M Heilig

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism
    Markus Heilig
    Karolinska Institutet, Neurotec Department, Division of Psychiatry, Huddinge University Hospital, M57, SE 141 86, Stockholm, Sweden
    J Psychiatr Res 38:113-21. 2004
  2. doi Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series
    Johan Kakko
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Drug Alcohol Depend 96:69-78. 2008
  3. doi Modulation of voluntary ethanol consumption by beta-arrestin 2
    K Bjork
    Laboratory of Clinical and Translational Studies, NIAAA NIH, 10 Center Dr, Bethesda, MD 20892 1108, USA
    FASEB J 22:2552-60. 2008
  4. pmc CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques
    Christina S Barr
    Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 65:934-44. 2008
  5. ncbi Functional genomics strategies to identify susceptibility genes and treatment targets in alcohol dependence
    Markus Heilig
    Division of Psychiatry, Neurotec Department, Karolinska Institutet, M57 Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Neurotox Res 6:363-72. 2004
  6. ncbi The dual-diagnosis concept used by Swedish social workers: limited validity upon examination using a structured diagnostic approach
    Markus Heilig
    Neurotec, Division of Psychiatry, Karolinska Institute, Sweden
    Eur Psychiatry 17:363-5. 2002
  7. ncbi Brain neuropeptide Y (NPY) in stress and alcohol dependence
    Markus Heilig
    Neurotec, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Rev Neurosci 13:85-94. 2002
  8. ncbi [Reduced drug craving and better social function with buprenorphine therapy. Combination therapy as an alternative to methadone therapy in heroin addiction]
    Markus Heilig
    Psykiatriska kliniken, Huddinge Universitetssjukhus
    Lakartidningen 100:2526-7. 2003
  9. ncbi [Documented effect of methadone, but not naltrexone]
    Markus Heilig
    Huddinge Universitetssjukhus
    Lakartidningen 99:551-2. 2002
  10. ncbi [Surprising conclusion by the SBU concerning the benefits of naltrexone in the treatment of heroin dependence]
    Markus Heilig
    Lakartidningen 99:200-4. 2002

Detail Information

Publications94

  1. ncbi Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism
    Markus Heilig
    Karolinska Institutet, Neurotec Department, Division of Psychiatry, Huddinge University Hospital, M57, SE 141 86, Stockholm, Sweden
    J Psychiatr Res 38:113-21. 2004
    ..Our present findings are in line with an extensive animal literature, and further support the notion that impaired NPY function could contribute to depressive illness...
  2. doi Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series
    Johan Kakko
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Drug Alcohol Depend 96:69-78. 2008
    ..To compare the effects of fetal buprenorphine and methadone exposure during maintenance treatment of pregnant heroin dependent subjects...
  3. doi Modulation of voluntary ethanol consumption by beta-arrestin 2
    K Bjork
    Laboratory of Clinical and Translational Studies, NIAAA NIH, 10 Center Dr, Bethesda, MD 20892 1108, USA
    FASEB J 22:2552-60. 2008
    ..Our results demonstrate that beta-arrestin 2 modulates acute responses to ethanol and is an important mediator of ethanol reward...
  4. pmc CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques
    Christina S Barr
    Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 65:934-44. 2008
    ..As such, CRH gene variation may influence risk for alcohol use and dependence...
  5. ncbi Functional genomics strategies to identify susceptibility genes and treatment targets in alcohol dependence
    Markus Heilig
    Division of Psychiatry, Neurotec Department, Karolinska Institutet, M57 Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Neurotox Res 6:363-72. 2004
    ..For this purpose, we have applied differential display and more recently Affymetrix oligonucleotide gene arrays to models of genetic susceptibility and alcohol-induced neuroadaptation...
  6. ncbi The dual-diagnosis concept used by Swedish social workers: limited validity upon examination using a structured diagnostic approach
    Markus Heilig
    Neurotec, Division of Psychiatry, Karolinska Institute, Sweden
    Eur Psychiatry 17:363-5. 2002
    ..A systematic individual evaluation in an alcohol- and drug-free state of sufficient duration is necessary to obtain a basis for an adequate individual treatment plan...
  7. ncbi Brain neuropeptide Y (NPY) in stress and alcohol dependence
    Markus Heilig
    Neurotec, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Rev Neurosci 13:85-94. 2002
    ..Recent data additionally point to a role of NPY in the regulation of alcohol intake, and alcohol dependence emerges as a novel potential indication for compounds targeting the NPY system...
  8. ncbi [Reduced drug craving and better social function with buprenorphine therapy. Combination therapy as an alternative to methadone therapy in heroin addiction]
    Markus Heilig
    Psykiatriska kliniken, Huddinge Universitetssjukhus
    Lakartidningen 100:2526-7. 2003
  9. ncbi [Documented effect of methadone, but not naltrexone]
    Markus Heilig
    Huddinge Universitetssjukhus
    Lakartidningen 99:551-2. 2002
  10. ncbi [Surprising conclusion by the SBU concerning the benefits of naltrexone in the treatment of heroin dependence]
    Markus Heilig
    Lakartidningen 99:200-4. 2002
  11. ncbi The NPY system in stress, anxiety and depression
    Markus Heilig
    Division of Psychiatry, Neurotec Department, Karolinska Institute, Huddinge University Hospital M57, Stockholm 141 86, Sweden Laboratory of Clinical Science, NIAAA NIH, Bethesda, MD, USA
    Neuropeptides 38:213-24. 2004
    ..Development of Y2 antagonists presently appears to offer the most promising strategy for developing these clinical treatments...
  12. ncbi Differential expression of NPY and its receptors in alcohol-preferring AA and alcohol-avoiding ANA rats
    L Caberlotto
    Neurotec, Karolinska Institute, Stockholm, Sweden
    Alcohol Clin Exp Res 25:1564-9. 2001
    ....
  13. ncbi Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats
    A Thorsell
    Neurotec, Karolinska Institutet, M46, Huddinge University Hospital, SE 141 86 Huddinge, Sweden
    Neurosci Lett 332:1-4. 2002
    ..This suggests that Y2 receptors might be candidate targets for developing novel pharmacological treatments of alcoholism...
  14. ncbi The search for candidate genes of alcoholism: evidence from expression profiling studies
    Wh Sommer
    Div of Psychiatry, Dept of Neurotec Karolinska Institutet, Stockholm, Sweden
    Addict Biol 10:71-9. 2005
    ..The accumulation of expression data from different animal models allows mining the database for patterns of overlap. Such second level analysis depends on the generation of uniform and reliable datasets...
  15. pmc Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress
    A C Hansson
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:15236-41. 2006
    ..These data demonstrate that Crhr1 genotype and expression interact with environmental stress to reinstate alcohol-seeking behavior...
  16. ncbi Plasticity and impact of the central renin-angiotensin system during development of ethanol dependence
    W H Sommer
    Laboratory of Clinical and Translational Studies, NIAAA, NIH, Bldg 10, CRC, Bethesda, MD, 20892 1108, USA
    J Mol Med (Berl) 85:1089-97. 2007
    ....
  17. ncbi Local 5,7-dihydroxytryptamine lesions of rat amygdala: release of punished drinking, unaffected plus-maze behavior and ethanol consumption
    W Sommer
    Addiction Centre South, Dept of NEUROTEC, Karolinska Institute, Stockholm, Sweden
    Neuropsychopharmacology 24:430-40. 2001
    ....
  18. ncbi A cluster of differentially expressed signal transduction genes identified by microarray analysis in a rat genetic model of alcoholism
    C Arlinde
    Neurotec, Karolinska Institute, Sweden
    Pharmacogenomics J 4:208-18. 2004
    ..Within the amygdala, a more loosely inter-related cluster of cytoskeleton-associated genes may point to structural abnormalities. The observed dysregulations may contribute to the alcohol-preferring phenotype...
  19. ncbi Glutathione-S-transferase expression in the brain: possible role in ethanol preference and longevity
    K Bjork
    Laboratory of Clinical and Translational Studies, NCI, National Institutes of Health, Bethesda, USA
    FASEB J 20:1826-35. 2006
    ..It could, however, underlie observed differences in life span between AA and ANA lines, prompting a utility of this animal model in aging research...
  20. ncbi Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar Rats
    Annika Thorsell
    Laboratory of Clinical and Translational Studies, NIAAA, NIH, Bethesda, Maryland 20892 1108, USA
    Alcohol Clin Exp Res 31:1302-7. 2007
    ....
  21. pmc Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence
    J D Tapocik
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Pharmacogenomics J 13:286-96. 2013
    ..MicroRNA-mediated alterations of transcriptional networks may be involved in disrupted prefrontal control over alcohol drinking observed in alcoholic patients...
  22. ncbi Leptin suppression of hypothalamic NPY expression and feeding, but not amygdala NPY expression and experimental anxiety
    A Thorsell
    Neurotec, Karolinska Institutet, SE 141 86, Stockholm, Sweden
    Pharmacol Biochem Behav 71:425-30. 2002
    ..e., feeding and endocrine stress responses. Despite modifying endocrine responses, leptin treatment does not affect behavioral measures of experimental anxiety...
  23. ncbi Neuropeptide Y (NPY) mRNA in rat brain tissue: effects of decapitation and high-energy microwave irradiation on post mortem stability
    A Thorsell
    Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Neuropeptides 35:168-73. 2001
    ..A general protective effect of high-energy radiation against degradation is not supported...
  24. pmc A genetic determinant of the striatal dopamine response to alcohol in men
    V A Ramchandani
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 16:809-17. 2011
    ..OPRM1 A118G variation is a genetic determinant of dopamine responses to alcohol, a mechanism by which it likely modulates alcohol reward...
  25. ncbi Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol
    Roberto Rimondini
    Neurotec, Karolinska Institutet, Stockholm, Sweden
    FASEB J 16:27-35. 2002
    ..These observations may have important implications for how alcoholism is managed clinically. Novel clinically effective treatments may be possible to develop by targeting the products of genes found to be regulated in our model...
  26. ncbi Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Neuropsychopharmacology 32:117-26. 2007
    ..These results show for the first time that impaired FAAH function may confer a phenotype of high voluntary alcohol intake, and point to a FAAH both as a potential susceptibility factor and a therapeutic target...
  27. doi Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 208:417-26. 2010
    ..Here, we examined whether neuropeptide Y (NPY), an endogenous anti-stress mediator, blocks reinstatement of alcohol-seeking induced by the pharmacological stressor yohimbine...
  28. ncbi Identifying hazardous alcohol consumption during pregnancy: implementing a research-based model in real life
    Mona Göransson
    Division of Psychiatry, Neurotec, Karolinska Institute, Stockholm, Sweden
    Acta Obstet Gynecol Scand 85:657-62. 2006
    ....
  29. ncbi A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomized controlled trial
    Johan Kakko
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Am J Psychiatry 164:797-803. 2007
    ..Buprenorphine offers lower overdose risk and improved access, but efficacy may be lower. The authors compared adaptive, buprenorphine-based stepped care to optimal methadone maintenance treatment...
  30. ncbi Beliefs and reality: detection and prevention of high alcohol consumption in Swedish antenatal clinics
    Mona Göransson
    Division of Psychiatry, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Acta Obstet Gynecol Scand 83:796-800. 2004
    ..Available statistics indicate, however, that this system is ineffective in dealing with psychosocial health problems, such as hazardous drug and alcohol use. Factors underlying this failure have not been explored...
  31. ncbi 1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial
    Johan Kakko
    Division of Psychiatry, Neurotec, Karolinska Institute, Huddinge University Hospital, S 141 86, Stockholm, Sweden
    Lancet 361:662-8. 2003
    ..We aimed to assess the 1-year efficacy of buprenorphine in combination with intensive psychosocial therapy for treatment of heroin dependence...
  32. ncbi Fetus at risk: prevalence of alcohol consumption during pregnancy estimated with a simple screening method in Swedish antenatal clinics
    Mona Göransson
    Division of Psychiatry, Neurotec, Karolinska Institute, Stockholm, Sweden
    Addiction 98:1513-20. 2003
    ..The aim of this study was to examine the prevalence of hazardous or harmful alcohol consumption during pregnancy in a consecutive series of Swedish pregnant females...
  33. ncbi Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence
    Roberto Rimondini
    Neurotec, Karolinska Institutet, M57, Huddinge University Hospital, SE 14186 Huddinge, Sweden
    Neurosci Lett 375:129-33. 2005
    ..This may render the NPY system, and Y2 receptors in particular, an attractive target for treatment of alcohol dependence...
  34. pmc Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Alcohol 44:67-80. 2010
    ....
  35. ncbi A temporal threshold for induction of persistent alcohol preference: behavioral evidence in a rat model of intermittent intoxication
    Roberto Rimondini
    Division of Psychiatry, Neurotec Department, Karolinska Institute, M57 Huddinge University Hospital, S141 86 Stockholm, Sweden
    J Stud Alcohol 64:445-9. 2003
    ..We addressed this question by examining the functional consequences of different exposure durations...
  36. ncbi Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum
    P Svenningsson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Eur J Neurosci 9:2135-41. 1997
    ..The findings illustrate the utility of blockade of gene expression with antisense oligonucleotides for in vivo studies of drug actions...
  37. ncbi Effects of tiagabine and diazepam on operant ethanol self-administration in the rat
    R Rimondini
    Department of Neurotec, Karolinska Institute, Addiction Center South, Huddinge Hospital, Stockholm, Sweden
    J Stud Alcohol 63:100-6. 2002
    ..The objective of the present study was to examine whether these two manners of modulating GABAergic transmission would affect ethanol self-administration in rats...
  38. pmc Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression
    A Thorsell
    Addiction Center South, Karolinska Institutet, M46, Huddinge Hospital, SE 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 97:12852-7. 2000
    ..Data obtained using this unique model support and extend a previously postulated anti-stress action of NPY and provide novel evidence for a role of NPY in learning and memory...
  39. ncbi Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats
    W Sommer
    Neurotec, Karolinska Institutet, 141 86 Huddinge, Sweden
    Mol Psychiatry 6:103-8; 5. 2001
    ..Differential display RT-PCR seems to provide a feasible strategy to identify previously unknown genes whose differential expression correlates with behavioral phenotypes related to dependence...
  40. doi Early onset alcohol dependence with high density of family history is not "male limited"
    Asa Magnusson
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Alcohol 44:131-9. 2010
    ..Despite its original description as male limited, early onset alcoholism with high density of family history is likely to be a valid construct in women. Its recognition has important implications for diagnosis, treatment, and research...
  41. ncbi Corticotropin-releasing hormone (CRH) mRNA expression in rat central amygdala in cannabinoid tolerance and withdrawal: evidence for an allostatic shift?
    Laura Caberlotto
    Division of Psychiatry, Neurotec, Karolinska Institute, Stockholm, Sweden
    Neuropsychopharmacology 29:15-22. 2004
    ..The expression of CRH-R1, CRH-R2alpha, NPY, and its Y1 receptor mRNA was analyzed in search of neural substrates for the allostatic shift observed, but did not seem to contribute to the dysregulated state...
  42. ncbi Persistent behavioral and autonomic supersensitivity to stress following prenatal stress exposure in rats
    Roberto Rimondini
    Neurotec, Karolinska Institute, M 57, Huddinge University Hospital, 14186 Stockholm, Sweden
    Behav Brain Res 140:75-80. 2003
    ..In summary, PS induces a persistent phenotype of increased behavioral and autonomic sensitivity to stress. This paradigm might serve as an attractive screening model for anti-anxiety compounds...
  43. ncbi Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, 10 Center Dr, 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 211:367-75. 2010
    ..Melanin-concentrating hormone (MCH) is involved in regulation of appetitive behaviors as well as emotional reactivity and reward, behavioral domains relevant to alcohol addiction...
  44. pmc Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques
    Stephen G Lindell
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Arch Gen Psychiatry 67:423-31. 2010
    ..In humans, low NPY expression predicts amygdala response and emotional reactivity. Genetic variation that affects the NPY system could moderate stress resilience and susceptibility to alcohol dependence...
  45. ncbi Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence
    Johan Kakko
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Biol Psychiatry 63:172-7. 2008
    ..Maintenance treatment with methadone normalizes HPA axis activity. Here, we examined HPA axis activity under maintenance treatment with the increasingly utilized partial opiate agonist buprenorphine...
  46. ncbi Unexpectedly high prevalence of alcohol use among pregnant Swedish women: failed detection by antenatal care and simple tools that improve detection
    Asa Magnusson
    Division of Psychiatry, Neurotec, Karolinska Institute, 14186 Stockholm, Sweden
    J Stud Alcohol 66:157-64. 2005
    ..We examined the use of alcohol during early pregnancy in urban Swedish women, the ability of Swedish antenatal care to identify alcohol-related risk pregnancies and the utility of some potential tools for improving its performance...
  47. ncbi A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence
    Salim Mottagui-Tabar
    Karolinska Institute, Center for Genomics and Bioinformatics, Stockholm, Sweden
    Alcohol Clin Exp Res 29:702-7. 2005
    ..The aim of this study was to examine whether polymorphic variants of the NPY gene are associated with the diagnosis of alcohol dependence...
  48. ncbi The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice
    Rose Marie Karlsson
    Laboratory of Clinical and Translational Studies, NIH, National Institute of Alcohol Abuse and Alcoholism, NIH, 10 Center Drive, 1 15330, Bethesda, MD 20892 1375, USA
    Psychopharmacology (Berl) 195:547-57. 2008
    ..Neuropeptide Y (NPY) is implicated in the pathophysiology of affective illness. Multiple receptor subtypes (Y1R, Y2R, and Y5R) have been suggested to contribute to NPY's effects on rodent anxiety and depression-related behaviors...
  49. pmc Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institutes of Health NIH National Institute on Alcohol Abuse and Alcoholism NIAAA, Bethesda, Maryland 20892 1108, USA
    Biol Psychiatry 67:78-80. 2010
    ..A functionally equivalent OPRM1 C77G polymorphism in rhesus macaques allows this to be addressed under controlled experimental conditions...
  50. pmc Neuroplasticity in brain reward circuitry following a history of ethanol dependence
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA NIH, Bethesda, MD 20892 1108, USA
    Eur J Neurosci 27:1912-22. 2008
    ..These two neuroadaptations could act in concert to facilitate progression into ethanol dependence...
  51. pmc Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?
    Markus Heilig
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Addict Biol 15:169-84. 2010
    ..due to heritable factors, similar to what animal models have indicated for susceptibility to physical aspects of withdrawal?; and (3) to what extent is susceptibility to negative affect that persists into protracted abstinence heritable?..
  52. pmc Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography
    J Hirvonen
    Molecular Imaging Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892 1108, USA
    Mol Psychiatry 18:916-21. 2013
    ..The correlation of reduced binding with years of alcohol abuse suggests an involvement of CB1 receptors in alcohol dependence in humans. ..
  53. doi Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 1108, USA
    Biol Psychiatry 67:823-30. 2010
    ..Here, we examined whether the group II metabotropic glutamate receptor agonist LY379268 prevents neuronal death and learning deficits in a rat model of binge-like exposure to alcohol...
  54. pmc Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers
    David Ted George
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, 10 CRC Hatfield Center, Rm 1 5330, MSC 1108, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 208:37-44. 2010
    ..There is an extensive literature showing that the CB(1) cannabinoid receptor antagonist rimonabant (SR141716) decreases alcohol consumption in animals, but little is known about its effects in human alcohol drinkers...
  55. pmc Suppressed neuroendocrine stress response in depressed women on job-stress-related long-term sick leave: a stable marker potentially suggestive of preexisting vulnerability
    Kristina Wahlberg
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biol Psychiatry 65:742-7. 2009
    ..Here, as a first step toward addressing this question, we assessed temporal stability of HPA axis reactivity in these subjects...
  56. pmc A key role for corticotropin-releasing factor in alcohol dependence
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, NIH, 10 Center Dr, 1 5334, Bethesda, MD 20892, USA
    Trends Neurosci 30:399-406. 2007
    ..Therefore, the CRF system is emerging as a key element of the neuroadaptive changes driving alcoholism and as a major target for its treatment...
  57. pmc Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors
    Karl Björk
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Addict Biol 15:299-303. 2010
    ..One of these is D2-dependent, while the other is not. These findings illustrate that pharmacology of ethanol reward is likely more complex than that for other addictive drugs...
  58. doi Neurokinin 1 receptor antagonism as a possible therapy for alcoholism
    David T George
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Science 319:1536-9. 2008
    ..Thus, as assessed by these surrogate markers of efficacy, NK1R antagonism warrants further investigation as a treatment in alcoholism...
  59. ncbi Anxiolytic-like actions of centrally-administered neuropeptide Y, but not galanin, in C57BL/6J mice
    Rose Marie Karlsson
    Division of Psychiatry, Neurotec, Karolinska Institute, Stockholm Laboratory of Clinical Science, NIAAA, NIH, Bethesda, MD, USA
    Pharmacol Biochem Behav 80:427-36. 2005
    ..These findings provide a basis for future studies of mice with targeted gene mutations, directed at delineating the anatomical regions and receptor subtypes mediating the effects of NPY and GAL on emotion...
  60. ncbi Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders
    Andrew Holmes
    Section on Behavioral Science and Genetics, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Pharmacol Sci 24:580-8. 2003
    ....
  61. ncbi Analysis of 5-hydroxytryptamine 2c receptor gene promoter variants as alcohol-dependence risk factors
    Salim Mottagui-Tabar
    Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    Alcohol Alcohol 39:380-5. 2004
    ..To examine whether polymorphic variants of the HTR2C gene are associated with diagnosis of alcohol dependence...
  62. pmc Functional CRH variation increases stress-induced alcohol consumption in primates
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institutes on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:14593-8. 2009
    ..Our data suggest that CRH promoter variation that confers increased stress reactivity increases the risk for alcohol use disorders in stress-exposed individuals...
  63. pmc Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:5277-81. 2008
    ..These findings suggest a role for OPRM1 variation in the expression of attachment behavior in human subjects, especially as a function of separation from the caregiver...
  64. ncbi Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test
    Christian Möller
    Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Prog Neuropsychopharmacol Biol Psychiatry 26:119-22. 2002
    ..GLP-1 may participate in the control of fear-induced suppression of behavior, probably via action in the amygdala...
  65. ncbi Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties
    Johanna Kela
    Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius vag 35, SE 171 77 Stockholm, Sweden
    Regul Pept 114:109-14. 2003
    ..Furthermore, MCH did not produce any changes in body core temperature. Together, these observations further support a role for MCH as an orexigenic neuropeptide and also suggest anti-anxiety properties for MCH...
  66. doi Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice
    Annika Thorsell
    The Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, 10 CRC 1 5330, Bethesda, MD 20892 1108, USA
    Psychopharmacology (Berl) 209:103-11. 2010
    ..It remains unknown whether this reflects developmental effects or direct regulation of alcohol consumption by NK1R:s, and whether the reduced consumption reflects motivational effects...
  67. pmc Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect
    Wolfgang H Sommer
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, USA
    Hum Mutat 31:E1594-608. 2010
    ..Our results show the importance of rs16147:T>C for regulation of NPY gene expression and brain function...
  68. pmc Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia
    Rose Marie Karlsson
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, 10 Center Drive, 10 Room 1E 5330, Bethesda, MD 20892, USA
    Neuropsychopharmacology 34:1578-89. 2009
    ..These findings demonstrate that gene deletion of GLAST produces select phenotypic abnormalities related to the negative and cognitive symptoms of schizophrenia...
  69. pmc Acute ethanol challenge inhibits glycogen synthase kinase-3beta in the rat prefrontal cortex
    Olga Neznanova
    Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA
    Int J Neuropsychopharmacol 12:275-80. 2009
    ..Together, these results identify candidate pathways for mediating high ethanol preference and emphasize the importance of the mPFC in controlling this behaviour...
  70. pmc Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist
    Rose Marie Karlsson
    Laboratory for Clinical and Translational Studies, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 64:810-4. 2008
    ....
  71. pmc Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study
    John C Umhau
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 1108, USA
    Arch Gen Psychiatry 67:1069-77. 2010
    ..Human translation of these findings is lacking...
  72. ncbi Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA NIH, Bethesda, MD 20892 1108, USA
    Addict Biol 12:30-4. 2007
    ....
  73. ncbi Changes in the occurrences of coercive interventions and staff injuries on a psychiatric intensive care unit
    Anna Björkdahl
    Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institute, Stockholm, Sweden
    Arch Psychiatr Nurs 21:270-7. 2007
    ..The results showed an increased proportion of coercive interventions without a corresponding increase in staff injuries. Use of coercive interventions is discussed in relation to a safe environment for both patients and staff...
  74. ncbi Imagen: implications for addiction science and science policy
    Markus Heilig
    NIAAA, 10 Center Drive, 10 1 5334, Bethesda, MD 20892 1108, USA
    Addiction 102:1699-700. 2007
  75. ncbi Gene discovery in neuropharmacological and behavioral studies using Affymetrix microarray data
    Mark Reimers
    Laboratory of Molecular Pharmacology, NCI, National Institutes of Health, Bethesda, USA
    Methods 37:219-28. 2005
    ..We also describe in detail the pre-processing methods we have found useful for Affymetrix data. Finally, we summarize the statistical literature and describe some pitfalls in the post-processing analysis...
  76. ncbi Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms
    Markus Heilig
    National Institute on Alcohol Abuse and Alcoholism NIH DHHS, 10 Center Drive, 10 1E 5334 Bethesda, MD 20892 1610, United States
    Pharmacol Ther 111:855-76. 2006
    ..Once novel treatments are developed, the field faces a major challenge to assure their delivery to patients...
  77. pmc Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system
    Roberto Ciccocioppo
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    Biol Psychiatry 61:4-12. 2007
    ..Here we evaluated whether buprenorphine, a partial agonist at micro-opioid and NOP receptors, would reduce ethanol consumption in msP rats via activation of NOP receptors...
  78. pmc Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Psychopharmacology (Berl) 172:170-8. 2004
    ....
  79. ncbi Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuropsychopharmacology 30:417-22. 2005
    ..1%. There was no difference in A118G genotype between type 1 and type 2 alcoholics. In central Sweden, the functional variant 118G allele in exon 1 of OPRM1 is associated with an increased attributable risk for alcohol dependence...
  80. ncbi Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats
    Andrea Cippitelli
    Fundacion Hospital Carlos Haya, Avenida Carlos Haya 82, 7 Planta, Pabellon A, 29010 Malaga, Spain
    Eur J Neurosci 21:2243-51. 2005
    ..In addition, current pharmacological and neuroanatomical data suggest that an altered function of the CB1 receptor system exists between genetically selected alcohol-preferring msP rats and a heterogeneous animal population...
  81. ncbi Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 64:369-76. 2007
    ..In humans, a variant of the mu-opioid receptor gene (OPRM1A118G) increases receptor affinity, alcohol-induced euphoria, and risk for alcohol use disorders...
  82. ncbi 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism
    Donald R Gehlert
    Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 27:2718-26. 2007
    ..Based on these findings, MTIP is a promising candidate for treatment of alcohol dependence...
  83. ncbi NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations
    Guanshan Zhu
    Laboratory of Neurogenetics, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, USA
    Alcohol Clin Exp Res 27:19-24. 2003
    ..Recently, this polymorphism was also reported to be associated with an actual diagnosis of alcohol dependence...
  84. ncbi Hazardous alcohol users during pregnancy: psychiatric health and personality traits
    Asa Magnusson
    Department of Clinical Neuroscience, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    Drug Alcohol Depend 89:275-81. 2007
    ..We examined alcohol use disorders, psychiatric symptoms and personality traits in women reporting alcohol use during pregnancy...
  85. doi Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence
    Jia Huang
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, Jupiter, FL 33458, USA
    Addict Biol 13:88-94. 2008
    ..These findings suggest that genetic variants of the OPRL1 gene play a role in alcohol dependence in the Scandinavian population, warranting further investigation at the OPRL1 locus...
  86. doi Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat
    Daina Economidou
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino MC, Italy
    Biol Psychiatry 64:211-8. 2008
    ....
  87. doi Rapid tolerance and locomotor sensitization in ethanol-naïve adolescent rhesus macaques
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center Poolesville, Maryland 20837 0529, USA
    Alcohol Clin Exp Res 32:1217-28. 2008
    ....
  88. ncbi Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence
    Subhash C Pandey
    Department of Psychiatry, Psychiatric Institute, University of Illinois, IL 60612, USA
    Alcohol Clin Exp Res 27:149-54. 2003
    ..Pandey; (4) Involvement of NPY in alcohol dependence: from animal models to human genetics, by Markus Heilig; and (5) Association of neuropeptide Y polymorphism with the occurrence of type 1 and type 2 alcoholism, by Erkki Ilveskoski...
  89. ncbi Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm
    Simona Spinelli
    National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, P O Box 529, Poolesville, MD 20837, USA
    Dev Psychopathol 19:977-87. 2007
    ....
  90. ncbi Long-lasting tolerance to alcohol following a history of dependence
    Roberto Rimondini
    Department of Pharmacology, University of Bologna, Italy
    Addict Biol 13:26-30. 2008
    ..In conclusion, a history of alcohol dependence induces long-lasting hypnotic tolerance. This process may play an important role in maintaining the dependent state...
  91. ncbi [Researchers and psychiatrists defending Gillberg's research on ADDH: Karfve's campaign is a form of personal persecution and scientific basis is missing]
    Rolf Adolfsson
    Umea Universitet
    Lakartidningen 100:636-7. 2003
  92. ncbi Addiction and its brain science
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
    Addiction 100:1813-22. 2005
    ..To illustrate how modern neurobiological approaches will help to identify the neurocircuits and genes involved in addictive behavior...
  93. ncbi [The brain behind stress and fatigue depression]
    Markus Heilig
    Huddinge Universitetssjukhus
    Lakartidningen 99:2515-8. 2002
  94. ncbi High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats
    Raffael Kalisch
    NMR Study Group, Max Planck Institute of Psychiatry, Munich, Germany
    Neuroimage 23:382-91. 2004
    ..In the context of an anxiety-inhibiting role of the dmPFC, we propose that failure to sufficiently activate this region in stressful situations may contribute to high trait anxiety...