Research Topics
Genomes and Genes | Tibor HarkanySummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptorPaul Berghuis
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
Proc Natl Acad Sci U S A 102:19115-20. 2005..Moreover, eCBs use TrkB receptor-dependent signaling pathways to regulate subtype-selective interneuron migration and specification...
Wiring and firing neuronal networks: endocannabinoids take center stageTibor Harkany
Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institute, SE 17177 Stockholm, Sweden
Curr Opin Neurobiol 18:338-45. 2008..Current challenges include fitting novel molecular candidates into regulatory eCB signaling pathways, and defining the temporal dynamics of context-dependent signaling mechanisms underpinning particular neuronal specification events...
The emerging functions of endocannabinoid signaling during CNS developmentTibor Harkany
Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE 17177, Sweden
Trends Pharmacol Sci 28:83-92. 2007..Here, we summarize recent findings regarding the ontogeny of the endocannabinoid system in neurons that sculpt the temporal and spatial diversity of cellular functions during CNS development...- Brain-derived neurotrophic factor selectively regulates dendritogenesis of parvalbumin-containing interneurons in the main olfactory bulb through the PLCgamma pathwayPaul Berghuis
Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
J Neurobiol 66:1437-51. 2006..Collectively, our results provide genetic evidence that BDNF and TrkB signaling selectively regulate PV expression and dendrite growth in a subset of neurochemically-defined GABAergic interneurons via activation of the PLCgamma pathway... - Hardwiring the brain: endocannabinoids shape neuronal connectivityPaul Berghuis
Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
Science 316:1212-6. 2007.... - Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterningJan Mulder
Department of Neuroscience, Retzius vag 8, and Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles vag 1, Karolinska Institutet, 17177 Stockholm, Sweden
Proc Natl Acad Sci U S A 105:8760-5. 2008..Likewise, axonal pathfinding becomes impaired after in utero pharmacological blockade of CB(1)Rs. Overall, eCBs are fundamental developmental cues controlling pyramidal cell development during corticogenesis... - Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneuronsPaul Berghuis
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
Eur J Neurosci 20:1290-306. 2004..Our results show that BDNF, along with membrane depolarization, is critical for FS cells to establish inhibitory circuitries during corticogenesis... - Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptorsIsaac Shemer
Department of Neuroscience, , Karolinska Institutet, S-17177 Stockholm, Sweden
Eur J Neurosci 23:2035-47. 2006..We propose that soluble Abeta(ol)s trigger the diminution of synaptic plasticity in neocortical pyramidal cell networks during early stages of AD pathogenesis by preferentially targeting postsynaptic AMPA receptors... - Turning the heterogeneous into homogeneous: studies on selectively isolated GABAergic interneuron subsetsPaul Berghuis
Department of Medical Biochemistry and Biophysics, Laboratory for Molecular Neurobiology, , Karolinska Institutet, S-17177 Stockholm, Sweden
Int J Dev Neurosci 22:533-43. 2004..In addition, we discuss therapeutic prospects of modulating increased excitatory output in the hippocampus and subthalamic nucleus by re-adjusting the inhibitory control of principal cells... - Dendritic release of retrograde messengers controls synaptic transmission in local neocortical networksYuri Zilberter
Karolinska Institute, Stockholm, Sweden
Neuroscientist 11:334-44. 2005..The present review discusses these findings and the mechanisms underlying synaptic retrograde signaling... - Input specificity and dependence of spike timing-dependent plasticity on preceding postsynaptic activity at unitary connections between neocortical layer 2/3 pyramidal cellsMisha Zilberter
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Cereb Cortex 19:2308-20. 2009..We also highlight differences in STDP at excitatory synapses onto L2/3 pyramidal cells which allow for input specific modulation of synaptic gain... - Sticking out of the crowd: the molecular identity and development of cholecystokinin-containing basket cellsErik Keimpema
Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
J Physiol 590:703-14. 2012.... - Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3Tibor Harkany
Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-17177 Stockholm, Sweden
J Neurosci 24:4978-88. 2004.... - Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigraRaquel Martín-Ibáñez
Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1
Eur J Neurosci 23:1063-70. 2006..Collectively, our data indicate that VGLUT3 identifies a novel excitatory terminal subset that contributes to the tuning of DA cell excitability in the substantia nigra... - WNT signaling in activated microglia is proinflammatoryCarina Halleskog
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Glia 59:119-31. 2011..In summary, our data suggest that the WNT family of lipoglycoproteins can instruct proinflammatory microglia transformation and emphasize the pathogenic significance of β-catenin-signaling networks in this cell type... - Region-specific generation of functional neurons from naive embryonic stem cells in adult brainTibor Harkany
Department of Medical Biochemistry and Biophysics/Center of Excellence in Developmental Biology, Karolinska Institutet, Stockholm, Sweden
J Neurochem 88:1229-39. 2004.... - Molecular reorganization of endocannabinoid signalling in Alzheimer's diseaseJan Mulder
European Neuroscience Institute at Aberdeen, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
Brain 134:1041-60. 2011..Thus, enhanced endocannabinoid signalling, particularly around senile plaques, can exacerbate synaptic failure in Alzheimer's disease... - En masse in vitro functional profiling of the axonal mechanosensitivity of sensory neuronsDmitry Usoskin
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
Proc Natl Acad Sci U S A 107:16336-41. 2010..This result allows for the characterization of two critical steps of mechanosensation in vivo: primary signal detection and signal conversion into specific action potential firing patterns in axons... - Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systemsSerguei O Fetissov
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
J Comp Neurol 513:1-20. 2009..Only in a few cases, however, there was evidence that these autoAbs can be associated with neurological manifestations in APS1 patients, as, e.g., shown in previous studies in stiff-man syndrome... - Complementary distribution of type 1 cannabinoid receptors and vesicular glutamate transporter 3 in basal forebrain suggests input-specific retrograde signalling by cholinergic neuronsTibor Harkany
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
Eur J Neurosci 18:1979-92. 2003.... - Pyramidal cell communication within local networks in layer 2/3 of rat neocortexCarl Holmgren
Karolinska Institute, Department of Neuroscience, , B2-2, S-17177 Stockholm, Sweden
J Physiol 551:139-53. 2003..With such a high degree of connectivity with surrounding pyramidal cells, local interneurons are ideally poised to both coordinate and expand the local pyramidal cell network via pyramidal-interneuron-pyramidal communication... - Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesiaGuilherme Lucas
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-17177 Stockholm, Sweden
Nat Neurosci 6:221-2. 2003 - Endocannabinoid functions controlling neuronal specification during brain developmentTibor Harkany
Institute of Medical Sciences, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom
Mol Cell Endocrinol 286:S84-90. 2008..Finally, we discuss how these novel principles affect the formation of complex neuronal networks... - Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitroMauricio G Martin
VIB and Department of Human Genetics, Catholic University of Leuven, B 3000 Leuven, Belgium
Mol Biol Cell 19:2101-12. 2008.... - Neonatal handling increases sensitivity to acute neurodegeneration in adult ratsKatalin M Horvath
Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, 9750 AA Haren, The Netherlands
J Neurobiol 60:463-72. 2004..The present results provide evidence for an enhanced vulnerability of postnatally handled rats to acute neurodegeneration in contrast to the previously reported attenuation of spontaneous aging-related neurodegenerative processes... - Post-lesion administration of 5-HT1A receptor agonist 8-OH-DPAT protects cholinergic nucleus basalis neurons against NMDA excitotoxicityBart J Oosterink
Department of Molecular Neurobiology, Graduate School of Behavioural and Cognitive Neurosciences, University of Groningen, Kerklaan 30, NL-9750 AA Haren, The Netherlands
Neuroreport 14:57-60. 2003....