K Hemminki

Summary

Affiliation: Karolinska Institute
Country: Sweden

Publications

  1. ncbi Familial risk for colorectal cancers are mainly due to heritable causes
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 13:1253-6. 2004
  2. ncbi University and medical education and the risk of cancer in Sweden
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Eur J Cancer Prev 13:199-205. 2004
  3. ncbi How fast are UV-dimers repaired in human skin DNA in situ?
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    J Invest Dermatol 119:699; discussion 700-2. 2002
  4. ncbi Age specific and attributable risks of familial prostate carcinoma from the family-cancer database
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Cancer 95:1346-53. 2002
  5. ncbi Attributable risks for familial breast cancer by proband status and morphology: a nationwide epidemiologic study from Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 100:214-9. 2002
  6. ncbi Cancer risks in twins: results from the Swedish family-cancer database
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 99:873-8. 2002
  7. ncbi Familial breast carcinoma risks by morphology: a nationwide epidemiologic study from Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Cancer 94:3063-70. 2002
  8. pmc Morphological types of breast cancer in family members and multiple primary tumours: is morphology genetically determined?
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Breast Cancer Res 4:R7. 2002
  9. pmc Cancer risks among long-standing spouses
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Br J Cancer 86:1737-40. 2002
  10. ncbi Molecular epidemiology of VHL gene mutations in renal cell carcinoma patients: relation to dietary and other factors
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Carcinogenesis 23:809-15. 2002

Collaborators

Detail Information

Publications184 found, 100 shown here

  1. ncbi Familial risk for colorectal cancers are mainly due to heritable causes
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 13:1253-6. 2004
    ..However, the risks were independent of the age difference. Data among spouses and siblings consistently point to the importance of heritable factors in familial CRC...
  2. ncbi University and medical education and the risk of cancer in Sweden
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Eur J Cancer Prev 13:199-205. 2004
    ..Cancer risks for physicians were not different from those of their academic colleagues. Some of the increased risks were probably due to lead-time bias, caused by early diagnosis...
  3. ncbi How fast are UV-dimers repaired in human skin DNA in situ?
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    J Invest Dermatol 119:699; discussion 700-2. 2002
    ....
  4. ncbi Age specific and attributable risks of familial prostate carcinoma from the family-cancer database
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Cancer 95:1346-53. 2002
    ....
  5. ncbi Attributable risks for familial breast cancer by proband status and morphology: a nationwide epidemiologic study from Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 100:214-9. 2002
    ..The data show that the familial PAF of breast cancer among a 0-66-year-old population of daughters was 7% and independent of the morphologic type. If contribution from the paternal side was allowed for, the PAF would be 11%...
  6. ncbi Cancer risks in twins: results from the Swedish family-cancer database
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 99:873-8. 2002
    ..In utero hormonal exposures may be related to the risk of testicular cancer. The protective effects in melanoma may be due to socioeconomic factors...
  7. ncbi Familial breast carcinoma risks by morphology: a nationwide epidemiologic study from Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Cancer 94:3063-70. 2002
    ..Familial risks in patients with breast carcinoma have not been assessed by morphologic types of medically verified cancers. Reliable data on familial risks would help to establish prevention programs and guide clinical decisions...
  8. pmc Morphological types of breast cancer in family members and multiple primary tumours: is morphology genetically determined?
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Breast Cancer Res 4:R7. 2002
    ..We conducted the present study to determine whether breast cancer morphology is genetically determined...
  9. pmc Cancer risks among long-standing spouses
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Br J Cancer 86:1737-40. 2002
    ..Because lifestyles are likely to differ more between parents and offspring than between spouses, familial cancer risks between parents and offspring are even more likely to be due to heritable than environmental effects...
  10. ncbi Molecular epidemiology of VHL gene mutations in renal cell carcinoma patients: relation to dietary and other factors
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Carcinogenesis 23:809-15. 2002
    ..Even though most of the associations are biologically plausible, and vegetables and fruit were an a priori hypothesis, fortuitous results cannot be ruled out in this relatively small study...
  11. pmc Cancer risks in childhood and adolescence among the offspring of immigrants to Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Br J Cancer 86:1414-8. 2002
    ....
  12. ncbi Cancer risks in second-generation immigrants to Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 99:229-37. 2002
    ..Birth in Sweden sets the Swedish pattern for cancer incidence, irrespective of the nationality of descent, while entering Sweden in the 20s is already too late to influence the environmentally imprinted program for the cancer destiny...
  13. ncbi Cancer risks in first-generation immigrants to Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 99:218-28. 2002
    ..Women from Yugoslavia and Turkey had an excess of thyroid tumours. All immigrant groups showed breast, endometrial and ovarian cancers at or below the Swedish level but the differences were no more than 2-fold...
  14. ncbi Demonstration of UV-dimers in human skin DNA in situ 3 weeks after exposure
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 14157 Huddinge, Sweden
    Carcinogenesis 23:605-9. 2002
    ..This is the first time the persistence of defined human DNA damage is demonstrated up to 3 weeks. Long-lasting DNA damage increases the likelihood of mutations...
  15. ncbi Familial and second gastric carcinomas: a nationwide epidemiologic study from Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Cancer 94:1157-65. 2002
    ..Reliable data on familial risks are needed for prevention and clinical decisions...
  16. ncbi Skilled use of DNA polymorphisms as a tool for polygenic cancers
    Kari Hemminki
    Department of Biosciences, Karolinska Institute, Novum, S 141 57 Huddinge, Sweden
    Carcinogenesis 23:379-80. 2002
    ..We discuss here the approaches in study design and reporting that will reduce the spread of false positive data and optimize scientific progress in the genotyping field...
  17. ncbi Age-incidence relationships and time trends in cervical cancer in Sweden
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Eur J Epidemiol 17:323-8. 2001
    ..The benefits of the organized screening were observed as a further decline in the incidence rates. The unique age-incidence relationships in cervical cancer call for biological explanations...
  18. ncbi The nation-wide Swedish family-cancer database--updated structure and familial rates
    K Hemminki
    Department of Biosciences, Karolinska Institute, Novum, Huddinge, Sweden
    Acta Oncol 40:772-7. 2001
    ..The rates were 7.47 for thyroid, 4.69 for testis, and over 2.00 for melanoma, ovary, prostate, skin, endocrine glands and endometrium...
  19. ncbi Gender effects in familial cancer
    Kari Hemminki
    Department of Biosciences, CNT Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Int J Cancer 102:184-7. 2002
    ..e., higher familial risk in the gender of low background risk. The high familial ratio, 2.85 (95% CI: 1.35-6.03), was due to thyroid adenocarcinoma, encompassing both papillary and follicular types...
  20. ncbi Familial risk of cancer by site and histopathology
    Kari Hemminki
    Department of Biosciences, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 103:105-9. 2003
    ..73). Many of the findings were novel and could be revealed only by applying codes for specific histopathology. These data call for a closer description of familial aggregations and probing for the underlying genetic mechanisms...
  21. ncbi Cancer risks in Nordic immigrants and their offspring in Sweden
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Eur J Cancer 38:2428-34. 2002
    ..Immigrant populations would appear to be attractive subjects to study etiological factors of cancer at sites where causes remain poorly understood, such as testicular cancer...
  22. ncbi Familial risks of cancer as a guide to gene identification and mode of inheritance
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 110:291-4. 2004
    ..The results from these analysis suggest that familial cluster of cancer at most sites is heritable, caused by dominant effects; for renal cancer recessive effects may be most important...
  23. ncbi Association of brain tumours with other neoplasms in families
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Eur J Cancer 40:253-9. 2004
    ..Although some of these may feature a true tumour cluster, they need to be confirmed in another setting...
  24. ncbi Familial risks in nervous system tumors
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 12:1137-42. 2003
    ..Yet, it is likely that many brain astrocytoma, meningioma, and mixed families represent yet unknown heritable conditions...
  25. ncbi Population-based study of familial medullary thyroid cancer
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, CNT Novum, 141 57 Huddinge, Sweden
    Fam Cancer 1:45-9. 2001
    ..We wanted to carry out a population-based study on medullary thyroid cancer (MTC) in order to quantify familial risks...
  26. ncbi Level of education and the risk of cancer in Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Cancer Epidemiol Biomarkers Prev 12:796-802. 2003
    ..57 for melanoma. The overall weighted population attributable fraction for educational level was 13.8% for men and 16.7% for women, and it was highest, >50%, for stomach cancer in both genders and for cervical and anal cancer in women...
  27. ncbi Time trends and familial risks in squamous cell carcinoma of the skin
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Arch Dermatol 139:885-9. 2003
    ..To study time trends and familial clustering of invasive and in situ squamous cell skin cancers (SCC), with particular reference to sun-exposed and covered sites of the body...
  28. pmc Familial invasive and in situ squamous cell carcinoma of the skin
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Br J Cancer 88:1375-80. 2003
    ..These results provide evidence that there is an underlying hereditary susceptibility for at least a part of the familial clustering for skin SCC...
  29. ncbi Familial invasive and borderline ovarian tumors by proband status, age and histology
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Int J Cancer 105:701-5. 2003
    ..Histopathology and age of onset appear to be important attributes of familial ovarian cancer, suggesting that further gene identification efforts should target a specific histopathology in early-onset patients...
  30. ncbi Socioeconomic factors in cancer in Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Int J Cancer 105:692-700. 2003
    ..The overall population-attributable fraction for selected sites was 16.7% for men and 10.9% for women and it was highest, over 50%, for lung cancer in both genders...
  31. ncbi Subsequent primary malignancies after endometrial carcinoma and ovarian carcinoma
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Cancer 97:2432-9. 2003
    ..Population-based data on subsequent neoplasms after women are diagnosed with endometrial and ovarian carcinomas are limited, particularly regarding specific histologic tumor types...
  32. ncbi Time trends and occupational risk factors for pleural mesothelioma in Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    J Occup Environ Med 45:456-61. 2003
    ..The SIRs of many academic/college-educated groups were two to six times higher than those of farmers, suggesting indirect exposure to asbestos in these groups...
  33. ncbi Time trends and occupational risk factors for peritoneal mesothelioma in Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    J Occup Environ Med 45:451-5. 2003
    ..22 and 5.12, respectively. Within limits of the sample size, no evidence was noted for risk from environmental exposures to asbestos because the risk of farmers and that of urban residents were not different...
  34. pmc Familial liver and gall bladder cancer: a nationwide epidemiological study from Sweden
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Gut 52:592-6. 2003
    ..Thus the degree of familial clustering for these cancers remains to be established...
  35. ncbi Familial and attributable risks in cutaneous melanoma: effects of proband and age
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    J Invest Dermatol 120:217-23. 2003
    ..Melanoma associated with breast, nervous system, and skin cancers, and in situ melanoma possibly also with connective tissue and thyroid tumors and multiple myeloma...
  36. ncbi Attributable risks of familial cancer from the Family-Cancer Database
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Cancer Epidemiol Biomarkers Prev 11:1638-44. 2002
    ..The data show that the familial PAF of prostate cancer was 20.55%, and breast cancer 10.61%, but for most other sites, it was between 1 and 3%...
  37. ncbi Familial and second primary pancreatic cancers: a nationwide epidemiologic study from Sweden
    Kari Hemminki
    Department of Biosciences, CNT Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Int J Cancer 103:525-30. 2003
    ..The strong association of pancreatic and lung cancers is puzzling, and it remains unclear to what extent this represents familial sharing of smoking habits...
  38. ncbi Familial colorectal adenocarcinoma from the Swedish Family-Cancer Database
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 94:743-8. 2001
    ..Other familial components appear heterogeneous, characterized by incomplete penetrance, recessive mode of inheritance and few associated tumor sites...
  39. ncbi A population-based study of familial central nervous system hemangioblastomas
    K Hemminki
    Department of Biosciences at Novum, CNT Novum, Karolinska Institute, S 141 57 Huddinge, Sweden
    Neuroepidemiology 20:257-61. 2001
    ..The late-onset component peaked at 40-44 years, and it was twice as prevalent as the early-onset component. Because there was no evidence of familial risks, this is suggested to be a sporadic form of HB...
  40. pmc Future research directions in the use of biomarkers
    K Hemminki
    Center for Nutrition and Toxicology, Karolinska Institute, Huddinge, Sweden
    Environ Health Perspect 104:459-64. 1996
    ..Adjustment for a metabolic phenotype or genotype may also increase the precision in the measurement. Mutations in oncogenes and tumor suppressor genes may give clues to the etiology of cancer...
  41. ncbi Tonsillar and other upper aerodigestive tract cancers among cervical cancer patients and their husbands
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Eur J Cancer Prev 9:433-7. 2000
    ..The excess of tonsillar cancer among husbands of women with HPV-associated neoplastic lesions of the cervix supports the a priori hypothesis that HPV may be involved in tonsillar carcinogenesis...
  42. ncbi Familial risks in invasive and in situ cervical cancer by histological type
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Eur J Cancer Prev 10:83-9. 2001
    ..The familial risks were unaffected in Poisson regression analysis on many possible intervening variables. The data suggest that host factors modulate an individual's response to human papillomavirus infections...
  43. ncbi Familial prostate cancer from the family-cancer database
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Eur J Cancer 36:229-34. 2000
    ..22 (0.95-1.53). No increased risk of malignancy was observed in wives of affected men excluding any shared environmental effect for PC and female cancers...
  44. ncbi A population-based study of familial soft tissue tumors
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57, Huddinge, Sweden
    J Clin Epidemiol 54:411-6. 2001
    ..66, 95% CI 1.32-7.17), particularly parathyroid tumors (SIR 4.46, 95% CI 1.41-9.23), were associated with offspring fibrosarcoma, and parental breast cancers with offspring leiomyosarcoma (SIR 2.04, 95% CI 1.08-3.30)...
  45. ncbi A population-based study of familial cutaneous melanoma
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Melanoma Res 11:133-40. 2001
    ..Other weaker associations were found to pancreatic, breast, testicular and nervous system cancers and non-Hodgkin lymphomas...
  46. ncbi Familial and second esophageal cancers: a nation-wide epidemiologic study from Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 98:106-9. 2002
    ..However, the high familial risk of 3.91 is unlikely without the involvement of heritable factors. The population-attributable proportion of familial esophageal cancer is small...
  47. ncbi Parental cancer as a risk factor for brain tumors (Sweden)
    K Hemminki
    Department of Biosciences, Novum, Karolinska Institute, Huddinge, Sweden
    Cancer Causes Control 12:195-9. 2001
    ..We used the nationwide Swedish Family-Cancer Database to analyze the risk for adult (15-61 years) brain tumors in offspring through parental cancer probands. Additionally, cancer risks were assessed among siblings of brain tumor probands...
  48. ncbi Second primary cancers after anogenital, skin, oral, esophageal and rectal cancers: etiological links?
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Int J Cancer 93:294-8. 2001
    ..However, whether the findings on rectal and skin cancer are due to HPV or other infections, transient or inherited depressed immune function or other constitutional factors remains to be established...
  49. ncbi Familial cancer risks to offspring from mothers with 2 primary breast cancers: leads to cancer syndromes
    K Hemminki
    Department of Biosciences, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 88:87-91. 2000
    ..The increases in squamous-cell carcinomas at many sites may reflect a new susceptibility syndrome...
  50. ncbi Environmental pollution and human exposure to polycyclic aromatic hydrocarbons in the east Baltic region
    K Hemminki
    Department of Bioscience at Novum, Karolinska Institute, Huddinge, Sweden
    Scand J Work Environ Health 25:33-9. 1999
    ..Further studies are needed to assess health risks of PAH exposure in central and eastern Europe...
  51. pmc DNA adducts and mutations in occupational and environmental biomonitoring
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Environ Health Perspect 105:823-7. 1997
    ..Future biomonitoring studies should make an effort to combine many end points, with emphasis on adducts, mutations, and constitutional metabolic factors...
  52. ncbi National database of familial cancer in Sweden
    K Hemminki
    Department of Biosciences, Karolinska Institute, Huddinge, Sweden
    Genet Epidemiol 15:225-36. 1998
    ..The molecular genetic explanation may be that rare dominant single genes increase susceptibility at many sites, or that overlapping sets of genes control susceptibility at multiple sites...
  53. ncbi Familial breast cancer in the family-cancer database
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 77:386-91. 1998
    ..In mothers and daughters, ovarian but not colon cancer was increased in combination with breast cancer...
  54. ncbi Age-specific familial risks in common cancers of the offspring
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 78:172-5. 1998
    ..The parental diagnostic age also affected offspring's risk of colon, rectal, uterine and ovarian cancers, but young individuals were not at a particular risk. No effect of age was noted for cervical cancer and lymphoma...
  55. ncbi Familial risks in in situ cancers from the Family-Cancer Database
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Cancer Epidemiol Biomarkers Prev 7:865-8. 1998
    ..Family histories of in situ cancers deserve clinical attention...
  56. ncbi Familial risks in cervical cancer: is there a hereditary component?
    K Hemminki
    Department of Biosciences, Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 82:775-81. 1999
    ....
  57. ncbi Familial risks in second primary breast cancer based on a family cancer database
    K Hemminki
    Department of Biosciences, Karolinska Institute, Huddinge, Sweden
    Eur J Cancer 35:455-8. 1999
    ..8 years younger than mothers whose daughters did not have breast cancer. The present results apply to a relatively young population of daughters (< 54 years of age)...
  58. ncbi Familial cancers in a nationwide family cancer database: age distribution and prevalence
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Eur J Cancer 35:1109-17. 1999
    ..The proportion of familial cancers depended on the site, ranging from 11% in prostate to 8.7% in female breast and to well below 1% at many sites...
  59. ncbi Second primary cancers after sporadic and familial colorectal cancer
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Cancer Epidemiol Biomarkers Prev 10:793-8. 2001
    ..The high risk of second cancer after early-onset CRC calls for evaluation of family history and clinical surveillance...
  60. ncbi XPD exon 10 and 23 polymorphisms and DNA repair in human skin in situ
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 14157 Huddinge, Sweden
    Carcinogenesis 22:1185-8. 2001
    ..However, the exon 23 C allele was associated with depressed repair among subjects aged 50 years or older and the result was consistent with both dimers...
  61. ncbi Second primary neoplasms after 19281 endocrine gland tumours: aetiological links?
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57, Huddinge, Sweden
    Eur J Cancer 37:1886-94. 2001
    ..These novel associations suggest shared risk factors for these sites. However, many endocrine tumours are benign and the diagnosis of the first tumour may increase the likelihood of a second diagnosis...
  62. ncbi Incidence trends and risk factors of carcinoid tumors: a nationwide epidemiologic study from Sweden
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Cancer 92:2204-10. 2001
    ..Carcinoids are rare indolent neuroendocrine tumors, mainly located in bowel, stomach, and lung. Their etiology is virtually unknown although a family history is a minor cause...
  63. ncbi Genetic epidemiology of multistage carcinogenesis
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 14157, Huddinge, Sweden
    Mutat Res 473:11-21. 2001
    ..The number of mutations required appears to be less in familial breast cancer compared to sporadic breast cancer. Study designs for gene identification should be revised to accommodate polygenic cancers...
  64. ncbi Risk of cancer at sites other than the breast in Swedish families eligible for BRCA1 or BRCA2 mutation testing
    J Lorenzo Bermejo
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Ann Oncol 15:1834-41. 2004
    ....
  65. ncbi Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 343:78-85. 2000
    ..The contribution of hereditary factors to the causation of sporadic cancer is unclear. Studies of twins make it possible to estimate the overall contribution of inherited genes to the development of malignant diseases...
  66. ncbi Modification of cancer risks in offspring by sibling and parental cancers from 2,112,616 nuclear families
    C Dong
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 92:144-50. 2001
    ..The search for pleiotropic recessive/X-linked susceptibility genes should be well motivated based on our results...
  67. ncbi Multiple primary cancers of the colon, breast and skin (melanoma) as models for polygenic cancers
    C Dong
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 92:883-7. 2001
    ..The high risk of second cancer, even in the absence of family history, would be consistent with a polygenic model of carcinogenesis...
  68. ncbi Familial risk of cancer shortly after diagnosis of the first familial tumor
    J Lorenzo Bermejo
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    J Natl Cancer Inst 97:1575-9. 2005
    ..If detection bias is present, familial risks could be overestimated soon after first diagnosis...
  69. doi The Swedish Family-Cancer Database 2009: prospects for histology-specific and immigrant studies
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Int J Cancer 126:2259-67. 2010
    ..Familial cancer studies are in the stimulating interphase of the flourishing disciplines of genetics and epidemiology...
  70. ncbi VHL gene alterations in renal cell carcinoma patients: novel hotspot or founder mutations and linkage disequilibrium
    X Ma
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Oncogene 20:5393-400. 2001
    ..A higher multiple mutation detected rate (33%) was observed in grade 3 CCRCCs than those in grade 1 (22%) and grade 2 (9%) (P=0.04). This is evidence on the association between VHL mutation and extent of nuclear atypia...
  71. doi Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression
    Asta Forsti
    Department of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Genes Chromosomes Cancer 49:270-81. 2010
    ..63, 95%CI: 1.08-2.46). As this is the first study about the influence of the polymorphisms in the TGFB1 pathway on CRC progression, further studies in large independent cohorts are warranted...
  72. ncbi Occupational risks for nasal cancer in Sweden
    Marjolein Hemelt
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    J Occup Environ Med 46:1033-40. 2004
    ..Among 182 female cases, significantly elevated SIRs were observed in glass, ceramic, and tile workers. The study identified some known risk occupations and suggested some new ones...
  73. ncbi Familial blood vessel tumors and subsequent cancers
    J Ji
    Center for Family and Community Medicine, Karolinska Institute, 141 83 Huddinge, Sweden
    Ann Oncol 18:1260-7. 2007
    ..Population-based data on the familial risk for vascular tumors are largely lacking. Such data are important for clinical counseling and cancer genetics...
  74. ncbi A population-based assessment of the clustering of breast cancer in families eligible for testing of BRCA1 and BRCA2 mutations
    J Lorenzo Bermejo
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Im Neuemheimer Feld 580, D 69120 Heidelberg, Germany
    Ann Oncol 16:322-9. 2005
    ..The prevalence of families eligible for BRCA1/2 mutation testing in the population burden of breast cancer was analysed and the aggregation of breast cancer in these families was explored...
  75. pmc Cancer risk in patients hospitalised for Graves' disease: a population-based cohort study in Sweden
    X Shu
    Center for Family and Community Medicine, Karolinska Institute, 141 83 Huddinge, Sweden
    Br J Cancer 102:1397-9. 2010
    ..The possibility of an association of Graves' disease (GD) with subsequent cancers raised by certain studies...
  76. doi Risk of subsequent solid tumors after non-Hodgkin's lymphoma: effect of diagnostic age and time since diagnosis
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Im Neuenheimer Feld 580, Heidelberg, Germany
    J Clin Oncol 26:1850-7. 2008
    ..Quantitative data on solid tumors are limited. We focus on survivors of non-Hodgkin's lymphoma (NHL) because the disease is diagnosed at a wide range of ages and treated uniformly primarily with chemotherapy...
  77. ncbi Familial papillary renal cell tumors and subsequent cancers: a nationwide epidemiological study from Sweden
    Kamila Czene
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    J Urol 169:1271-5. 2003
    ..Familial risks in papillary renal cell carcinoma and association with second primary malignancies were studied using the nationwide Swedish Family Cancer Data Base...
  78. ncbi A single-nucleotide polymorphism in the XPG gene, and tumour stage, grade, and clinical course in patients with nonmuscle-invasive neoplasms of the urinary bladder
    Shigeru Sakano
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    BJU Int 97:847-51. 2006
    ....
  79. ncbi Differential interactions between GSTM1 and NAT2 genotypes on aromatic DNA adduct level and HPRT mutant frequency in lung cancer patients and population controls
    S M Hou
    Department of Biosciences, The Karolinska Institute, Huddinge, Sweden
    Cancer Epidemiol Biomarkers Prev 10:133-40. 2001
    ..The NAT2 slow genotype, in particular when combined with the GSTM1 null genotype, may confer increased susceptibility to adduct formation, gene mutation, and lung cancer when the smoking dose is low...
  80. ncbi Familial carcinoid tumors and subsequent cancers: a nation-wide epidemiologic study from Sweden
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 94:444-8. 2001
    ..Risks for second cancers were increased, particularly at sites where familial risks were found, including carcinoids in the small intestine...
  81. ncbi Inherited predisposition to early onset lung cancer according to histological type
    Xinjun Li
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 112:451-7. 2004
    ....
  82. ncbi Familial clustering of cancer at human papillomavirus-associated sites according to the Swedish Family-Cancer Database
    Shehnaz K Hussain
    Center for Family and Community Medicine, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 122:1873-8. 2008
    ..These data suggest that common host factors exist among individuals affected with anogenital and upper aerodigestive tract cancers...
  83. doi Repair of UV dimers in skin DNA of patients with basal cell carcinoma
    Dan Segerbäck
    Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden
    Cancer Epidemiol Biomarkers Prev 17:2388-92. 2008
    ..The data suggest that patients with basal cell carcinoma have a reduced capacity to repair UV-induced DNA lesions...
  84. ncbi Genetic status of cell cycle regulators in squamous cell carcinoma of the oesophagus: the CDKN2A (p16(INK4a) and p14(ARF) ) and p53 genes are major targets for inactivation
    Johanna Smeds
    Department of Biosciences, Karolinska Institute, Novum, 141 57 Huddinge, Sweden
    Carcinogenesis 23:645-55. 2002
    ..Our results suggest that the CDKN2A (p16(INK4a) and p14(ARF) ) and p53 genes involved in the two cell cycle pathways are major and independent targets of inactivation in OSCC...
  85. ncbi Clinical course of bladder neoplasms and single nucleotide polymorphisms in the CDKN2A gene
    Shigeru Sakano
    Department of Biosciences, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 104:98-103. 2003
    ..Further, the results indicate, a role for the 3' UTR polymorphisms in the CDKN2A gene in tumor invasiveness...
  86. doi Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    J Natl Cancer Inst 100:437-42. 2008
    ..10 (95% CI = 1.04 to 1.17, P = .001). Among the combined subset of 2795 familial breast cancer patients, the respective ORs were 1.27 (95% CI = 1.12 to 1.45, P = .0003) and 1.16 (95% CI = 1.06 to 1.27, P = .001)...
  87. pmc Birth order, family size, and the risk of cancer in young and middle-aged adults
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Br J Cancer 84:1466-71. 2001
    ..Testis cancer showed no significant effect and prostate cancer was excluded from analysis because of the small number of cases...
  88. ncbi Single nucleotide polymorphisms in DNA repair genes and basal cell carcinoma of skin
    Ranjit Kumar Thirumaran
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Carcinogenesis 27:1676-81. 2006
    ..10-36.8), compared with the genotype TT (XRCC3)/GG (NBS1). The data from this study show overall risk modulation of BCC by variant allele for T241M polymorphism in XRCC3 and gender-specific effect by E185Q polymorphism in NBS1...
  89. ncbi Sex-specific familial risks of urinary bladder cancer and associated neoplasms in Sweden
    Justo Lorenzo Bermejo
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, 69120 Heidelberg, Germany
    Int J Cancer 124:2166-71. 2009
    ..The present data may guide the design of forthcoming gene identification studies and the interpretation of the genome-wide association studies that are about to be published...
  90. doi A case-control study of childhood acute lymphoblastic leukaemia and polymorphisms in the TGF-beta and receptor genes
    Liping Dai
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Pediatr Blood Cancer 52:819-23. 2009
    ..Inherited genetic variants in critical genes can putatively modulate susceptibility to childhood acute lymphoblastic leukemia (ALL)...
  91. ncbi Population attributable risks for breast cancer in Swedish women by morphological type
    Charlotta Granström
    Center for Family and Community Medicine, Karolinska Institute, Huddinge, Sweden
    Breast Cancer Res Treat 111:559-68. 2008
    ..The risks for women with a family history were the highest, but these women accounted for the smallest proportion of the cases, thus resulting in the lowest PAFs...
  92. ncbi Risk for contralateral breast cancers in a population covered by mammography: effects of family history, age at diagnosis and histology
    Jianguang Ji
    Center for Family Medicine, Karolinska Institute, Alfred Nobels alle 12, 14183 Huddinge, Sweden
    Breast Cancer Res Treat 105:229-36. 2007
    ..As mammography has become widely used, it is important to quantify the risks for contralateral breast cancer in a population with a national access to mammographic screening service...
  93. ncbi Incidence of multiple primary malignancies among patients with bone cancers in Sweden
    Jianguang Ji
    Department of Bioscience at Novum, Karolinska Institute, 14157, Huddinge, Sweden
    J Cancer Res Clin Oncol 132:529-35. 2006
    ..The present study aimed at quantifying risks for second malignancies in patients with bone cancers, and risks for second bone cancers after other primary tumors...
  94. ncbi Familial and second lung cancers: a nation-wide epidemiologic study from Sweden
    Xinjun Li
    Department of Biosciences at Novum, Karolinska Institute, 141 57, Huddinge, Sweden
    Lung Cancer 39:255-63. 2003
    ..97%. Risks for second lung cancers were increased in men and women after smoking and life style related sites, and after skin cancer, non-Hodgkin's lymphoma and Hodgkin's disease...
  95. ncbi Kinetics of formation of specific styrene oxide adducts in double-stranded DNA
    M Koskinen
    Department of Biosciences at Novum, Karolinska Institute, S 141 57, Huddinge, Sweden
    Chem Biol Interact 138:111-24. 2001
    ..However, in the case of chronic styrene exposures the chemically more stable DNA adducts may become important...
  96. doi Cancer risk in hospitalized rheumatoid arthritis patients
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Rheumatology (Oxford) 47:698-701. 2008
    ..Patients diagnosed with RA have been at an increased risk of many cancers and at a decreased risk of some cancers. We planned to revisit the theme by using a nation-wide population of RA patients...
  97. ncbi No association between MDM2 SNP309 promoter polymorphism and basal cell carcinoma of the skin
    S Wilkening
    Department of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Br J Dermatol 157:375-7. 2007
    ..Basal cell carcinoma of the skin (BCC) is one of the most common neoplasms in the world. BCC development is associated with environmental factors (especially sun exposure) as well as heritable factors...
  98. ncbi Regional, socioeconomic and occupational groups and risk of hospital admission for multiple sclerosis: a cohort study in Sweden
    X Li
    Center for Family and Community Medicine, Karolinska Institute, Huddinge, Sweden
    Mult Scler 14:522-9. 2008
    ..The aim of this study was to investigate possible associations between hospitalization for multiple sclerosis (MS) and region, socioeconomic status and occupation...
  99. pmc Survival in bladder and renal cell cancers is familial
    Jianguang Ji
    Center for Family and Community Medicine, Karolinska Institute, Alfred Nobels alle 12, 14183 Huddinge, Sweden
    J Am Soc Nephrol 19:985-91. 2008
    ..16 to 0.87, for overall mortality). These population-level findings suggest heritability of prognosis for bladder and renal cell cancers. Genetic factors likely contribute to the mechanism underlying this observation...
  100. ncbi Familial multiple primary lung cancers: a population-based analysis from Sweden
    Xinjun Li
    Department of Biosciences at Novum, Karolinska Institute, Huddinge 14157, Sweden
    Lung Cancer 47:301-7. 2005
    ..43) for men and women, respectively. The present study suggests that the development from the first primary lung cancer to the second primary lung cancer may be more strongly affected by genetic factor than the first primary lung cancer...
  101. ncbi Familial risk for lung cancer by histology and age of onset: evidence for recessive inheritance
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Exp Lung Res 31:205-15. 2005
    ..The present data suggest that 1.7% of lung cancers up to age 68 years are heritable and probably due to a high-penetrant recessive gene or genes that predispose to tobacco carcinogens...