Johan Grunewald

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Human leukocyte antigen class I alleles and the disease course in sarcoidosis patients
    Johan Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden
    Am J Respir Crit Care Med 169:696-702. 2004
  2. ncbi request reprint Lung accumulations of eosinophil granulocytes after exposure to cornstarch glove powder
    J Grunewald
    Division of Respiratory Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden
    Eur Respir J 21:646-51. 2003
  3. pmc Lung restricted T cell receptor AV2S3+ CD4+ T cell expansions in sarcoidosis patients with a shared HLA-DRbeta chain conformation
    J Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden
    Thorax 57:348-52. 2002
  4. ncbi request reprint Specific bronchoalveolar lavage fluid T cells associate with disease in a pair of monozygotic twins discordant for sarcoidosis
    I Grunewald
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    J Intern Med 250:535-9. 2001
  5. doi request reprint Autoimmune T cell responses to antigenic peptides presented by bronchoalveolar lavage cell HLA-DR molecules in sarcoidosis
    Jan Wahlstrom
    Karolinska Institutet, Department of Medicine, Lung Research Laboratory, L4 01, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden
    Clin Immunol 133:353-63. 2009
  6. doi request reprint Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients
    Bettina Levänen
    Respiratory Medicine Unit, Department of Medicine, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 131:894-903. 2013
  7. pmc Sex-specific manifestations of Löfgren's syndrome
    Johan Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet Lung Research Laboratory L4 01, Karolinska University Hospital Solna, S 171 76 Stockholm, Sweden
    Am J Respir Crit Care Med 175:40-4. 2007
  8. doi request reprint Löfgren's syndrome: human leukocyte antigen strongly influences the disease course
    Johan Grunewald
    Department of Medicine, Division of Respiratory Medicine, Lung Research Laboratory L4 01, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Am J Respir Crit Care Med 179:307-12. 2009
  9. pmc Altered expression of T cell immunoglobulin-mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis
    Farah Idali
    Department of Medicine, Unit of Respiratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Respir Res 10:42. 2009
  10. pmc Bronchoalveolar lavage results are independent of season, age, gender and collection site
    Helga H Olsen
    Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden
    PLoS ONE 7:e43644. 2012

Research Grants

  1. Antigen Specificity in Lofgren's syndrome
    Johan Grunewald; Fiscal Year: 2005

Detail Information

Publications78

  1. ncbi request reprint Human leukocyte antigen class I alleles and the disease course in sarcoidosis patients
    Johan Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden
    Am J Respir Crit Care Med 169:696-702. 2004
    ..The influence of HLA class I alleles on sarcoidosis thus seems more pronounced than previously thought, and both HLA class I and class II should be relevant to evaluate in the clinical management of sarcoidosis patients...
  2. ncbi request reprint Lung accumulations of eosinophil granulocytes after exposure to cornstarch glove powder
    J Grunewald
    Division of Respiratory Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden
    Eur Respir J 21:646-51. 2003
    ..The authors suggest that such exposure may be an interesting model for studying factors contributing to lung accumulations of eosinophil granulocytes in humans...
  3. pmc Lung restricted T cell receptor AV2S3+ CD4+ T cell expansions in sarcoidosis patients with a shared HLA-DRbeta chain conformation
    J Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden
    Thorax 57:348-52. 2002
    ..Sarcoidosis is a systemic disease of unknown aetiology frequently affecting the lungs. CD4+ T cells, in particular, accumulate in the lungs, implicating them in the pathogenesis of the disease...
  4. ncbi request reprint Specific bronchoalveolar lavage fluid T cells associate with disease in a pair of monozygotic twins discordant for sarcoidosis
    I Grunewald
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    J Intern Med 250:535-9. 2001
    ..This report shows the T-cell repertoire of BAL fluid T cells to correlate with the disease (sarcoidosis). indicating a local and specific immune response triggered by an unknown antigen in sarcoidosis...
  5. doi request reprint Autoimmune T cell responses to antigenic peptides presented by bronchoalveolar lavage cell HLA-DR molecules in sarcoidosis
    Jan Wahlstrom
    Karolinska Institutet, Department of Medicine, Lung Research Laboratory, L4 01, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden
    Clin Immunol 133:353-63. 2009
    ..By using antigenic peptides presented in vivo in the lungs of sarcoidosis patients, we have identified blood and lung T cell autoimmune responses that may help sustain the inflammation in this disease...
  6. doi request reprint Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients
    Bettina Levänen
    Respiratory Medicine Unit, Department of Medicine, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 131:894-903. 2013
    ..In this study we characterized the microRNA (miRNA) content of exosomes in healthy control subjects and patients with mild intermittent asthma both at unprovoked baseline and in response to environmental challenge...
  7. pmc Sex-specific manifestations of Löfgren's syndrome
    Johan Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet Lung Research Laboratory L4 01, Karolinska University Hospital Solna, S 171 76 Stockholm, Sweden
    Am J Respir Crit Care Med 175:40-4. 2007
    ..This study is important because it may lead to a more accurate definition of Löfgren's syndrome, and an exact phenotype of patients is crucial in modern medical research...
  8. doi request reprint Löfgren's syndrome: human leukocyte antigen strongly influences the disease course
    Johan Grunewald
    Department of Medicine, Division of Respiratory Medicine, Lung Research Laboratory L4 01, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Am J Respir Crit Care Med 179:307-12. 2009
    ..There is a known association between HLA-DRB1*03 and Löfgren's syndrome...
  9. pmc Altered expression of T cell immunoglobulin-mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis
    Farah Idali
    Department of Medicine, Unit of Respiratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Respir Res 10:42. 2009
    ..Recently, T-cell immunoglobulin and mucin domain (TIM) molecules were suggested to be important regulators of immune function. In this study, we wanted to investigate whether TIM molecules could play a role in sarcoidosis...
  10. pmc Bronchoalveolar lavage results are independent of season, age, gender and collection site
    Helga H Olsen
    Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden
    PLoS ONE 7:e43644. 2012
    ..We aim to investigate the influence of age, gender, collection site and season on bronchoalveolar lavage fluid results and to establish reference values for use in clinical practice...
  11. pmc Cell recovery in bronchoalveolar lavage fluid in smokers is dependent on cumulative smoking history
    Reza Karimi
    Division of Respiratory Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    PLoS ONE 7:e34232. 2012
    ..In this study we aimed to evaluate the effect of smoking on BAL cellular components in asymptomatic smokers. The effects of smoking cessation, age and gender were also investigated in groups of smokers and exsmokers...
  12. pmc Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation
    Susanna L Lundström
    Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e33780. 2012
    ..Progression of allergic inflammation is driven by T-helper type 2 (Th2) mediators and is associated with alterations in the levels of lipid mediators...
  13. ncbi request reprint T-lymphocyte activity in HLA-DR17 positive patients with active and clinically recovered sarcoidosis
    Anders Planck
    Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden
    Sarcoidosis Vasc Diffuse Lung Dis 20:110-7. 2003
    ....
  14. pmc No evidence of altered alveolar macrophage polarization, but reduced expression of TLR2, in bronchoalveolar lavage cells in sarcoidosis
    Maria Wikén
    Respiratory Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Respir Res 11:121. 2010
    ..We aimed to investigate whether the degree of functional polarization of alveolar macrophages (AMs), or Toll-like receptor (TLR) expression, is associated with sarcoidosis or with distinct clinical manifestations of this disease...
  15. ncbi request reprint Effects of neurotrophins on human bronchial smooth muscle cell migration and matrix metalloproteinase-9 secretion
    Charlotta Dagnell
    Department of Medicine Solna, Division of Respiratory Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Transl Res 150:303-10. 2007
    ..BDNF and NT-3, but not NGF, stimulated HBSMC migration as evaluated by Boyden chamber. Taken together, our data indicate that the neurotrophins may stimulate events important for airway remodeling...
  16. pmc Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure
    Susanna L Lundström
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e23864. 2011
    ..Air pollutants such as particulate matter (PM) and oxidants are important factors in causing exacerbations in asthmatics, and the source and composition of pollutants greatly affects pathological implications...
  17. ncbi request reprint A quantitative proteomic analysis of soluble bronchoalveolar fluid proteins from patients with sarcoidosis and chronic beryllium disease
    Ernesto Silva
    Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden
    Sarcoidosis Vasc Diffuse Lung Dis 24:24-32. 2007
    ..These diseases have several similarities from their clinical aspects. The aim of this study was to compare the protein profile at the site of active inflammation i.e. the lungs of patients with sarcoidosis and CBD...
  18. pmc Neurotrophins and neurotrophin receptors in pulmonary sarcoidosis - granulomas as a source of expression
    Charlotta Dagnell
    Department of Medicine Solna, Respiratory Medicine Unit, Karolinska Institutet Karolinska University Hospital Solna, Stockholm, Sweden
    Respir Res 11:156. 2010
    ..However, less is known about levels of BDNF and NT-3, and moreover, knowledge in the cellular sources of neurotrophins and the distribution of the corresponding neurotrophin receptors in airway tissue in sarcoidosis is lacking...
  19. doi request reprint Proinflammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis
    Khaleda R Qazi
    Department of Medicine, Clinical Allergy Research Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden
    Thorax 65:1016-24. 2010
    ..Exosomes are nano-sized immunomodulatory vesicles of endosomal origin released from a diverse range of cells and are also found in physiological fluids including bronchoalveolar lavage fluid (BALF) from healthy individuals...
  20. pmc Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients
    Johan Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital Solna, Sweden
    Respir Res 11:25. 2010
    ..This may possibly be caused by actual differences between distinct ethnic groups, too small sample sizes, or because of lack of accurate clinical subgrouping...
  21. doi request reprint Smoking, use of moist snuff, and risk of chronic inflammatory diseases
    Cecilia Carlens
    Rheumatology Unit, Department of Medicine, Karolinska Universitetssjukhuset Solna, SE 171 76 Stockholm, Sweden
    Am J Respir Crit Care Med 181:1217-22. 2010
    ..Nicotine is a powerful modifier of the inflammatory response. By comparing risks associated with tobacco smoking and with smokeless tobacco, the role of nicotine in the development of chronic inflammation may be evaluated...
  22. pmc Assessing recent smoking status by measuring exhaled carbon monoxide levels
    Annsofi Sandberg
    Science for Life Laboratory, Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e28864. 2011
    ..Our aim was to extend the use of exhaled carbon monoxide (CO(breath)), a well-established method for separating smokers from non-smokers, to assessment of recent smoking status...
  23. pmc Identification of HLA-DR-bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis
    Jan Wahlstrom
    Lung Research Laboratory, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Clin Invest 117:3576-82. 2007
    ..For the first time, to our knowledge, we have identified HLA-bound peptides presented in vivo during an inflammatory condition. This approach can be extended to characterize HLA-bound peptides in various autoimmune settings...
  24. ncbi request reprint Restricted T cell receptor BV gene usage in the lungs and muscles of patients with idiopathic inflammatory myopathies
    Pernilla Englund
    Karolinska University Hospital at Solna, and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 56:372-83. 2007
    ..To investigate T cell receptor (TCR) expression in 3 different compartments that could be involved in patients with myositis: muscle, lung, and peripheral blood...
  25. doi request reprint Genetics of sarcoidosis
    Johan Grunewald
    Division of Respiratory Medicine, Department of Medicine, Karolinska Institute and Karolinska University Hospital Solna, Stockholm, Sweden
    Curr Opin Pulm Med 14:434-9. 2008
    ..Also, genetic analyses have revealed a number of chromosomal regions and specific genes associated with sarcoidosis. This review brings up some recent discoveries on the genetic contribution to sarcoidosis...
  26. doi request reprint Limited airway effects in mild asthmatics after exposure to air pollution in a road tunnel
    Britt Marie Larsson
    Department of Public Health Sciences, Division of Occupational and Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Respir Med 104:1912-8. 2010
    ..Our findings may further emphasize asthmatics as a vulnerable group to common air pollutants...
  27. doi request reprint Increased pulmonary Wnt (wingless/integrated)-signaling in patients with sarcoidosis
    Bettina Levänen
    Department of Medicine Solna, Respiratory Medicine Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Respir Med 105:282-91. 2011
    ..We hypothesised that Wnts secreted from T cells or other inflammatory cells have a role in the pathogenesis of sarcoidosis...
  28. doi request reprint Clinical aspects and immune reactions in sarcoidosis
    Johan Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden
    Clin Respir J 1:64-73. 2007
    ..Sarcoidosis is a granulomatous disorder of unknown aetiology, affecting young adults and frequently involving the lungs...
  29. doi request reprint Hypoxia but not cigarette smoke modulates VEGF secretion from human T cells
    Mikael Mikko
    Unit of Respiratory Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
    Growth Factors 27:352-61. 2009
    ..Our data suggest that both cigarette smoke extract and hypoxia modulate the T cell response. This may be of importance in diseases characterized by T cell accumulation, such as COPD...
  30. doi request reprint Review: role of genetics in susceptibility and outcome of sarcoidosis
    Johan Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet, Solna, Stockholm, Sweden
    Semin Respir Crit Care Med 31:380-9. 2010
    ..Although a large number of genes are associated with sarcoidosis, this review focuses on gene associations and their influence on the disease phenotype, including the disease course...
  31. ncbi request reprint Expression of Th1 markers by lung accumulated T cells in pulmonary sarcoidosis
    K Katchar
    Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden
    J Intern Med 254:564-71. 2003
    ....
  32. ncbi request reprint Reduced Th1 response in the lungs of HLA-DRB1*0301 patients with pulmonary sarcoidosis
    F Idali
    Dept of Medicine, Division of Respiratory Medicine, Immune and Gene Therapy Laboratory, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden
    Eur Respir J 27:451-9. 2006
    ..In conclusion, the present data show a reduced expression of T-helper cell type-1 cytokines in human leukocyte-associated antigen-DRB1*0301 positive patients, which may relate to their good prognosis...
  33. doi request reprint Quantitative intact proteomics investigations of alveolar macrophages in sarcoidosis
    Ernesto Silva
    Dept of Medicine, Division of Respiratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Eur Respir J 41:1331-9. 2013
    ..These alterations primarily affect biological pathways related to phagocytic macrophage functionality. These findings provide important insights into the role of macrophages in sarcoidosis pathogenesis...
  34. doi request reprint Higher monocyte expression of TLR2 and TLR4, and enhanced pro-inflammatory synergy of TLR2 with NOD2 stimulation in sarcoidosis
    Maria Wikén
    Department of Medicine, Respiratory Medicine Unit, Karolinska Institutet, Lung Research Laboratory L4 01, Karolinska University Hospital, Solna, 171 76, Stockholm, Sweden
    J Clin Immunol 29:78-89. 2009
    ....
  35. pmc Role of CD4+ T cells in sarcoidosis
    Johan Grunewald
    Department of Medicine, Division of Respiratory Medicine, Lung Research Laboratory L4 01, Karolinska University Hospital Solna, S 171 76 Stockholm, Sweden
    Proc Am Thorac Soc 4:461-4. 2007
    ..These findings are exciting news and will be of help in designing new treatment strategies...
  36. ncbi request reprint Serum protein pattern in sarcoidosis analysed by a proteomics approach
    Fariba Sabounchi-Schütt
    Karolinska Institutet, Department of Medicine, Lung Research Laboratory, L4 01, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Sarcoidosis Vasc Diffuse Lung Dis 21:182-90. 2004
    ..In the present study we therefore analysed the total serum protein profile of the patients earlier reported, with active sarcoidosis...
  37. ncbi request reprint Lung T-helper cells expressing T-cell receptor AV2S3 associate with clinical features of pulmonary sarcoidosis
    J Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden
    Am J Respir Crit Care Med 161:814-8. 2000
    ..Moreover, the association of these cells with a good prognosis indicates that AV2S3(+) T cells may have a protective role against a presumed sarcoidosis antigen...
  38. ncbi request reprint Highly activated T-cell receptor AV2S3(+) CD4(+) lung T-cell expansions in pulmonary sarcoidosis
    K Katchar
    Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden
    Am J Respir Crit Care Med 163:1540-5. 2001
    ..These results support our hypothesis of an ongoing and selective stimulation of AV2S3 T cells by a specific antigen and the participation of this subset in the inflammatory process in the lungs of patients with sarcoidosis...
  39. doi request reprint Allergen provocation increases TH2-cytokines and FOXP3 expression in the asthmatic lung
    S Thunberg
    Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institute, University Hospital, Stockholm, Sweden
    Allergy 65:311-8. 2010
    ..The objective of this study was to investigate local and systemic regulatory mechanisms in the early asthmatic response to bronchial allergen provocation...
  40. doi request reprint Increased levels of nerve growth factor in the airways of patients with sarcoidosis
    C Dagnell
    Department of Medicine Solna, Karolinska Institutet and Division of Respiratory Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    J Intern Med 264:463-71. 2008
    ....
  41. ncbi request reprint Markers of activity in clinically recovered human leukocyte antigen-DR17-positive sarcoidosis patients
    A Planck
    Dept of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden
    Eur Respir J 21:52-7. 2003
    ..These results indicate that the locally accumulated AV2S3 positive T-lymphocytes in bronchoalveolar lavage are involved in the pathogenic process of sarcoidosis in this patient group...
  42. pmc Analysis of regulatory T cell associated forkhead box P3 expression in the lungs of patients with sarcoidosis
    F Idali
    Karolinska Institutet, Department of Medicine, Unit of Respiratory Medicine, Stockholm, Sweden
    Clin Exp Immunol 152:127-37. 2008
    ..In addition, our data suggest an effector function of AV2S3+ lung-accumulated T cells in sarcoidosis...
  43. doi request reprint Structural changes and antibody enrichment in the lungs are early features of anti-citrullinated protein antibody-positive rheumatoid arthritis
    Gudrun Reynisdottir
    Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheumatol 66:31-9. 2014
    ..The aim of this study was to investigate the structural and immunologic features of the lungs in incident cases of early RA in relation to ACPA presence and smoking status...
  44. doi request reprint Effects of examination stress on psychological responses, sleep and allergic symptoms in atopic and non-atopic students
    Susanna Jernelöv
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Int J Behav Med 16:305-10. 2009
    ..Recent findings indicate that atopics may be more vulnerable to stress than non-atopics. However, the roles of psychological well-being and sleep in this presumed increased sensitivity are not known...
  45. doi request reprint In the eye of the beholder: does the master see the SameSpots as the novice?
    Ernesto Silva
    Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet, Stockholm, Sweden
    J Proteome Res 9:1522-32. 2010
    ..In conclusion, we found that SameSpots represents improvements both in reproducibility and objectivity in relation to previous generations of 2-DE analysis software...
  46. ncbi request reprint A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, 171 76 Stockholm, Sweden
    Arthritis Rheum 54:38-46. 2006
    ..To investigate whether smoking and HLA-DR shared epitope (SE) genes may interact in triggering immune reactions to citrulline-modified proteins...
  47. ncbi request reprint Wheat flour exposure results in recruitment of inflammatory cells in the lungs of healthy individuals
    Sofia Gripenbäck
    Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Ind Med 44:75-82. 2003
    ..The aim of this study was to investigate any effects on bronchoalveolar lavage (BAL) cells and peripheral blood lymphocytes (PBL) of healthy individuals exposed to airborne wheat flour dust with or without fungal alpha-amylase added...
  48. ncbi request reprint Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid
    C Admyre
    Dept of Medicine, Unit of Clinical Allergy Research, Karolinska Hospital and Institutet, Stockholm, Sweden
    Eur Respir J 22:578-83. 2003
    ....
  49. ncbi request reprint Phenotypic analysis of alveolar macrophages and lymphocytes following allergen inhalation by atopic subjects with mild asthma
    C Lensmar
    Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital Solna and Karolinska Institutet, S 171 76 Stockholm, Sweden
    Respir Med 100:918-25. 2006
    ..In the present study the state of alveolar macrophage (AM) and T cell activation was investigated following induction of allergic airway inflammation in individuals with atopic asthma...
  50. ncbi request reprint Changes in bronchoalveolar lavage fluid proteins in sarcoidosis: a proteomics approach
    F Sabounchi-Schütt
    Dept of Medicine, Karolinska Institute, Division of Respiratory Medicine, Lung Research Laboratory, Karolinska Hospital, Stockholm, Sweden
    Eur Respir J 21:414-20. 2003
    ..The described proteomics approach will in the future be used to asses overall changes in the protein content associated with sarcoidosis and may offer the possibility of identifying disease-specific proteins...
  51. ncbi request reprint Analysis of intracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis
    J Wahlstrom
    Microbiology and Tumour Biology Centre, Karolinska Institutet, and Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Am J Respir Crit Care Med 163:115-21. 2001
    ..This was most pronounced for CD8+ cells, which may therefore make an important contribution to the inflammatory process in the lungs in pulmonary sarcoidosis...
  52. ncbi request reprint T cell receptor Vbeta expression in patients with allergic asthma before and after repeated low-dose allergen inhalation
    J Wahlstrom
    Microbiology and Tumour Biology Centre, Karolinska Institutet, Stockholm, Sweden
    Clin Immunol 100:31-9. 2001
    ..TCR repertoire alterations after allergen challenge differed between individuals, with relatively mild changes...
  53. ncbi request reprint Characterisation of natural killer cells and CD56+ T-cells in sarcoidosis patients
    K Katchar
    Dept of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden
    Eur Respir J 26:77-85. 2005
    ....
  54. ncbi request reprint The lymphocytic alveolitis in sarcoidosis is associated with increased amounts of soluble and cell-bound adhesion molecules in bronchoalveolar lavage fluid and serum
    M Berlin
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    J Intern Med 244:333-40. 1998
    ..We investigated the expression of adhesion molecules on alveolar T-lymphocytes and in bronchoalveolar lavage (BAL) fluid and serum to elucidate mechanisms behind the accumulation of cells in the lung in sarcoidosis...
  55. ncbi request reprint Changes in immune regulation in response to examination stress in atopic and healthy individuals
    C Olgart Höglund
    Department of Medicine Solna, Division of Respiratory Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Clin Exp Allergy 36:982-92. 2006
    ..Stress can aggravate the allergic inflammation, but determinants of disturbed immune regulation are largely unknown...
  56. pmc Apoptosis resistant bronchoalveolar lavage (BAL) fluid lymphocytes in sarcoidosis
    H Stridh
    Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Thorax 57:897-901. 2002
    ..Since mechanisms governing the normal resolution of inflammatory processes are poorly understood, this study aimed to investigate the apoptotic phenotype of peripheral blood and lung T lymphocytes from patients with sarcoidosis...
  57. doi request reprint HLA associations and Löfgren's syndrome
    Johan Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet, Lung Research Laboratory L4 01, Karolinska University Hospital Solna, S 171 76 Stockholm, Sweden
    Expert Rev Clin Immunol 8:55-62. 2012
    ..This article will mainly discuss genetic associations with LS, and the possible implications of such associations...
  58. pmc Differential regulation of neurotrophin expression in human bronchial smooth muscle cells
    Cecilia Kemi
    Division of Respiratory Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden
    Respir Res 7:18. 2006
    ..We studied if HBSMC may be a source of NGF, BDNF and NT-3, and if so, how inflammatory cytokines may influence their production...
  59. ncbi request reprint CD4(+) T cells in sarcoidosis: targets and tools
    Johan Grunewald
    Professor of Experimental Pulmonary Medicine, Karolinska Institutet Karolinska University Hospital, Lung Research Laboratory L4 01 Respiratory Medicine Unit, Department of Medicine, 171 76, Stockholm, Sweden
    Expert Rev Clin Immunol 2:877-86. 2006
    ..These findings are exciting news and may be of help for designing new treatment strategies...
  60. ncbi request reprint T-cell expansions with conserved T-cell receptor beta chain motifs in the peripheral blood of HLA-DRB1*0401 positive patients with necrotizing vasculitis
    J Grunewald
    Microbiology and Tumorbiology Center MTC, Karolinska Institute, Stockholm, Sweden
    Blood 92:3737-44. 1998
    ..These results strongly suggest that BV8(+) CD4(+) T cells with the described CDR3 motif recognize a specific antigen presented by DR4 molecules, indicating the existence of a common vasculitis-associated antigen...
  61. ncbi request reprint Bronchoalveolar lavage cells from sarcoidosis patients and healthy controls can efficiently present antigens
    J Grunewald
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    J Intern Med 245:353-7. 1999
    ..This study was aimed at increasing the understanding of the capacity to present antigens by APC in the lung compartment...
  62. doi request reprint Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells
    D Makrygiannakis
    Department of Medicine, Division of Rheumatology, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 67:1488-92. 2008
    ..Identification of citrullinated proteins in bronchoalveolar lavage (BAL) cells from smokers has led to the suggestion that citrullination induced by smoking might be the first step in the pathogenic chain of RA...
  63. ncbi request reprint Inflammatory BAL-fluid and serum parameters in HLA DR17 positive vs. DR17 negative patients with pulmonary sarcoidosis
    A Planck
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Sarcoidosis Vasc Diffuse Lung Dis 18:64-9. 2001
    ..By studying inflammatory parameters in these patients we wished to increase the knowledge of the involved mechanisms that may underlie good prognosis...
  64. ncbi request reprint T cell receptor V gene usage by CD4+ and CD8+ peripheral blood T lymphocytes in immune thrombocytopenic purpura
    I Hedlund-Treutiger
    Sach s Children s Hospital, Karolinska Institutet at Södersjukhuset, Stockholm, Sweden
    Acta Paediatr 93:633-7. 2004
    ..To identify T cell expansions, i.e. increased frequencies of T cells using a particular T cell receptor (TCR) V alpha or V beta gene segment, in patients with immune thrombocytopenic purpura (ITP)...
  65. ncbi request reprint Human leukocyte antigen genes may outweigh racial background when generating a specific immune response in sarcoidosis
    J Grunewald
    Dept of Medicine, Karolinska Hospital, Stockholm, Sweden
    Eur Respir J 17:1046-8. 2001
    ..If such an immune response were important for the subsequent clinical manifestations, this case would argue for the importance of human leukocyte antigen genes in the genetic predisposition to sarcoidosis...
  66. ncbi request reprint T-cell activation and the development of an apoptosis-resistant CD45RO+ T-cell population
    M Muller
    Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Immunol 57:254-60. 2003
    ....
  67. ncbi request reprint Altered apoptosis in bronchoalveolar lavage lymphocytes after allergen exposure of atopic asthmatic subjects
    M Muller
    Dept of Medicine, Division of Respiratory Medicine, Lung Research Laboratory, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Eur Respir J 28:513-22. 2006
    ....
  68. ncbi request reprint Cytokine mRNA expression in patients with mild allergic asthma following low dose or cumulative dose allergen provocation
    J Prieto
    Department of Medicine, Division of Respiratory Medicine, St. Erik's Eye Hospital, Karolinska Institute, S-171 76 Stockholm, Sweden
    Clin Exp Allergy 31:791-800. 2001
    ..CONCLUSION: Thus, the cumulative dose provocation regimen can induce a more pronounced Th2-like immune response in asthmatic patients than the low dose provocation model...
  69. pmc Human T cells stimulate fibroblast-mediated degradation of extracellular matrix in vitro
    M Mikko
    Karolinska Institutet, Department of Medicine, Unit of Respiratory Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    Clin Exp Immunol 151:317-25. 2008
    ..In conclusion, activated CD4+ T cells can stimulate fibroblast-mediated degradation of ECM in vitro. This could be a mechanism by which activated T cells stimulate degradation of lung tissue leading to pulmonary emphysema...
  70. ncbi request reprint Detection and identification of human bronchoalveolar lavage proteins using narrow-range immobilized pH gradient DryStrip and the paper bridge sample application method
    F Sabounchi-Schütt
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Electrophoresis 22:1851-60. 2001
    ..The mapping of BALF proteins with inclusion of those at low concentration increases the possibility to subsequently screen patient material for disease markers...
  71. ncbi request reprint Increased risk for cancer following sarcoidosis
    J Askling
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Am J Respir Crit Care Med 160:1668-72. 1999
    ..4; 95% CI 0.8 to 2.2). Thus, sarcoidosis appears to be associated with a significantly increased risk for cancer in affected organs. Chronic inflammation is a putative mediator of this risk...
  72. ncbi request reprint Organic dust-induced interleukin-12 production activates T- and natural killer cells
    C Muller-Suur
    Dept of Medicine, Karolinska Hospital, Stockholm, Sweden
    Eur Respir J 20:686-90. 2002
    ..In conclusion, this study indicates that swine dust can, at least in part, stimulate phagocytic cells to activate natural killer cells and T-lymphocytes through the production of interleukin-12...
  73. doi request reprint Major histocompatibility complex class II transactivator gene polymorphism: associations with Löfgren's syndrome
    J Grunewald
    Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Tissue Antigens 76:96-101. 2010
    ....
  74. ncbi request reprint Decreased pulmonary levels of the anti-inflammatory Clara cell 16 kDa protein after induction of airway inflammation in asthmatics
    C Lensmar
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Cell Mol Life Sci 57:976-81. 2000
    ..Reduced levels of pulmonary CC16 may cause loss of anti-inflammatory activity in the airways and contribute to the development of airway inflammation in asthma...
  75. ncbi request reprint Angiotensin-converting enzyme gene polymorphism in relation to HLA-DR in sarcoidosis
    A Planck
    Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden
    J Intern Med 251:217-22. 2002
    ..Serum ACE level (S-ACE) was measured in all controls and 72 patients. Sixty-one patients were classified as chronic or nonchronic after 2 years follow-up. All patients were recruited and followed at our outpatient clinic...
  76. ncbi request reprint [Studies of T-lymphocytes in pursuit of sarcoidosis antigens]
    Johan Grunewald
    Institutionen för medicin, enheten för lungmedicin, Lungkliniken, Karolinska institutet Karolinska sjukhuset, Stockholm
    Lakartidningen 99:3508-13, 3515. 2002
    ..Future studies in this field may reveal how candidate antigens, identified by other techniques, play a role in the sarcoid inflammation...
  77. ncbi request reprint Identification of a potent antibacterial factor isolated from bronchoalveolar lavage fluid: guanidine, N-[3-[(aminoiminomethyl)amino]propyl]-N-dodecyl-, a potential source of error in the analysis of antibacterial agents
    Mirna Abraham-Nordling
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Rapid Commun Mass Spectrom 17:183-91. 2003
    ..The biological effects of guanidine, N-[3-[(aminoiminomethyl)amino]propyl]-N-dodecyl- have not previously been described in the literature...
  78. ncbi request reprint [Patient with sarcoidosis and Lofgren syndrome: can the inflammatory reaction be physiologically favourable for healing?]
    Anders Eklund
    Lakartidningen 101:3274; author reply 3274. 2004

Research Grants1

  1. Antigen Specificity in Lofgren's syndrome
    Johan Grunewald; Fiscal Year: 2005
    ..With improved understanding of innate and adaptive immune mechanisms in sarcoidosis, in particular the identification of a sarcoidosis antigen, novel strategies aimed at curing or even preventing sarcoidosis can be devised. ..