditions
    Galia Spectre
    Department of Medicine Solna, Clinical Pharmacology Unit, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, Sweden
    Thromb Haemost 108:328-37. 2012
    ..In conclusion, platelets support lymphocyte adhesion on SEMP-coated surfaces under arterial shear. The enhancement is selective for large T and NK cells and small B cells...
  6. doi request reprint Risk prediction in stable angina pectoris
    Thomas Kahan
    Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, SE 182 88, Stockholm, Sweden
    Eur J Clin Invest 43:141-51. 2013
    ..Many new markers of disease activity and prognosis have been described. We evaluated whether common and easily accessible markers in everyday care provide sufficient prognostic information...
  7. ncbi request reprint High glucose levels enhance platelet activation: involvement of multiple mechanisms
    Dzana Sudic
    Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital Solna, Stockholm, Sweden
    Br J Haematol 133:315-22. 2006
    ..This occurred via superoxide anion production, which enhanced platelet P-selectin expression (secretion), and PKC signalling, which enhanced TRAP-induced fibrinogen binding (aggregablity)...
  8. ncbi request reprint No effect of lipid lowering on platelet activity in patients with coronary artery disease and type 2 diabetes or impaired glucose tolerance
    Rickard E Malmström
    Department of Medicine Solna, Clinical Pharmacology Unit, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Thromb Haemost 101:157-64. 2009
    ....
  9. doi request reprint Long-term stability of heart rate variability in chronic stable angina pectoris, and the impact of an acute myocardial infarction
    Inge Bjorkander
    Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Clin Physiol Funct Imaging 29:201-8. 2009
    ..Reduced HRV has adverse prognostic implications. The time course for changes in HRV over prolonged periods of time and the influence of an acute coronary event on HRV are not well established...
  10. ncbi request reprint Contrast medium attenuates platelet activation and platelet-leukocyte cross-talk
    Qiushang Ji
    Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital Solna, Stockholm, Sweden
    Thromb Haemost 93:922-6. 2005
    ..Inhibitory effects of the contrast agents on this cross-talk are apparently exerted by reducing heterotypic conjugation, and may be beneficial in connection with PCI...
  11. doi request reprint Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications
    Galia Spectre
    Department of Medicine Solna, Clinical Pharmacology Unit, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
    Thromb Haemost 106:491-9. 2011
    ..In conclusion, twice daily dosing improved laboratory responses to aspirin in high risk T2DM patients. Studies of whether BID dosing of aspirin can improve clinical outcomes in such patients are of interest...
  12. ncbi request reprint Aspirin treatment does not attenuate platelet or leukocyte activation as monitored by whole blood flow cytometry
    Nailin Li
    Division of Clinical Pharmacology, Department of Medicine, Karolinska Hospital, SE 171 76, Stockholm, Sweden
    Thromb Res 111:165-70. 2003
    ..Multiple mechanisms may contribute to the remarkable clinical anti-thrombotic effect of aspirin...
  13. doi request reprint Effects of lipid-lowering treatment on platelet reactivity and platelet-leukocyte aggregation in diabetic patients without and with chronic kidney disease: a randomized trial
    Tora Almquist
    Department Medicine Solna, Clinical Pharmacology Unit, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm SE 171 76, Sweden
    Nephrol Dial Transplant 27:3540-6. 2012
    ..The objective of this mechanistic study was to investigate the impact of CKD on platelet function and inflammatory parameters in patients with DM and the effects of LLT...
  14. ncbi request reprint Is left ventricular diastolic function an independent marker of prognosis after acute myocardial infarction?
    Miguel Quintana
    Department of Cardiology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
    Int J Cardiol 96:183-9. 2004
    ..The present study assessed whether this assumption applies to a large population of patients with acute MI who underwent thrombolytic therapy...
  15. ncbi request reprint Platelet-leukocyte aggregation under shear stress: differential involvement of selectins and integrins
    Hu Hu
    Department of Medicine, Division of Clinical Pharmacology, Karolinska Hospital, Stockholm, Sweden
    Thromb Haemost 90:679-87. 2003
    ..The present results indicate that P-selectin-mediated bridging is essential for the initiation of PLA formation, while integrin-bridgings contribute importantly to the stability of heterotypic conjugates under high shear stress...
  16. ncbi request reprint Platelet activity, coagulation, and fibrinolysis during exercise in healthy males: effects of thrombin inhibition by argatroban and enoxaparin
    Nailin Li
    Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 27:407-13. 2007
    ..Relationships between exercise-induced activation of platelets, blood coagulation, and fibrinolysis, and the importance of thrombin for responses to exercise are not clear...
  17. ncbi request reprint Food intake enhances thromboxane receptor-mediated platelet activation in type 2 diabetic patients but not in healthy subjects
    Masoud Razmara
    Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital Solina Karolinska Institute, SE 171 76 Stockholm, Sweden
    Diabetes Care 30:138-40. 2007
  18. doi request reprint Platelets regulate CD4⁺ T-cell differentiation via multiple chemokines in humans
    Norbert Gerdes
    Experimental Cardiovascular Research Unit at the Center for Molecular Medicine Solna, Karolinska Institute, Stockholm, Sweden
    Thromb Haemost 106:353-62. 2011
    ..Our study provides new insights into the cross-talk between thrombosis and adaptive immunity, and indicates that platelets can enhance T-effector cell development...
  19. doi request reprint Inhibition of the renin-angiotensin system does not reduce platelet activity at rest or during stress in hypertension
    Jonas H Schwieler
    Cardiology Unit, Department of Medicine Solna, Sweden
    J Hypertens 31:1676-82. 2013
    ..Secondary aims were effects on inflammation, coagulation, and endothelial function...
  20. doi request reprint The 'wise list'- a comprehensive concept to select, communicate and achieve adherence to recommendations of essential drugs in ambulatory care in Stockholm
    Lars L Gustafsson
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Basic Clin Pharmacol Toxicol 108:224-33. 2011
    ....
  21. ncbi request reprint Dose- and time-dependent antiplatelet effects of aspirin
    Christina Perneby
    Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Thromb Haemost 95:652-8. 2006
    ..Since recovery of COX-dependent platelet aggregation occurred within 24 hours, once daily dosing of aspirin might be insufficient in patients with increased platelet turnover...
  22. doi request reprint Lipid-lowering treatment and inflammatory mediators in diabetes and chronic kidney disease
    Tora Almquist
    Department of Medicine Solna, Clinical Pharmacology Unit, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden Division of Nephrology, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden
    Eur J Clin Invest 44:276-84. 2014
    ..Lipid-lowering treatment (LLT) with statins may have anti-inflammatory effects, and ezetimibe cotreatment provides additional cholesterol lowering...
  23. doi request reprint Risk scoring and thromboprophylactic treatment of patients with atrial fibrillation with and without access to primary healthcare data: experience from the Stockholm health care system
    Tomas Forslund
    Karolinska Institutet, Department of Medicine Solna, Clinical Pharmacology Unit, Karolinska University Hospital, SE 171 76 Stockholm, Sweden Electronic address
    Int J Cardiol 170:208-14. 2013
    ....
  24. pmc Forecasting drug utilization and expenditure in a metropolitan health region
    Björn Wettermark
    Department of Drug Management and Informatics, Stockholm County Council, Stockholm, Sweden
    BMC Health Serv Res 10:128. 2010
    ..The aim of this paper is to present the forecasting model and the predicted growth in all therapeutic areas in 2010 and 2011...
  25. ncbi request reprint Adenosine treatment attenuates cytokine interleukin-6 responses to endotoxin challenge in healthy volunteers
    Anne Soop
    Department of Anaesthesiology and Intensive Care, Center for Surgical Sciences, Huddinge University Hospital, Stockholm, Sweden
    Shock 19:503-7. 2003
    ..In conclusion, systemic adenosine infusion counteracts the release of IL-6 in healthy volunteers, indicating an anti-inflammatory effect of adenosine which should be further explored...
  26. ncbi request reprint Effects of insulin on platelet and leukocyte activity in whole blood
    Hu Hu
    Department of Medicine, Karolinska Hospital, SE 171 76, Stockholm, Sweden
    Thromb Res 107:209-15. 2002
    ..Our results suggest that insulin may modulate thrombotic and inflammatory processes in vivo in a complex manner...
  27. ncbi request reprint Pharmacological prevention of reperfusion injury in acute myocardial infarction. A potential role for adenosine as a therapeutic agent
    Miguel Quintana
    Departments of Cardiology and Clinical Physiology, Huddinge University Hospital, Stockholm, Sweden
    Am J Cardiovasc Drugs 4:159-67. 2004
    ....
  28. doi request reprint Regional variation and adherence to guidelines for drug treatment of asthma
    Marianne Heibert Arnlind
    Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    Eur J Clin Pharmacol 66:187-98. 2010
    ..To describe the utilization of antiasthmatic drugs in Sweden and to explore regional variations in drug utilization and adherence to guidelines for rational drug prescribing of antiasthmatics and their rationale...
  29. ncbi request reprint Effects of improved metabolic control on platelet reactivity in patients with type 2 diabetes mellitus following coronary angioplasty
    Marianne Yngen
    Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
    Diab Vasc Dis Res 3:52-6. 2006
    ..34 and R=0.31; p<0.05). We conclude from this study that improved glycaemic control reduces platelet reactivity in type 2 diabetes patients following PCI...
  30. ncbi request reprint Neurohormonal activation in heart failure after acute myocardial infarction treated with beta-receptor antagonists
    Hans Persson
    Section of Cardiology, Division of Internal Medicine, Karolinska Institutet Danderyd Hospital, S 182 88, Stockholm, Sweden
    Eur J Heart Fail 4:73-82. 2002
    ..The aims were to describe neurohormonal activity in relation to other variables and to investigate treatment effects of a beta(1) receptor-antagonist compared to a partial beta(1) receptor-agonist...
  31. ncbi request reprint Left ventricular function and cardiovascular events following adjuvant therapy with adenosine in acute myocardial infarction treated with thrombolysis, results of the ATTenuation by Adenosine of Cardiac Complications (ATTACC) study
    Miguel Quintana
    The Karolinska Institute at the Department of Cardiology, Huddinge University Hospital, 141 86 Huddinge, Stockholm, Sweden
    Eur J Clin Pharmacol 59:1-9. 2003
    ..The present study tested the hypothesis that adjuvant therapy with a low anti-inflammatory dose of adenosine might prevent reperfusion injury and preserve left ventricular function...
  32. ncbi request reprint [Strong lobbying for direct -to-consumer advertising of prescription drugs. Beneficial for the patient or for the increase of sales?]
    Paul Hjemdahl
    Institutionen för medicin, enheten för klinisk farmakologi, Karolinska sjukhuset, Stockholm
    Lakartidningen 99:2374-5. 2002
  33. ncbi request reprint Brief questionnaires for patient-reported outcomes in asthma: validation and usefulness in a primary care setting
    Per Olof Ehrs
    Clinical Pharmacology Unit L7 05, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Chest 129:925-32. 2006
    ..The Asthma Control Questionnaire (ACQ) was validated against the symptoms domain of the AQLQ(S). Patients were characterized by the Short Form-36 Health Survey (SF-36)...
  34. ncbi request reprint No effect of oral hormone replacement therapy on platelet function in postmenopausal women with coronary artery disease
    N Håkan Wallén
    Thromb Haemost 96:862-3. 2006
  35. ncbi request reprint Should we monitor platelet function during antiplatelet therapy?
    Paul Hjemdahl
    Heart 94:685-7. 2008
  36. ncbi request reprint Insulin, but not proinsulin C-peptide, enhances platelet fibrinogen binding in vitro in Type 1 diabetes mellitus patients and healthy subjects
    Hu Hu
    Department of Medicine, Division of Clinical Pharmacology, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Thromb Res 106:91-5. 2002
    ..We thus investigated how insulin, C-peptide, and their combination influence platelets from DM patients and healthy subjects...
  37. ncbi request reprint Endothelial COX-2 inhibition: possible relevance for hypertension and cardiovascular risk?
    Carl Olav Stiller
    J Hypertens 21:1615-8. 2003
  38. ncbi request reprint [Reply from the SBU about salt and high blood pressure: More controlled long-term trials are required]
    Mats Halldin
    Lakartidningen 101:4257. 2004
  39. ncbi request reprint Marked increase of fibrin gel permeability with very low dose ASA treatment
    Aleksandra Antovic
    Dept of Surgical Sciences, Coagulation Research Division, Karolinska University Hospital, Sweden
    Thromb Res 116:509-17. 2005
    ..The present study was performed to extend the dose-response curve for effects of ASA on fibrinogen clotting properties and to examine the variability of these effects during a 24-h dose interval...
  40. ncbi request reprint Megakaryocytic cells synthesize and platelets secrete alpha5-laminins, and the endothelial laminin isoform laminin 10 (alpha5beta1gamma1) strongly promotes adhesion but not activation of platelets
    Ayele Nigatu
    Department of Odontology, Karolinska Institutet, SE 141 04 Stockholm, Sweden
    Thromb Haemost 95:85-93. 2006
    ..This study demonstrates synthesis/expression of heterotrimeric alpha5-laminins in hematopoietic/blood cells, and provides evidence for the adhesive, but not activating, role of endothelial laminin isoforms in platelet biology...
  41. ncbi request reprint Long-term calcium antagonist treatment of human hypertension with mibefradil or amlodipine increases sympathetic nerve activity
    Madeleine Lindqvist
    Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Division of Clinical Physiology, S 182 88 Stockholm, Sweden
    J Hypertens 25:169-75. 2007
    ..We studied the effects of long-term treatment with amlodipine, a long-acting dihydropyridine-type calcium antagonist, and mibefradil, a phenylalkylamine-type calcium antagonist, on sympathetic nerve activity...