Goran K Hansson

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Inflammatory mechanisms in atherosclerosis
    G K Hansson
    Karolinska Institutet, Center for Molecular Medicine L8 03, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    J Thromb Haemost 7:328-31. 2009
  2. ncbi request reprint Medicine. LIGHT hits the liver
    Goran K Hansson
    Department of Medicine and Center for Molecular Medicine, Karolinska Institute, Stockholm, SE 17176, Sweden
    Science 316:206-7. 2007
  3. ncbi request reprint Inflammation and atherosclerosis
    Goran K Hansson
    Department of Medicine, Center for Molecular Medicine, Karolinska Institute, Stockholm SE 17176, Sweden
    Annu Rev Pathol 1:297-329. 2006
  4. doi request reprint Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall
    D F J Ketelhuth
    Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Thromb Haemost 106:779-86. 2011
  5. doi request reprint The discovery of cellular immunity in the atherosclerotic plaque
    Goran K Hansson
    Karolinska Institutet, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 29:1714-7. 2009
  6. doi request reprint Vaccination against atherosclerosis? Induction of atheroprotective immunity
    Goran K Hansson
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital L8 03, Stockholm, 17176, Sweden
    Semin Immunopathol 31:95-101. 2009
  7. doi request reprint Atherosclerosis--an immune disease: The Anitschkov Lecture 2007
    Goran K Hansson
    Center for Molecular Medicine and Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 202:2-10. 2009
  8. ncbi request reprint Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis
    Xinghua Zhou
    Department of Medicine and Centre for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Circ Res 96:427-34. 2005
  9. doi request reprint Hypercholesterolemia leads to elevated TGF-beta1 activity and T helper 3-dependent autoimmune responses in atherosclerotic mice
    Xinghua Zhou
    Centre for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Atherosclerosis 204:381-7. 2009
  10. ncbi request reprint Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation
    Kristina Edfeldt
    Center for Molecular Medicine and the Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Circulation 105:1158-61. 2002

Detail Information

Publications67

  1. doi request reprint Inflammatory mechanisms in atherosclerosis
    G K Hansson
    Karolinska Institutet, Center for Molecular Medicine L8 03, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    J Thromb Haemost 7:328-31. 2009
    ..Inflammatory markers are already used to monitor the disease process and anti-inflammatory therapy may be useful to control disease activity...
  2. ncbi request reprint Medicine. LIGHT hits the liver
    Goran K Hansson
    Department of Medicine and Center for Molecular Medicine, Karolinska Institute, Stockholm, SE 17176, Sweden
    Science 316:206-7. 2007
  3. ncbi request reprint Inflammation and atherosclerosis
    Goran K Hansson
    Department of Medicine, Center for Molecular Medicine, Karolinska Institute, Stockholm SE 17176, Sweden
    Annu Rev Pathol 1:297-329. 2006
    ..Inflammatory markers are already used to monitor the disease process and anti-inflammatory therapy may be useful to control disease activity...
  4. doi request reprint Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall
    D F J Ketelhuth
    Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Thromb Haemost 106:779-86. 2011
    ..This review provides an overview of the research field of cellular immunity in atherosclerosis. It emphasises the events and findings involving antigen specific T cells, in particular low-density lipoprotein-specific T cells...
  5. doi request reprint The discovery of cellular immunity in the atherosclerotic plaque
    Goran K Hansson
    Karolinska Institutet, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 29:1714-7. 2009
    ..This notion was met with general skepticism but has gained support from experimental and clinical studies. Here we describe some of the early studies that helped developing this concept...
  6. doi request reprint Vaccination against atherosclerosis? Induction of atheroprotective immunity
    Goran K Hansson
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital L8 03, Stockholm, 17176, Sweden
    Semin Immunopathol 31:95-101. 2009
    ..This review summarizes our current understanding of the role immunity in atherosclerosis and outlines strategies for antigen-specific prevention of this disease...
  7. doi request reprint Atherosclerosis--an immune disease: The Anitschkov Lecture 2007
    Goran K Hansson
    Center for Molecular Medicine and Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 202:2-10. 2009
    ..Intensified inflammatory activation may lead to local proteolysis, plaque rupture, thrombus formation, ischemia and infarction. Novel therapeutic opportunities may emerge from understanding the role of inflammation in atherosclerosis...
  8. ncbi request reprint Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis
    Xinghua Zhou
    Department of Medicine and Centre for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Circ Res 96:427-34. 2005
    ..These findings demonstrate complex roles of immune cell-cell interactions in the regulation of the atherosclerotic process and point to several possible targets in the treatment and prevention of atherosclerosis...
  9. doi request reprint Hypercholesterolemia leads to elevated TGF-beta1 activity and T helper 3-dependent autoimmune responses in atherosclerotic mice
    Xinghua Zhou
    Centre for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Atherosclerosis 204:381-7. 2009
    ..The present study was performed to investigate whether Th3 immune effector responses and their inducing cytokine, transforming growth factor-beta (TGF-beta) are affected by hypercholesterolemia...
  10. ncbi request reprint Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation
    Kristina Edfeldt
    Center for Molecular Medicine and the Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Circulation 105:1158-61. 2002
    ..To explore the molecular mechanism by which microbe recognition occurs in the artery wall, we characterized the expression of toll-like receptors (TLRs), a family of pathogen pattern recognition receptors, in atherosclerotic lesions...
  11. doi request reprint Activation of VPAC1 receptors aggravates early atherosclerosis in hypercholesterolemic apolipoprotein E-deficient mice
    Yuri Sheikine
    Experimental Cardiovascular Research Unit, Center for Molecular Medicine, Department of Medicine at Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 402:471-6. 2010
    ....
  12. pmc T-cell activation leads to reduced collagen maturation in atherosclerotic plaques of Apoe(-/-) mice
    Olga Ovchinnikova
    Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Am J Pathol 174:693-700. 2009
    ..Our results suggest that exaggerated T-cell-driven inflammation limits collagen maturation in the atherosclerotic plaque while having little effect on collagen degradation...
  13. doi request reprint T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice
    Ariane Sultan
    Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Circ Res 104:961-8. 2009
    ..In conclusion, T-cell activation causes inflammation in adipose tissue but does not lead to insulin resistance in this tissue in the absence of interleukin-6...
  14. ncbi request reprint Adoptive transfer of CD4+ T cells reactive to modified low-density lipoprotein aggravates atherosclerosis
    Xinghua Zhou
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 26:864-70. 2006
    ..We have previously shown that transfer of CD4+ T cells from apolipoprotein E knockout mice (apoE(-/-)) into immunodeficient apoE(-/-) scid/scid mice accelerates disease...
  15. ncbi request reprint Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction
    Anne Louise Hemdahl
    Center for Molecular Medicine, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 26:136-42. 2006
    ..This study aimed to analyze the expression of NGAL in atherosclerotic plaques and myocardial infarction (MI)...
  16. pmc Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis
    Roland Klingenberg
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    J Clin Invest 123:1323-34. 2013
    ..These results demonstrate that FOXP3(+) Tregs inhibit atherosclerosis by modulating lipoprotein metabolism...
  17. doi request reprint Immunotherapy with tolerogenic apolipoprotein B-100-loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice
    Andreas Hermansson
    Department of Medicine at Karolinska University Hospital Solna, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden
    Circulation 123:1083-91. 2011
    ..Atherosclerosis is a chronic inflammatory disease characterized by a massive intimal accumulation of low-density lipoprotein that triggers chronic vascular inflammation with an autoimmune response to low-density lipoprotein components...
  18. doi request reprint Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis
    Roland Klingenberg
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 30:946-52. 2010
    ..The objective of this study was to develop an atheroprotective vaccine by targeting a peptide of the LDL protein constituent apolipoprotein B-100 (apoB-100) to the nasal mucosa to induce a protective mucosal immune response...
  19. pmc Disruption of TGF-beta signaling in T cells accelerates atherosclerosis
    Anna Karin L Robertson
    Center for Molecular Medicine, L8 03 Karolinska Hospital, SE 17176 Stockholm, Sweden
    J Clin Invest 112:1342-50. 2003
    ..Inhibition of T cell activation may therefore represent a strategy for antiatherosclerotic therapy...
  20. doi request reprint Lack of invariant natural killer T cells affects lipid metabolism in adipose tissue of diet-induced obese mice
    Daniela Strodthoff
    Department of Medicine, Center for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 33:1189-96. 2013
    ..Here, we examine the role of invariant natural killer T (iNKT) cells, a subtype of T cells activated by lipid antigens, on glucose and lipid metabolism in obesity...
  21. ncbi request reprint 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation
    Magnus Bäck
    Department of Medicine, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Circ Res 100:946-9. 2007
    ..In conclusion, the results of the present study suggest a key role for mediators of the 5-lipoxygenase pathway in inflammatory reactions of atherosclerosis and metabolic disease...
  22. ncbi request reprint CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor expressed in atherosclerotic lesions
    Dirk M Wuttge
    Center for Molecular Medicine and the Department of Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 24:750-5. 2004
    ..We investigated whether CXCL16 expression is controlled by interferon-gamma (IFN-gamma)-cytokine abundant in atherosclerotic lesions...
  23. pmc CD1d-dependent activation of NKT cells aggravates atherosclerosis
    Emmanuel Tupin
    Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden
    J Exp Med 199:417-22. 2004
    ..Early activation of both T and B cells was followed by recruitment of T and NKT cells to the aorta and activation of inflammatory genes. These results show that activation of CD1d-restricted NKT cells exacerbates atherosclerosis...
  24. ncbi request reprint Gene expression signals involved in ischemic injury, extracellular matrix composition and fibrosis defined by global mRNA profiling of the human left ventricular myocardium
    Anders Gabrielsen
    Center for Molecular Medicine, Dept of Medicine, Experimental Cardiovascular Research, CMM L8 03, Karolinska Hospital, SE 17176, Stockholm, Sweden
    J Mol Cell Cardiol 42:870-83. 2007
    ..In addition, the findings support an important role of CTGF signalling in chronic extracellular matrix remodelling in chronic coronary artery disease...
  25. doi request reprint Platelets regulate CD4⁺ T-cell differentiation via multiple chemokines in humans
    Norbert Gerdes
    Experimental Cardiovascular Research Unit at the Center for Molecular Medicine Solna, Karolinska Institute, Stockholm, Sweden
    Thromb Haemost 106:353-62. 2011
    ..Our study provides new insights into the cross-talk between thrombosis and adaptive immunity, and indicates that platelets can enhance T-effector cell development...
  26. pmc Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability
    Hong Qiu
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 103:8161-6. 2006
    ..The abundant expression of LTA4H and correlation with plaque instability identify LTA4H as a potential target for pharmacological intervention in treatment of human atherosclerosis...
  27. doi request reprint Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion
    Anders Gabrielsen
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Mol Med (Berl) 88:795-806. 2010
    ..The findings suggest that intraplaque TXA(2) generation may contribute to the development of atherosclerosis and its thrombotic complications in humans...
  28. pmc Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis
    Andreas Hermansson
    Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm SE 17176, Sweden
    J Exp Med 207:1081-93. 2010
    ....
  29. doi request reprint CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice
    Peder S Olofsson
    Center for Molecular Medicine, L8 03, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden
    Circulation 117:1292-301. 2008
    ..Costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40L and OX40/OX40L have been implicated in atherosclerosis...
  30. ncbi request reprint Innate and adaptive immunity in the pathogenesis of atherosclerosis
    Goran K Hansson
    Center for Molecular Medicine and Department of Medicine, Karolinska Institute, Stockholm, Sweden Goran Hansson cmm ki se
    Circ Res 91:281-91. 2002
    ..As we fill in the molecular details, new potential targets for therapies will doubtless emerge...
  31. ncbi request reprint Deficiency of nitric oxide synthase 2 results in increased neointima formation in a mouse model of vascular injury
    Allan Sirsjo
    Crafoord Laboratory of Experimental Surgery Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden
    J Cardiovasc Pharmacol 41:897-902. 2003
    ..14 and P < 0.01, respectively). Inhibition of NOS2 by two different approaches increased neointima formation in a mouse model of mechanical vessel injury, indicating that the NOS2 expressed in the injured vessel wall is beneficial...
  32. doi request reprint Transforming Growth Factor-β Signaling in T Cells Promotes Stabilization of Atherosclerotic Plaques Through an Interleukin-17-Dependent Pathway
    Anton Gisterå
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Sci Transl Med 5:196ra100. 2013
    ..These data link IL-17A to induction of a stable plaque phenotype, could lead to new plaque-stabilizing therapies, and should prompt an evaluation of cardiovascular events in patients treated with IL-17 receptor blockade. ..
  33. doi request reprint Dendritic cells pulsed with malondialdehyde modified low density lipoprotein aggravate atherosclerosis in Apoe(-/-) mice
    Charlotta Hjerpe
    Centre for Molecular Medicine and Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 209:436-41. 2010
    ..Dendritic cells (DCs), which are professional antigen-presenting cells that activate T cells, are present in atherosclerotic lesions but their role for atherosclerosis-related immunity is unclear...
  34. ncbi request reprint Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice
    Rima Elhage
    Department of Medicine at Karolinska Hospital and Center for Molecular Medicine L8 03, Karolinska Institute, SE 17176 Stockholm, Sweden
    Cardiovasc Res 59:234-40. 2003
    ..Nai;ve CD4+ T cells differentiate into interferon-gamma (IFN-gamma) producing Th1 effector cells when stimulated by interleukin-18 (IL-18) and IL-12. We wanted to directly test whether the Th1 pathway is proatherogenic...
  35. ncbi request reprint IKKbeta-dependent NF-kappaB pathway controls vascular inflammation and intimal hyperplasia
    De xiu Bu
    Cardiovascular Research Unit L8 03, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    FASEB J 19:1293-5. 2005
    ..Collectively, these findings show that the IKKbeta-mediated late-phase NF-kappaB activation contributes to intimal hyperplasia and the accompanied vascular inflammatory responses...
  36. ncbi request reprint Inflammation, atherosclerosis, and coronary artery disease
    Goran K Hansson
    Karolinska Institute, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    N Engl J Med 352:1685-95. 2005
  37. pmc Prediction of ischemic events on the basis of transcriptomic and genomic profiling in patients undergoing carotid endarterectomy
    Lasse Folkersen
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Mol Med 18:669-75. 2012
    ..The method may be developed to identify subjects at very high risk of ischemic events...
  38. ncbi request reprint Thrombin inhibitor reduces myocardial infarction in apoE-/- x LDLR-/- mice
    Anne Louise Hemdahl
    Department of Medicine, Karolinska Institute, SE 171 76, Stockholm, Sweden
    Am J Physiol Heart Circ Physiol 287:H872-7. 2004
    ..Exposure of atherosclerotic mice to hypoxia leads to myocardial infarction through a two-phase pathway in which acute transient ischemia is followed by thrombin-dependent, irreversible, myocardial ischemia and myocardial cell death...
  39. ncbi request reprint Accumulation of foam cells in liver X receptor-deficient mice
    Gertrud U Schuster
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    Circulation 106:1147-53. 2002
    ..The present study aimed to elucidate the physiological relevance of both LXRs with regard to lipid metabolism and macrophage cholesterol efflux...
  40. doi request reprint Osteoprotegerin promotes fibrous cap formation in atherosclerotic lesions of ApoE-deficient mice--brief report
    Olga Ovchinnikova
    Department of Medicine, Center for Molecular Medicine, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 29:1478-80. 2009
    ..Osteoprotegerin (OPG) is a tumor necrosis factor receptor-related cytokine, initially found to inhibit osteoclastogenesis. In the present study we investigated the effect of OPG treatment on atherosclerosis...
  41. doi request reprint Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis
    Anna M Lundberg
    Center for Molecular Medicine, Department of Medicine at Karolinska University Hospital Solna, Karolinska Institutet, Stockholm SE 17176, Sweden
    Cardiovasc Res 99:364-73. 2013
    ....
  42. doi request reprint The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice
    Lei Zhang
    Department of Medicine, Center for Molecular Medicine, L8 03, Karolinska University Hospital, Karolinska Institute, Stockholm SE 17176, Sweden
    Eur Heart J 33:2025-34. 2012
    ..The tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) has been shown to inhibit inflammation in different experimental autoimmune disease models. However, the effect of 3-HAA in atherosclerosis has never been explored...
  43. ncbi request reprint The immune response in atherosclerosis: a double-edged sword
    Goran K Hansson
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, SE 17176, Sweden
    Nat Rev Immunol 6:508-19. 2006
    ..We also outline possible future targets for prevention, diagnosis and treatment of atherosclerosis...
  44. doi request reprint Subcutaneous immunization with heat shock protein-65 reduces atherosclerosis in Apoe⁻/⁻ mice
    Roland Klingenberg
    Experimental Cardiovascular Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Hospital, L8 03, SE 17176 Stockholm, Sweden
    Immunobiology 217:540-7. 2012
    ..To modulate atherosclerosis by combining subcutaneous immunization with heat shock protein 65 (hsp65) in alum adjuvant and anti-CD45RB monoclonal antibodies (mAb)...
  45. doi request reprint Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts
    Edit Nagy
    Center for Molecular Medicine, CMM L8 03, Karolinska University Hospital, Stockholm, Sweden
    Circulation 123:1316-25. 2011
    ..The aim of this study was to determine the role of proinflammatory signaling through the leukotriene (LT) pathway in aortic stenosis...
  46. doi request reprint Identification of a danger-associated peptide from apolipoprotein B100 (ApoBDS-1) that triggers innate proatherogenic responses
    Daniel F J Ketelhuth
    Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Circulation 124:2433-43, 1-7. 2011
    ..In this study, we analyzed the proinflammatory activity of ApoB100 peptides in atherosclerosis...
  47. ncbi request reprint Innate immunity, macrophage activation, and atherosclerosis
    Zhong qun Yan
    Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Immunol Rev 219:187-203. 2007
    ..In its final section, we propose a model for the role of macrophages in bridging inflammation and atherosclerosis from the perspective of innate immune recognition and activation...
  48. ncbi request reprint Effect of sex and age on serum biochemical reference ranges in C57BL/6J mice
    Xinghua Zhou
    Centre for Molecular Medicine L8 03, Department of Medicine, Karolinska Hospital, S 17176 Stockholm, Sweden
    Comp Med 54:176-8. 2004
    ..The reference values for murine clinical biochemical analytes obtained during the study reported here should be useful for characterizing the biochemical phenotype of experimental mice...
  49. doi request reprint Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk
    Karl Gertow
    Atherosclerosis Research Unit, Karolinska University Hospital Solna, Center for Molecular Medicine, Stockholm, Sweden
    Circ Cardiovasc Genet 5:656-65. 2012
    ..Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse...
  50. doi request reprint Fatty acid binding protein 4 in circulating leucocytes reflects atherosclerotic lesion progression in Apoe(-/-) mice
    Hanna E Agardh
    Experimental Cardiovascular Research, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    J Cell Mol Med 17:303-10. 2013
    ..The increased expression is primarily localized to neutrophils, but also in monocytes. We have identified FABP4 in leucocytes as a potential and easy accessible biomarker of atherosclerosis which could be of future clinical relevance...
  51. ncbi request reprint Immunomodulation and vaccination for atherosclerosis
    Xinghua Zhou
    Center for Molecular Medicine and Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Expert Opin Biol Ther 4:599-612. 2004
    ..This review provides an overview of our current understanding of how immunomodulation changes the course of atherosclerosis and how vaccination may be used for preventing the disease...
  52. doi request reprint 12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms
    Karl Gertow
    Department of Medicine, Center for Molecular Medicine, Unit of Experimental Cardiovascular Research, Karolinska Institutet, Stockholm SE 17176, Sweden
    Atherosclerosis 215:411-6. 2011
    ..These findings suggest a link between ALOX15B and atherothrombotic events that merits further investigation...
  53. doi request reprint Association of genetic risk variants with expression of proximal genes identifies novel susceptibility genes for cardiovascular disease
    Lasse Folkersen
    Atherosclerosis Research Unit, Experimental Cardiovascular Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Circ Cardiovasc Genet 3:365-73. 2010
    ..Genes in close proximity to these risk-SNPs are often thought to be pathogenetically important based on their location alone. However, the actual connections between SNPs and disease mechanisms remain largely unknown...
  54. ncbi request reprint Immunomodulation of atherosclerosis: implications for vaccine development
    Jan Nilsson
    Department of Medicine, Malmo University Hospital, Lund University, Sweden
    Arterioscler Thromb Vasc Biol 25:18-28. 2005
    ..In this review, we summarize recent experimental studies using immunomodulatory approaches for treatment of atherosclerosis...
  55. ncbi request reprint Leukotriene receptors in atherosclerosis
    Magnus Bäck
    Department of Medicine, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Med 38:493-502. 2006
    ..Taken together, recent evidence suggests that leukotriene receptors may be a potential target in the treatment of atherosclerosis and in the prevention of restenosis after coronary interventions...
  56. doi request reprint Adaptive immunity and atherosclerosis
    John Andersson
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm SE 17176, Sweden
    Clin Immunol 134:33-46. 2010
    ..Furthermore, we outline future areas of research and potential clinical intervention strategies...
  57. ncbi request reprint Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice
    Roland Klingenberg
    Department of Cardiology, University Hospital Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 27:2392-9. 2007
    ..The sphingolipid analogue drug FTY720 mediates retrafficking of immune cells and inhibits their homing to inflammatory sites. We have evaluated the effect of FTY720 on atherogenesis and lipid metabolism...
  58. doi request reprint Innate immune signals in atherosclerosis
    Anna M Lundberg
    Center for Molecular Medicine, L8 03, Department of Medicine, Karolinska Institute, Stockholm SE 17176, Sweden
    Clin Immunol 134:5-24. 2010
    ..In this review we describe the innate mechanisms present in the plaque. We focus on TLRs, their cross-talk with other PRRs, and how their signalling cascades influence inflammation within the atherosclerotic lesion...
  59. pmc Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia
    Magnus Bäck
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:17501-6. 2005
    ..Inhibition of LTB(4)/BLT(1) signaling during the response to vascular injury reduced intimal hyperplasia, suggesting this pathway as a possible target for therapy...
  60. ncbi request reprint T Cell-based Therapies for Atherosclerosis
    Daniel F J Ketelhuth
    Center for Molecular Medicine, L8 03, Karolinska University Hospital, S 17176 Stockholm, Sweden
    Curr Pharm Des 19:5850-8. 2013
    ..The clinical benefit of T cell-based therapies in humans still requires further investigation. ..
  61. ncbi request reprint Chemokines and atherosclerosis
    Yuri Sheikine
    Center for Molecular Medicine, Cardiovascular Research Unit, Karolinska Institute, Stockholm, Sweden
    Ann Med 36:98-118. 2004
    ..Modulation of chemokines and chemokine receptors' expression as well as their signaling pathways may provide important anti-atherogenic strategies...
  62. ncbi request reprint Reduced perlecan expression and accumulation in human carotid atherosclerotic lesions
    Phan Kiet Tran
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Atherosclerosis 190:264-70. 2007
    ..The study demonstrates a reduction of perlecan mRNA-expression and protein deposition in human atherosclerosis, which in part explains the low levels of heparan sulfate in this disease...
  63. ncbi request reprint Vaccination and atherosclerosis
    Xinghua Zhou
    Center for Molecular Medicine L8 03, Karolinska Hospital, Karolinska Institutet, S 17176 Stockholm, Sweden
    Curr Atheroscler Rep 6:158-64. 2004
    ..This review provides an overview of our current understanding of effects and proposed mechanisms of immunization on preventing atherosclerosis...
  64. ncbi request reprint Expression of matrix metalloproteinase 9 and its regulators in the unstable coronary atherosclerotic plaque
    Fei Chen
    Crafoord Laboratory, South Hospital, Stockholm, Sweden
    Int J Mol Med 15:57-65. 2005
    ..Plasma MMP9 antigen was elevated in unstable patients. MMP9 is expressed in the unstable coronary atherosclerotic plaque, as are its transcriptional and posttranscriptional regulators...
  65. doi request reprint The immune system in atherosclerosis
    Goran K Hansson
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Nat Immunol 12:204-12. 2011
    ..Studies are now under way to develop new therapies based on these concepts of the involvement of the immune system in atherosclerosis...
  66. ncbi request reprint Association of hypo-responsive toll-like receptor 4 variants with risk of myocardial infarction
    Kristina Edfeldt
    Experimental Cardiovascular Research Unit, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Eur Heart J 25:1447-53. 2004
    ..Recent studies imply that TLR4 polymorphisms might affect atherogenesis. In this study we investigated the impact of LPS-hypo-responsive TLR4 variants on the risk of myocardial infarction (MI)...
  67. pmc Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice
    Giuseppina Caligiuri
    Center for Molecular Medicine and Department of Medicine, Karolinska Institute, SE 171 76 Stockholm, Sweden
    J Clin Invest 109:745-53. 2002
    ..These results demonstrate that B cell-associated protective immunity develops during atherosclerosis and reduces disease progression...