M Hamberg

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Alpha-dioxygenases
    Mats Hamberg
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institute, S 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 338:169-74. 2005
  2. ncbi Hexadecanoid pathway in plants: Lipoxygenase dioxygenation of (7Z,10Z,13Z)-hexadecatrienoic acid
    E V Osipova
    Kazan Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Sciences, Russia
    Biochemistry (Mosc) 75:708-16. 2010
  3. ncbi Biosynthesis of new divinyl ether oxylipins in Ranunculus plants
    Mats Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Lipids 37:427-33. 2002
  4. ncbi Hidden stereospecificity in the biosynthesis of divinyl ether fatty acids
    Mats Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Sweden
    FEBS J 272:736-43. 2005
  5. ncbi Isolation and structures of two divinyl ether fatty acids from Clematis vitalba
    Mats Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Lipids 39:565-9. 2004
  6. ncbi Activation of the fatty acid alpha-dioxygenase pathway during bacterial infection of tobacco leaves. Formation of oxylipins protecting against cell death
    Mats Hamberg
    Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 278:51796-805. 2003
  7. ncbi Fatty acid alpha-dioxygenases
    Mats Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Prostaglandins Other Lipid Mediat 68:363-74. 2002
  8. ncbi New cyclopentenone fatty acids formed from linoleic and linolenic acids in potato
    M Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Lipids 35:353-63. 2000
  9. ncbi An epoxy alcohol synthase pathway in higher plants: biosynthesis of antifungal trihydroxy oxylipins in leaves of potato
    M Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Lipids 34:1131-42. 1999
  10. ncbi A pathway for biosynthesis of divinyl ether fatty acids in green leaves
    M Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Lipids 33:1061-71. 1998

Collaborators

  • Ines Ponce de Leon
  • A Sanz
  • E H Oliw
  • C Wasternack
  • I R Chechetkin
  • Igor A Butovich
  • Alexander N Grechkin
  • Jean Pierre Blein
  • William J Griffiths
  • Mats X Andersson
  • Gerard Bannenberg
  • Didier Marion
  • Liam Dolan
  • Nancy P Keller
  • Jesper Z Haeggstrom
  • Olof Radmark
  • Yuqin Wang
  • Benedicte Bakan
  • Cornelia Gobel
  • Ivo Feussner
  • Anders S Carlsson
  • Carmen Castresana
  • E V Osipova
  • Tove Hammarberg
  • Dong Sun Lee
  • Svetlana Leonova
  • Dominika Przybyla
  • Ulrike Garscha
  • Tamara Vellosillo
  • Kersti Karu
  • Olga Kourtchenko
  • Bengt Samuelsson
  • Jorge Vicente
  • Mayken W Wadman
  • Isabelle Prost
  • Sabine Rosahl
  • Georg Granér
  • Maria E Bohlin
  • Staffan Thorén
  • Inés Ponce de León
  • F K Mukhitova
  • N V Lantsova
  • Henrik Hansson
  • Anders Wetterholm
  • J Ziegler
  • Klaus Apel
  • André Imboden
  • Tatiana Shelenga
  • Alexey V Konarev
  • Pierre Nioche
  • C S Raman
  • Igor Loskutov
  • Kerry L McPhail
  • Jan Sjövall
  • Fredrik Jernerén
  • Mats Ellerström
  • Martin Hornshaw
  • William H Gerwick
  • Gary Woffendin
  • Karl Bodin
  • Gunvor Alvelius
  • DaWoon Chung
  • Tomas Cascón
  • John Turton
  • Miguel Angel Lopez
  • Asa Brunnström
  • Marta Martinez
  • Johannes F G Vliegenthart
  • Sandrine Dhondt
  • Joelle Fournier
  • Gerrit A Veldink
  • Maria Jose Rodriguez
  • Neil Kift
  • Tom Visser
  • Grit Rothe
  • Guus van Zadelhoff
  • Gareth Griffiths
  • Marie Thérèse Esquerré-Tugayé
  • Francis Carbonne
  • Sten Stymne
  • Stefan Thomaeus
  • Hans Hebert
  • Marcus Ohman
  • Caroline Jegerschöld
  • Johan Meijer
  • Par L Pettersson
  • Ralf Morgenstern
  • Per Johan Jakobsson
  • Lars G Blomberg
  • Rolf Weinander

Detail Information

Publications44

  1. ncbi Alpha-dioxygenases
    Mats Hamberg
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institute, S 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 338:169-74. 2005
    ..The present paper gives a brief overview of the literature dealing with these enzymes and additionally reports the new finding of an alpha-dioxygenase in the moss, Physcomitrella patens, and some properties of this enzyme...
  2. ncbi Hexadecanoid pathway in plants: Lipoxygenase dioxygenation of (7Z,10Z,13Z)-hexadecatrienoic acid
    E V Osipova
    Kazan Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Sciences, Russia
    Biochemistry (Mosc) 75:708-16. 2010
    ..Interestingly, HHTs occur not only in "16:3 plants", but also in typical "18:3 plants" like pea and soybean seedlings...
  3. ncbi Biosynthesis of new divinyl ether oxylipins in Ranunculus plants
    Mats Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Lipids 37:427-33. 2002
    ..The experiments demonstrated the existence in R. lingua and R. peltatus of a divinyl ether synthase distinct from those previously encountered in higher plants and algae...
  4. ncbi Hidden stereospecificity in the biosynthesis of divinyl ether fatty acids
    Mats Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Sweden
    FEBS J 272:736-43. 2005
    ....
  5. ncbi Isolation and structures of two divinyl ether fatty acids from Clematis vitalba
    Mats Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Lipids 39:565-9. 2004
    ..vitalba of a new divinyl ether synthase acting on 9-lipoxygenase-generated hydroperoxides. A close structural relationship between this enzyme and the well-studied divinyl ether synthase in the potato and tomato seems likely...
  6. ncbi Activation of the fatty acid alpha-dioxygenase pathway during bacterial infection of tobacco leaves. Formation of oxylipins protecting against cell death
    Mats Hamberg
    Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 278:51796-805. 2003
    ..alpha-Dioxygenase-generated 2-hydroxylinolenic acid, and to a lesser extent lipoxygenase-generated 9-hydroxyoctadecatrienoic acid, exerted a tissue-protective effect in bacterially infected tobacco leaves...
  7. ncbi Fatty acid alpha-dioxygenases
    Mats Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Prostaglandins Other Lipid Mediat 68:363-74. 2002
    ..Alpha-dioxygenase treated in this review has emerged as a third group of fatty acid dioxygenases along with lipoxygenases and endoperoxide synthases...
  8. ncbi New cyclopentenone fatty acids formed from linoleic and linolenic acids in potato
    M Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Lipids 35:353-63. 2000
    ....
  9. ncbi An epoxy alcohol synthase pathway in higher plants: biosynthesis of antifungal trihydroxy oxylipins in leaves of potato
    M Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Lipids 34:1131-42. 1999
    ....
  10. ncbi A pathway for biosynthesis of divinyl ether fatty acids in green leaves
    M Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Lipids 33:1061-71. 1998
    ..In contrast, neither the 9(S)-hydroperoxides of linoleic or alpha-linolenic acids nor the 13(R)-hydroperoxide of alpha-linolenic acid served as precursors of divinyl ethers...
  11. ncbi Myoglobin-catalyzed bis-allylic hydroxylation and epoxidation of linoleic acid
    M Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Arch Biochem Biophys 344:194-9. 1997
    ....
  12. ncbi Stereochemistry of oxygenation of linoleic acid catalyzed by prostaglandin-endoperoxide H synthase-2
    M Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Arch Biochem Biophys 349:376-80. 1998
    ..It is concluded that the initial steps of the PGHS-2- and PGHS-1-catalyzed oxygenations proceed with identical stereochemistry and involve stereospecific removal of the pro-S hydrogen from the omega 8-methylene group of the substrate...
  13. ncbi alpha-oxidation of fatty acids in higher plants. Identification of a pathogen-inducible oxygenase (piox) as an alpha-dioxygenase and biosynthesis of 2-hydroperoxylinolenic acid
    M Hamberg
    Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 274:24503-13. 1999
    ..It was concluded that the recombinant enzymes from tobacco and Arabidopsis were both alpha-dioxygenases, and that members of this new class of enzymes catalyze the first step of alpha-oxidation in plant tissue...
  14. ncbi Manganese lipoxygenase. Discovery of a bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction
    M Hamberg
    Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 273:13080-8. 1998
    ..The hydroperoxide rearrangement occurred by oxygen rebound, although, as demonstrated by the 18O experiments, the oxygen molecule released from (11S)-HPOD exchanged with surrounding molecular oxygen prior to its reincorporation...
  15. ncbi Isolation and structure of a new galactolipid from oat seeds
    M Hamberg
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Lipids 33:355-63. 1998
    ..The content of the new galactolipid in oat seeds was 0.5-0.6 mg per g of seed...
  16. ncbi Synthesis of 3-oxalinolenic acid and beta-oxidation-resistant 3-oxa-oxylipins
    Mats Hamberg
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Lipids 41:499-506. 2006
    ..Lipoxygenase-generated 3-oxa-oxylipins are resistant toward beta-oxidation and have the potential for displaying enhanced biological activity in situations where activity is limited by metabolic degradation...
  17. ncbi Isolation of 19,20-dehydroprostaglandins E1 and E2 in human seminal fluid and further studies on 18,19-dehydroprostaglandins E1 and E2
    E H Oliw
    Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Arch Biochem Biophys 258:272-86. 1987
    ....
  18. ncbi Novel oxylipins formed from docosahexaenoic acid by potato lipoxygenase--10(S)-hydroxydocosahexaenoic acid and 10,20-dihydroxydocosahexaenoic acid
    Igor A Butovich
    Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 171 77, Stockholm, Sweden
    Lipids 40:249-57. 2005
    ..Our observation that ptLOX could convert 17-HDHA to 10,17-diH(P)DHA indicates that this dihydroxylated derivative of DHA also can be formed via a double lipoxygenation mechanism...
  19. ncbi On the specificity of allene oxide cyclase
    J Ziegler
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Lipids 34:1005-15. 1999
    ..2.1.92) from corn seeds indicated that fatty acid hydroperoxides with a double bond at n-3 and with the hydroperoxide function at n-6 exhibit the highest affinity but the slowest reaction velocity...
  20. pmc Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha
    Tove Hammarberg
    Department of Medical Biochemistry and Biophysics, Division of Chemistry II, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 284:301-5. 2009
    ..Our data show that Arg-126 is a catalytic residue in mPGES-1 and suggest that MAPEG enzymes share significant structural components of their active sites...
  21. pmc Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade
    Tamara Vellosillo
    Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Campus Universidad Autonoma, Cantoblanco, E 28049 Madrid, Spain
    Plant Cell 19:831-46. 2007
    ..The nature of the changes detected suggests that oxylipins from the 9-LOX pathway function in cell wall modifications required for lateral root development and pathogen arrest...
  22. ncbi Specific adduction of plant lipid transfer protein by an allene oxide generated by 9-lipoxygenase and allene oxide synthase
    Benedicte Bakan
    Unité de Recherche Biopolymères Interactions Assemblages, Institut National de la Recherche Agronomique INRA, Nantes F 44316 Cedex, France
    J Biol Chem 281:38981-8. 2006
    ..Additionally, the LTP-allene oxide synthase interaction opens new perspectives regarding the roles of LTPs in the signaling of plant defense and development...
  23. ncbi Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism
    Ulrike Garscha
    Department of Pharmaceutical Bioscience, Uppsala Biomedical Center, SE 75124 Uppsala, Sweden
    J Biol Chem 282:34707-18. 2007
    ..Identification of these oxygenases and their products will provide tools for analyzing the biological impact of oxylipin biosynthesis in Aspergilli...
  24. ncbi Oxylipin profiling of the hypersensitive response in Arabidopsis thaliana. Formation of a novel oxo-phytodienoic acid-containing galactolipid, arabidopside E
    Mats X Andersson
    Department of Plant and Environmental Sciences, Goteborg University, SE 405 30 Goteborg, Sweden
    J Biol Chem 281:31528-37. 2006
    ..In conclusion, the data presented suggest a role of enzymatically formed oxylipins, especially the octadecanoids and arabidopside E in race-specific resistance against bacterial pathogens...
  25. pmc Oxo-phytodienoic acid-containing galactolipids in Arabidopsis: jasmonate signaling dependence
    Olga Kourtchenko
    Department of Plant and Environmental Sciences, Goteborg University, SE 405 30 Gothenburg, Sweden
    Plant Physiol 145:1658-69. 2007
    ..Thus, arabidopsides may have a dual function: as antipathogenic substances and as storage compounds that allow the slow release of free jasmonates...
  26. doi A lipoxygenase-divinyl ether synthase pathway in flax (Linum usitatissimum L.) leaves
    Ivan R Chechetkin
    Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Russia
    Phytochemistry 69:2008-15. 2008
    ....
  27. ncbi Hydroperoxide lyases (CYP74C and CYP74B) catalyze the homolytic isomerization of fatty acid hydroperoxides into hemiacetals
    Alexander N Grechkin
    Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P O Box 30, Kazan, 420111 Russia
    Biochim Biophys Acta 1761:1419-28. 2006
    ....
  28. ncbi Conversion of linoleic acid into novel oxylipins by the mushroom Agaricus bisporus
    Mayken W Wadman
    Department of Bio Organic Chemistry, Utrecht University, 3584 CH, Utrecht, The Netherlands
    Lipids 40:1163-70. 2005
    ..In the latter case, the reaction should be catalyzed by dioxygenase with novel specificity...
  29. pmc Evaluation of the antimicrobial activities of plant oxylipins supports their involvement in defense against pathogens
    Isabelle Prost
    Unité Mixte de Recherche 5546 Centre National de la Recherche Scientifique Université Paul Sabatier, Pole de Biotechnologie Vegetale, 31326 Castanet Tolosan, France
    Plant Physiol 139:1902-13. 2005
    ....
  30. ncbi Involvement of the Arabidopsis alpha-DOX1 fatty acid dioxygenase in protection against oxidative stress and cell death
    Inés Ponce de León
    Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma, Cantoblanco, E 28049 Madrid, Spain
    Plant J 29:61-2. 2002
    ..Our results suggest that plant alpha-dioxygenases are used to generate lipid-derived molecules for a process that protects plant tissues from oxidative stress and cell death...
  31. doi Enzymatic, but not non-enzymatic, 1O2-mediated peroxidation of polyunsaturated fatty acids forms part of the EXECUTER1-dependent stress response program in the flu mutant of Arabidopsis thaliana
    Dominika Przybyla
    Swiss Federal Institute of Technology ETH, Institute of Plant Sciences, Universitatsstrasse 2, CH 8092 Zurich, Switzerland
    Plant J 54:236-48. 2008
    ....
  32. ncbi Properties of two multifunctional plant fatty acid acetylenase/desaturase enzymes
    Anders S Carlsson
    Department of Crop Science, Swedish University of Agricultural Sciences, Alnarp, Sweden
    Eur J Biochem 271:2991-7. 2004
    ..The Delta6 double bond was efficiently further converted to an acetylenic bond by a second round of desaturation but only if the acyl substrate had a Delta12 double bond and that this was in the Z configuration...
  33. ncbi The "heterolytic hydroperoxide lyase" is an isomerase producing a short-lived fatty acid hemiacetal
    Alexander N Grechkin
    Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P O Box 30, Kazan 420111, Russia
    Biochim Biophys Acta 1636:47-58. 2004
    ....
  34. ncbi Detection of an enol intermediate in the hydroperoxide lyase chain cleavage reaction
    Alexander N Grechkin
    Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Russia
    FEBS Lett 549:31-4. 2003
    ..The data obtained demonstrate that formation of (9Z)-12-oxo-9-dodecenoic acid in the HPL reaction is preceded by unstable enol oxylipin, and further suggest that hemiacetals are the true products of HPL catalysis...
  35. ncbi Oxylipin profiling in pathogen-infected potato leaves
    Cornelia Gobel
    Department of Stress and Developmental Biology, Institute of Plant Biochemistry, Weinberg 3, D 06120, Halle Saale, Germany
    Biochim Biophys Acta 1584:55-64. 2002
    ..Jasmonic acid (JA), a 13-LOX-derived oxylipin, accumulates in potato leaves after infiltration with P. syringae pv. maculicola, but not after infection with P. infestans...
  36. doi Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes
    Dong Sun Lee
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, Texas 77030, USA
    Nature 455:363-8. 2008
    ..These results indicate that oxylipin biosynthetic genes were present in the last common ancestor of plants and animals, but were subsequently lost in all metazoan lineages except Placozoa, Cnidaria and Cephalochordata...
  37. doi Analysis of oil composition in cultivars and wild species of oat (Avena sp.)
    Svetlana Leonova
    Department of Plant Breeding and Biotechnology, Swedish University of Agricultural Sciences, P O Box 101, 230 53 Alnarp, Sweden
    J Agric Food Chem 56:7983-91. 2008
    ..Consequently, developing oat cultivars with highly unsaturated oils will need involvement of other techniques such as biotechnology...
  38. ncbi Role of structure and pH in cyclization of allene oxide fatty acids: implications for the reaction mechanism
    Alexander N Grechkin
    Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P O Box 30, 420503, Kazan, Russia
    Chem Phys Lipids 120:87-99. 2002
    ..The finding that the cyclizations of 12,13-EOT and (9E)-12,13-EOD were differently affected by changes in pH suggested that the mechanisms of cyclization of these allene oxides are distinct...
  39. ncbi Biosynthesis and isomerization of 11-hydroperoxylinoleates by manganese- and iron-dependent lipoxygenases
    Ernst H Oliw
    Department of Pharmaceutical Biosciences, Uppsala University, Uppsala Biomedical Center, SE 751 24 Uppsala, Sweden
    Lipids 39:319-23. 2004
    ....
  40. ncbi Separation of conjugated trienoic fatty acid isomers by capillary electrophoresis
    Maria E Bohlin
    Department of Chemistry, Karlstad University, SE 651 88 Karlstad, Sweden
    J Chromatogr A 985:471-8. 2003
    ..Beta-cyclodextrin (uncharged) and sodium dodecylsulfate. Under optimized conditions, all seven isomers were well separated. On average, separation efficiency was 2.9 x 10(5) plates/m...
  41. ncbi Screening of oxylipins for control of oilseed rape (Brassica napus) fungal pathogens
    Georg Granér
    Department of Plant Biology, Genetics Center, POBox 7080, Swedish University of Agricultural Sciences, SE 750 07 Uppsala, Sweden
    Phytochemistry 63:89-95. 2003
    ..Several of the oxylipins also inhibited germination of L. maculans spores but the relative potency differed compared to the effects on hyphae. The study suggests that selected oxylipins may be used for disease control on Brassica plants...
  42. ncbi Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination
    Staffan Thorén
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Biol Chem 278:22199-209. 2003
    ..891 cm3/g, and a Stokes radius of 5.09 nm corresponding to a calculated molecular weight of 215,000. This molecular weight, including bound Triton X-100 (2.8 g/g protein), is fully consistent with a trimeric organization of mPGES-1...
  43. pmc Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols
    Kersti Karu
    The School of Pharmacy, University of London, 29 39 Brunswick Square, London, WC1N 1AX, UK
    J Lipid Res 48:976-87. 2007
    ..In addition, 3beta-hydroxy-5-oxo-5,6-secocholestan-6-al and its aldol, two molecules linked to amyloidogenesis of proteins, were characterized in rat brain...
  44. ncbi Thermal conversions of trimethylsilyl peroxides of linoleic and linolenic acids
    Alexander N Grechkin
    Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P O Box 30, Kazan 420111, Russia
    Chem Phys Lipids 138:93-101. 2005
    ....