E Hellström-Lindahl

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Comparison of Abeta levels in the brain of familial and sporadic Alzheimer's disease
    E Hellström-Lindahl
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Sweden
    Neurochem Int 55:243-52. 2009
  2. ncbi request reprint Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levels
    E Hellström-Lindahl
    Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Geriatric lab, Novum, Floor 4, S 141 86 Stockholm, Sweden
    Neurobiol Aging 29:210-21. 2008
  3. ncbi request reprint Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord
    E Hellström-Lindahl
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden
    Brain Res Dev Brain Res 108:147-60. 1998
  4. ncbi request reprint Nicotine-induced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain
    E Hellström-Lindahl
    Department of Clinical Neuroscience, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Neuroscience 105:527-34. 2001
  5. ncbi request reprint Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain
    E Hellström-Lindahl
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Molecular Neuropharmacology, Karolinska Institute, Huddinge University Hospital, S 14186 Huddinge, Sweden
    Brain Res Mol Brain Res 66:94-103. 1999
  6. ncbi request reprint Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months
    T Darreh-Shori
    Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Neurology 59:563-72. 2002
  7. ncbi request reprint Reduced levels of Abeta 40 and Abeta 42 in brains of smoking controls and Alzheimer's patients
    E Hellström-Lindahl
    Department of Neurotec, Division of Molecular Neuropharmacology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Neurobiol Dis 15:351-60. 2004
  8. ncbi request reprint Modulation of beta-amyloid precursor protein processing and tau phosphorylation by acetylcholine receptors
    E Hellström-Lindahl
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Molecular Neuropharmacology, Karolinska Institutet, Huddinge University Hospital, Sweden
    Eur J Pharmacol 393:255-63. 2000
  9. ncbi request reprint Cerebral glucose metabolism, cerebrospinal fluid-beta-amyloid1-42 (CSF-Abeta42), tau and apolipoprotein E genotype in long-term rivastigmine and tacrine treated Alzheimer disease (AD) patients
    E Stefanova
    Karolinska Institutet, Department of Clinical Neuroscience Occupational Therapy and Elderly Care Research NEUROTEC, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, 141 86, Stockholm, Sweden
    Neurosci Lett 338:159-63. 2003
  10. ncbi request reprint Increased levels of tau protein in SH-SY5Y cells after treatment with cholinesterase inhibitors and nicotinic agonists
    E Hellström-Lindahl
    Department of Clinical Neuroscience, Occupational Therapy, and Elderly Care Research, Karolinska Institute, Huddinge University Hospital, Sweden
    J Neurochem 74:777-84. 2000

Detail Information

Publications16

  1. pmc Comparison of Abeta levels in the brain of familial and sporadic Alzheimer's disease
    E Hellström-Lindahl
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Neurobiology, Sweden
    Neurochem Int 55:243-52. 2009
    ..Our results indicate that the pattern of Abeta deposition in PS1 mutation carriers differs from that in both APPsw and SAD, whereas the pattern in APPsw mutation carriers is more similar to that in SAD...
  2. ncbi request reprint Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levels
    E Hellström-Lindahl
    Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Geriatric lab, Novum, Floor 4, S 141 86 Stockholm, Sweden
    Neurobiol Aging 29:210-21. 2008
    ..The similar rate of decline in neprilysin with age may not be the major cause of the high levels of A beta associated with AD but is likely to be a trigger of AD pathology...
  3. ncbi request reprint Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord
    E Hellström-Lindahl
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden
    Brain Res Dev Brain Res 108:147-60. 1998
    ..The early presence of nAChR proteins and gene transcripts shown in the present study suggests an important role for nAChRs in modulating dendritic outgrowth, establishment of neuronal connections and synaptogenesis during development...
  4. ncbi request reprint Nicotine-induced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain
    E Hellström-Lindahl
    Department of Clinical Neuroscience, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Neuroscience 105:527-34. 2001
    ..These findings support the assumption of a potential risk of disturbance in the functional role of nicotinic receptors during brain development as a consequence of maternal smoking during pregnancy...
  5. ncbi request reprint Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain
    E Hellström-Lindahl
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Molecular Neuropharmacology, Karolinska Institute, Huddinge University Hospital, S 14186 Huddinge, Sweden
    Brain Res Mol Brain Res 66:94-103. 1999
    ..The increased mRNA level of alpha7 previously found in lymphocytes, and now also in the hippocampus of AD patients, indicate that subunit specific changes in gene expression of nAChRs is associated with AD...
  6. ncbi request reprint Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months
    T Darreh-Shori
    Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Neurology 59:563-72. 2002
    ..To study the long-term dual inhibitory effects of rivastigmine on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in patients with AD...
  7. ncbi request reprint Reduced levels of Abeta 40 and Abeta 42 in brains of smoking controls and Alzheimer's patients
    E Hellström-Lindahl
    Department of Neurotec, Division of Molecular Neuropharmacology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Neurobiol Dis 15:351-60. 2004
    ..These results indicate that selective nicotinic receptor agonists may be a novel protective therapy in AD by reducing Abeta levels as well as the loss of nicotinic receptors in AD brain...
  8. ncbi request reprint Modulation of beta-amyloid precursor protein processing and tau phosphorylation by acetylcholine receptors
    E Hellström-Lindahl
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Molecular Neuropharmacology, Karolinska Institutet, Huddinge University Hospital, Sweden
    Eur J Pharmacol 393:255-63. 2000
    ....
  9. ncbi request reprint Cerebral glucose metabolism, cerebrospinal fluid-beta-amyloid1-42 (CSF-Abeta42), tau and apolipoprotein E genotype in long-term rivastigmine and tacrine treated Alzheimer disease (AD) patients
    E Stefanova
    Karolinska Institutet, Department of Clinical Neuroscience Occupational Therapy and Elderly Care Research NEUROTEC, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, 141 86, Stockholm, Sweden
    Neurosci Lett 338:159-63. 2003
    ..There was no significant change in Abeta42 after 1-year treatment with either rivastigmine or tacrine. This study shows that the two long-term cholinesterase inhibitor treatments exert different effects on biological markers for AD...
  10. ncbi request reprint Increased levels of tau protein in SH-SY5Y cells after treatment with cholinesterase inhibitors and nicotinic agonists
    E Hellström-Lindahl
    Department of Clinical Neuroscience, Occupational Therapy, and Elderly Care Research, Karolinska Institute, Huddinge University Hospital, Sweden
    J Neurochem 74:777-84. 2000
    ..Additional work is needed to determine the exact mechanism by which cholinesterase inhibitors and nicotinic agonists modulate phosphorylation and levels of tau protein...
  11. ncbi request reprint Changes in the activity and protein levels of CSF acetylcholinesterases in relation to cognitive function of patients with mild Alzheimer's disease following chronic donepezil treatment
    T Darreh-Shori
    Division of Molecular Neuropharmacology, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Neural Transm 113:1791-801. 2006
    ..To evaluate long-term changes in acetylcholinesterase (AChE) activity in CSF and blood following donepezil treatment in relation to the concentration of donepezil and cognition in AD patients...
  12. doi request reprint Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro
    M Mousavi
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
    Neurochem Int 54:237-44. 2009
    ..Nicotinic drugs directed towards specific nAChR subtypes might therefore be beneficial for the treatment of AD not only by lowering Abeta production but also by enhance release of neuroprotective sAPPalpha...
  13. ncbi request reprint Smoking during early pregnancy affects the expression pattern of both nicotinic and muscarinic acetylcholine receptors in human first trimester brainstem and cerebellum
    L Falk
    Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, S 141 86, Stockholm, Sweden
    Neuroscience 132:389-97. 2005
    ..The findings indicate that early prenatal nicotine exposure affects the normal developmental pattern of the cholinergic system in human fetal brain...
  14. ncbi request reprint Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients
    T Darreh-Shori
    Karolinska Institute, Neurotec Department, Stockholm, Sweden
    J Neurochem 88:1102-13. 2004
    ..0001). Thus, evaluation of changes in the composition of CSF AChE variants may yield important information referring to the therapeutic efficacy and/or development of drug tolerance in AD patients treated with anti-cholinesterases...
  15. ncbi request reprint Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease
    M Mousavi
    Karolinska Institute, Department of Neurotec, Division of Molecular Neuropharmacology, Huddinge University Hospital, B84, 141 86, Stockholm, Sweden
    Neuroscience 122:515-20. 2003
    ..The up-regulation of nAChRs in smoking groups and the loss of these receptors in AD patients were not correlated to any changes at the mRNA level suggesting that these changes may reflect post-transcriptional events...
  16. ncbi request reprint Nicotinic acetylcholine receptors during prenatal development and brain pathology in human aging
    E Hellström-Lindahl
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Karolinska Institutet, Huddinge University Hospital, Sweden
    Behav Brain Res 113:159-68. 2000
    ....