Per M Hellstrom

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Early changes in rectal nitric oxide and mucosal inflammatory mediators in Crohn's colitis in response to infliximab treatment
    T Ljung
    Department of Gastroenterology and Hepatology, Karolinska University Hospital, Stockholm, Sweden
    Aliment Pharmacol Ther 25:925-32. 2007
  2. ncbi request reprint [Biological drugs in inflammatory bowel disease. Valuable supplement--but only when conventional therapy is not sufficient]
    Per M Hellstrom
    Karolinska Universitetssjukhuset Solna
    Lakartidningen 104:2973-6. 2007
  3. doi request reprint GLP-1 suppresses gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome
    P M Hellstrom
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Neurogastroenterol Motil 20:649-59. 2008
  4. doi request reprint Clinical trial: the glucagon-like peptide-1 analogue ROSE-010 for management of acute pain in patients with irritable bowel syndrome: a randomized, placebo-controlled, double-blind study
    P M Hellstrom
    Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Solna, Sweden
    Aliment Pharmacol Ther 29:198-206. 2009
  5. doi request reprint Faces of ghrelin--research for the 21st century
    P M Hellstrom
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Neurogastroenterol Motil 21:2-5. 2009
  6. doi request reprint GLP-1: broadening the incretin concept to involve gut motility
    Per M Hellstrom
    Department of Medicine, Unit of Gastroenterology, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
    Regul Pept 156:9-12. 2009
  7. ncbi request reprint The physiology of gastric emptying
    Per M Hellstrom
    Department of Gastroenterology and Hepatology, Karolinska University Hospital, Solna, Sweden
    Best Pract Res Clin Anaesthesiol 20:397-407. 2006
  8. ncbi request reprint Rectal nitric oxide as biomarker in the treatment of inflammatory bowel disease: responders versus nonresponders
    Tryggve Ljung
    Department of Gastroenterology and Hepatology, Karolinska University Hospital, Site Solna, Stockholm, Sweden
    World J Gastroenterol 12:3386-92. 2006
  9. ncbi request reprint Increased rectal nitric oxide in children with active inflammatory bowel disease
    Tryggve Ljung
    Departments of Gastroenterology and Hepatology, Karolinska Hospital, Stockholm, Sweden
    J Pediatr Gastroenterol Nutr 34:302-6. 2002
  10. ncbi request reprint Infliximab in clinical routine: experience with Crohn's disease and biomarkers of inflammation over 5 years
    Maria H Lönnkvist
    Department of Medicine, Gastroenterology and Hepatology Unit, Karolinska Institutet, Stockholm, Sweden
    Eur J Gastroenterol Hepatol 21:1168-76. 2009

Detail Information

Publications62

  1. ncbi request reprint Early changes in rectal nitric oxide and mucosal inflammatory mediators in Crohn's colitis in response to infliximab treatment
    T Ljung
    Department of Gastroenterology and Hepatology, Karolinska University Hospital, Stockholm, Sweden
    Aliment Pharmacol Ther 25:925-32. 2007
    ..Treatment with tumor necrosis factor-alpha monoclonal antibody (infliximab) reduces clinical activity and intestinal inflammation in Crohn's disease...
  2. ncbi request reprint [Biological drugs in inflammatory bowel disease. Valuable supplement--but only when conventional therapy is not sufficient]
    Per M Hellstrom
    Karolinska Universitetssjukhuset Solna
    Lakartidningen 104:2973-6. 2007
  3. doi request reprint GLP-1 suppresses gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome
    P M Hellstrom
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Neurogastroenterol Motil 20:649-59. 2008
    ..Presence of the GLP-1 receptor in the gut was verified by reverse transcriptase PCR. In conclusion, the gut peptide GLP-1 decreases motility in the antro-duodeno-jejunal region and inhibits the MMC in healthy subjects and IBS patients...
  4. doi request reprint Clinical trial: the glucagon-like peptide-1 analogue ROSE-010 for management of acute pain in patients with irritable bowel syndrome: a randomized, placebo-controlled, double-blind study
    P M Hellstrom
    Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Solna, Sweden
    Aliment Pharmacol Ther 29:198-206. 2009
    ..There is currently no treatment available to manage acute pain attacks in IBS patients regardless of subtype...
  5. doi request reprint Faces of ghrelin--research for the 21st century
    P M Hellstrom
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Neurogastroenterol Motil 21:2-5. 2009
    ....
  6. doi request reprint GLP-1: broadening the incretin concept to involve gut motility
    Per M Hellstrom
    Department of Medicine, Unit of Gastroenterology, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
    Regul Pept 156:9-12. 2009
    ..Taken together, the GLP-1 analogue ROSE-010 is believed to cause relaxation of the gut and can thereby relieve an acute pain attack of IBS, even though its precise mechanism is yet to be defined...
  7. ncbi request reprint The physiology of gastric emptying
    Per M Hellstrom
    Department of Gastroenterology and Hepatology, Karolinska University Hospital, Solna, Sweden
    Best Pract Res Clin Anaesthesiol 20:397-407. 2006
    ..These data suggest possibilities for governing the rate of gastric emptying as a natural step in achieving metabolic balance and control...
  8. ncbi request reprint Rectal nitric oxide as biomarker in the treatment of inflammatory bowel disease: responders versus nonresponders
    Tryggve Ljung
    Department of Gastroenterology and Hepatology, Karolinska University Hospital, Site Solna, Stockholm, Sweden
    World J Gastroenterol 12:3386-92. 2006
    ....
  9. ncbi request reprint Increased rectal nitric oxide in children with active inflammatory bowel disease
    Tryggve Ljung
    Departments of Gastroenterology and Hepatology, Karolinska Hospital, Stockholm, Sweden
    J Pediatr Gastroenterol Nutr 34:302-6. 2002
    ..The aim of the current study was to determine whether this method could be applied to identify inflammatory activity in ulcerative colitis and Crohn disease in children...
  10. ncbi request reprint Infliximab in clinical routine: experience with Crohn's disease and biomarkers of inflammation over 5 years
    Maria H Lönnkvist
    Department of Medicine, Gastroenterology and Hepatology Unit, Karolinska Institutet, Stockholm, Sweden
    Eur J Gastroenterol Hepatol 21:1168-76. 2009
    ..Infliximab was launched for the treatment of Crohn's disease (CD) in 1999. We set up a follow-up protocol to meticulously study disease development with repeated infusions of infliximab...
  11. ncbi request reprint Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons
    Therese Edholm
    Department of Medicine, Gastroenterology Unit, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Regul Pept 121:25-30. 2004
    ....
  12. ncbi request reprint Peripheral and central signals in the control of eating in normal, obese and binge-eating human subjects
    Per M Hellstrom
    Department of Gastroenterology and Hepatology, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Br J Nutr 92:S47-57. 2004
    ..Understanding the host of neuropeptides and peptide hormones through which hunger and satiety operate should lead to novel therapeutic approaches for obesity; potential therapeutic strategies are highlighted...
  13. doi request reprint Blood chemistry markers for evaluation of inflammatory activity in Crohn's disease during infliximab therapy
    Maria H Lönnkvist
    Department of Medicine, Gastroenterology and Hepatology Unit, Karolinska University Hospital Solna, Sweden
    Scand J Gastroenterol 46:420-7. 2011
    ....
  14. ncbi request reprint Rectal nitric oxide and fecal calprotectin in inflammatory bowel disease
    Claudia A Reinders
    Department of Physiology and Pharmacology Karolinska Institutet, Stockholm, Sweden
    Scand J Gastroenterol 42:1151-7. 2007
    ..Both rectal nitric oxide (NO) and fecal calprotectin can be measured using non-invasive methods and are emerging as promising inflammatory markers in IBD. In this study the aim was to compare calprotectin and NO levels in IBD patients...
  15. ncbi request reprint Different concentrations of various radiopharmaceuticals in the two main liver lobes: a preliminary study in clinical patients
    Hans Jacobsson
    Department of Radiology, Karolinska University Hospital, SE 171 76, Stockholm, Sweden
    J Gastroenterol 40:733-8. 2005
    ..This was studied retrospectively in clinical patients...
  16. doi request reprint Women with bulimia nervosa exhibit attenuated secretion of glucagon-like peptide 1, pancreatic polypeptide, and insulin in response to a meal
    Sabine Naessén
    Department of Women s and Children s Health, Division of Obstetrics and Gynecology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Am J Clin Nutr 94:967-72. 2011
    ..The eating disorder bulimia nervosa (BN) is characterized by frequent episodes of binge eating, followed regularly by inappropriate compensatory behavior, such as self-induced vomiting...
  17. ncbi request reprint Eating behavior and gastric emptying in adults with Prader-Willi syndrome
    Charlotte Hoybye
    Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Solna, Sweden
    Ann Nutr Metab 51:264-9. 2007
    ..The etiology of the hyperphagia is unknown, but eating behaviors and gastrointestinal motility could play a pivotal role. In this pilot study, we therefore sought to give a closer description of the two...
  18. ncbi request reprint Physiological regulation and NO-dependent inhibition of migrating myoelectric complex in the rat small bowel by OXA
    M Ehrström
    Division of Surgery, Danderyd Hospital, Stockholm, Sweden
    Am J Physiol Gastrointest Liver Physiol 285:G688-95. 2003
    ..Endogenous OXA may have a physiological role in regulating the MMC...
  19. ncbi request reprint Technology insight: calprotectin, lactoferrin and nitric oxide as novel markers of inflammatory bowel disease
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Nat Clin Pract Gastroenterol Hepatol 2:96-102. 2005
    ..Here, we discuss what is known about these markers, how they could be used in clinical practice and how they can complement existing techniques used for the diagnosis and monitoring of inflammatory bowel disease...
  20. ncbi request reprint Rectal mucosal nitric oxide in differentiation of inflammatory bowel disease and irritable bowel syndrome
    Claudia I Reinders
    Division of Pharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Clin Gastroenterol Hepatol 3:777-83. 2005
    ..To further evaluate this disease marker, we compared NO in patients with irritable bowel syndrome (IBS) with those found in patients with active IBD and in healthy control subjects...
  21. ncbi request reprint No evidence for a clear link between active intestinal inflammation and autism based on analyses of faecal calprotectin and rectal nitric oxide
    Elisabeth Fernell
    Department of Neuropaediatrics, Astrid Lindgren Children s Hospital, Karolinska Institutet, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden
    Acta Paediatr 96:1076-9. 2007
    ....
  22. ncbi request reprint Inflammation as a cause of functional bowel disorders
    Hans Tornblom
    Karolinska Institutet, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Scand J Gastroenterol 40:1140-8. 2005
  23. ncbi request reprint Gut peptide hormones: importance for food intake
    Erik Naslund
    Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
    Scand J Gastroenterol 40:250-8. 2005
  24. doi request reprint Nitric oxide pathway-related gene alterations in inflammatory bowel disease
    Linda Gillberg
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Gastroenterol 47:1283-97. 2012
    ..To reveal specific gene activation in nitric oxide (NO)-related inflammation we studied differential gene expression in inflammatory bowel disease (IBD)...
  25. doi request reprint Infliximab or cyclosporine as rescue therapy in hospitalized patients with steroid-refractory ulcerative colitis: a retrospective observational study
    Mats Sjöberg
    Department of Medicine, Skaraborgs Hospital, Lidköping, Sweden
    Inflamm Bowel Dis 18:212-8. 2012
    ..Cyclosporine (CsA) or infliximab (IFX) are used as rescue therapies in steroid-refractory, severe attacks of ulcerative colitis (UC). There are no data comparing the efficacy of these two alternatives...
  26. ncbi request reprint Gastrointestinal function and metabolic control after construction of an orthotopic ileal neobladder in bladder cancer
    Andreas Thorstenson
    Department of Molecular Medicine, Section of Urology, Stockholm, Sweden
    Scand J Urol Nephrol 41:14-9. 2007
    ..To investigate the effects of ileum resection in orthotopic neobladder construction on gastrointestinal function and metabolic control...
  27. ncbi request reprint Stimulatory effect of endogenous orexin A on gastric emptying and acid secretion independent of gastrin
    Marcus Ehrström
    Division of Surgery, Danderyd Hospital, Karolinska Institutet, Danderyd Hospital, SE 182 88 Stockholm, Sweden
    Regul Pept 132:9-16. 2005
    ..This indicates a role for endogenous OXA, not only in metabolic homeostasis, but also in the pre-absorptive processing of nutrients in the gut...
  28. ncbi request reprint The pancreatic polypeptide family and the migrating motor complex of the rat: differential effects in the duodenum and jejunum
    P T Schmidt
    Department of Medicine, Gastroenterology Unit, Karolinska University Hospital Solna, Karolinska Institutet, Sweden
    Regul Pept 139:59-64. 2007
    ..To investigate the effects of members of the pancreatic polypeptide family on migrating myoelectric complexes in rats in vivo...
  29. ncbi request reprint Expression of iNOS mRNA associated with suppression of colonic contraction in rat colitis
    S Lundberg
    Department of Medicine, Unit of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 187:489-94. 2006
    ..The aim was to investigate which subtype of NOS that is activated in experimental colitis...
  30. ncbi request reprint Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study
    Gunnar Järnerot
    Department of Medicine, Division of Gastroenterology, Orebro University Hospital, Sweden
    Gastroenterology 128:1805-11. 2005
    ..We intended to find a rescue therapy other than cyclosporin A, which imposes a high risk of side effects and cyclosporine-related mortality...
  31. doi request reprint Explorative study on the predictive value of systematic inflammatory and metabolic markers on weight loss in head and neck cancer patients undergoing radiotherapy
    Ylva Tiblom Ehrsson
    Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Support Care Cancer 18:1385-91. 2010
    ..This study aimed to explore the predictive value of systematic inflammatory and metabolic markers in head and neck (H&N) cancer patients during radiotherapy (RT)...
  32. ncbi request reprint Appetite signaling: from gut peptides and enteric nerves to brain
    Erik Naslund
    Karolinska Institutet, Division of Surgery, Danderyd Hospital, and Department of Gastroenterology and Hepatology, Karolinska University Hospital, Stockholm, Sweden
    Physiol Behav 92:256-62. 2007
    ..We have primarily focused on GI effects of various gut peptides involved in the regulation of food intake, using motor activity as a biomarker for the understanding of gut peptide effects promoting satiety...
  33. pmc A novel tachykinin NK2 receptor antagonist prevents motility-stimulating effects of neurokinin A in small intestine
    M Lördal
    Department of Medicine, Section of Gastroenterology and Hepatology, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Br J Pharmacol 134:215-23. 2001
    ..7. In conclusion, intravenous MEN 11420 effectively inhibited NKA-stimulated, but not basal gastrointestinal motility, and was well tolerated by all subjects...
  34. ncbi request reprint Validated accuracy of a novel urea breath test for rapid Helicobacter pylori detection and in-office analysis
    Olga Hegedus
    Department of Medicine, Unit of Gastroenterology and Hepatology, Karolinska Hospital, Karolinska Institutet, Sweden
    Eur J Gastroenterol Hepatol 14:513-20. 2002
    ..A novel 14C-urea breath test (UBT) was developed to detect the presence of Helicobacter pylori by bench analysis in office, enabling the practitioner to readily reveal H. pylori infection...
  35. ncbi request reprint Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and inflammatory bowel disease: comparison with peptide YY
    Peter T Schmidt
    Department of Medicine, Gastroenterology Unit, Karolinska Hospital, Stockholm, Sweden
    Eur J Gastroenterol Hepatol 17:207-12. 2005
    ..Therefore, tissue levels and meal-stimulated secretion of GLP-2 and PYY were studied in IBD patients and compared to controls...
  36. ncbi request reprint Integrin alpha2beta1 regulates neutrophil recruitment and inflammatory activity in experimental colitis in mice
    Sofie Lundberg
    Department of Medicine, Unit of Gastroenterology and Hepatology, Karolinska Institutet, Karolinska University Hospital, Stockholm
    Inflamm Bowel Dis 12:172-7. 2006
    ..The aim of this study was to investigate the role of the collagen-binding alpha2beta1 integrin (CD49b/CD29) in dextran sodium sulfate-induced colitis in mice...
  37. ncbi request reprint Effect of intravenous L-NMMA on nitric oxide production in collagenous colitis
    C I Reinders
    Dept of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institute, Stockholm, Sweden
    Scand J Gastroenterol 39:32-6. 2004
    ..We investigated the effect of the NO synthase inhibitor L-NMMA on intestinal concentrations of NO in patients with clinically active collagenous colitis. In addition, we measured NO levels from the respiratory tract...
  38. doi request reprint The incretin hormones GIP and GLP-1 in diabetic rats: effects on insulin secretion and small bowel motility
    T Edholm
    Department of Medicine, Gastroenterology Unit, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Neurogastroenterol Motil 21:313-21. 2009
    ..The initially high, but later low insulin responsiveness to stimulation with GIP and GLP-1 along with inhibition of small bowel motility in the GK rat indicates a preserved incretin response on motility in diabetes type 2...
  39. pmc Tachykinins potently stimulate human small bowel blood flow: a laser Doppler flowmetry study in humans
    P T Schmidt
    Department of Medicine, Unit of Gastroenterology, Karolinska Hospital, Stockholm, Sweden
    Gut 52:53-6. 2003
    ..Tachykinin effects on intestinal mucosal blood flow in humans are not known...
  40. ncbi request reprint The inhibitory mechanism of GLP-1, but not glucagon, on fasted gut motility is dependent on the L-arginine/nitric oxide pathway
    T Tolessa
    Department of Medicine, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Regul Pept 98:33-40. 2001
    ..In conclusion, inhibition of fasted motility by GLP-1 at low doses is dependent on NO, while high doses of GLP-1 and glucagon exert effects on motility independently from NO...
  41. pmc Infliximab in inflammatory bowel disease: clinical outcome in a population based cohort from Stockholm County
    T Ljung
    Department of Gastroenterology and Hepatology, Karolinska Hospital, Stockholm, Sweden
    Gut 53:849-53. 2004
    ..Several placebo controlled studies have demonstrated the efficacy of infliximab in inflammatory bowel disease (IBD) but the potential toxicity of this new biological compound has been less studied...
  42. pmc Concordance of Helicobacter pylori strains within families
    Marten Kivi
    Department of Clinical Microbiology, Microbiology and Tumor Biology Center, Karolinska Hospital, Stockholm, Sweden
    J Clin Microbiol 41:5604-8. 2003
    ..Transmission between spouses seems to be appreciable. The data support mother-child and sib-sib transmission as the primary transmission pathways of H. pylori...
  43. ncbi request reprint Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats
    Lars Göran Axelsson
    Section of Gastroenterology and Hepatology, Department of Internal Medicine, Karolinska Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Eur J Pharmacol 467:211-8. 2003
    ..Blockade of 5-HT(4) receptors seems to exert a powerful inhibitory effect on motility, 5-HT(3) receptor blockade is less efficient and muscarinic receptor blockade has low efficacy...
  44. doi request reprint Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial
    Pedram Kharaziha
    Urology and Nephrology Research Center UNRC, Karolinska Institutet, Stockholm, Sweden, Karolinska University Hospital Solna, Sweden
    Eur J Gastroenterol Hepatol 21:1199-205. 2009
    ..End-stage liver disease is a medical problem with high morbidity and mortality. We have investigated the feasibility, safety, and efficacy of using autologous mesenchymal stem cells (MSCs) as a treatment...
  45. ncbi request reprint Different concentrations of I-123 MIBG and In-111 pentetreotide in the two main liver lobes in children: persisting regional functional differences after birth?
    Hans Jacobsson
    Department of Radiology, Karolinska University Hospital Solna, Stockholm, Sweden
    Clin Nucl Med 32:24-8. 2007
    ..This phenomenon was studied in retrospect from clinical examinations...
  46. ncbi request reprint Tachykinin-stimulated small bowel myoelectric pattern: sensitization by NO inhibition, reversal by neurokinin receptor blockade
    Peter Thelin Schmidt
    Gastroenterology Unit, Department of Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Regul Pept 105:15-21. 2002
    ..Tachykinins stimulate motility whereas NO inhibits motility in the gastrointestinal tract...
  47. ncbi request reprint Cisapride induces clustered spikes and irregular spiking of the small intestine of the rat
    M Lördal
    Dept of Internal Medicine, Karolinska Hospital, Stockholm, Sweden
    Scand J Gastroenterol Suppl 152:48-53. 1988
    ..It is concluded that cisapride induces clustered spikes and irregular spiking. These effects require intact cholinergic pathways, involving both muscarinic and nicotinic receptor mechanisms...
  48. ncbi request reprint Circulating ghrelin levels after food intake during different phases of the migrating motor complex in man
    P T Schmidt
    Department of Gastroenterology and Hepatology, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur J Clin Invest 36:503-8. 2006
    ..This report studies the relationships between phases I (motor quiescence) and II (intermediate frequency contractions) of MMC and prandial gut hormone response...
  49. ncbi request reprint Rectal nitric oxide assessment in children with Crohn disease and ulcerative colitis. Indicator of ileocaecal and colorectal affection
    T Ljung
    Dept. of Gastroenterology, Karolinska Hospital, Stockholm, Sweden
    Scand J Gastroenterol 36:1073-6. 2001
    ..Rectal sampling of luminal NO is a simple and minimally invasive method and should be considered a diagnostic tool for intestinal inflammatory activity in children regardless of primary disease location...
  50. ncbi request reprint Occurrence, release, and effects of multiple tachykinins in cat colonic tissues and nerves
    P M Hellstrom
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Gastroenterology 100:431-40. 1991
    ..05) but unchanged after treatment with hexamethonium. Our findings indicate that tachykinins are released from the pelvic nerve to induce a nonadrenergic noncholinergic contraction and vasodilatation of the colon in the cat...
  51. ncbi request reprint Serotonin stimulates migrating myoelectric complex via 5-HT3-receptors dependent on cholinergic pathways in rat small intestine
    M Lördal
    Department of Gastroenterology and Hepatology, Karolinska Hospital, Stockholm, Sweden
    Neurogastroenterol Motil 11:1-10. 1999
    ..Our findings encourage further studies on the role of the 5-HT3-receptor in the control of gastrointestinal motility...
  52. ncbi request reprint Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin
    Erik Naslund
    Division of Surgery, Karolinska Institutet Danderyd Hospital, SE 182 88 Danderyd, Stockholm, Sweden
    Regul Pept 106:89-95. 2002
    ..The effect of LY315902 on motor control is mediated through the GLP-1 receptor and seems partly dependent on the L-arginine/NO pathway...
  53. ncbi request reprint Abrogation of mitochondrial transcription in smooth muscle cells impairs smooth muscle contractility and vascular tone
    J Jawien
    Department of Medicine Karolinska Institute, Stockholm, Sweden
    J Physiol Pharmacol 59:239-52. 2008
    ..Mitochondrial activity may also modulate smooth muscle tone by biotransformation of vasoactive mediators. Here, we study the role of mitochondrial DNA gene expression for vascular function in vivo...
  54. ncbi request reprint A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control
    P T Schmidt
    Department of Gastroenterology and Hepatology, Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
    J Clin Endocrinol Metab 90:5241-6. 2005
    ..Previous studies using pancreatic polypeptide (PP) infusions in humans have failed to show an effect on gastric emptying, glucose metabolism, and insulin secretion. This might be due to the use of nonhuman sequences of the peptide...
  55. ncbi request reprint Gastric emptying in myotonic dystrophy
    A Rönnblom
    Department of Medicine, Section of Gastroenterology and Hepatology, University Hospital, Uppsala, Sweden
    Eur J Clin Invest 32:570-4. 2002
    ..Gastric emptying was studied in patients with MD who suffered from symptoms suggesting slow gastric emptying and the effect of prokinetic treatment was evaluated...
  56. ncbi request reprint Cholinergic mechanisms involved in release and effect of prostaglandin E2 in HCl-stimulated duodenal HCO-3 secretion in the conscious rat
    B Smedfors
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Acta Physiol Scand 139:485-92. 1990
    ..Perfusion of the duodenal loop with 0.1 mmol l-1 prostaglandin E2 produced a HCO3- response that was abolished by hexamethonium (20 mg kg-1 i.v.), but not affected by atropine (0.5 mg kg-1 s.c.).(ABSTRACT TRUNCATED AT 250 WORDS)..
  57. ncbi request reprint Gastric myoelectrical activity and gut hormone secretion in myotonic dystrophy
    A Rönnblom
    Department of Medicine, Section of Gastroenterology and Hepatology, University Hospital, Uppsala, Sweden, bGastroenterology and Hepatology, Karolinska Hospital, Stockholm, Sweden
    Eur J Gastroenterol Hepatol 13:825-31. 2001
    ..Myotonic dystrophy (MD) is a systemic disease affecting striated, cardiac and smooth muscles, as well as nerve structures and endocrine glands. Patients with MD may suffer from slow gastric emptying...
  58. doi request reprint Differential effect of PYY1-36 and PYY3-36 on gastric emptying in man
    A B Witte
    Department of Medicine, Unit of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Karolinska Institutet, 171 76 Stockholm, Sweden
    Regul Pept 158:57-62. 2009
    ..PYY3-36 induced nausea (VAS increase 47.5+/-22.6 mm) and decreased prospective consumption (VAS change 39.5+/-7.7 mm). In conclusion, PYY3-36's reducing effect upon food intake might be mediated by a decreased gastric emptying rate...
  59. ncbi request reprint Motilin- and neuropeptide Y-like immunoreactivity in a psychophysiological stress experiment on patients with functional dyspepsia
    B H Jonsson
    Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden
    Integr Physiol Behav Sci 35:256-65. 2000
    ..The aim of the study was to compare plasma motilin-like immunoreactivity (MOT-LI) and neuropeptide Y (NPY)-like immunoreactivity (NPY-LI) in patients with functional dyspepsia (FD) during a controlled psychophysiological experiment...
  60. ncbi request reprint GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans
    E Naslund
    Division of Surgery, Danderyd Hospital, Karolinska Institutet, SE 182 88, Stockholm, Sweden
    Am J Physiol 277:R910-6. 1999
    ..In addition, the release of PYY into the circulation is inhibited by GLP-1 infusion, suggesting a negative feedback of GLP-1 on the function of the L-cell...
  61. ncbi request reprint Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity
    E Naslund
    Department of Surgery, Karolinska Institute, Stockholm, Sweden
    Obes Surg 8:253-60. 1998
    ..The aim of the present study was to examine the long-term effect of JIB on glucose metabolism...
  62. ncbi request reprint Increased nitric oxide production in collagenous and lymphocytic colitis
    J O Lundberg
    Department of Pharmacology, Karolinska Institute, Stockholm, Sweden
    Eur J Clin Invest 27:869-71. 1997
    ..Moreover, it is tempting to speculate that these measurements could be clinically useful in the diagnosis and therapy monitoring of these two inflammatory bowel diseases...