Research Topics
| Sten GrillnerSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Detail Information
Publications
Synaptically evoked membrane potential oscillations induced by substance P in lamprey motor neuronsErik Svensson
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
J Neurophysiol 87:113-21. 2002..Substance P thus has a distributed excitatory effect in the spinal cord. While it can activate premotor networks, this activation alone is not able to evoke a coordinated behaviorally relevant motor output...- Microcircuits in action--from CPGs to neocortexSten Grillner
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
Trends Neurosci 28:525-33. 2005..The long-term goal is to identify the components of a molecular and synaptic tool kit for the design of different microcircuits... - Neural bases of goal-directed locomotion in vertebrates--an overviewSten Grillner
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
Brain Res Rev 57:2-12. 2008.... - Biological pattern generation: the cellular and computational logic of networks in motionSten Grillner
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 171 77 Stockholm, Sweden
Neuron 52:751-66. 2006..In addition, I will outline the utility of computational models in analysis of the dynamic actions of these motor networks... 
Measured motion: searching for simplicity in spinal locomotor networksSten Grillner
Department of Neuroscience, Nobel institute for Neurophysiology and Stockholm Brain Institute, Karolinska Institute, Stockholm, Sweden
Curr Opin Neurobiol 19:572-86. 2009..We also describe recent molecular genetic approaches to map and manipulate the connectivity and interactions of spinal interneurons and to assess the impact of such perturbations on network function and motor behavior...- Modeling a vertebrate motor system: pattern generation, steering and control of body orientationSten Grillner
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Insititutet, Retzius vag 8, SE 171 77 Stockholm, Sweden
Prog Brain Res 165:221-34. 2007..In the same way the modeling of the control system for steering and control of body orientation is reviewed, including neuromechanical simulations and robotic devices... - Effects of flufenamic acid on fictive locomotion, plateau potentials, calcium channels and NMDA receptors in the lamprey spinal cordDi Wang
Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institute, SE-171 77 Stockholm, Sweden
Neuropharmacology 51:1038-46. 2006..These non-selective effects of FFA can account for its influence on fictive locomotion and on membrane potential oscillations and thus, a specific involvement of the I(CAN) current in the lamprey spinal cord is not supported... - Roles of ionic currents in lamprey CpG neurons: a modeling studyMikael Huss
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
J Neurophysiol 97:2696-711. 2007..In particular, the balance between the simulated slow sodium-dependent and calcium-dependent potassium currents has been explored, as well as the possible involvement of dendritic conductances... 
Endocannabinoids mediate tachykinin-induced effects in the lamprey locomotor networkCarolina Thörn Pérez
Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institute, 171 77 Stockholm, Sweden
J Neurophysiol 102:1358-65. 2009..The present findings suggest that the effects of substance P on the increase in the locomotor burst frequency and depression of IPSPs are mediated partially via release of endocannabinoids acting through CB1 receptors...- Diencephalic locomotor region in the lamprey--afferents and efferent controlAriane Menard
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
J Neurophysiol 100:1343-53. 2008.... - Endogenous tachykinin release contributes to the locomotor activity in lampreyCarolina Thörn Pérez
Dept of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
J Neurophysiol 97:3331-9. 2007..1 Hz) of the amplitude of the motor activity. These effects occurred during an initial period of approximately 1 h, whereas a modest long-lasting increase of the burst rate remained after >2 h... - Tectal control of locomotion, steering, and eye movements in lampreyKazuya Saitoh
Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm Brain Institute, Retzius vag 8, SE 171 77 Stockholm, Sweden
J Neurophysiol 97:3093-108. 2007..These results show that tectum can provide integrated motor responses of eye, body orientation, and locomotion of the type that would be required in goal-directed locomotion... - GABA distribution in lamprey is phylogenetically conservedBrita Robertson
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
J Comp Neurol 503:47-63. 2007..Since the lamprey diverged from the main vertebrate line around 450 million years ago, this implies that already at that time the basic vertebrate plan for the GABA innervation in different parts of the brain had been developed... - 5-HT and dopamine modulates CaV1.3 calcium channels involved in postinhibitory rebound in the spinal network for locomotion in lampreyDi Wang
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
J Neurophysiol 105:1212-24. 2011..3 and Ca(V)3 subtypes of LVA calcium channels together underlie the PIR response. 5-HT and dopamine both target PIR via Ca(V)1.3 channels, which may contribute significantly to their modulatory influence on locomotor network activity... - Mechanisms of rhythm generation in a spinal locomotor network deprived of crossed connections: the lamprey hemicordLorenzo Cangiano
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE-17177 Stockholm, Sweden
J Neurosci 25:923-35. 2005.... - Role of AMPA receptor desensitization and the side effects of a DMSO vehicle on reticulospinal EPSPs and locomotor activityNataliya A Tsvyetlynska
Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden
J Neurophysiol 94:3951-60. 2005..From the effects of CTZ it is apparent that AMPA receptor desensitization plays an important role in determining locomotor frequency and that this is likely a result of its limiting function on AMPA receptor-mediated EPSPs... - Fast and slow locomotor burst generation in the hemispinal cord of the lampreyLorenzo Cangiano
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE-17177 Stockholm, Sweden
J Neurophysiol 89:2931-42. 2003..Swimming is thus produced by pairs of unilateral burst generating networks with reciprocal inhibitory connections that not only ensure left/right alternation but also downregulate frequency... - Nitric oxide potentiation of locomotor activity in the spinal cord of the lampreyAlexandros Kyriakatos
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
J Neurosci 29:13283-91. 2009..Our results demonstrate a significant role of NO in adult vertebrate motor control which, via modulation of both excitatory and inhibitory transmission, increases the locomotor burst frequency... - 5-HT inhibits N-type but not L-type Ca(2+) channels via 5-HT1A receptors in lamprey spinal neuronsRussell H Hill
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
Eur J Neurosci 18:2919-24. 2003..As N-type, but not L-type, Ca(2+) channels are known to mediate the activation of KCa channels and presynaptic transmitter release at lamprey synapses, the effects of 5-HT reported here can contribute to a reduction in both actions... - Striatal cellular properties conserved from lampreys to mammalsJesper Ericsson
Nobel Institute for Neurophysiology, Department of Neuroscience, Stockholm Brain Institute, Karolinska Institutet, SE 171 77 Stockholm, Sweden
J Physiol 589:2979-92. 2011..This is a cellular property of critical importance for the operations of the striatum in mammals... - The activity of spinal commissural interneurons during fictive locomotion in the lampreyZoltán Biró
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
J Neurophysiol 100:716-22. 2008..Thus in lamprey commissural interneurons, we found a broad distribution of firing rates and phases during fictive locomotion... - Dynamics of synaptic transmission between fast-spiking interneurons and striatal projection neurons of the direct and indirect pathwaysHenrike Planert
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
J Neurosci 30:3499-507. 2010..Our findings show that the two intrastriatal inhibitory pathways have fundamentally different dynamic properties that are, however, similarly applied to both direct and indirect striatal projections... - Endogenous and exogenous dopamine presynaptically inhibits glutamatergic reticulospinal transmission via an action of D2-receptors on N-type Ca2+ channelsErik Svensson
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden
Eur J Neurosci 17:447-54. 2003..DA did not affect the response to extracellularly ejected d-glutamate, the postsynaptic membrane potential, or the electrical component of the EPSPs. DA thus acts at the presynaptic level to modulate reticulospinal transmission... - Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neuronsPeter Wallén
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
J Physiol 585:75-90. 2007..This is, to our knowledge, the first demonstration of a functional role for the Slack gene in contributing to the slow AHP... - 5-HT Modulation of identified segmental premotor interneurons in the lamprey spinal cordZoltán Biró
Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
J Neurophysiol 96:931-5. 2006..Such modulation of locomotor network interneurons can partially account for the observed effects of 5-HT on the swimming pattern in lamprey... - The spinal GABAergic system is a strong modulator of burst frequency in the lamprey locomotor networkDavid E Schmitt
Nobel Inst. for Neurophysiology, Dept. of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
J Neurophysiol 92:2357-67. 2004..It is not required for burst generation, but acts as a powerful modulator... - Evolutionary conservation of the habenular nuclei and their circuitry controlling the dopamine and 5-hydroxytryptophan (5-HT) systemsMarcus Stephenson-Jones
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 109:E164-73. 2012..Our results indicate that the habenular nuclei provide a common vertebrate circuitry to adapt behavior in response to rewards, stress, and other motivating factors... - Pattern of motor coordination underlying backward swimming in the lampreySalma S Islam
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
J Neurophysiol 96:451-60. 2006..The role of the spinal cord in generation of different forms of undulatory locomotion (FS and BS) is discussed... - Descending GABAergic projections to the mesencephalic locomotor region in the lamprey Petromyzon marinusAriane Menard
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
J Comp Neurol 501:260-73. 2007..The GABA agonist inhibited locomotion, whereas the GABA antagonist initiated it. These results suggest that the GABAergic projections to the MLR modulate the activity of MLR neurons, which would be inhibited by GABA at rest... - Synaptic pathways in neural microcircuitsGilad Silberberg
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S-17177 Stockholm, Sweden
Trends Neurosci 28:541-51. 2005.... - Endogenous dopaminergic modulation of the lamprey spinal locomotor networkErik Svensson
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S-17177 Stockholm, Sweden
Brain Res 970:1-8. 2003.... - Evolutionary conservation of the basal ganglia as a common vertebrate mechanism for action selectionMarcus Stephenson-Jones
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Curr Biol 21:1081-91. 2011.... - Evolution of the basal ganglia: dual-output pathways conserved throughout vertebrate phylogenyMarcus Stephenson-Jones
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
J Comp Neurol 520:2957-73. 2012..Our results suggest that dual-output nuclei are part of the ancestral basal ganglia and that the PPN appears to have coevolved as part of a mechanism for action selection common to all vertebrates... - Input specificity and dependence of spike timing-dependent plasticity on preceding postsynaptic activity at unitary connections between neocortical layer 2/3 pyramidal cellsMisha Zilberter
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Cereb Cortex 19:2308-20. 2009..We also highlight differences in STDP at excitatory synapses onto L2/3 pyramidal cells which allow for input specific modulation of synaptic gain... - Cellular bases of a vertebrate locomotor system-steering, intersegmental and segmental co-ordination and sensory controlSten Grillner
Department of Neuroscience, The Retzius Laboratory Karolinska Institutet, SE 17177, Stockholm, Sweden
Brain Res Brain Res Rev 40:92-106. 2002.... - The dopamine D2 receptor gene in lamprey, its expression in the striatum and cellular effects of D2 receptor activationBrita Robertson
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 7:e35642. 2012..2011, 2012) further emphasize the high degree of conservation of the basal ganglia, also with regard to the indirect loop, and its role as a basic mechanism for action selection in all vertebrates... - Integrative neuroscience: linking levels of analysesSten Grillner
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 17177 Stockholm, Sweden
Curr Opin Neurobiol 15:614-21. 2005..The dynamic processing within any neural system is such that an intuitive interpretation is rarely sufficient... - Mechanisms for selection of basic motor programs--roles for the striatum and pallidumSten Grillner
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
Trends Neurosci 28:364-70. 2005..It is argued that the striatum has a prominent role in selecting which motor program should be called into action... - The motor infrastructure: from ion channels to neuronal networksSten Grillner
Nobel Institute for Neurophysiology, Department of Neuroscience, The Retzius Laboratory, Karolinska Institute, SE-17177 Stockholm, Sweden
Nat Rev Neurosci 4:573-86. 2003 - The pattern of motor coordination underlying the roll in the lampreyPavel V Zelenin
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 171 77, Stockholm, Sweden
J Exp Biol 206:2557-66. 2003..We argue that these modifications of the locomotor pattern generate the moments of force necessary for initiation and termination of the corrective roll turn. Possible neuronal mechanisms causing the corrective movements are discussed... - Afferents of the lamprey optic tectum with special reference to the GABA input: combined tracing and immunohistochemical studyBrita Robertson
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-17177 Stockholm, Sweden
J Comp Neurol 499:106-19. 2006..The afferent input to the optic tectum in the lamprey brain is similar to that described for other vertebrate species, which is of particular interest considering its position in phylogeny... - Role of apamin-sensitive k(ca) channels for reticulospinal synaptic transmission to motoneuron and for the afterhyperpolarizationLorenzo Cangiano
Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institute, 17177 Stockholm, Sweden
J Neurophysiol 88:289-99. 2002..Thus the integration of synaptic signals at the dendritic level in motoneurons appears simpler than would otherwise have been the case... - The spinal locomotor CPG: a target after spinal cord injurySten Grillner
Nobel Institute for Neurophysiology, Department of Neuroscience, Retzius Laboratory, Karolinska Institutet, SE-17177 Stockholm, Sweden
Prog Brain Res 137:97-108. 2002 - Selective projection patterns from subtypes of retinal ganglion cells to tectum and pretectum: distribution and relation to behaviorMarcus Robert Jones
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm SE 171 77, Sweden
J Comp Neurol 517:257-75. 2009..Due to its distribution, morphology, and projections we suggest that this cell may control the dorsal light response... - Evolutionarily conserved differences in pallial and thalamic short-term synaptic plasticity in striatumJesper Ericsson
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
J Physiol 591:859-74. 2013..The difference observed between Th and LPal (cortical) input is also observed in mammals, suggesting a conserved trait throughout vertebrate evolution... - Electrotonic signals along intracellular membranes may interconnect dendritic spines and nucleusIsaac Shemer
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
PLoS Comput Biol 4:e1000036. 2008..This study considers a novel computational role for dendritic spines, and sheds new light on how spines and ER may jointly create an additional level of processing within the single neuron... - Mechanisms for lateral turns in lamprey in response to descending unilateral commands: a modeling studyAlexander K Kozlov
SANS NADA, KTH Royal Institute of Technology, Stockholm, Sweden
Biol Cybern 86:1-14. 2002..This gives a suppressed activity on the turning side and a contralateral rebound after the turn, through activation of calcium-dependent potassium channels... - Innate versus learned movements--a false dichotomy?Sten Grillner
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
Prog Brain Res 143:3-12. 2004..We thus argue that the all-too-common distinction between learned and innate movements is based on a fundamental misconception about the neural control of the vertebrate motor system... - Chapter 13--on walking, chewing, and breathing--a tribute to Serge, Jim, and JackSten Grillner
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Prog Brain Res 188:199-211. 2011..In this brief chapter, I highlight some of their main findings, while I also include some reminiscences of my interaction with them over more than 30 years... - Muscle twitches during sleep shape the precise muscles of the withdrawal reflexSten Grillner
Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Trends Neurosci 27:169-71. 2004..Petersson et al. show that the tactile input produced during muscle twitches occurring during sleep are essential for this process to develop... - Neuronal networks in motion from ion channels to behaviourSten Grillner
Professor-Nobel Institute for Neurophysiology, Karolinska Institute
An R Acad Nac Med (Madr) 123:297-8. 2006 - Intracellular QX-314 causes depression of membrane potential oscillations in lamprey spinal neurons during fictive locomotionGuo-Yuan Hu
Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
J Neurophysiol 87:2676-83. 2002.... - Neuronal substrates for state-dependent changes in coordination between motoneuron pools during fictive locomotion in the lamprey spinal cordTim Mentel
Department of Animal Physiology, Zoological Institute, University of Cologne, 50923 Cologne, North Rhine Westfalia, Germany
J Neurosci 28:868-79. 2008..The spinal organization thus also provides circuitry for different patterns of coordination, i.e., alternation or coactivation of the two pools of motoneurons, which may subserve different forms of locomotor behavior... - From swimming to walking: a single basic network for two different behaviorsTiaza Bem
Department of Bionics, Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, 4 Trojdena, 02 109 Warsaw, Poland
Biol Cybern 88:79-90. 2003..Taken together, our findings support the hypothesis of a phylogenetic conservatism of the spinal locomotor networks generating axial motor patterns from agnathans to amphibians...