S Grillner

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Bridging the gap - from ion channels to networks and behaviour
    S Grillner
    Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, SE 171 77, Sweden
    Curr Opin Neurobiol 9:663-9. 1999
  2. ncbi The spinal locomotor CPG: a target after spinal cord injury
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Retzius Laboratory, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Prog Brain Res 137:97-108. 2002
  3. ncbi Cellular bases of a vertebrate locomotor system-steering, intersegmental and segmental co-ordination and sensory control
    Sten Grillner
    Department of Neuroscience, The Retzius Laboratory Karolinska Institutet, SE 17177, Stockholm, Sweden
    Brain Res Brain Res Rev 40:92-106. 2002
  4. pmc Ion channels of importance for the locomotor pattern generation in the lamprey brainstem-spinal cord
    S Grillner
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden
    J Physiol 533:23-30. 2001
  5. ncbi From egg to action
    S Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain Res Bull 53:473-7. 2000
  6. ncbi The motor infrastructure: from ion channels to neuronal networks
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, The Retzius Laboratory, Karolinska Institute, SE 17177 Stockholm, Sweden
    Nat Rev Neurosci 4:573-86. 2003
  7. ncbi The intrinsic function of a motor system--from ion channels to networks and behavior
    S Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    Brain Res 886:224-236. 2000
  8. ncbi Innate versus learned movements--a false dichotomy?
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Prog Brain Res 143:3-12. 2004
  9. ncbi Muscle twitches during sleep shape the precise muscles of the withdrawal reflex
    Sten Grillner
    Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Trends Neurosci 27:169-71. 2004
  10. ncbi Microcircuits in action--from CPGs to neocortex
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Trends Neurosci 28:525-33. 2005

Collaborators

Detail Information

Publications75

  1. ncbi Bridging the gap - from ion channels to networks and behaviour
    S Grillner
    Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, SE 171 77, Sweden
    Curr Opin Neurobiol 9:663-9. 1999
    ..Recent advances in our understanding of the cellular and circuit properties of motor networks are making it possible to decipher the mechanisms involved in vertebrate motor pattern generation...
  2. ncbi The spinal locomotor CPG: a target after spinal cord injury
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Retzius Laboratory, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Prog Brain Res 137:97-108. 2002
  3. ncbi Cellular bases of a vertebrate locomotor system-steering, intersegmental and segmental co-ordination and sensory control
    Sten Grillner
    Department of Neuroscience, The Retzius Laboratory Karolinska Institutet, SE 17177, Stockholm, Sweden
    Brain Res Brain Res Rev 40:92-106. 2002
    ....
  4. pmc Ion channels of importance for the locomotor pattern generation in the lamprey brainstem-spinal cord
    S Grillner
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden
    J Physiol 533:23-30. 2001
    ....
  5. ncbi From egg to action
    S Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain Res Bull 53:473-7. 2000
    ..Based primarily on the issues presented in the review articles in this issue, I have added some reflections as to what I find most challenging and important...
  6. ncbi The motor infrastructure: from ion channels to neuronal networks
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, The Retzius Laboratory, Karolinska Institute, SE 17177 Stockholm, Sweden
    Nat Rev Neurosci 4:573-86. 2003
  7. ncbi The intrinsic function of a motor system--from ion channels to networks and behavior
    S Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    Brain Res 886:224-236. 2000
    ..This experimental model is bridging the gap between the molecular and cellular level to the network and behavioral level...
  8. ncbi Innate versus learned movements--a false dichotomy?
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Prog Brain Res 143:3-12. 2004
    ..We thus argue that the all-too-common distinction between learned and innate movements is based on a fundamental misconception about the neural control of the vertebrate motor system...
  9. ncbi Muscle twitches during sleep shape the precise muscles of the withdrawal reflex
    Sten Grillner
    Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Trends Neurosci 27:169-71. 2004
    ..Petersson et al. show that the tactile input produced during muscle twitches occurring during sleep are essential for this process to develop...
  10. ncbi Microcircuits in action--from CPGs to neocortex
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Trends Neurosci 28:525-33. 2005
    ..The long-term goal is to identify the components of a molecular and synaptic tool kit for the design of different microcircuits...
  11. ncbi [Health insurance money can be used to increase medical research support]
    Sten Grillner
    Karolinska Institutet, Stockholm
    Lakartidningen 101:2124-6. 2004
  12. ncbi Mechanisms for selection of basic motor programs--roles for the striatum and pallidum
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Trends Neurosci 28:364-70. 2005
    ..It is argued that the striatum has a prominent role in selecting which motor program should be called into action...
  13. ncbi Vertebrate locomotion--a lamprey perspective
    S Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Ann N Y Acad Sci 860:1-18. 1998
    ..Neuropeptides target different cellular and synaptic mechanisms and cause long-lasting changes (> 24 h) in network function...
  14. ncbi Intrinsic function of a neuronal network - a vertebrate central pattern generator
    S Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Brain Res Brain Res Rev 26:184-97. 1998
    ..This is one of the few vertebrate networks that is understood at a cellular level...
  15. ncbi Integrative neuroscience: linking levels of analyses
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 17177 Stockholm, Sweden
    Curr Opin Neurobiol 15:614-21. 2005
    ..The dynamic processing within any neural system is such that an intuitive interpretation is rarely sufficient...
  16. ncbi Modeling of substance P and 5-HT induced synaptic plasticity in the lamprey spinal CPG: consequences for network pattern generation
    A Kozlov
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 171 77 Stockholm, Sweden
    J Comput Neurosci 11:183-200. 2001
    ..The cellular effects of these substances will in the 5-HT case further contribute to its network effect...
  17. ncbi Heterogeneity of the population of command neurons in the lamprey
    P V Zelenin
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE-171 77, Stockholm, Sweden
    J Neurosci 21:7793-803. 2001
    ..The widespread projections and heterogeneity of the population of command neurons present a basis for formation of different gross motor synergies...
  18. ncbi Diencephalic projection to reticulospinal neurons involved in the initiation of locomotion in adult lampreys Lampetra fluviatilis
    A El Manira
    Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden
    J Comp Neurol 389:603-16. 1997
    ..The ventral thalamus, therefore, receives inputs from several different regions in the brain and controls the level of excitability in reticulospinal neurons...
  19. ncbi Impairment and recovery of postural control in rabbits with spinal cord lesions
    V F Lyalka
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Neurophysiol 94:3677-90. 2005
    ..When a part of these pathways is spared, postural reflexes can be restored rapidly, but not the postural limb/trunk configuration. Spinal and supraspinal mechanisms responsible for postural deficits and their compensation are discussed...
  20. ncbi Crossed reciprocal inhibition evoked by electrical stimulation of the lamprey spinal cord
    P Fagerstedt
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Exp Brain Res 134:147-54. 2000
    ..The inhibition was abolished when the split reached nine segments in length. From these experiments, the longitudinal distribution of the commissural axons responsible for inhibition of contralateral motor output could be estimated...
  21. ncbi Modulation of burst frequency by calcium-dependent potassium channels in the lamprey locomotor system: dependence of the activity level
    J Tegner
    Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden
    J Comput Neurosci 5:121-40. 1998
    ..The present simulation model of the spinal network in the lamprey can thus account for earlier experimental results with apamin on the network and cellular level that previously appeared enigmatic...
  22. ncbi GABA(B)-ergic modulation of burst rate and intersegmental coordination in lamprey: experiments and simulations
    J Tegner
    Department of Neuroscience, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Brain Res 864:81-6. 2000
    ..Computer simulations revealed that either a reduced AHP or calcium current could alter the phase coordination between the segments similar to earlier experiments...
  23. pmc Effect of intrathecal administration of serotoninergic and noradrenergic drugs on postural performance in rabbits with spinal cord lesions
    V F Lyalka
    Department of Neuroscience, Karolinska Institute, SE 17177 Stockholm, Sweden
    J Neurophysiol 100:723-32. 2008
    ..We conclude that activation of the serotoninergic system (but not the noradrenergic one) causes selective enhancement of spinal postural reflexes during the earlier postlesion period...
  24. ncbi The activity-dependent plasticity of segmental and intersegmental synaptic connections in the lamprey spinal cord
    D Parker
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    Eur J Neurosci 12:2135-46. 2000
    ..Activity-dependent plasticity could thus contribute to the patterning of the rhythmic network output...
  25. ncbi Gating and braking of short- and long-term modulatory effects by interactions between colocalized neuromodulators
    E Svensson
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, S-17177, Stockholm, Sweden
    J Neurosci 21:5984-92. 2001
    ..Neuromodulator effects and their interactions can thus be modulated. By selecting components from the modulatory repertoire of substance P, these interactions evoke dynamic changes in short- and long-term synaptic and network plasticity...
  26. ncbi Roles of ionic currents in lamprey CpG neurons: a modeling study
    Mikael Huss
    School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
    J Neurophysiol 97:2696-711. 2007
    ..In particular, the balance between the simulated slow sodium-dependent and calcium-dependent potassium currents has been explored, as well as the possible involvement of dendritic conductances...
  27. ncbi Lateral turns in the Lamprey. II. Activity of reticulospinal neurons during the generation of fictive turns
    P Fagerstedt
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden
    J Neurophysiol 86:2257-65. 2001
    ..g., for lateral turns evoked by other types of stimuli, initiation of locomotion, and turns in the vertical planes...
  28. ncbi Long-lasting substance-P-mediated modulation of NMDA-induced rhythmic activity in the lamprey locomotor network involves separate RNA- and protein-synthesis-dependent stages
    D Parker
    Nobel Institute for Neurophysiology, Department of Neurosciences, Karolinska Institute, Stockholm, Sweden
    Eur J Neurosci 11:1515-22. 1999
    ..The change in burst regularity is protein-synthesis-independent, but may depend on activation of protein kinase A for at least 8 h after substance P application...
  29. ncbi Anatomical study of spinobulbar neurons in lampreys
    L Vinay
    Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden
    J Comp Neurol 397:475-92. 1998
    ..These cells may, together with the rostral edge cells, be responsible for the locomotor-related modulation of activity in reticulospinal and vestibulospinal neurons...
  30. ncbi The spinal 5-HT system contributes to the generation of fictive locomotion in lamprey
    W Zhang
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 17177, Stockholm, Sweden
    Brain Res 879:188-92. 2000
    ..The quantitative differences with regard to the 5-HT plexus between P. marinus and L. fluviatilis may account for the observed discrepancy between the two species...
  31. ncbi Mechanisms of rhythm generation in a spinal locomotor network deprived of crossed connections: the lamprey hemicord
    Lorenzo Cangiano
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 17177 Stockholm, Sweden
    J Neurosci 25:923-35. 2005
    ....
  32. doi Nitric oxide potentiation of locomotor activity in the spinal cord of the lamprey
    Alexandros Kyriakatos
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurosci 29:13283-91. 2009
    ..Our results demonstrate a significant role of NO in adult vertebrate motor control which, via modulation of both excitatory and inhibitory transmission, increases the locomotor burst frequency...
  33. ncbi Co-localized neuropeptide Y and GABA have complementary presynaptic effects on sensory synaptic transmission
    D Parker
    Department of Neuroscience, The Karolinska Institute, Stockholm, Sweden
    Eur J Neurosci 10:2856-70. 1998
    ..We conclude that NPY and GABA are colocalized in terminals in the dorsal spinal cord of the lamprey, and that they have complementary actions in modulating sensory inputs...
  34. ncbi Role of AMPA receptor desensitization and the side effects of a DMSO vehicle on reticulospinal EPSPs and locomotor activity
    Nataliya A Tsvyetlynska
    Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden
    J Neurophysiol 94:3951-60. 2005
    ..From the effects of CTZ it is apparent that AMPA receptor desensitization plays an important role in determining locomotor frequency and that this is likely a result of its limiting function on AMPA receptor-mediated EPSPs...
  35. ncbi Endogenous tachykinin release contributes to the locomotor activity in lamprey
    Carolina Thörn Pérez
    Dept of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Neurophysiol 97:3331-9. 2007
    ..1 Hz) of the amplitude of the motor activity. These effects occurred during an initial period of approximately 1 h, whereas a modest long-lasting increase of the burst rate remained after >2 h...
  36. ncbi Endogenous and exogenous dopamine presynaptically inhibits glutamatergic reticulospinal transmission via an action of D2-receptors on N-type Ca2+ channels
    Erik Svensson
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Eur J Neurosci 17:447-54. 2003
    ..DA did not affect the response to extracellularly ejected d-glutamate, the postsynaptic membrane potential, or the electrical component of the EPSPs. DA thus acts at the presynaptic level to modulate reticulospinal transmission...
  37. ncbi Biological pattern generation: the cellular and computational logic of networks in motion
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Neuron 52:751-66. 2006
    ..In addition, I will outline the utility of computational models in analysis of the dynamic actions of these motor networks...
  38. doi Endocannabinoids mediate tachykinin-induced effects in the lamprey locomotor network
    Carolina Thörn Pérez
    Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institute, 171 77 Stockholm, Sweden
    J Neurophysiol 102:1358-65. 2009
    ..The present findings suggest that the effects of substance P on the increase in the locomotor burst frequency and depression of IPSPs are mediated partially via release of endocannabinoids acting through CB1 receptors...
  39. ncbi The spinal GABAergic system is a strong modulator of burst frequency in the lamprey locomotor network
    David E Schmitt
    Nobel Inst for Neurophysiology, Dept of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
    J Neurophysiol 92:2357-67. 2004
    ..It is not required for burst generation, but acts as a powerful modulator...
  40. ncbi Tectal control of locomotion, steering, and eye movements in lamprey
    Kazuya Saitoh
    Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm Brain Institute, Retzius vag 8, SE 171 77 Stockholm, Sweden
    J Neurophysiol 97:3093-108. 2007
    ..These results show that tectum can provide integrated motor responses of eye, body orientation, and locomotion of the type that would be required in goal-directed locomotion...
  41. ncbi Role of glutamate receptor subtypes in the lamprey respiratory network
    F Bongianni
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden
    Brain Res 826:298-302. 1999
    ....
  42. ncbi Postural control in the rabbit maintaining balance on the tilting platform
    I N Beloozerova
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 17177 Stockholm, Sweden
    J Neurophysiol 90:3783-93. 2003
    ..Fourth, we found that the mechanisms for postural corrections respond only to tilts that exceed a certain (threshold) value...
  43. ncbi Slow dorsal-ventral rhythm generator in the lamprey spinal cord
    F Aoki
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden
    J Neurophysiol 85:211-8. 2001
    ..During steering, a selective activation of dorsal and ventral myotomes is required and the neural network generating the slow rhythm may represent activity in the spinal machinery used for steering...
  44. ncbi 5-HT Modulation of identified segmental premotor interneurons in the lamprey spinal cord
    Zoltán Biró
    Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Neurophysiol 96:931-5. 2006
    ..Such modulation of locomotor network interneurons can partially account for the observed effects of 5-HT on the swimming pattern in lamprey...
  45. ncbi Pattern of motor coordination underlying backward swimming in the lamprey
    Salma S Islam
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Neurophysiol 96:451-60. 2006
    ..The role of the spinal cord in generation of different forms of undulatory locomotion (FS and BS) is discussed...
  46. ncbi Effects of flufenamic acid on fictive locomotion, plateau potentials, calcium channels and NMDA receptors in the lamprey spinal cord
    Di Wang
    Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Neuropharmacology 51:1038-46. 2006
    ..These non-selective effects of FFA can account for its influence on fictive locomotion and on membrane potential oscillations and thus, a specific involvement of the I(CAN) current in the lamprey spinal cord is not supported...
  47. ncbi Neural bases of goal-directed locomotion in vertebrates--an overview
    Sten Grillner
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Brain Res Rev 57:2-12. 2008
    ....
  48. ncbi Comparison of the motor effects of individual vestibulo- and reticulospinal neurons on dorsal and ventral myotomes in lamprey
    P V Zelenin
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 171 77 Stockholm, Sweden
    J Neurophysiol 90:3161-7. 2003
    ..By contrast, larger RS neurons can elicit head movement only together with movement of a considerable part of the body and thus seem to be responsible for formation of gross motor synergies...
  49. doi Forebrain dopamine depletion impairs motor behavior in lamprey
    R H Thompson
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, SE 17177, Sweden
    Eur J Neurosci 27:1452-60. 2008
    ..The motor deficits arising after striatal dopamine depletion are thus qualitatively similar in cyclostomes and mammals. The role of the dopamine innervation of the striatum thus appears to be conserved throughout vertebrate evolution...
  50. pmc Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons
    Peter Wallén
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Physiol 585:75-90. 2007
    ..This is, to our knowledge, the first demonstration of a functional role for the Slack gene in contributing to the slow AHP...
  51. doi The activity of spinal commissural interneurons during fictive locomotion in the lamprey
    Zoltán Biró
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Neurophysiol 100:716-22. 2008
    ..Thus in lamprey commissural interneurons, we found a broad distribution of firing rates and phases during fictive locomotion...
  52. ncbi Fast and slow locomotor burst generation in the hemispinal cord of the lamprey
    Lorenzo Cangiano
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 17177 Stockholm, Sweden
    J Neurophysiol 89:2931-42. 2003
    ..Swimming is thus produced by pairs of unilateral burst generating networks with reciprocal inhibitory connections that not only ensure left/right alternation but also downregulate frequency...
  53. ncbi Synaptically evoked membrane potential oscillations induced by substance P in lamprey motor neurons
    Erik Svensson
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Neurophysiol 87:113-21. 2002
    ..Substance P thus has a distributed excitatory effect in the spinal cord. While it can activate premotor networks, this activation alone is not able to evoke a coordinated behaviorally relevant motor output...
  54. ncbi Mechanisms for lateral turns in lamprey in response to descending unilateral commands: a modeling study
    Alexander K Kozlov
    SANS NADA, KTH Royal Institute of Technology, Stockholm, Sweden
    Biol Cybern 86:1-14. 2002
    ..This gives a suppressed activity on the turning side and a contralateral rebound after the turn, through activation of calcium-dependent potassium channels...
  55. ncbi 5-HT inhibits N-type but not L-type Ca(2+) channels via 5-HT1A receptors in lamprey spinal neurons
    Russell H Hill
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 18:2919-24. 2003
    ..As N-type, but not L-type, Ca(2+) channels are known to mediate the activation of KCa channels and presynaptic transmitter release at lamprey synapses, the effects of 5-HT reported here can contribute to a reduction in both actions...
  56. ncbi The pattern of motor coordination underlying the roll in the lamprey
    Pavel V Zelenin
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 171 77, Stockholm, Sweden
    J Exp Biol 206:2557-66. 2003
    ..We argue that these modifications of the locomotor pattern generate the moments of force necessary for initiation and termination of the corrective roll turn. Possible neuronal mechanisms causing the corrective movements are discussed...
  57. ncbi The NO-cGMP pathway in the rat locus coeruleus: electrophysiological, immunohistochemical and in situ hybridization studies
    Z Q Xu
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Eur J Neurosci 10:3508-16. 1998
    ..1994), a few neurons may influence a large population of noradrenergic LC neurons, which in turn may control activity in many regions of the central nervous system...
  58. ncbi Endogenous dopaminergic modulation of the lamprey spinal locomotor network
    Erik Svensson
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Brain Res 970:1-8. 2003
    ....
  59. ncbi GABA distribution in lamprey is phylogenetically conserved
    Brita Robertson
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Comp Neurol 503:47-63. 2007
    ..Since the lamprey diverged from the main vertebrate line around 450 million years ago, this implies that already at that time the basic vertebrate plan for the GABA innervation in different parts of the brain had been developed...
  60. doi Diencephalic locomotor region in the lamprey--afferents and efferent control
    Ariane Menard
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurophysiol 100:1343-53. 2008
    ....
  61. ncbi Role of apamin-sensitive k(ca) channels for reticulospinal synaptic transmission to motoneuron and for the afterhyperpolarization
    Lorenzo Cangiano
    Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institute, 17177 Stockholm, Sweden
    J Neurophysiol 88:289-99. 2002
    ..Thus the integration of synaptic signals at the dendritic level in motoneurons appears simpler than would otherwise have been the case...
  62. pmc Measured motion: searching for simplicity in spinal locomotor networks
    Sten Grillner
    Department of Neuroscience, Nobel institute for Neurophysiology and Stockholm Brain Institute, Karolinska Institute, Stockholm, Sweden
    Curr Opin Neurobiol 19:572-86. 2009
    ..We also describe recent molecular genetic approaches to map and manipulate the connectivity and interactions of spinal interneurons and to assess the impact of such perturbations on network function and motor behavior...
  63. ncbi Modeling a vertebrate motor system: pattern generation, steering and control of body orientation
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Insititutet, Retzius vag 8, SE 171 77 Stockholm, Sweden
    Prog Brain Res 165:221-34. 2007
    ..In the same way the modeling of the control system for steering and control of body orientation is reviewed, including neuromechanical simulations and robotic devices...
  64. pmc Electrotonic signals along intracellular membranes may interconnect dendritic spines and nucleus
    Isaac Shemer
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS Comput Biol 4:e1000036. 2008
    ..This study considers a novel computational role for dendritic spines, and sheds new light on how spines and ER may jointly create an additional level of processing within the single neuron...
  65. doi Selective projection patterns from subtypes of retinal ganglion cells to tectum and pretectum: distribution and relation to behavior
    Marcus Robert Jones
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm SE 171 77, Sweden
    J Comp Neurol 517:257-75. 2009
    ..Due to its distribution, morphology, and projections we suggest that this cell may control the dorsal light response...
  66. doi Dynamics of synaptic transmission between fast-spiking interneurons and striatal projection neurons of the direct and indirect pathways
    Henrike Planert
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Neurosci 30:3499-507. 2010
    ..Our findings show that the two intrastriatal inhibitory pathways have fundamentally different dynamic properties that are, however, similarly applied to both direct and indirect striatal projections...
  67. ncbi Synaptic pathways in neural microcircuits
    Gilad Silberberg
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Trends Neurosci 28:541-51. 2005
    ....
  68. doi The hemisegmental locomotor network revisited
    L Cangiano
    Department of Physiological Sciences, University of Pisa, Via San Zeno 31, I 56123 Pisa, Italy
    Neuroscience 210:33-7. 2012
    ..The wider significance of these data stems from the lamprey being a model of axial locomotion, and from the many lesion studies previously performed in other animals...
  69. ncbi Descending GABAergic projections to the mesencephalic locomotor region in the lamprey Petromyzon marinus
    Ariane Menard
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
    J Comp Neurol 501:260-73. 2007
    ..The GABA agonist inhibited locomotion, whereas the GABA antagonist initiated it. These results suggest that the GABAergic projections to the MLR modulate the activity of MLR neurons, which would be inhibited by GABA at rest...
  70. pmc Input specificity and dependence of spike timing-dependent plasticity on preceding postsynaptic activity at unitary connections between neocortical layer 2/3 pyramidal cells
    Misha Zilberter
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Cereb Cortex 19:2308-20. 2009
    ..We also highlight differences in STDP at excitatory synapses onto L2/3 pyramidal cells which allow for input specific modulation of synaptic gain...
  71. ncbi Afferents of the lamprey optic tectum with special reference to the GABA input: combined tracing and immunohistochemical study
    Brita Robertson
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
    J Comp Neurol 499:106-19. 2006
    ..The afferent input to the optic tectum in the lamprey brain is similar to that described for other vertebrate species, which is of particular interest considering its position in phylogeny...
  72. ncbi Intracellular QX-314 causes depression of membrane potential oscillations in lamprey spinal neurons during fictive locomotion
    Guo Yuan Hu
    Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurophysiol 87:2676-83. 2002
    ....
  73. doi Neuronal substrates for state-dependent changes in coordination between motoneuron pools during fictive locomotion in the lamprey spinal cord
    Tim Mentel
    Department of Animal Physiology, Zoological Institute, University of Cologne, 50923 Cologne, North Rhine Westfalia, Germany
    J Neurosci 28:868-79. 2008
    ..The spinal organization thus also provides circuitry for different patterns of coordination, i.e., alternation or coactivation of the two pools of motoneurons, which may subserve different forms of locomotor behavior...
  74. ncbi From swimming to walking: a single basic network for two different behaviors
    Tiaza Bem
    Department of Bionics, Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, 4 Trojdena, 02 109 Warsaw, Poland
    Biol Cybern 88:79-90. 2003
    ..Taken together, our findings support the hypothesis of a phylogenetic conservatism of the spinal locomotor networks generating axial motor patterns from agnathans to amphibians...
  75. ncbi Neuronal networks in motion from ion channels to behaviour
    Sten Grillner
    Professor Nobel Institute for Neurophysiology, Karolinska Institute
    An R Acad Nac Med (Madr) 123:297-8. 2006