B Gulyas

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106
    Akihiro Takano
    Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm SE 171 77, Sweden
    EJNMMI Res 3:30. 2013
  2. pmc Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1
    Takeshi Fuchigami
    Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska University Hospital, R5 02, Stockholm 171 76, Sweden
    EJNMMI Res 2:37. 2012
  3. doi request reprint Evolution of microglial activation in ischaemic core and peri-infarct regions after stroke: a PET study with the TSPO molecular imaging biomarker [((11))C]vinpocetine
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, S 171 76 Stockholm, Sweden
    J Neurol Sci 320:110-7. 2012
  4. ncbi request reprint New PET radiopharmaceuticals beyond FDG for brain tumor imaging
    B Gulyas
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Q J Nucl Med Mol Imaging 56:173-90. 2012
  5. doi request reprint Distribution and binding of 18F-labeled and 125I-labeled analogues of ACI-80, a prospective molecular imaging biomarker of disease: a whole hemisphere post mortem autoradiography study in human brains obtained from Alzheimer's disease patients
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Neurochem Int 60:153-62. 2012
  6. ncbi request reprint Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Curr Radiopharm 5:19-28. 2012
  7. doi request reprint Age and disease related changes in the translocator protein (TSPO) system in the human brain: positron emission tomography measurements with [11C]vinpocetine
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Centrum for Psychiatry Research, Stockholm, Sweden
    Neuroimage 56:1111-21. 2011
  8. doi request reprint Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-L-deprenyl using whole hemisphere autoradiography
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden
    Neurochem Int 58:60-8. 2011
  9. doi request reprint The norepinephrine transporter (NET) radioligand (S,S)-[18F]FMeNER-D2 shows significant decreases in NET density in the human brain in Alzheimer's disease: a post-mortem autoradiographic study
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden
    Neurochem Int 56:789-98. 2010
  10. doi request reprint A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) syst
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neurosciences, Psychiatry Section, S 171 76 Stockholm, Sweden
    Neurochem Int 54:28-36. 2009

Collaborators

Detail Information

Publications30

  1. pmc In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106
    Akihiro Takano
    Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm SE 171 77, Sweden
    EJNMMI Res 3:30. 2013
    ..18F]FEDAA1106 is a recently developed PET radioligand for the in vivo quantification of TSPO. In the present study, we aimed at investigating the diagnostic usefulness of [18F]FEDAA1106 in patients with MS...
  2. pmc Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1
    Takeshi Fuchigami
    Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska University Hospital, R5 02, Stockholm 171 76, Sweden
    EJNMMI Res 2:37. 2012
    ..abstract:..
  3. doi request reprint Evolution of microglial activation in ischaemic core and peri-infarct regions after stroke: a PET study with the TSPO molecular imaging biomarker [((11))C]vinpocetine
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, S 171 76 Stockholm, Sweden
    J Neurol Sci 320:110-7. 2012
    ..The findings indicate an increased microglial activation in the peri-stroke region for several weeks after the insult...
  4. ncbi request reprint New PET radiopharmaceuticals beyond FDG for brain tumor imaging
    B Gulyas
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Q J Nucl Med Mol Imaging 56:173-90. 2012
    ....
  5. doi request reprint Distribution and binding of 18F-labeled and 125I-labeled analogues of ACI-80, a prospective molecular imaging biomarker of disease: a whole hemisphere post mortem autoradiography study in human brains obtained from Alzheimer's disease patients
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Neurochem Int 60:153-62. 2012
    ..Further studies are warranted to explore the usefulness of the (18)F-labeled analogues as in vivo molecular imaging biomarkers in diagnostic PET studies...
  6. ncbi request reprint Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Curr Radiopharm 5:19-28. 2012
    ....
  7. doi request reprint Age and disease related changes in the translocator protein (TSPO) system in the human brain: positron emission tomography measurements with [11C]vinpocetine
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Centrum for Psychiatry Research, Stockholm, Sweden
    Neuroimage 56:1111-21. 2011
    ....
  8. doi request reprint Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-L-deprenyl using whole hemisphere autoradiography
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden
    Neurochem Int 58:60-8. 2011
    ....
  9. doi request reprint The norepinephrine transporter (NET) radioligand (S,S)-[18F]FMeNER-D2 shows significant decreases in NET density in the human brain in Alzheimer's disease: a post-mortem autoradiographic study
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden
    Neurochem Int 56:789-98. 2010
    ....
  10. doi request reprint A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) syst
    Balazs Gulyas
    Karolinska Institutet, Department of Clinical Neurosciences, Psychiatry Section, S 171 76 Stockholm, Sweden
    Neurochem Int 54:28-36. 2009
    ....
  11. ncbi request reprint The receptor fingerprint of the human brain and its changes during life
    B Gulyas
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Bull Mem Acad R Med Belg 162:225-37; discussion 237-8. 2007
    ..Pathological conditions, including neurological and psychiatric diseases strongly affect the normal neuroreceptor-neurotransmitter balance of the brain, as do pharmacological treatments or drug abuse...
  12. ncbi request reprint Autoradiographic evaluation of [11C]vinpocetine binding in the human postmortem brain
    H Hall
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden
    Acta Biol Hung 53:59-66. 2002
    ....
  13. doi request reprint Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity
    S Nag
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 17176, Stockholm, Sweden
    Bioorg Med Chem 21:186-95. 2013
    ..In conclusion, compound 18 is a selective inhibitor of MAO-B in vitro and demonstrated a MAO-B specific binding pattern in vivo by PET in monkey. It can, therefore, be considered as a candidate for further investigation in human by PET...
  14. ncbi request reprint Limbic reductions of 5-HT1A receptor binding in human temporal lobe epilepsy
    I Savic
    Division of Human Brain Research, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neurology 62:1343-51. 2004
    ....
  15. ncbi request reprint Visual form discrimination from texture cues: a PET study
    B Gulyas
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Hum Brain Mapp 6:115-27. 1998
    ..These results suggest that the perception and discrimination of forms in the visual system requires the joint-activation of neuronal populations in the visual cortex...
  16. doi request reprint Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B)
    S Nag
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 17176 Stockholm, Sweden
    Bioorg Med Chem 20:3065-71. 2012
    ..Thus, it could serve as a novel potential candidate for human PET studies...
  17. doi request reprint Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain
    S J Finnema
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Synapse 64:573-7. 2010
    ..This preliminary study supports that [(11)C]AZ10419369 is sensitive to endogenous 5-HT levels in vivo and may serve as a tool to examine the pathophysiology and treatment of major psychiatric disorders...
  18. ncbi request reprint Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans
    I Savic
    Division of Human Brain Research, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuron 31:661-8. 2001
    ..This sex-dissociated hypothalamic activation suggests a potential physiological substrate for a sex-differentiated behavioral response in humans...
  19. doi request reprint The dopamine D₁ receptor agonist (S)-[¹¹C]N-methyl-NNC 01-0259 is not sensitive to changes in dopamine concentration--a positron emission tomography examination in the monkey brain
    S J Finnema
    Translational Science Center at Karolinska Institutet, AstraZeneca, Stockholm, Sweden
    Synapse 67:586-95. 2013
    ..The partial dopamine D₁ receptor agonist radioligand has, however, no enhanced sensitivity to endogenous dopamine concentrations in comparison with antagonist radioligands...
  20. ncbi request reprint PET studies with carbon-11 radioligands in neuropsychopharmacological drug development
    C Halldin
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, Stockholm, S 17176, Sweden
    Curr Pharm Des 7:1907-29. 2001
    ....
  21. ncbi request reprint [The effect of a single-dose intravenous vinpocetine on brain metabolism in patients with ischemic stroke]
    B Gulyas
    Department of Neuroscience, Karolinska Institute, Stockholm
    Orv Hetil 142:443-9. 2001
    ..A slightly increased (not significant, N. S.) cerebral blood flow could be observed in the contralateral and a decreased flow (N. S.) in the symptomatic hemisphere...
  22. ncbi request reprint Brain radioligands--state of the art and new trends
    C Halldin
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden
    Q J Nucl Med 45:139-52. 2001
    ..This section will discuss these important criteria and also review recent examples in neuroreceptor radioligand development such as selective radioligands for brain monoamine transporters...
  23. ncbi request reprint Visual imagery and visual representation
    P E Roland
    Dept of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Trends Neurosci 17:281-7; discussion 294-7. 1994
    ..This hypothesis is consistent with the view that objects, scenes and living beings are represented, stored and re-evoked outside the domain of the primary visual cortex and its immediate neighbours...
  24. ncbi request reprint Brain activation during odor perception in males and females
    S Bengtsson
    Division of Human Brain Research, Department of Neuroscience, Huddinge University Hospital, Karolinska Institute, Berzelius v. 3, S-171 77 Stockholm, Sweden
    Neuroreport 12:2027-33. 2001
    ..The reported female superiority in assessing olfactory information including odor identification is probably an effect of a difference at a cognitive, rather than perceptive level of olfactory processing...
  25. ncbi request reprint Neural networks for internal reading and visual imagery of reading: a PET study
    B Gulyas
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Brain Res Bull 54:319-28. 2001
    ..The core network is complemented in a task-specific manner by the recruitment of additional cortical neuronal populations...
  26. ncbi request reprint PET studies on the brain uptake and regional distribution of [11C]vinpocetine in human subjects
    B Gulyas
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden
    Acta Neurol Scand 106:325-32. 2002
    ..The main objective of the present investigation was to determine the global uptake and regional distribution of radiolabelled vinpocetine in the human brain in order to explore whether it may have direct central nervous system effects...
  27. ncbi request reprint Neuronal correlates of real and illusory contour perception: functional anatomy with PET
    J Larsson
    Division of Human Brain Research, Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    Eur J Neurosci 11:4024-36. 1999
    ..At the regional level, perception of illusory contours thus appears to differ from perception of real contours by the degree of involvement of higher visual areas as well as by the nature of interaction between early visual areas...
  28. ncbi request reprint An overview on functional receptor autoradiography using [35S]GTPgammaS
    J Sovago
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, SE 17176 Stockholm, Sweden
    Brain Res Brain Res Rev 38:149-64. 2001
    ..A number of experiments performed with [35S]GTPgammaS binding autoradiography so far, and some possible applications for the future, are also reviewed...
  29. doi request reprint Correlation between crossed cerebellar diaschisis and clinical neurological scales
    G Szilagyi
    Department of Neurology, State Health Center, Budapest, Hungary
    Acta Neurol Scand 125:373-81. 2012
    ..Former studies indicated a post-stroke time-dependent relationship between the degree of CCD and the clinical status of acute and sub-acute stroke patients, but no study has been performed in post-stroke patients...
  30. ncbi request reprint Continuous monitoring of post mortem temperature changes in the human brain
    B Gulyas
    Department of Neuroscience, Karolinska Institute, S 171 77, Stockholm, Sweden
    Neurochem Res 31:157-66. 2006
    ..These measurements can, in combination with further neurochemical studies, contribute to our better understanding of the human brain's time- and temperature-related post mortem biochemical changes...