C M Gustafsson

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Mediator--a universal complex in transcriptional regulation
    C M Gustafsson
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Mol Microbiol 41:1-8. 2001
  2. pmc Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells
    H Spahr
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 98:11985-90. 2001
  3. ncbi Mediator-nucleosome interaction
    Y Lorch
    Department of Structural Biology, Stanford School of Medicine, Stanford, California 94305, USA
    Mol Cell 6:197-201. 2000
  4. ncbi Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme
    C M Gustafsson
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400, USA
    J Biol Chem 272:48-50. 1997
  5. ncbi Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces pombe
    H Spahr
    Institute of Medical Biochemistry, Goteborg University, P O Box 440, 405 30 Goteborg, Sweden
    J Biol Chem 275:1351-6. 2000
  6. ncbi Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation
    G Otero
    Mechanisms of Transcription Laboratory, Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, United Kingdom
    Mol Cell 3:109-18. 1999
  7. ncbi Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae
    C M Gustafsson
    Department of Clinical Chemistry and Transfusion Medicine, Goteborg University, Bruna Straket 16, 413 45 Goteborg, Sweden
    J Biol Chem 273:30851-4. 1998
  8. pmc Mediator protein mutations that selectively abolish activated transcription
    L C Myers
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 96:67-72. 1999
  9. pmc Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression
    J Wang
    Department of Molecular Medicine, Karolinska Institutet, L8 02, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 98:4038-43. 2001
  10. ncbi Subunit interactions in yeast transcription/repair factor TFIIH. Requirement for Tfb3 subunit in nucleotide excision repair
    W J Feaver
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9072, USA
    J Biol Chem 275:5941-6. 2000

Collaborators

  • Y Li
  • H Spahr
  • R D Kornberg
  • L C Myers
  • J Wang
  • Y Lorch
  • J Beve
  • W J Feaver
  • G Otero
  • C O Samuelsen
  • J P Silva
  • P Rustin
  • J E Remacle
  • S Holmberg
  • D Huylebroeck
  • I Ernest
  • N G Larsson
  • T Samuelsson
  • V Baraznenok
  • T Kieselbach
  • J Bergstrom
  • K A Karlsson
  • L Myers
  • T Larsson
  • E C Friedberg
  • W Huang
  • O Gileadi
  • P O Brown
  • K C Hayashibara
  • J Fellows
  • J Q Svejstrup
  • P Tempst
  • T de Bizemont
  • A M Dirac
  • H Erdjument-Bromage

Detail Information

Publications10

  1. ncbi Mediator--a universal complex in transcriptional regulation
    C M Gustafsson
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Mol Microbiol 41:1-8. 2001
    ..As an appendix to this review, we have created a database, MEDB, in which we have compiled information about all the S. cerevisiae Mediator subunits and their homologues in other eukaryotic cells (http://bio.lundberg.gu.se/medb/)...
  2. pmc Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells
    H Spahr
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 98:11985-90. 2001
    ..Our data suggest a closer functional relationship between yeast and metazoan Mediator than previously anticipated...
  3. ncbi Mediator-nucleosome interaction
    Y Lorch
    Department of Structural Biology, Stanford School of Medicine, Stanford, California 94305, USA
    Mol Cell 6:197-201. 2000
    ..Sequence alignment shows significant similarity of Nut1 to the GCN5-related N-acetyltransferase superfamily. Finally, recombinant Nut1 exhibits HAT activity in an in-gel assay...
  4. ncbi Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme
    C M Gustafsson
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400, USA
    J Biol Chem 272:48-50. 1997
    ....
  5. ncbi Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces pombe
    H Spahr
    Institute of Medical Biochemistry, Goteborg University, P O Box 440, 405 30 Goteborg, Sweden
    J Biol Chem 275:1351-6. 2000
    ..cerevisiae. We suggest that the overall structure and mechanism of the Mediator is evolutionary conserved. The subunit composition, however, has evolved to respond properly to physiological signals...
  6. ncbi Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation
    G Otero
    Mechanisms of Transcription Laboratory, Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, United Kingdom
    Mol Cell 3:109-18. 1999
    ..Our data indicate that the transition from transcriptional initiation to elongation involves an exchange of the multiprotein mediator complex for elongator in a reaction coupled to CTD hyperphosphorylation...
  7. ncbi Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae
    C M Gustafsson
    Department of Clinical Chemistry and Transfusion Medicine, Goteborg University, Bruna Straket 16, 413 45 Goteborg, Sweden
    J Biol Chem 273:30851-4. 1998
    ..MED11 is a previously uncharacterized gene. The existence of these proteins in the mediator complex was verified by copurification and co-immunoprecipitation with RNA polymerase II holoenzyme...
  8. pmc Mediator protein mutations that selectively abolish activated transcription
    L C Myers
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 96:67-72. 1999
    ..These findings make an important connection between transcriptional activation in vitro and in vivo, and identify Mediator as a "global" transcriptional coactivator...
  9. pmc Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression
    J Wang
    Department of Molecular Medicine, Karolinska Institutet, L8 02, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 98:4038-43. 2001
    ..It would therefore be of interest to determine whether manipulation of respiratory chain function can be used to inhibit or enhance apoptosis in these conditions...
  10. ncbi Subunit interactions in yeast transcription/repair factor TFIIH. Requirement for Tfb3 subunit in nucleotide excision repair
    W J Feaver
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9072, USA
    J Biol Chem 275:5941-6. 2000
    ..These interactions have facilitated a more complete model of the structure of TFIIH and the nucleotide excision repairosome...