G K Hansson

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Regulation of immune mechanisms in atherosclerosis
    G K Hansson
    Department of Medicine and Center for Molecular Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Ann N Y Acad Sci 947:157-65; discussion 165-6. 2001
  2. ncbi request reprint Cell-mediated immunity in atherosclerosis
    G K Hansson
    Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Curr Opin Lipidol 8:301-11. 1997
  3. ncbi request reprint Immune mechanisms in atherosclerosis
    G K Hansson
    Center for Molecular Medicine and the Department of Medicine at Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 21:1876-90. 2001
  4. pmc Disruption of TGF-beta signaling in T cells accelerates atherosclerosis
    Anna Karin L Robertson
    Center for Molecular Medicine, L8 03 Karolinska Hospital, SE 17176 Stockholm, Sweden
    J Clin Invest 112:1342-50. 2003
  5. ncbi request reprint Inflammation, atherosclerosis, and coronary artery disease
    Goran K Hansson
    Karolinska Institute, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    N Engl J Med 352:1685-95. 2005
  6. ncbi request reprint Atherosclerosis and the immune system
    G K Hansson
    Centre for Molecular Medicine and Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Acta Paediatr Suppl 93:63-9. 2004
  7. ncbi request reprint Detection of B cells and proinflammatory cytokines in atherosclerotic plaques of hypercholesterolaemic apolipoprotein E knockout mice
    X Zhou
    Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Scand J Immunol 50:25-30. 1999
  8. ncbi request reprint Chlamydia pneumoniae infection does not induce or modify atherosclerosis in mice
    G Caligiuri
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Circulation 103:2834-8. 2001
  9. ncbi request reprint LDL immunization induces T-cell-dependent antibody formation and protection against atherosclerosis
    X Zhou
    Centre for Molecular Medicine and King Gustaf V Research Institute, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 21:108-14. 2001
  10. pmc Expression of interleukin-15 in mouse and human atherosclerotic lesions
    D M Wuttge
    Department of Medicine, Karolinska Hospital, Karolinska Institute, S 171 76 Stockholm, Sweden
    Am J Pathol 159:417-23. 2001

Detail Information

Publications39

  1. ncbi request reprint Regulation of immune mechanisms in atherosclerosis
    G K Hansson
    Department of Medicine and Center for Molecular Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Ann N Y Acad Sci 947:157-65; discussion 165-6. 2001
    ..These data emphasize the importance of inflammation and immune responses in the pathogenesis of atherosclerosis...
  2. ncbi request reprint Cell-mediated immunity in atherosclerosis
    G K Hansson
    Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Curr Opin Lipidol 8:301-11. 1997
    ..This review provides a brief overview of cellular immunology and an analysis of its potential role in atherogenesis...
  3. ncbi request reprint Immune mechanisms in atherosclerosis
    G K Hansson
    Center for Molecular Medicine and the Department of Medicine at Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 21:1876-90. 2001
    ..This review provides an overview of our current understanding of the role of immune mechanisms in atherosclerosis...
  4. pmc Disruption of TGF-beta signaling in T cells accelerates atherosclerosis
    Anna Karin L Robertson
    Center for Molecular Medicine, L8 03 Karolinska Hospital, SE 17176 Stockholm, Sweden
    J Clin Invest 112:1342-50. 2003
    ..Inhibition of T cell activation may therefore represent a strategy for antiatherosclerotic therapy...
  5. ncbi request reprint Inflammation, atherosclerosis, and coronary artery disease
    Goran K Hansson
    Karolinska Institute, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    N Engl J Med 352:1685-95. 2005
  6. ncbi request reprint Atherosclerosis and the immune system
    G K Hansson
    Centre for Molecular Medicine and Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Acta Paediatr Suppl 93:63-9. 2004
    ..The notion that immunity plays an important role in the development of atherosclerosis has focused attention on a number of potential novel targets for intervention based on modulation of such immune responses...
  7. ncbi request reprint Detection of B cells and proinflammatory cytokines in atherosclerotic plaques of hypercholesterolaemic apolipoprotein E knockout mice
    X Zhou
    Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Scand J Immunol 50:25-30. 1999
    ..These factors are likely to be important in the pathogenesis of atherosclerosis...
  8. ncbi request reprint Chlamydia pneumoniae infection does not induce or modify atherosclerosis in mice
    G Caligiuri
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Circulation 103:2834-8. 2001
    ..Further studies will be necessary to clarify the explanation for the seroepidemiological association between CP and coronary heart disease in humans...
  9. ncbi request reprint LDL immunization induces T-cell-dependent antibody formation and protection against atherosclerosis
    X Zhou
    Centre for Molecular Medicine and King Gustaf V Research Institute, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 21:108-14. 2001
    ....
  10. pmc Expression of interleukin-15 in mouse and human atherosclerotic lesions
    D M Wuttge
    Department of Medicine, Karolinska Hospital, Karolinska Institute, S 171 76 Stockholm, Sweden
    Am J Pathol 159:417-23. 2001
    ..In conclusion, IL-15 is up-regulated in both human and animal atherosclerotic lesions and may contribute to the recruitment of T cells and their activation during atherogenesis...
  11. ncbi request reprint Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice
    G Paulsson
    Center for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 20:10-7. 2000
    ..The strongly skewed pattern of the CDR3 region in the TCR is indicative of oligoclonal expansions of T cells and suggests the occurrence of antigen-driven T-cell proliferation in atherosclerosis...
  12. ncbi request reprint Activation of inducible nitric oxide synthase/nitric oxide by curli fibers leads to a fall in blood pressure during systemic Escherichia coli infection in mice
    Z Bian
    Microbiology and Tumorbiology Center, Novum, Huddinge University Hospital, Karolinska Institute, 141 57, Huddinge, Sweden
    J Infect Dis 183:612-9. 2001
    ..Study results suggest that expression of curli fibers by E. coli activates the NO/NOS2 arm of the innate immune system, which leads to a significant fall in blood pressure...
  13. ncbi request reprint Augmented expression of inducible NO synthase in vascular smooth muscle cells during aging is associated with enhanced NF-kappaB activation
    Z Q Yan
    Cardiovascular Research Laboratory, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 19:2854-62. 1999
    ..This results in differential capability to express NF-kappaB-dependent genes such as iNOS and ICAM-1, which could have implications for host defense and the pathogenesis of vascular diseases...
  14. pmc Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice
    X Zhou
    Centre for Molecular Medicine, Karolinska Institute, S 17176 Stockholm, Sweden
    J Clin Invest 101:1717-25. 1998
    ..Since the two subsets of T cells counteract each other, this switch may have important consequences for the inflammatory/immune process in atherosclerosis...
  15. ncbi request reprint The macrophage scavenger receptor type A directs modified proteins to antigen presentation
    A Nicoletti
    Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Eur J Immunol 29:512-21. 1999
    ..These observations show that scavenger receptors participate in immune recognition of oxidized protein antigens; this system may be important for recognition of damaged macromolecules but could also play a role in autoimmunity...
  16. pmc Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice
    A Nicoletti
    Center for Molecular Medicine, Karolinska Institute, S 17176 Stockholm, Sweden
    J Clin Invest 102:910-8. 1998
    ..Therefore, immunomodulation may be an effective way to prevent and/or treat atherosclerosis...
  17. ncbi request reprint Evidence for antigen-driven T-cell response in unstable angina
    G Caligiuri
    Center for Molecular Medicine, Karolinska Institute, Stockholm
    Circulation 102:1114-9. 2000
    ..Activation of T cells and macrophages has been associated with unstable angina (UA), but whether this reflects specific immune responses remains unclear...
  18. ncbi request reprint Gene expression of inflammatory mediators in different chambers of the human heart
    G Valen
    Department of Thoracic Surgery, Center for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Ann Thorac Surg 70:562-7. 2000
    ..Inflammatory genes may be unevenly expressed in different heart chambers...
  19. ncbi request reprint Severe hypercholesterolaemia leads to strong Th2 responses to an exogenous antigen
    A K L Robertson
    Department of Medicine and Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Scand J Immunol 59:285-93. 2004
    ..Nuclear receptors ligated by oxidized lipid derivatives modulate T-cell responses, and it is speculated that this mechanism may cause the switch to Th2 in severe hypercholesterolaemia...
  20. pmc Enhanced phenylephrine-induced rhythmic activity in the atherosclerotic mouse aorta via an increase in opening of KCa channels: relation to Kv channels and nitric oxide
    J Jiang
    Department of Medicine, Division of Cardiology, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Br J Pharmacol 128:637-46. 1999
    ..Such mechanisms may be decreased sensitivity to vasoconstrictors, or increased opening of KCa channels by NO via a cyclic GMP-dependent mechanism...
  21. ncbi request reprint Hydrogen peroxide induces mRNA for tumour necrosis factor alpha in human endothelial cells
    G Valen
    Department of Thoracic Surgery, Center for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Free Radic Res 31:503-12. 1999
    ..In conclusion, H2O2 induces TNFalpha mRNA in HUVECs and PBMC. In HUVECs an increase of intracellular TNFalpha protein was also detected, indicating that endothelial cells can produce small amounts of TNFalpha...
  22. ncbi request reprint Electrocardiographic characterization of stress-induced myocardial infarction in atherosclerotic mice
    A L Hemdahl
    Center for Molecular Medicine L8 03 and Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol Scand 184:87-94. 2005
    ....
  23. pmc Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice
    X Zhou
    King Gustaf V Research Institute, Stockholm, Sweden
    Am J Pathol 149:359-66. 1996
    ..They suggest that immune activation is part of the disease process, and we speculate that a direct link may exist between cholesterol accumulation and T cell activation, possibly by autoimmune responses to modified lipoproteins...
  24. ncbi request reprint Unstable angina activates myocardial heat shock protein 72, endothelial nitric oxide synthase, and transcription factors NFkappaB and AP-1
    G Valen
    Crafoord Laboratory of Experimental Surgery, Karolinska Hospital, S 171 76, Stockholm, Sweden
    Cardiovasc Res 47:49-56. 2000
    ....
  25. doi request reprint Genetic variants of TNFSF4 and risk for carotid artery disease and stroke
    P S Olofsson
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    J Mol Med (Berl) 87:337-46. 2009
    ..This study shows that TNFSF4 is expressed on antigen-presenting cells in human carotid atherosclerotic lesions but provides no evidence for an association of TNFSF4 gene variation with the risk for ischemic stroke...
  26. pmc Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice
    G Caligiuri
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Proc Natl Acad Sci U S A 96:6920-4. 1999
    ..Thus, stress elicits myocardial infarction through endothelin receptor signaling in coronary atherosclerosis caused by hypercholesterolemia...
  27. ncbi request reprint Retinoic acid inhibits nitric oxide synthase-2 expression through the retinoic acid receptor-alpha
    A Sirsjo
    Center for Molecular Medicine, Karolinska Institute at the Karolinska Hospital, Stockholm, S 171 76, Sweden
    Biochem Biophys Res Commun 270:846-51. 2000
    ..These results indicate that retinoids modulate NO production in VSMC via RARalpha, which inhibits the transcription of the NOS2 gene...
  28. ncbi request reprint Pyrrolidine dithiocarbamate-induced apoptosis depends on cell type, density, and the presence of Cu(2+) and Zn(2+)
    W Erl
    Cardiovascular Research Unit, Karolinska Institute, Stockholm, Sweden
    Am J Physiol Cell Physiol 278:C1116-25. 2000
    ..Such differential effects may have implications for studies of PDTC as an anti-atherosclerotic or immunomodulatory drug...
  29. ncbi request reprint Hyaluronic acid and chondroitin sulphate A rapidly promote differentiation of immature DC with upregulation of costimulatory and antigen-presenting molecules, and enhancement of NF-kappaB and protein kinase activity
    R Yang
    Immuno and Gene therapy Laboratory, Cancer Center of Karolinska, Stockholm, Sweden
    Scand J Immunol 55:2-13. 2002
    ..Thus, our data demonstrate that HA or CSA can effectively and rapidly promote the differentiation of immature DC, suggesting that HA and CSA may possess a potential capacity in regulating immune responses...
  30. ncbi request reprint Nuclear factor-kappa B regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells
    W Erl
    Cardiovascular Research Unit, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Circ Res 84:668-77. 1999
    ..Interference with pathways that control the susceptibility to programmed cell death may be helpful in the treatment of diseases where dysregulation of apoptosis is involved, eg, atherosclerosis and restenosis...
  31. ncbi request reprint Chemokines as potential therapeutic targets in atherosclerosis
    Y A Sheikine
    Experimental Cardiovascular Research Unit, Center for Molecular Medicine, Karolinska Hospital Karolinska Institute, Stockholm, Sweden
    Curr Drug Targets 7:13-27. 2006
    ..Hopefully we will be able to solve many of these issues in the near future and use this approach to control atherosclerotic disease in man...
  32. doi request reprint Correlations between clinical variables and gene-expression profiles in carotid plaque instability
    A Razuvaev
    Center for Molecular Medicine and Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Eur J Vasc Endovasc Surg 42:722-30. 2011
    ..For this purpose, we investigated the relationship between clinical parameters of plaque instability and expression of genes previously shown to be associated with either plaque instability or healing processes in the vessel wall...
  33. ncbi request reprint Expression of inducible nitric oxide synthase inhibits platelet adhesion and restores blood flow in the injured artery
    Z Q Yan
    Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Circ Res 79:38-44. 1996
    ..Thus, expression of iNOS in lesions may represent a protective mechanism that compensates for the loss of endothelium...
  34. doi request reprint Introduction: atherosclerosis as inflammation: a controversial concept becomes accepted
    G K Hansson
    Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden
    J Intern Med 263:462-3. 2008
  35. ncbi request reprint The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents
    P S Olofsson
    Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 25:e113-6. 2005
    ..To find new inflammatory genes, we explored the vascular transcriptional response to an activator of innate immunity bacterial lipopolysaccharides (LPSs)...
  36. doi request reprint Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall
    D F J Ketelhuth
    Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Thromb Haemost 106:779-86. 2011
    ..This review provides an overview of the research field of cellular immunity in atherosclerosis. It emphasises the events and findings involving antigen specific T cells, in particular low-density lipoprotein-specific T cells...
  37. ncbi request reprint Abrogation of mitochondrial transcription in smooth muscle cells impairs smooth muscle contractility and vascular tone
    J Jawien
    Department of Medicine Karolinska Institute, Stockholm, Sweden
    J Physiol Pharmacol 59:239-52. 2008
    ..Mitochondrial activity may also modulate smooth muscle tone by biotransformation of vasoactive mediators. Here, we study the role of mitochondrial DNA gene expression for vascular function in vivo...
  38. doi request reprint Inflammatory mechanisms in atherosclerosis
    G K Hansson
    Karolinska Institutet, Center for Molecular Medicine L8 03, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    J Thromb Haemost 7:328-31. 2009
    ..Inflammatory markers are already used to monitor the disease process and anti-inflammatory therapy may be useful to control disease activity...
  39. ncbi request reprint Nuclear factor kappa-B and the heart
    G Valen
    Crafoord Laboratory of Experimental Surgery, Karolinska Hospital, Stockholm, Sweden
    J Am Coll Cardiol 38:307-14. 2001
    ..A possible role of NFkappaB in the development of atherosclerosis and unstable coronary syndromes is discussed. Nuclear factor kappa-B may be a new therapeutic target for myocardial protection...