Research Topics
| Jonas HedlundSummaryAffiliation: Karolinska Hospital Country: Sweden Publications
| Collaborators
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Detail Information
Publications
Negligible adjuvant effect for antibody responses and frequent adverse events associated with IL-12 treatment in humans vaccinated with pneumococcal polysaccharideJ Hedlund
Department of Infectious Diseases, Karolinska Institute, Karolinska Hospital, S 17176, Stockholm, Sweden
Vaccine 20:164-9. 2001..The rhIL-12 recipients had a high incidence of local and systemic side effects. Given the lack of convincing evidence that rhIL-12 enhances the antibody response to PPV, the frequency and severity of the side effects was unacceptable...- Management of patients with community-acquired pneumonia treated in hospital in SwedenJonas Hedlund
Department of Infectious Diseases, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
Scand J Infect Dis 34:887-92. 2002..These findings suggest that a majority of patients who are hospitalized with moderately severe pneumonia can be treated initially with penicillin alone... - Effects of a large-scale intervention with influenza and 23-valent pneumococcal vaccines in elderly people: a 1-year follow-upJ Hedlund
Department of Infectious Diseases, Karolinska Institutet, Karolinska Hospital, S 17176 Stockholm, Sweden
Vaccine 21:3906-11. 2003..68), pneumonia (RR 0.78), and invasive pneumococcal disease (RR 0.46). In the vaccinated cohort, the in-hospital mortality was lower for pneumonia (RR 0.55), COPD (RR 0.53) and cardiac failure (RR 0.72)... - Capsular types and antibiotic susceptibility of invasive Streptococcus pneumoniae among children in SwedenJonas Hedlund
Department of Infectious Diseases, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
Scand J Infect Dis 35:452-8. 2003..The majority of isolates were susceptible to penicillin and other antibiotics tested... 
Effects of a large-scale introduction of the pneumococcal polysaccharide vaccine among elderly persons in Stockholm, SwedenCarl Spindler
Karolinska Institutet, Department of Medicine Solna, Infectious Diseases Unit, Karolinska University Hospital, Stockholm, Sweden
Vaccine 26:5541-6. 2008..The incidence of vaccine-type IPD in Stockholm declined significantly during the study period (1997-2001) in elderly persons, from 50 to 28.9/100,000, but not in other age groups in Stockholm, nor in any age group in Skåne...- Swedish guidelines for the management of community-acquired pneumonia in immunocompetent adultsJonas Hedlund
Department of Infectious Diseases, Karolinska University Hospital, S 17176 Stockholm, Sweden
Scand J Infect Dis 37:791-805. 2005..Recommended measures for prevention of CAP include influenza -- and pneumococcal -- vaccination to risk groups and efforts for smoking cessation... - Swedish guidelines on the management of community-acquired pneumonia in immunocompetent adults--Swedish Society of Infectious Diseases 2012Carl Spindler
Department of Infectious Diseases, Karolinska University Hospital, Stockholm
Scand J Infect Dis 44:885-902. 2012..Recommended measures for the prevention of CAP include vaccination for influenza and pneumococci, as well as smoking cessation... - Streptococcus pneumoniae: epidemiology, risk factors, and clinical featuresAke Ortqvist
Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
Semin Respir Crit Care Med 26:563-74. 2005.... - Etiology of community-acquired pneumonia: increased microbiological yield with new diagnostic methodsNiclas Johansson
Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Clin Infect Dis 50:202-9. 2010..The aim of this study was to determine the etiology of CAP among adults-especially the occurrence of mixed infections among patients with CAP-by implementing a new diagnostic PCR platform combined with conventional methods... - Revaccination with the 23-valent pneumococcal polysaccharide vaccine in middle-aged and elderly persons previously treated for pneumoniaJan Törling
Department of Medicine, Unit of Infectious Diseases, Karolinska Hospital, Karolinska Institutet, S 17176 Stockholm, Sweden
Vaccine 22:96-103. 2003..We conclude that revaccination of elderly with PPV after 5-10 years is safe and induce a significant immune response in a majority of persons... - Quantitative detection of Streptococcus pneumoniae from sputum samples with real-time quantitative polymerase chain reaction for etiologic diagnosis of community-acquired pneumoniaNiclas Johansson
Infectious Diseases Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
Diagn Microbiol Infect Dis 60:255-61. 2008..S. pneumoniae may be rapidly diagnosed by analyzing induced sputum samples by RQ-PCR and may be particularly valuable in patients in whom antibiotic therapy has been initiated... - Improvement of CRB-65 as a prognostic scoring system in adult patients with bacteraemic pneumococcal pneumoniaRichard Dwyer
Department of Infectious Diseases, Karolinska Institutet, Karolinska University Hospital Huddinge Södersjukhuset, Infektionsenheten, Sweden
Scand J Infect Dis 43:448-55. 2011.... - Clinical impact of combined viral and bacterial infection in patients with community-acquired pneumoniaNiclas Johansson
Karolinska Institutet, Department of Medicine, Solna, Infectious Diseases Unit, Karolinska University Hospital, Stockholm, Sweden
Scand J Infect Dis 43:609-15. 2011..We aimed to compare patients with a pure bacterial etiology with those with findings of both bacteria and virus regarding severity of illness and length of hospital stay... - [Management of adult patients with community-acquired pneumonia. Evidence-based guidelines from the Swedish Infectious Diseases Association]Kristoffer Stralin
Infektionskliniken, Universitetssjukhuset, Orebro
Lakartidningen 105:2582-7. 2008