K Hemminki


Affiliation: Karolinska Institute
Country: Sweden


  1. Hemminki K, Li X, Vaittinen P. Time trends in the incidence of cervical and other genital squamous cell carcinomas and adenocarcinomas in Sweden, 1958-1996. Eur J Obstet Gynecol Reprod Biol. 2002;101:64-9 pubmed
    ..The increase is not seen in SCC because of effective screening. ..
  2. Hemminki K, Li X. Familial liver and gall bladder cancer: a nationwide epidemiological study from Sweden. Gut. 2003;52:592-6 pubmed
    ..The risks were so high that heritable factors were likely to contribute, possibly modified by environmental factors. The demonstration of candidate genes would help to further characterise the familial risks. ..
  3. Hemminki K, Li X. A population-based study of familial soft tissue tumors. J Clin Epidemiol. 2001;54:411-6 pubmed
    ..66, 95% CI 1.32-7.17), particularly parathyroid tumors (SIR 4.46, 95% CI 1.41-9.23), were associated with offspring fibrosarcoma, and parental breast cancers with offspring leiomyosarcoma (SIR 2.04, 95% CI 1.08-3.30). ..
  4. Hemminki K, Jiang Y, Dong C. Second primary cancers after anogenital, skin, oral, esophageal and rectal cancers: etiological links?. Int J Cancer. 2001;93:294-8 pubmed
    ..However, whether the findings on rectal and skin cancer are due to HPV or other infections, transient or inherited depressed immune function or other constitutional factors remains to be established. ..
  5. Hemminki K, Jiang Y. Second primary neoplasms after 19281 endocrine gland tumours: aetiological links?. Eur J Cancer. 2001;37:1886-94 pubmed
    ..These novel associations suggest shared risk factors for these sites. However, many endocrine tumours are benign and the diagnosis of the first tumour may increase the likelihood of a second diagnosis. ..
  6. Hemminki K, Dong C, Frisch M. Tonsillar and other upper aerodigestive tract cancers among cervical cancer patients and their husbands. Eur J Cancer Prev. 2000;9:433-7 pubmed
    ..The excess of tonsillar cancer among husbands of women with HPV-associated neoplastic lesions of the cervix supports the a priori hypothesis that HPV may be involved in tonsillar carcinogenesis. ..
  7. Hemminki K, Li X. Cancer risks in childhood and adolescence among the offspring of immigrants to Sweden. Br J Cancer. 2002;86:1414-8 pubmed
  8. Hemminki K, Granström C. Morphological types of breast cancer in family members and multiple primary tumours: is morphology genetically determined?. Breast Cancer Res. 2002;4:R7 pubmed
    ..However, because of mixed morphologies and the overwhelming prevalence of ductal morphology, the results for rare morphologies should be interpreted with caution. ..
  9. Hemminki K. Genetic Epidemiology--science and ethics on familial cancers. Acta Oncol. 2001;40:439-44 pubmed
    ..The results have implications for design of genetic studies and for clinical counselling...

More Information


  1. Hemminki K, Granström C. Familial invasive and borderline ovarian tumors by proband status, age and histology. Int J Cancer. 2003;105:701-5 pubmed
    ..Histopathology and age of onset appear to be important attributes of familial ovarian cancer, suggesting that further gene identification efforts should target a specific histopathology in early-onset patients...
  2. Hemminki K, Li X. Familial risks in nervous system tumors. Cancer Epidemiol Biomarkers Prev. 2003;12:1137-42 pubmed
    ..Yet, it is likely that many brain astrocytoma, meningioma, and mixed families represent yet unknown heritable conditions...